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P10371

- HIS4_ECOLI

UniProt

P10371 - HIS4_ECOLI

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Protein
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Gene
hisA, b2024, JW2006
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei7 – 71Proton acceptor By similarity
Active sitei129 – 1291Proton donor By similarity

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: EcoCyc

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: EcoliWiki
  2. histidine biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:PRIBFAICARPISOM-MONOMER.
ECOL316407:JW2006-MONOMER.
MetaCyc:PRIBFAICARPISOM-MONOMER.
UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene namesi
Name:hisA
Ordered Locus Names:b2024, JW2006
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10444. hisA.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2452451-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation
PRO_0000142004Add
BLAST

Proteomic databases

PaxDbiP10371.
PRIDEiP10371.

2D gel databases

SWISS-2DPAGEP10371.

Expressioni

Gene expression databases

GenevestigatoriP10371.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

IntActiP10371. 3 interactions.
STRINGi511145.b2024.

Structurei

3D structure databases

ProteinModelPortaliP10371.
SMRiP10371. Positions 2-244.

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.

Phylogenomic databases

eggNOGiCOG0106.
HOGENOMiHOG000224614.
KOiK01814.
OMAiQRDYGSD.
OrthoDBiEOG6H1Q3W.
PhylomeDBiP10371.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01014. HisA.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR006063. HisA.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00007. TIGR00007. 1 hit.

Sequencei

Sequence statusi: Complete.

P10371-1 [UniParc]FASTAAdd to Basket

« Hide

MIIPALDLID GTVVRLHQGD YGKQRDYGND PLPRLQDYAA QGAEVLHLVD    50
LTGAKDPAKR QIPLIKTLVA GVNVPVQVGG GVRSEEDVAA LLEAGVARVV 100
VGSTAVKSQD MVKGWFERFG ADALVLALDV RIDEQGNKQV AVSGWQENSG 150
VSLEQLVETY LPVGLKHVLC TDISRDGTLA GSNVSLYEEV CARYPQVAFQ 200
SSGGIGDIDD VAALRGTGVR GVIVGRALLE GKFTVKEAIA CWQNA 245
Length:245
Mass (Da):26,033
Last modified:November 1, 1997 - v2
Checksum:iB21D590E4214EE7E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841S → T in CAA31816. 1 Publication
Sequence conflicti126 – 1261L → V in CAA31816. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13462 Genomic DNA. Translation: CAA31816.1.
U00096 Genomic DNA. Translation: AAC75085.2.
AP009048 Genomic DNA. Translation: BAA15855.1.
PIRiG64967. ISECIC.
RefSeqiNP_416528.2. NC_000913.3.
YP_490267.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75085; AAC75085; b2024.
BAA15855; BAA15855; BAA15855.
GeneIDi12931426.
946521.
KEGGiecj:Y75_p1987.
eco:b2024.
PATRICi32119383. VBIEscCol129921_2101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13462 Genomic DNA. Translation: CAA31816.1 .
U00096 Genomic DNA. Translation: AAC75085.2 .
AP009048 Genomic DNA. Translation: BAA15855.1 .
PIRi G64967. ISECIC.
RefSeqi NP_416528.2. NC_000913.3.
YP_490267.1. NC_007779.1.

3D structure databases

ProteinModelPortali P10371.
SMRi P10371. Positions 2-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P10371. 3 interactions.
STRINGi 511145.b2024.

2D gel databases

SWISS-2DPAGE P10371.

Proteomic databases

PaxDbi P10371.
PRIDEi P10371.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75085 ; AAC75085 ; b2024 .
BAA15855 ; BAA15855 ; BAA15855 .
GeneIDi 12931426.
946521.
KEGGi ecj:Y75_p1987.
eco:b2024.
PATRICi 32119383. VBIEscCol129921_2101.

Organism-specific databases

EchoBASEi EB0439.
EcoGenei EG10444. hisA.

Phylogenomic databases

eggNOGi COG0106.
HOGENOMi HOG000224614.
KOi K01814.
OMAi QRDYGSD.
OrthoDBi EOG6H1Q3W.
PhylomeDBi P10371.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .
BioCyci EcoCyc:PRIBFAICARPISOM-MONOMER.
ECOL316407:JW2006-MONOMER.
MetaCyc:PRIBFAICARPISOM-MONOMER.

Miscellaneous databases

PROi P10371.

Gene expression databases

Genevestigatori P10371.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01014. HisA.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR006063. HisA.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR00007. TIGR00007. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons."
    Carlomagno M.S., Chiariotti L., Alifano P., Nappo A.G., Bruni C.B.
    J. Mol. Biol. 203:585-606(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiHIS4_ECOLI
AccessioniPrimary (citable) accession number: P10371
Secondary accession number(s): P78078
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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