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P10355

- PT122_YEAST

UniProt

P10355 - PT122_YEAST

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Protein

Protein PET122, mitochondrial

Gene
PET122, YER153C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Required for expression of the mitochondrial gene for cytochrome c oxidase subunit 3 (COX3). PET122 seems to work by directly interacting with the small ribosomal subunit to promote translation initiation on the COX3 mRNA.

GO - Molecular functioni

  1. translation initiation factor activity Source: SGD

GO - Biological processi

  1. mitochondrial respiratory chain complex IV biogenesis Source: SGD
  2. positive regulation of mitochondrial translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Translation regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30314-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PET122, mitochondrial
Gene namesi
Name:PET122
Ordered Locus Names:YER153C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER153c.
SGDiS000000955. PET122.

Subcellular locationi

Mitochondrion inner membrane; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of mitochondrial inner membrane Source: SGD
  2. mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 88Mitochondrion1 Publication
Chaini9 – 254246Protein PET122, mitochondrialPRO_0000022177Add
BLAST

Proteomic databases

PaxDbiP10355.

Expressioni

Gene expression databases

GenevestigatoriP10355.

Interactioni

Protein-protein interaction databases

BioGridi36903. 85 interactions.
DIPiDIP-5415N.
IntActiP10355. 2 interactions.
MINTiMINT-529419.
STRINGi4932.YER153C.

Structurei

3D structure databases

ProteinModelPortaliP10355.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni185 – 25470Essential for PET122 functionAdd
BLAST

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG84030.
KOiK17668.
OrthoDBiEOG76HQDQ.

Family and domain databases

InterProiIPR008732. PET122.
[Graphical view]
PfamiPF05476. PET122. 1 hit.
[Graphical view]
PIRSFiPIRSF003326. PET122. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10355-1 [UniParc]FASTAAdd to Basket

« Hide

MLTITKRLVT TDVRSRILLS SLNGKMSDAL ALLRQQQQTS VDVELLHTML    50
ARAAALAHAD TIAYMWYQHV MPRRLPVEGR LLCEMAGVAL YQDRLFLPAQ 100
FLQHYQAMNR DRRTSPEDEL IEYELRRIKV EAFARGTMHS TALREKWKVF 150
LQEMDTLPGQ PPLRLRDFPQ MTKAMGIALM QQDEQAAALA LFGRQPLVIK 200
NEWSLPLLLA GVLWHVPGPA QARRVLAEFR QSYRGLPLLD AELVIKRRGF 250
EINT 254
Length:254
Mass (Da):29,155
Last modified:December 1, 1992 - v2
Checksum:i321E76E204B93209
GO

Sequence cautioni

The sequence CAA30439.1 differs from that shown. Reason: Frameshift at position 199.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07558 Genomic DNA. Translation: CAA30439.1. Frameshift.
U18917 Genomic DNA. Translation: AAB64680.1.
AY557785 Genomic DNA. Translation: AAS56111.1.
BK006939 Genomic DNA. Translation: DAA07814.1.
PIRiB36328. BVBY22.
RefSeqiNP_011080.1. NM_001179043.1.

Genome annotation databases

EnsemblFungiiYER153C; YER153C; YER153C.
GeneIDi856897.
KEGGisce:YER153C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X07558 Genomic DNA. Translation: CAA30439.1 . Frameshift.
U18917 Genomic DNA. Translation: AAB64680.1 .
AY557785 Genomic DNA. Translation: AAS56111.1 .
BK006939 Genomic DNA. Translation: DAA07814.1 .
PIRi B36328. BVBY22.
RefSeqi NP_011080.1. NM_001179043.1.

3D structure databases

ProteinModelPortali P10355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36903. 85 interactions.
DIPi DIP-5415N.
IntActi P10355. 2 interactions.
MINTi MINT-529419.
STRINGi 4932.YER153C.

Proteomic databases

PaxDbi P10355.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER153C ; YER153C ; YER153C .
GeneIDi 856897.
KEGGi sce:YER153C.

Organism-specific databases

CYGDi YER153c.
SGDi S000000955. PET122.

Phylogenomic databases

eggNOGi NOG84030.
KOi K17668.
OrthoDBi EOG76HQDQ.

Enzyme and pathway databases

BioCyci YEAST:G3O-30314-MONOMER.

Miscellaneous databases

NextBioi 983313.

Gene expression databases

Genevestigatori P10355.

Family and domain databases

InterProi IPR008732. PET122.
[Graphical view ]
Pfami PF05476. PET122. 1 hit.
[Graphical view ]
PIRSFi PIRSF003326. PET122. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and nucleotide sequence of the nuclear PET122 gene required for expression of the mitochondrial COX3 gene in S. cerevisiae."
    Ohmen J.D., Kloeckener-Gruissem B., McEwen J.E.
    Nucleic Acids Res. 16:10783-10802(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204510 / AB320.
  2. "Divergent overlapping transcripts at the PET122 locus in Saccharomyces cerevisiae."
    Ohmen J.D., Burke K.A., McEwen J.E.
    Mol. Cell. Biol. 10:3027-3035(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "COX3 mRNA-specific translational activator proteins are associated with the inner mitochondrial membrane in Saccharomyces cerevisiae."
    McMullin T.W., Fox T.D.
    J. Biol. Chem. 268:11737-11741(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 9-19, SUBCELLULAR LOCATION.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPT122_YEAST
AccessioniPrimary (citable) accession number: P10355
Secondary accession number(s): D3DM60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 1992
Last modified: May 14, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 468 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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