Reviewed, UniProtKB/Swiss-Prot P10357 (V70K_TYMV)

Names and origin

Protein names	Recommended name:     69 kDa protein Alternative name(s):     p69
Organism	Turnip yellow mosaic virus
Taxonomic identifier	12154 [NCBI]
Taxonomic lineage	Viruses › ssRNA positive-strand viruses, no DNA stage › Tymoviridae › Tymovirus
Virus host	Brassica [TaxID: 3705] Cardamine lilacina [TaxID: 82359]

Protein attributes

Sequence length	628 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Ref.2
Sequence similarities	Belongs to the tymoviruses 45 to 70 kDa protein family.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 628	628	69 kDa protein		PRO_0000222943

Sequences

	Sequence		Length	Mass (Da)
	P10357-1 [UniParc]. Last modified August 1, 1992. Version 2. Checksum: 9B01CE5ADFCEAC77	FASTA	628	69,195
	10 20 30 40 50 60 MSNGLPISIG RPCTHDSQRS LSAPDSRIHS GFNSLLDTDL PMVHSEGTST PTQLLRHPNI 70 80 90 100 110 120 WFGNLPPPPR RPQDNRDFSP LHPLVFPGHH SQLRHVHETQ QVQQTCPGKL KLSGAEELPP 130 140 150 160 170 180 APQRQHSLPL HITRPSRFPH HFHARRPDVL PSVPDHGPVL TETKPRTSVR QPRSATRGPS 190 200 210 220 230 240 FRPILLPKVV HVHDDPPHSS LRPRGSRSRQ LQPTVRRPLL APNQFHSPRQ PPPLSDDPGI 250 260 270 280 290 300 LGPRPLAPHS TRDPPPRPIT PGPSNTHDLR PLSVLPRTSP RRGLLPNPRR HRTSTGHIPP 310 320 330 340 350 360 TTTSRPTGPP SRLQRPVHLY QSSPHTPNFR PSSIRKDALL QTGPRLGHLE RLGQPANLRT 370 380 390 400 410 420 SERSPPTKRR LPRSSEPNRL PKPLPEATLA PSYRHRRPYP LLPNPPAALP SIAYTSSRGK 430 440 450 460 470 480 IHHSLPKGAL PKEGAPPPPR RLPSPAPRPQ LPLRDLGRTP GFPTPPKTPT RTPESRITAS 490 500 510 520 530 540 PTDIAPLDSD PVLSVRTEVH APERRTFMDP EALRSALASL PSPPRSVGII HTAPQTVLPA 550 560 570 580 590 600 NPPSPTRHLP PTSPPWILQS PVGEDAIVDS EDDSISSFHS HDFDSPSGPL RSQSPSRFRL 610 620 HLRSPSTSSG IEPWSPASYD YGSAPDTD

References

[1]	"Overlapping open reading frames revealed by complete nucleotide sequencing of turnip yellow mosaic virus genomic RNA." Morch M.D., Boyer J.C., Haenni A.L. Nucleic Acids Res. 16:6157-6173(1988) [PubMed: 3399388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]	"Viral virulence protein suppresses RNA silencing-mediated defense but upregulates the role of microrna in host gene expression." Chen J., Li W.X., Xie D., Peng J.R., Ding S.W. Plant Cell 16:1302-1313(2004) [PubMed: 15100397] [Abstract] Cited for: FUNCTION. Strain: Blue Lake.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X07441 Genomic RNA. Translation: CAA30321.1. Sequence problems.
PIR	S01955.
RefSeq	NP_663296.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	951156.
Family and domain databases
InterPro	IPR004935. 45/70kDa_tymoviral. [Graphical view]
Pfam	PF03251. Tymo_45kd_70kd. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

V70K_TYMV

Accession

Primary (citable) accession number: P10357

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	August 1, 1992
Last modified:	July 22, 2008
This is version 33 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)