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Protein

Outer membrane lipoprotein pcp

Gene

pcp

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane lipoprotein pcp
Alternative name(s):
15 kDa lipoprotein
PAL cross-reacting lipoprotein
Gene namesi
Name:pcp
Synonyms:lpp
Ordered Locus Names:HI_1579
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 155137Outer membrane lipoprotein pcpPRO_0000018159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi19 – 191N-palmitoyl cysteine1 PublicationPROSITE-ProRule annotation
Lipidationi19 – 191S-diacylglycerol cysteine1 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiP10325.

Interactioni

Protein-protein interaction databases

STRINGi71421.HI1579.

Family & Domainsi

Sequence similaritiesi

Belongs to the Pcp/SlyB lipoprotein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3133.
KOiK06077.
OMAiNSAYTSY.
OrthoDBiEOG60W7X5.
PhylomeDBiP10325.

Family and domain databases

InterProiIPR008816. Gly_zipper_2TM_dom.
[Graphical view]
PfamiPF05433. Rick_17kDa_Anti. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTNMALAL LVAFSVTGCA NTDIFSGDVY SASQAKEARS ITYGTIVSVR
60 70 80 90 100
PVKIQADNQG VVGTLGGGAL GGIAGSTIGG GRGQAIAAVV GAIGGAIAGS
110 120 130 140 150
KIEEKMSQVN GAELVIKKDD GQEIVVVQKA DSSFCSLVAE FVFVGGGSSL

NVSVL
Length:155
Mass (Da):15,425
Last modified:November 1, 1995 - v2
Checksum:iD7880327FCF0C985
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1439CSLVAEFVF → VAGRRVRI in AAA24938 (PubMed:2828309).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18877 mRNA. Translation: AAA24938.1.
L42023 Genomic DNA. Translation: AAC23228.1.
PIRiI64130.
RefSeqiNP_439725.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23228; AAC23228; HI_1579.
GeneIDi950439.
KEGGihin:HI1579.
PATRICi20191889. VBIHaeInf48452_1652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18877 mRNA. Translation: AAA24938.1.
L42023 Genomic DNA. Translation: AAC23228.1.
PIRiI64130.
RefSeqiNP_439725.1. NC_000907.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1579.

Proteomic databases

PRIDEiP10325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23228; AAC23228; HI_1579.
GeneIDi950439.
KEGGihin:HI1579.
PATRICi20191889. VBIHaeInf48452_1652.

Phylogenomic databases

eggNOGiCOG3133.
KOiK06077.
OMAiNSAYTSY.
OrthoDBiEOG60W7X5.
PhylomeDBiP10325.

Family and domain databases

InterProiIPR008816. Gly_zipper_2TM_dom.
[Graphical view]
PfamiPF05433. Rick_17kDa_Anti. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of genes encoding a 15,000-dalton peptidoglycan-associated outer membrane lipoprotein and an antigenically related 15,000-dalton protein from Haemophilus influenzae."
    Deich R.A., Metcalf B.J., Finn C.W., Farley J.E., Green B.A.
    J. Bacteriol. 170:489-498(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DIACYLGLYCEROL AT CYS-19, PALMITOYLATION AT CYS-19.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiPCP_HAEIN
AccessioniPrimary (citable) accession number: P10325
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.