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Protein

Protein PET122, mitochondrial

Gene

PET122

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for expression of the mitochondrial gene for cytochrome c oxidase subunit 3 (COX3). PET122 seems to work by directly interacting with the small ribosomal subunit to promote translation initiation on the COX3 mRNA.

Miscellaneous

Present with 468 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • translation initiation factor activity Source: SGD

GO - Biological processi

  • mitochondrial respiratory chain complex IV biogenesis Source: SGD
  • positive regulation of mitochondrial translation Source: SGD

Keywordsi

Molecular functionActivator
Biological processTranslation regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30314-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PET122, mitochondrial
Gene namesi
Name:PET122
Ordered Locus Names:YER153C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER153C.
SGDiS000000955. PET122.

Subcellular locationi

  • Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  • integral component of mitochondrial inner membrane Source: SGD
  • mitochondrial inner membrane Source: SGD

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 8Mitochondrion1 Publication8
ChainiPRO_00000221779 – 254Protein PET122, mitochondrialAdd BLAST246

Proteomic databases

PRIDEiP10355.

Interactioni

Protein-protein interaction databases

BioGridi36903. 174 interactors.
DIPiDIP-5415N.
IntActiP10355. 2 interactors.
MINTiMINT-529419.
STRINGi4932.YER153C.

Structurei

3D structure databases

ProteinModelPortaliP10355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni185 – 254Essential for PET122 functionAdd BLAST70

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiP10355.
KOiK17668.
OrthoDBiEOG092C4A82.

Family and domain databases

InterProiView protein in InterPro
IPR008732. Pet122.
PfamiView protein in Pfam
PF05476. PET122. 1 hit.
PIRSFiPIRSF003326. PET122. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTITKRLVT TDVRSRILLS SLNGKMSDAL ALLRQQQQTS VDVELLHTML
60 70 80 90 100
ARAAALAHAD TIAYMWYQHV MPRRLPVEGR LLCEMAGVAL YQDRLFLPAQ
110 120 130 140 150
FLQHYQAMNR DRRTSPEDEL IEYELRRIKV EAFARGTMHS TALREKWKVF
160 170 180 190 200
LQEMDTLPGQ PPLRLRDFPQ MTKAMGIALM QQDEQAAALA LFGRQPLVIK
210 220 230 240 250
NEWSLPLLLA GVLWHVPGPA QARRVLAEFR QSYRGLPLLD AELVIKRRGF

EINT
Length:254
Mass (Da):29,155
Last modified:December 1, 1992 - v2
Checksum:i321E76E204B93209
GO

Sequence cautioni

The sequence CAA30439 differs from that shown. Reason: Frameshift at position 199.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07558 Genomic DNA. Translation: CAA30439.1. Frameshift.
U18917 Genomic DNA. Translation: AAB64680.1.
AY557785 Genomic DNA. Translation: AAS56111.1.
BK006939 Genomic DNA. Translation: DAA07814.1.
PIRiB36328. BVBY22.
RefSeqiNP_011080.1. NM_001179043.1.

Genome annotation databases

EnsemblFungiiYER153C; YER153C; YER153C.
GeneIDi856897.
KEGGisce:YER153C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPT122_YEAST
AccessioniPrimary (citable) accession number: P10355
Secondary accession number(s): D3DM60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 1992
Last modified: July 5, 2017
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names