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P10321

- 1C07_HUMAN

UniProt

P10321 - 1C07_HUMAN

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Protein

HLA class I histocompatibility antigen, Cw-7 alpha chain

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. peptide antigen binding Source: UniProt

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytokine-mediated signaling pathway Source: Reactome
  6. interferon-gamma-mediated signaling pathway Source: Reactome
  7. positive regulation of T cell mediated cytotoxicity Source: InterPro
  8. regulation of immune response Source: Reactome
  9. type I interferon signaling pathway Source: Reactome
  10. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, Cw-7 alpha chain
Alternative name(s):
MHC class I antigen Cw*7
Gene namesi
Name:HLA-C
Synonyms:HLAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4933. HLA-C.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. early endosome membrane Source: Reactome
  3. endoplasmic reticulum Source: UniProt
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. extracellular vesicular exosome Source: UniProt
  6. Golgi apparatus Source: UniProt
  7. Golgi membrane Source: Reactome
  8. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  9. MHC class I protein complex Source: UniProt
  10. phagocytic vesicle membrane Source: Reactome
  11. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 366342HLA class I histocompatibility antigen, Cw-7 alpha chainPRO_0000018874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP10321.
PRIDEiP10321.

Expressioni

Gene expression databases

BgeeiP10321.
CleanExiHS_HLA-C.
ExpressionAtlasiP10321. baseline and differential.
GenevestigatoriP10321.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.By similarity

Protein-protein interaction databases

BioGridi109352. 62 interactions.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BZFX-ray2.50P/Q3-11[»]
ProteinModelPortaliP10321.
SMRiP10321. Positions 26-298.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10321.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
BLAST
Topological domaini334 – 36633CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei309 – 33325HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29789Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
KOiK06751.
OrthoDBiEOG7JT6WQ.
PhylomeDBiP10321.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10321-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV
110 120 130 140 150
SLRNLRGYYN QSEDGSHTLQ RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP
310 320 330 340 350
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC
360
SNSAQGSDES LITCKA
Length:366
Mass (Da):40,649
Last modified:December 20, 2005 - v3
Checksum:i59C23D95FD1D0BC8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 162GG → AA in AAA50217. 1 PublicationCurated
Sequence conflicti41 – 411R → A in AAA52665. (PubMed:3863816)Curated
Sequence conflicti309 – 3091M → V in AAA53259. (PubMed:2714852)Curated

Polymorphismi

The following alleles of Cw-7 are known: Cw*07:01, Cw*07:02, Cw*07:03, Cw*07:04, Cw*07:06, Cw*07:09 and Cw*07:11. The sequence shown is that of Cw*07:02.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101L → I.
Corresponds to variant rs2308527 [ dbSNP | Ensembl ].
VAR_059506
Natural varianti43 – 431E → K.
Corresponds to variant rs1050438 [ dbSNP | Ensembl ].
VAR_050345
Natural varianti48 – 481S → A.
Corresponds to variant rs707911 [ dbSNP | Ensembl ].
VAR_061450
Natural varianti48 – 481S → P.
Corresponds to variant rs707911 [ dbSNP | Ensembl ].
VAR_061451
Natural varianti48 – 481S → T.
Corresponds to variant rs707911 [ dbSNP | Ensembl ].
VAR_061452
Natural varianti73 – 731A → E.
Corresponds to variant rs1050409 [ dbSNP | Ensembl ].
VAR_050346
Natural varianti76 – 761V → M.
Corresponds to variant rs1065382 [ dbSNP | Ensembl ].
VAR_050347
Natural varianti90 – 901K → N in allele Cw*07:01.
Corresponds to variant rs28626310 [ dbSNP | Ensembl ].
VAR_016590
Natural varianti97 – 971A → T.
Corresponds to variant rs41543814 [ dbSNP | Ensembl ].
VAR_050348
Natural varianti101 – 1011S → N in allele Cw*07:09.
Corresponds to variant rs2308557 [ dbSNP | Ensembl ].
VAR_016591
Natural varianti104 – 1041N → K in allele Cw*07:09.
Corresponds to variant rs17408553 [ dbSNP | Ensembl ].
VAR_016592
Natural varianti119 – 1191L → F in allele Cw*07:04 and allele Cw*07:11.
Corresponds to variant rs1071649 [ dbSNP | Ensembl ].
VAR_016593
Natural varianti123 – 1231S → C.
Corresponds to variant rs1131115 [ dbSNP | Ensembl ].
VAR_059507
Natural varianti123 – 1231S → F.
Corresponds to variant rs1131115 [ dbSNP | Ensembl ].
VAR_059508
Natural varianti123 – 1231S → Y in allele Cw*07:01.
Corresponds to variant rs1131115 [ dbSNP | Ensembl ].
VAR_016594
Natural varianti137 – 1371Y → H.
Corresponds to variant rs2308574 [ dbSNP | Ensembl ].
VAR_050349
Natural varianti140 – 1401S → F in allele Cw*07:04 and allele Cw*07:11.
Corresponds to variant rs713032 [ dbSNP | Ensembl ].
VAR_016595
Natural varianti171 – 1711L → W in allele Cw*07:03.
Corresponds to variant rs1050366 [ dbSNP | Ensembl ].
VAR_016646
Natural varianti180 – 1801L → D in allele Cw*07:04 and allele Cw*07:11; requires 2 nucleotide substitutions.
VAR_016596
Natural varianti182 – 1821A → V.
Corresponds to variant rs1059539 [ dbSNP | Ensembl ].
VAR_050350
Natural varianti187 – 1871T → L in allele Cw*07:03; requires 2 nucleotide substitutions.
VAR_016647
Natural varianti201 – 2011E → K in allele Cw*07:04 and allele Cw0711.
Corresponds to variant rs1131103 [ dbSNP | Ensembl ].
VAR_016597
Natural varianti208 – 2081P → H.
Corresponds to variant rs1131096 [ dbSNP | Ensembl ].
VAR_061453
Natural varianti208 – 2081P → R.
Corresponds to variant rs1131096 [ dbSNP | Ensembl ].
VAR_061454
Natural varianti272 – 2721V → M.
Corresponds to variant rs1050276 [ dbSNP | Ensembl ].
VAR_050351
Natural varianti328 – 3281V → I.
Corresponds to variant rs1050118 [ dbSNP | Ensembl ].
VAR_050352
Natural varianti330 – 3301A → V.
Corresponds to variant rs1050105 [ dbSNP | Ensembl ].
VAR_050353
Natural varianti331 – 3311M → K in allele Cw*07:06.
Corresponds to variant rs41542414 [ dbSNP | Ensembl ].
VAR_016598
Natural varianti331 – 3311M → V.
Corresponds to variant rs1130935 [ dbSNP | Ensembl ].
VAR_050354
Natural varianti348 – 3481A → V in allele Cw*07:06.
Corresponds to variant rs41559915 [ dbSNP | Ensembl ].
VAR_016599
Natural varianti350 – 3501C → S.
Corresponds to variant rs35708511 [ dbSNP | Ensembl ].
VAR_061455
Natural varianti363 – 3631T → A in allele Cw*07:11.
Corresponds to variant rs1130838 [ dbSNP | Ensembl ].
VAR_016600

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83394 mRNA. Translation: CAA58313.1.
D38526 mRNA. Translation: BAA07531.1.
D49819 mRNA. Translation: BAA08625.1.
D49552 mRNA. Translation: BAA08500.1.
X97321 mRNA. Translation: CAA65986.1.
AJ001977 Genomic DNA. Translation: CAA05125.1. Sequence problems.
AJ010749 mRNA. Translation: CAA09341.1.
AJ293016 Genomic DNA. Translation: CAC04321.1.
AJ293017 Genomic DNA. Translation: CAC04322.1.
AJ291815 Genomic DNA. Translation: CAC19191.1.
U09853 mRNA. Translation: AAA50217.1.
AL671883 Genomic DNA. No translation available.
Z46810 mRNA. Translation: CAA86840.1.
M11886 mRNA. Translation: AAA52665.1.
AH006132 Genomic DNA. Translation: AAC17722.1.
Y18533
, Y18534, Y18535, Y18536 Genomic DNA. Translation: CAB71800.1.
M28207 mRNA. Translation: AAA53259.1.
CCDSiCCDS34393.1.
PIRiA24512. HLHUC4.
I37078.
I37529.
I68750.
RefSeqiNP_002108.4. NM_002117.5.
UniGeneiHs.656020.
Hs.743218.
Hs.77961.

Genome annotation databases

EnsembliENST00000376228; ENSP00000365402; ENSG00000204525.
GeneIDi3107.
KEGGihsa:3107.
UCSCiuc003nsy.3. human.

Polymorphism databases

DMDMi84028168.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83394 mRNA. Translation: CAA58313.1 .
D38526 mRNA. Translation: BAA07531.1 .
D49819 mRNA. Translation: BAA08625.1 .
D49552 mRNA. Translation: BAA08500.1 .
X97321 mRNA. Translation: CAA65986.1 .
AJ001977 Genomic DNA. Translation: CAA05125.1 . Sequence problems.
AJ010749 mRNA. Translation: CAA09341.1 .
AJ293016 Genomic DNA. Translation: CAC04321.1 .
AJ293017 Genomic DNA. Translation: CAC04322.1 .
AJ291815 Genomic DNA. Translation: CAC19191.1 .
U09853 mRNA. Translation: AAA50217.1 .
AL671883 Genomic DNA. No translation available.
Z46810 mRNA. Translation: CAA86840.1 .
M11886 mRNA. Translation: AAA52665.1 .
AH006132 Genomic DNA. Translation: AAC17722.1 .
Y18533
, Y18534 , Y18535 , Y18536 Genomic DNA. Translation: CAB71800.1 .
M28207 mRNA. Translation: AAA53259.1 .
CCDSi CCDS34393.1.
PIRi A24512. HLHUC4.
I37078.
I37529.
I68750.
RefSeqi NP_002108.4. NM_002117.5.
UniGenei Hs.656020.
Hs.743218.
Hs.77961.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3BZF X-ray 2.50 P/Q 3-11 [» ]
ProteinModelPortali P10321.
SMRi P10321. Positions 26-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109352. 62 interactions.

Polymorphism databases

DMDMi 84028168.

Proteomic databases

MaxQBi P10321.
PRIDEi P10321.

Protocols and materials databases

DNASUi 3107.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376228 ; ENSP00000365402 ; ENSG00000204525 .
GeneIDi 3107.
KEGGi hsa:3107.
UCSCi uc003nsy.3. human.

Organism-specific databases

CTDi 3107.
GeneCardsi GC06M031236.
HGNCi HGNC:4933. HLA-C.
MIMi 142840. gene.
neXtProti NX_P10321.
PharmGKBi PA35057.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG016709.
KOi K06751.
OrthoDBi EOG7JT6WQ.
PhylomeDBi P10321.
TreeFami TF336617.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-C. human.
EvolutionaryTracei P10321.
GeneWikii HLA-C.
GenomeRNAii 3107.
NextBioi 12327.
SOURCEi Search...

Gene expression databases

Bgeei P10321.
CleanExi HS_HLA-C.
ExpressionAtlasi P10321. baseline and differential.
Genevestigatori P10321.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Anchored PCR cloning of the novel HLA-Cw*0704 allele detected by PCR-SSP."
    Vilches C., Bunce M., de Pablo R., Herrero M.J., Kreisler M.
    Tissue Antigens 46:19-23(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*07:04).
  2. "Identification and DNA typing of two Cw7 alleles (Cw*0702 and Cw*0704) in Japanese, with the corrected sequence of Cw*0702."
    Wang H., Tokunaga K., Ishikawa Y., Asahina A., Kuwata S., Akaza T., Tadokoro K., Shibata Y., Takiguchi M., Juji T.
    Hum. Immunol. 45:52-58(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES CW*07:02 AND CW*07:04).
    Tissue: Blood.
  3. "Molecular cloning of two new HLA-C alleles: Cw*1801 and Cw*0706."
    Vilches C., Bunce M., Sanz L., de Pablo R., Puente S., Kreisler M.
    Tissue Antigens 48:698-702(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*07:06).
  4. "A major histocompatibility complex class I allele shared by two species of chimpanzee."
    Cooper S.L., Adams E.J., Wells R.S., Walker C.M., Parham P.
    Immunogenetics 47:212-217(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*07:02).
  5. "Correction of HLA-Cw*0501 and identification of HLA-Cw*0711."
    Baurain J.-F., Coulie P.G.
    Tissue Antigens 53:510-512(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*07:11).
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES CW*07:02 AND CW*07:04).
    Tissue: Blood.
  7. "Identification of a new HLA-Cw7 allele."
    Coulie P.G.
    Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*07:04).
    Tissue: Melanoma.
  8. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "HLA class I alleles of LCL 721 and 174 x CEM.T2 (T2)."
    Steinle A., Schendel D.J.
    Tissue Antigens 44:268-270(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-206 (ALLELE CW*07:01).
  10. "Comparison of HLA class I gene sequences. Derivation of locus-specific oligonucleotide probes specific for HLA-A, HLA-B, and HLA-C genes."
    Davidson W.F., Kress M., Khoury G., Jay G.
    J. Biol. Chem. 260:13414-13423(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-366 (ALLELE CW*07:03).
  11. "Sequence-based typing provides a new look at HLA-C diversity."
    Turner S., Ellexson M.E., Hickman H.D., Sidebottom D.A., Fernandez-Vina M., Confer D.L., Hildebrand W.H.
    J. Immunol. 161:1406-1413(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE CW*07:09).
  12. "There is more to HLA -C than exons 2 and 3: sequencing exons 1, 4 and 5."
    van der Vlies S.A., Voorter C.E., van den Berg-Loonen E.M.
    Tissue Antigens 54:169-177(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-338 (ALLELE CW*07:01).
  13. "Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles."
    Pohla H., Kuon W., Tabaczewski P., Doerner C., Weiss E.H.
    Immunogenetics 29:297-307(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-309 (ALLELE CW*07:01).

Entry informationi

Entry namei1C07_HUMAN
AccessioniPrimary (citable) accession number: P10321
Secondary accession number(s): O78061
, O78083, Q29631, Q29652, Q29867, Q29990, Q95463, Q95603, Q9MY31, Q9TQP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3