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Protein

Retrovirus-related Pol polyprotein from transposon 412

Gene

POL

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63For protease activityPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Retrovirus-related Pol polyprotein from transposon 412
Including the following 3 domains:
Protease (EC:3.4.23.-)
Reverse transcriptase (EC:2.7.7.49)
Endonuclease
Gene namesi
Name:POL
Synonyms:ORF3
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0043847. 412\ORF3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001995581 – 1237Retrovirus-related Pol polyprotein from transposon 412Add BLAST1237

Proteomic databases

PRIDEiP10394.

Structurei

3D structure databases

ProteinModelPortaliP10394.
SMRiP10394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 131Peptidase A2PROSITE-ProRule annotationAdd BLAST74
Domaini338 – 523Reverse transcriptasePROSITE-ProRule annotationAdd BLAST186
Domaini957 – 1119Integrase catalyticPROSITE-ProRule annotationAdd BLAST163

Sequence similaritiesi

Contains 1 integrase catalytic domain.PROSITE-ProRule annotation
Contains 1 peptidase A2 domain.PROSITE-ProRule annotation
Contains 1 reverse transcriptase domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
3.30.420.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR012337. RNaseH-like_dom.
IPR000477. RT_dom.
IPR015416. Znf_H2C2_histone_UAS-bd.
[Graphical view]
PfamiPF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF09337. zf-H2C2. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10394-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QQSEQLQQKQ CQCTSNPRTG QLATAFRYSV EEDRRVYTIN YNLNIFSTFI
60 70 80 90 100
HAKTGVKLVF LLDTGADISI LKENSDKFSN IQITNKINIQ GIGQQKIQSR
110 120 130 140 150
GQTFIEIQTG KYVIPHDFHL VDKNFPIPCD GIIGIDFIKK YNCQIDLNQE
160 170 180 190 200
EDWFIIRPNN LKFPIYIPIA YSSGINTTLL PARSQVVRRL IVSSKDDNIL
210 220 230 240 250
IPNQEIQTGI YVANTIATSS NTFVRILNTT DSDQLVNMDT LKYEPLSNYN
260 270 280 290 300
VVQANSEHRN KTVLSQLKKN FPELFKSQLE NICSEYIDIF ALESEPITVN
310 320 330 340 350
NLYKQQLRLK DDEPVYTKNY RSPHSQVEEI QAQVQKLIKD KIVEPSVSQY
360 370 380 390 400
NSPLLLVPKK SSPNSDKKKW RLVIDYRQIN KKLLADKFPL PRIDDILDQL
410 420 430 440 450
GRAKYFSCLD LMSGFHQIEL DEGSRDITSF STSNGSYRFT RLPFGLKIAP
460 470 480 490 500
NSFQRMMTIA FSGIEPSQAF LYMDDLIVIG CSEKHMLKNL TEVFGKCREY
510 520 530 540 550
NLKLHPEKCS FFMHEVTFLG HKCTDKGILP DDKKYDVIQN YPVPHDADSA
560 570 580 590 600
RRFVAFCNYY RRFIKNFADY SRHITRLCKK NVPFEWTDEC QKAFIHLKSQ
610 620 630 640 650
LINPTLLQYP DFSKEFCITT DASKQACGAV LTQNHNGHQL PVAYASRAFT
660 670 680 690 700
KGESNKSTTE QELAAIHWAI IHFRPYIYGK HFTVKTDHRP LTYLFSMVNP
710 720 730 740 750
SSKLTRIRLE LEEYNFTVEY LKGKDNHVAD ALSRITIKEL KDITGNILKV
760 770 780 790 800
TTRFQSRQKS CAGKEQLDLQ KQTKEIASEP NVYEVITNDE VRKVVTLQLN
810 820 830 840 850
DSICLFKHGK KIIARYDVGD LYTNGILDLD QFLQRLELQA GIYDISQIKM
860 870 880 890 900
APWKKIFEHV SIDKFKNMGN KILKNLKVAL LNPVTQINNE KEKEAILSTL
910 920 930 940 950
HDDPIQGGHT GITKTLAKVK RHYYWKNMSK YIKEYVRKCQ KCQKAKTTKH
960 970 980 990 1000
TKTPMTITET PEHAFDRVVV DTIGPLPKSE NGNEYAVTLI CDLTKYLVAI
1010 1020 1030 1040 1050
PIANKSAKTV AKAIFESFIL KYGPMKTFIT DMGTEYKNSI ITDLCKYLKI
1060 1070 1080 1090 1100
KNITSTAHHH QTVGVVERSH RTLNEYIRSY ISTDKTDWDV WLQYFVYCFN
1110 1120 1130 1140 1150
TTQSMVHNYC PYELVFGRTS NLPKHFNKLH SIEPIYNIDD YAKESKYRLE
1160 1170 1180 1190 1200
VAYARARKLL EAHKEKNKEN YDLKVKDIEL EVGDKVLLRN EVGHKLDFKY
1210 1220 1230
TGPYKIESIG DNNNITLLTN KNKKQIVHKD RLKKFHS
Length:1,237
Mass (Da):143,042
Last modified:July 1, 1989 - v1
Checksum:iAC57F1C159D14B65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04132 Genomic DNA. Translation: CAA27750.1.
PIRiD29349. GNFF42.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04132 Genomic DNA. Translation: CAA27750.1.
PIRiD29349. GNFF42.

3D structure databases

ProteinModelPortaliP10394.
SMRiP10394.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP10394.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0043847. 412\ORF3.

Miscellaneous databases

ChiTaRSiCG10561. fly.
PROiP10394.

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
3.30.420.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR012337. RNaseH-like_dom.
IPR000477. RT_dom.
IPR015416. Znf_H2C2_histone_UAS-bd.
[Graphical view]
PfamiPF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF09337. zf-H2C2. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOL4_DROME
AccessioniPrimary (citable) accession number: P10394
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Transposable element

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.