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P10355 (PT122_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein PET122, mitochondrial
Gene names
Name:PET122
Ordered Locus Names:YER153C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for expression of the mitochondrial gene for cytochrome c oxidase subunit 3 (COX3). PET122 seems to work by directly interacting with the small ribosomal subunit to promote translation initiation on the COX3 mRNA.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein Ref.6.

Miscellaneous

Present with 468 molecules/cell in log phase SD medium.

Sequence caution

The sequence CAA30439.1 differs from that shown. Reason: Frameshift at position 199.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 88Mitochondrion Ref.6
Chain9 – 254246Protein PET122, mitochondrial
PRO_0000022177

Regions

Region185 – 25470Essential for PET122 function

Sequences

Sequence LengthMass (Da)Tools
P10355 [UniParc].

Last modified December 1, 1992. Version 2.
Checksum: 321E76E204B93209

FASTA25429,155
        10         20         30         40         50         60 
MLTITKRLVT TDVRSRILLS SLNGKMSDAL ALLRQQQQTS VDVELLHTML ARAAALAHAD 

        70         80         90        100        110        120 
TIAYMWYQHV MPRRLPVEGR LLCEMAGVAL YQDRLFLPAQ FLQHYQAMNR DRRTSPEDEL 

       130        140        150        160        170        180 
IEYELRRIKV EAFARGTMHS TALREKWKVF LQEMDTLPGQ PPLRLRDFPQ MTKAMGIALM 

       190        200        210        220        230        240 
QQDEQAAALA LFGRQPLVIK NEWSLPLLLA GVLWHVPGPA QARRVLAEFR QSYRGLPLLD 

       250 
AELVIKRRGF EINT 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and nucleotide sequence of the nuclear PET122 gene required for expression of the mitochondrial COX3 gene in S. cerevisiae."
Ohmen J.D., Kloeckener-Gruissem B., McEwen J.E.
Nucleic Acids Res. 16:10783-10802(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204510 / AB320.
[2]"Divergent overlapping transcripts at the PET122 locus in Saccharomyces cerevisiae."
Ohmen J.D., Burke K.A., McEwen J.E.
Mol. Cell. Biol. 10:3027-3035(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"COX3 mRNA-specific translational activator proteins are associated with the inner mitochondrial membrane in Saccharomyces cerevisiae."
McMullin T.W., Fox T.D.
J. Biol. Chem. 268:11737-11741(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 9-19, SUBCELLULAR LOCATION.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X07558 Genomic DNA. Translation: CAA30439.1. Frameshift.
U18917 Genomic DNA. Translation: AAB64680.1.
AY557785 Genomic DNA. Translation: AAS56111.1.
BK006939 Genomic DNA. Translation: DAA07814.1.
PIRBVBY22. B36328.
RefSeqNP_011080.1. NM_001179043.1.

3D structure databases

ProteinModelPortalP10355.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36903. 85 interactions.
DIPDIP-5415N.
IntActP10355. 2 interactions.
MINTMINT-529419.
STRING4932.YER153C.

Proteomic databases

PaxDbP10355.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER153C; YER153C; YER153C.
GeneID856897.
KEGGsce:YER153C.

Organism-specific databases

CYGDYER153c.
SGDS000000955. PET122.

Phylogenomic databases

eggNOGNOG84030.
KOK17668.
OrthoDBEOG76HQDQ.

Enzyme and pathway databases

BioCycYEAST:G3O-30314-MONOMER.

Gene expression databases

GenevestigatorP10355.

Family and domain databases

InterProIPR008732. PET122.
[Graphical view]
PfamPF05476. PET122. 1 hit.
[Graphical view]
PIRSFPIRSF003326. PET122. 1 hit.
ProtoNetSearch...

Other

NextBio983313.

Entry information

Entry namePT122_YEAST
AccessionPrimary (citable) accession number: P10355
Secondary accession number(s): D3DM60
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD