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Protein

HLA class I histocompatibility antigen, Cw-7 alpha chain

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, Cw-7 alpha chain
Alternative name(s):
MHC class I antigen Cw*7
Gene namesi
Name:HLA-C
Synonyms:HLAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204525.15
HGNCiHGNC:4933 HLA-C
MIMi142840 gene
neXtProtiNX_P10321

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 333HelicalSequence analysisAdd BLAST25
Topological domaini334 – 366CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3107
MalaCardsiHLA-C
OpenTargetsiENSG00000204525
PharmGKBiPA35057

Polymorphism and mutation databases

BioMutaiTET2
DMDMi84028168

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001887425 – 366HLA class I histocompatibility antigen, Cw-7 alpha chainAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiP10321
PaxDbiP10321
PeptideAtlasiP10321
PRIDEiP10321

PTM databases

iPTMnetiP10321
SwissPalmiP10321

Expressioni

Gene expression databases

BgeeiENSG00000204525
CleanExiHS_HLA-C
ExpressionAtlasiP10321 baseline and differential
GenevisibleiP10321 HS

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KIR2DL3P436282EBI-9978491,EBI-8632435

Protein-protein interaction databases

BioGridi109352112 interactors.
IntActiP10321 6 interactors.
STRINGi9606.ENSP00000365402

Structurei

Secondary structure

1366
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 36Combined sources9
Turni39 – 41Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Turni74 – 78Combined sources5
Helixi81 – 108Combined sources28
Beta strandi118 – 127Combined sources10
Beta strandi129 – 131Combined sources3
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 161Combined sources5
Helixi163 – 174Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 235Combined sources26
Beta strandi237 – 243Combined sources7
Turni249 – 251Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 287Combined sources7
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BZFX-ray2.50P/Q3-11[»]
5VGEX-ray2.60A26-300[»]
ProteinModelPortaliP10321
SMRiP10321
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10321

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 297Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00760000118960
HOVERGENiHBG016709
KOiK06751
PhylomeDBiP10321
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.101 hit
3.30.500.101 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV
110 120 130 140 150
SLRNLRGYYN QSEDGSHTLQ RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP
310 320 330 340 350
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC
360
SNSAQGSDES LITCKA
Length:366
Mass (Da):40,649
Last modified:December 20, 2005 - v3
Checksum:i59C23D95FD1D0BC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15 – 16GG → AA in AAA50217 (Ref. 7) Curated2
Sequence conflicti41R → A in AAA52665 (PubMed:3863816).Curated1
Sequence conflicti309M → V in AAA53259 (PubMed:2714852).Curated1

Polymorphismi

The following alleles of Cw-7 are known: Cw*07:01, Cw*07:02, Cw*07:03, Cw*07:04, Cw*07:06, Cw*07:09 and Cw*07:11. The sequence shown is that of Cw*07:02.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05950610L → I. Corresponds to variant dbSNP:rs2308527Ensembl.1
Natural variantiVAR_05034543E → K. Corresponds to variant dbSNP:rs1050438Ensembl.1
Natural variantiVAR_06145048S → A. Corresponds to variant dbSNP:rs707911Ensembl.1
Natural variantiVAR_06145148S → P. Corresponds to variant dbSNP:rs707911Ensembl.1
Natural variantiVAR_06145248S → T. Corresponds to variant dbSNP:rs707911Ensembl.1
Natural variantiVAR_05034673A → E. Corresponds to variant dbSNP:rs1050409Ensembl.1
Natural variantiVAR_05034776V → M. Corresponds to variant dbSNP:rs1065382Ensembl.1
Natural variantiVAR_01659090K → N in allele Cw*07:01. Corresponds to variant dbSNP:rs28626310Ensembl.1
Natural variantiVAR_05034897A → T. Corresponds to variant dbSNP:rs41543814Ensembl.1
Natural variantiVAR_016591101S → N in allele Cw*07:09. Corresponds to variant dbSNP:rs2308557Ensembl.1
Natural variantiVAR_016592104N → K in allele Cw*07:09. Corresponds to variant dbSNP:rs17408553Ensembl.1
Natural variantiVAR_016593119L → F in allele Cw*07:04 and allele Cw*07:11. Corresponds to variant dbSNP:rs1071649Ensembl.1
Natural variantiVAR_059507123S → C. Corresponds to variant dbSNP:rs1131115Ensembl.1
Natural variantiVAR_059508123S → F. Corresponds to variant dbSNP:rs1131115Ensembl.1
Natural variantiVAR_016594123S → Y in allele Cw*07:01. Corresponds to variant dbSNP:rs1131115Ensembl.1
Natural variantiVAR_050349137Y → H. Corresponds to variant dbSNP:rs2308574Ensembl.1
Natural variantiVAR_016595140S → F in allele Cw*07:04 and allele Cw*07:11. Corresponds to variant dbSNP:rs713032Ensembl.1
Natural variantiVAR_016646171L → W in allele Cw*07:03. Corresponds to variant dbSNP:rs1050366Ensembl.1
Natural variantiVAR_016596180L → D in allele Cw*07:04 and allele Cw*07:11; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016647187T → L in allele Cw*07:03; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016597201E → K in allele Cw*07:04 and allele Cw0711. Corresponds to variant dbSNP:rs1131103Ensembl.1
Natural variantiVAR_061453208P → H. Corresponds to variant dbSNP:rs1131096Ensembl.1
Natural variantiVAR_061454208P → R. Corresponds to variant dbSNP:rs1131096Ensembl.1
Natural variantiVAR_050351272V → M. Corresponds to variant dbSNP:rs1050276Ensembl.1
Natural variantiVAR_050352328V → I. Corresponds to variant dbSNP:rs1050118Ensembl.1
Natural variantiVAR_050353330A → V. Corresponds to variant dbSNP:rs1050105Ensembl.1
Natural variantiVAR_016598331M → K in allele Cw*07:06. Corresponds to variant dbSNP:rs41542414Ensembl.1
Natural variantiVAR_050354331M → V. Corresponds to variant dbSNP:rs1130935Ensembl.1
Natural variantiVAR_016599348A → V in allele Cw*07:06. Corresponds to variant dbSNP:rs41559915Ensembl.1
Natural variantiVAR_061455350C → SCombined sourcesCorresponds to variant dbSNP:rs35708511Ensembl.1
Natural variantiVAR_016600363T → A in allele Cw*07:11. Corresponds to variant dbSNP:rs1130838Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83394 mRNA Translation: CAA58313.1
D38526 mRNA Translation: BAA07531.1
D49819 mRNA Translation: BAA08625.1
D49552 mRNA Translation: BAA08500.1
X97321 mRNA Translation: CAA65986.1
AJ001977 Genomic DNA Translation: CAA05125.1 Sequence problems.
AJ010749 mRNA Translation: CAA09341.1
AJ293016 Genomic DNA Translation: CAC04321.1
AJ293017 Genomic DNA Translation: CAC04322.1
AJ291815 Genomic DNA Translation: CAC19191.1
U09853 mRNA Translation: AAA50217.1
AL671883 Genomic DNA No translation available.
Z46810 mRNA Translation: CAA86840.1
M11886 mRNA Translation: AAA52665.1
AH006132 Genomic DNA Translation: AAC17722.1
Y18533
, Y18534, Y18535, Y18536 Genomic DNA Translation: CAB71800.1
M28207 mRNA Translation: AAA53259.1
CCDSiCCDS34393.1
PIRiA24512 HLHUC4
I37078
I37529
I68750
RefSeqiNP_002108.4, NM_002117.5
UniGeneiHs.656020
Hs.743218

Genome annotation databases

EnsembliENST00000376228; ENSP00000365402; ENSG00000204525
GeneIDi3107
KEGGihsa:3107

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei1C07_HUMAN
AccessioniPrimary (citable) accession number: P10321
Secondary accession number(s): O78061
, O78083, Q29631, Q29652, Q29867, Q29990, Q95463, Q95603, Q9MY31, Q9TQP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 20, 2005
Last modified: February 28, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome