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Protein

Outer membrane protein P6

Gene

pal

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thought to play a role in bacterial envelope integrity. Links the outer membrane to the peptidoglycan layer.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein P6
Short name:
OMP P6
Alternative name(s):
15 kDa peptidoglycan-associated lipoprotein
Short name:
PC protein
Gene namesi
Name:pal
Synonyms:ompP6
Ordered Locus Names:HI_0381
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Protein family/group databases

Allergomei7668. Hae in P6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 153134Outer membrane protein P6PRO_0000020123Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi20 – 201N-palmitoyl cysteinePROSITE-ProRule annotation1 Publication
Lipidationi20 – 201S-diacylglycerol cysteinePROSITE-ProRule annotation1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0381.

Structurei

Secondary structure

1
153
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 294Combined sources
Helixi41 – 444Combined sources
Turni45 – 473Combined sources
Beta strandi50 – 523Combined sources
Helixi62 – 7716Combined sources
Beta strandi83 – 886Combined sources
Beta strandi91 – 933Combined sources
Helixi95 – 11521Combined sources
Helixi120 – 1223Combined sources
Beta strandi123 – 1275Combined sources
Turni129 – 1313Combined sources
Helixi140 – 1467Combined sources
Beta strandi147 – 1526Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AIZNMR-P20-153[»]
ProteinModelPortaliP10324.
SMRiP10324. Positions 20-153.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10324.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 153114OmpA-likePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni55 – 562Peptidoglycan binding
Regioni97 – 1015Peptidoglycan binding

Sequence similaritiesi

Belongs to the OmpA family. Pal subfamily.Curated
Contains 1 OmpA-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105KCK. Bacteria.
COG2885. LUCA.
KOiK03640.
OMAiQLNVVSY.
OrthoDBiEOG6PP9QB.
PhylomeDBiP10324.

Family and domain databases

Gene3Di3.30.1330.60. 1 hit.
InterProiIPR006664. OMP_bac.
IPR006665. OmpA-like.
IPR006690. OMPA-like_CS.
IPR014169. Pal_lipo.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
SUPFAMiSSF103088. SSF103088. 1 hit.
TIGRFAMsiTIGR02802. Pal_lipo. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKFVKSLLV AGSVAALAAC SSSNNDAAGN GAAQTFGGYS VADLQQRYNT
60 70 80 90 100
VYFGFDKYDI TGEYVQILDA HAAYLNATPA AKVLVEGNTD ERGTPEYNIA
110 120 130 140 150
LGQRRADAVK GYLAGKGVDA GKLGTVSYGE EKPAVLGHDE AAYSKNRRAV

LAY
Length:153
Mass (Da):16,108
Last modified:July 1, 1989 - v1
Checksum:i3DF358122EF17A11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19391 Genomic DNA. Translation: AAA24994.1.
M18878 Genomic DNA. Translation: AAA24940.1.
L42023 Genomic DNA. Translation: AAC22039.1.
PIRiA28543.
RefSeqiNP_438542.1. NC_000907.1.
WP_005652235.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22039; AAC22039; HI_0381.
GeneIDi949485.
KEGGihin:HI0381.
PATRICi20189311. VBIHaeInf48452_0399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19391 Genomic DNA. Translation: AAA24994.1.
M18878 Genomic DNA. Translation: AAA24940.1.
L42023 Genomic DNA. Translation: AAC22039.1.
PIRiA28543.
RefSeqiNP_438542.1. NC_000907.1.
WP_005652235.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AIZNMR-P20-153[»]
ProteinModelPortaliP10324.
SMRiP10324. Positions 20-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0381.

Protein family/group databases

Allergomei7668. Hae in P6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22039; AAC22039; HI_0381.
GeneIDi949485.
KEGGihin:HI0381.
PATRICi20189311. VBIHaeInf48452_0399.

Phylogenomic databases

eggNOGiENOG4105KCK. Bacteria.
COG2885. LUCA.
KOiK03640.
OMAiQLNVVSY.
OrthoDBiEOG6PP9QB.
PhylomeDBiP10324.

Miscellaneous databases

EvolutionaryTraceiP10324.

Family and domain databases

Gene3Di3.30.1330.60. 1 hit.
InterProiIPR006664. OMP_bac.
IPR006665. OmpA-like.
IPR006690. OMPA-like_CS.
IPR014169. Pal_lipo.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
SUPFAMiSSF103088. SSF103088. 1 hit.
TIGRFAMsiTIGR02802. Pal_lipo. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of genes encoding a 15,000-dalton peptidoglycan-associated outer membrane lipoprotein and an antigenically related 15,000-dalton protein from Haemophilus influenzae."
    Deich R.A., Metcalf B.J., Finn C.W., Farley J.E., Green B.A.
    J. Bacteriol. 170:489-498(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, DIACYLGLYCEROL AT CYS-20, PALMITOYLATION AT CYS-20.
  2. "Cloning and sequencing of Haemophilus influenzae outer membrane protein P6."
    Nelson M.B., Apicella M.A., Murphy T.F., Vankeulen H., Spotila L.D., Rekosh D.
    Infect. Immun. 56:128-134(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  4. "Peptidoglycan recognition by Pal, an outer membrane lipoprotein."
    Parsons L.M., Lin F., Orban J.
    Biochemistry 45:2122-2128(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 20-153 IN COMPLEX WITH PEPTIDOGLYCAN.

Entry informationi

Entry nameiPAL_HAEIN
AccessioniPrimary (citable) accession number: P10324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 11, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.