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Protein

Protein PET122, mitochondrial

Gene

PET122

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for expression of the mitochondrial gene for cytochrome c oxidase subunit 3 (COX3). PET122 seems to work by directly interacting with the small ribosomal subunit to promote translation initiation on the COX3 mRNA.

Miscellaneous

Present with 468 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • translation initiation factor activity Source: SGD

GO - Biological processi

  • mitochondrial respiratory chain complex IV biogenesis Source: SGD
  • positive regulation of mitochondrial translation Source: SGD

Keywordsi

Molecular functionActivator
Biological processTranslation regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30314-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PET122, mitochondrial
Gene namesi
Name:PET122
Ordered Locus Names:YER153C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER153C
SGDiS000000955 PET122

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 8Mitochondrion1 Publication8
ChainiPRO_00000221779 – 254Protein PET122, mitochondrialAdd BLAST246

Proteomic databases

PaxDbiP10355
PRIDEiP10355

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOR1P538392EBI-14103,EBI-28263

Protein-protein interaction databases

BioGridi36903, 176 interactors
DIPiDIP-5415N
IntActiP10355, 3 interactors
MINTiP10355
STRINGi4932.YER153C

Structurei

3D structure databases

ProteinModelPortaliP10355
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni185 – 254Essential for PET122 functionAdd BLAST70

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiP10355
KOiK17668
OrthoDBiEOG092C4A82

Family and domain databases

InterProiView protein in InterPro
IPR008732 Pet122
PfamiView protein in Pfam
PF05476 PET122, 1 hit
PIRSFiPIRSF003326 PET122, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTITKRLVT TDVRSRILLS SLNGKMSDAL ALLRQQQQTS VDVELLHTML
60 70 80 90 100
ARAAALAHAD TIAYMWYQHV MPRRLPVEGR LLCEMAGVAL YQDRLFLPAQ
110 120 130 140 150
FLQHYQAMNR DRRTSPEDEL IEYELRRIKV EAFARGTMHS TALREKWKVF
160 170 180 190 200
LQEMDTLPGQ PPLRLRDFPQ MTKAMGIALM QQDEQAAALA LFGRQPLVIK
210 220 230 240 250
NEWSLPLLLA GVLWHVPGPA QARRVLAEFR QSYRGLPLLD AELVIKRRGF

EINT
Length:254
Mass (Da):29,155
Last modified:December 1, 1992 - v2
Checksum:i321E76E204B93209
GO

Sequence cautioni

The sequence CAA30439 differs from that shown. Reason: Frameshift at position 199.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07558 Genomic DNA Translation: CAA30439.1 Frameshift.
U18917 Genomic DNA Translation: AAB64680.1
AY557785 Genomic DNA Translation: AAS56111.1
BK006939 Genomic DNA Translation: DAA07814.1
PIRiB36328 BVBY22
RefSeqiNP_011080.1, NM_001179043.1

Genome annotation databases

EnsemblFungiiYER153C; YER153C; YER153C
GeneIDi856897
KEGGisce:YER153C

Similar proteinsi

Entry informationi

Entry nameiPT122_YEAST
AccessioniPrimary (citable) accession number: P10355
Secondary accession number(s): D3DM60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 1992
Last modified: March 28, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health