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P10321

- 1C07_HUMAN

UniProt

P10321 - 1C07_HUMAN

Protein

HLA class I histocompatibility antigen, Cw-7 alpha chain

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 3 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.

    GO - Molecular functioni

    1. peptide antigen binding Source: UniProt

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. cytokine-mediated signaling pathway Source: Reactome
    6. interferon-gamma-mediated signaling pathway Source: Reactome
    7. positive regulation of T cell mediated cytotoxicity Source: InterPro
    8. regulation of immune response Source: Reactome
    9. type I interferon signaling pathway Source: Reactome
    10. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class I histocompatibility antigen, Cw-7 alpha chain
    Alternative name(s):
    MHC class I antigen Cw*7
    Gene namesi
    Name:HLA-C
    Synonyms:HLAC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4933. HLA-C.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProt
    2. early endosome membrane Source: Reactome
    3. endoplasmic reticulum Source: UniProt
    4. ER to Golgi transport vesicle membrane Source: Reactome
    5. extracellular vesicular exosome Source: UniProt
    6. Golgi apparatus Source: UniProt
    7. Golgi membrane Source: Reactome
    8. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    9. MHC class I protein complex Source: UniProt
    10. phagocytic vesicle membrane Source: Reactome
    11. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, MHC I

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35057.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Chaini25 – 366342HLA class I histocompatibility antigen, Cw-7 alpha chainPRO_0000018874Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
    Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
    Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

    Post-translational modificationi

    Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP10321.
    PRIDEiP10321.

    Expressioni

    Gene expression databases

    ArrayExpressiP10321.
    BgeeiP10321.
    CleanExiHS_HLA-C.
    GenevestigatoriP10321.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109352. 25 interactions.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3BZFX-ray2.50P/Q3-11[»]
    ProteinModelPortaliP10321.
    SMRiP10321. Positions 26-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP10321.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini334 – 36633CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei309 – 33325HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 29789Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 11490Alpha-1Add
    BLAST
    Regioni115 – 20692Alpha-2Add
    BLAST
    Regioni207 – 29892Alpha-3Add
    BLAST
    Regioni299 – 30810Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG016709.
    KOiK06751.
    OrthoDBiEOG7JT6WQ.
    PhylomeDBiP10321.
    TreeFamiTF336617.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10321-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG    50
    YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV 100
    SLRNLRGYYN QSEDGSHTLQ RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL 150
    NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK 200
    ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 250
    DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 300
    SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC 350
    SNSAQGSDES LITCKA 366
    Length:366
    Mass (Da):40,649
    Last modified:December 20, 2005 - v3
    Checksum:i59C23D95FD1D0BC8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 162GG → AA in AAA50217. 1 PublicationCurated
    Sequence conflicti41 – 411R → A in AAA52665. (PubMed:3863816)Curated
    Sequence conflicti309 – 3091M → V in AAA53259. (PubMed:2714852)Curated

    Polymorphismi

    The following alleles of Cw-7 are known: Cw*07:01, Cw*07:02, Cw*07:03, Cw*07:04, Cw*07:06, Cw*07:09 and Cw*07:11. The sequence shown is that of Cw*07:02.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101L → I.
    Corresponds to variant rs2308527 [ dbSNP | Ensembl ].
    VAR_059506
    Natural varianti43 – 431E → K.
    Corresponds to variant rs1050438 [ dbSNP | Ensembl ].
    VAR_050345
    Natural varianti48 – 481S → A.
    Corresponds to variant rs707911 [ dbSNP | Ensembl ].
    VAR_061450
    Natural varianti48 – 481S → P.
    Corresponds to variant rs707911 [ dbSNP | Ensembl ].
    VAR_061451
    Natural varianti48 – 481S → T.
    Corresponds to variant rs707911 [ dbSNP | Ensembl ].
    VAR_061452
    Natural varianti73 – 731A → E.
    Corresponds to variant rs1050409 [ dbSNP | Ensembl ].
    VAR_050346
    Natural varianti76 – 761V → M.
    Corresponds to variant rs1065382 [ dbSNP | Ensembl ].
    VAR_050347
    Natural varianti90 – 901K → N in allele Cw*07:01.
    Corresponds to variant rs28626310 [ dbSNP | Ensembl ].
    VAR_016590
    Natural varianti97 – 971A → T.
    Corresponds to variant rs41543814 [ dbSNP | Ensembl ].
    VAR_050348
    Natural varianti101 – 1011S → N in allele Cw*07:09.
    Corresponds to variant rs2308557 [ dbSNP | Ensembl ].
    VAR_016591
    Natural varianti104 – 1041N → K in allele Cw*07:09.
    Corresponds to variant rs17408553 [ dbSNP | Ensembl ].
    VAR_016592
    Natural varianti119 – 1191L → F in allele Cw*07:04 and allele Cw*07:11.
    Corresponds to variant rs1071649 [ dbSNP | Ensembl ].
    VAR_016593
    Natural varianti123 – 1231S → C.
    Corresponds to variant rs1131115 [ dbSNP | Ensembl ].
    VAR_059507
    Natural varianti123 – 1231S → F.
    Corresponds to variant rs1131115 [ dbSNP | Ensembl ].
    VAR_059508
    Natural varianti123 – 1231S → Y in allele Cw*07:01.
    Corresponds to variant rs1131115 [ dbSNP | Ensembl ].
    VAR_016594
    Natural varianti137 – 1371Y → H.
    Corresponds to variant rs2308574 [ dbSNP | Ensembl ].
    VAR_050349
    Natural varianti140 – 1401S → F in allele Cw*07:04 and allele Cw*07:11.
    Corresponds to variant rs713032 [ dbSNP | Ensembl ].
    VAR_016595
    Natural varianti171 – 1711L → W in allele Cw*07:03.
    Corresponds to variant rs1050366 [ dbSNP | Ensembl ].
    VAR_016646
    Natural varianti180 – 1801L → D in allele Cw*07:04 and allele Cw*07:11; requires 2 nucleotide substitutions.
    VAR_016596
    Natural varianti182 – 1821A → V.
    Corresponds to variant rs1059539 [ dbSNP | Ensembl ].
    VAR_050350
    Natural varianti187 – 1871T → L in allele Cw*07:03; requires 2 nucleotide substitutions.
    VAR_016647
    Natural varianti201 – 2011E → K in allele Cw*07:04 and allele Cw0711.
    Corresponds to variant rs1131103 [ dbSNP | Ensembl ].
    VAR_016597
    Natural varianti208 – 2081P → H.
    Corresponds to variant rs1131096 [ dbSNP | Ensembl ].
    VAR_061453
    Natural varianti208 – 2081P → R.
    Corresponds to variant rs1131096 [ dbSNP | Ensembl ].
    VAR_061454
    Natural varianti272 – 2721V → M.
    Corresponds to variant rs1050276 [ dbSNP | Ensembl ].
    VAR_050351
    Natural varianti328 – 3281V → I.
    Corresponds to variant rs1050118 [ dbSNP | Ensembl ].
    VAR_050352
    Natural varianti330 – 3301A → V.
    Corresponds to variant rs1050105 [ dbSNP | Ensembl ].
    VAR_050353
    Natural varianti331 – 3311M → K in allele Cw*07:06.
    Corresponds to variant rs41542414 [ dbSNP | Ensembl ].
    VAR_016598
    Natural varianti331 – 3311M → V.
    Corresponds to variant rs1130935 [ dbSNP | Ensembl ].
    VAR_050354
    Natural varianti348 – 3481A → V in allele Cw*07:06.
    Corresponds to variant rs41559915 [ dbSNP | Ensembl ].
    VAR_016599
    Natural varianti350 – 3501C → S.
    Corresponds to variant rs35708511 [ dbSNP | Ensembl ].
    VAR_061455
    Natural varianti363 – 3631T → A in allele Cw*07:11.
    Corresponds to variant rs1130838 [ dbSNP | Ensembl ].
    VAR_016600

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83394 mRNA. Translation: CAA58313.1.
    D38526 mRNA. Translation: BAA07531.1.
    D49819 mRNA. Translation: BAA08625.1.
    D49552 mRNA. Translation: BAA08500.1.
    X97321 mRNA. Translation: CAA65986.1.
    AJ001977 Genomic DNA. Translation: CAA05125.1. Sequence problems.
    AJ010749 mRNA. Translation: CAA09341.1.
    AJ293016 Genomic DNA. Translation: CAC04321.1.
    AJ293017 Genomic DNA. Translation: CAC04322.1.
    AJ291815 Genomic DNA. Translation: CAC19191.1.
    U09853 mRNA. Translation: AAA50217.1.
    AL671883 Genomic DNA. No translation available.
    Z46810 mRNA. Translation: CAA86840.1.
    M11886 mRNA. Translation: AAA52665.1.
    AH006132 Genomic DNA. Translation: AAC17722.1.
    Y18533
    , Y18534, Y18535, Y18536 Genomic DNA. Translation: CAB71800.1.
    M28207 mRNA. Translation: AAA53259.1.
    CCDSiCCDS34393.1.
    PIRiA24512. HLHUC4.
    I37078.
    I37529.
    I68750.
    RefSeqiNP_002108.4. NM_002117.5.
    UniGeneiHs.656020.
    Hs.743218.
    Hs.77961.

    Genome annotation databases

    EnsembliENST00000376228; ENSP00000365402; ENSG00000204525.
    GeneIDi3107.
    KEGGihsa:3107.
    UCSCiuc003nsy.3. human.

    Polymorphism databases

    DMDMi84028168.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83394 mRNA. Translation: CAA58313.1 .
    D38526 mRNA. Translation: BAA07531.1 .
    D49819 mRNA. Translation: BAA08625.1 .
    D49552 mRNA. Translation: BAA08500.1 .
    X97321 mRNA. Translation: CAA65986.1 .
    AJ001977 Genomic DNA. Translation: CAA05125.1 . Sequence problems.
    AJ010749 mRNA. Translation: CAA09341.1 .
    AJ293016 Genomic DNA. Translation: CAC04321.1 .
    AJ293017 Genomic DNA. Translation: CAC04322.1 .
    AJ291815 Genomic DNA. Translation: CAC19191.1 .
    U09853 mRNA. Translation: AAA50217.1 .
    AL671883 Genomic DNA. No translation available.
    Z46810 mRNA. Translation: CAA86840.1 .
    M11886 mRNA. Translation: AAA52665.1 .
    AH006132 Genomic DNA. Translation: AAC17722.1 .
    Y18533
    , Y18534 , Y18535 , Y18536 Genomic DNA. Translation: CAB71800.1 .
    M28207 mRNA. Translation: AAA53259.1 .
    CCDSi CCDS34393.1.
    PIRi A24512. HLHUC4.
    I37078.
    I37529.
    I68750.
    RefSeqi NP_002108.4. NM_002117.5.
    UniGenei Hs.656020.
    Hs.743218.
    Hs.77961.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3BZF X-ray 2.50 P/Q 3-11 [» ]
    ProteinModelPortali P10321.
    SMRi P10321. Positions 26-298.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109352. 25 interactions.

    Polymorphism databases

    DMDMi 84028168.

    Proteomic databases

    MaxQBi P10321.
    PRIDEi P10321.

    Protocols and materials databases

    DNASUi 3107.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376228 ; ENSP00000365402 ; ENSG00000204525 .
    GeneIDi 3107.
    KEGGi hsa:3107.
    UCSCi uc003nsy.3. human.

    Organism-specific databases

    CTDi 3107.
    GeneCardsi GC06M031236.
    HGNCi HGNC:4933. HLA-C.
    MIMi 142840. gene.
    neXtProti NX_P10321.
    PharmGKBi PA35057.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG016709.
    KOi K06751.
    OrthoDBi EOG7JT6WQ.
    PhylomeDBi P10321.
    TreeFami TF336617.

    Enzyme and pathway databases

    Reactomei REACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    ChiTaRSi HLA-C. human.
    EvolutionaryTracei P10321.
    GeneWikii HLA-C.
    GenomeRNAii 3107.
    NextBioi 12327.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10321.
    Bgeei P10321.
    CleanExi HS_HLA-C.
    Genevestigatori P10321.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Anchored PCR cloning of the novel HLA-Cw*0704 allele detected by PCR-SSP."
      Vilches C., Bunce M., de Pablo R., Herrero M.J., Kreisler M.
      Tissue Antigens 46:19-23(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*07:04).
    2. "Identification and DNA typing of two Cw7 alleles (Cw*0702 and Cw*0704) in Japanese, with the corrected sequence of Cw*0702."
      Wang H., Tokunaga K., Ishikawa Y., Asahina A., Kuwata S., Akaza T., Tadokoro K., Shibata Y., Takiguchi M., Juji T.
      Hum. Immunol. 45:52-58(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES CW*07:02 AND CW*07:04).
      Tissue: Blood.
    3. "Molecular cloning of two new HLA-C alleles: Cw*1801 and Cw*0706."
      Vilches C., Bunce M., Sanz L., de Pablo R., Puente S., Kreisler M.
      Tissue Antigens 48:698-702(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*07:06).
    4. "A major histocompatibility complex class I allele shared by two species of chimpanzee."
      Cooper S.L., Adams E.J., Wells R.S., Walker C.M., Parham P.
      Immunogenetics 47:212-217(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CW*07:02).
    5. "Correction of HLA-Cw*0501 and identification of HLA-Cw*0711."
      Baurain J.-F., Coulie P.G.
      Tissue Antigens 53:510-512(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*07:11).
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES CW*07:02 AND CW*07:04).
      Tissue: Blood.
    7. "Identification of a new HLA-Cw7 allele."
      Coulie P.G.
      Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE CW*07:04).
      Tissue: Melanoma.
    8. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "HLA class I alleles of LCL 721 and 174 x CEM.T2 (T2)."
      Steinle A., Schendel D.J.
      Tissue Antigens 44:268-270(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-206 (ALLELE CW*07:01).
    10. "Comparison of HLA class I gene sequences. Derivation of locus-specific oligonucleotide probes specific for HLA-A, HLA-B, and HLA-C genes."
      Davidson W.F., Kress M., Khoury G., Jay G.
      J. Biol. Chem. 260:13414-13423(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-366 (ALLELE CW*07:03).
    11. "Sequence-based typing provides a new look at HLA-C diversity."
      Turner S., Ellexson M.E., Hickman H.D., Sidebottom D.A., Fernandez-Vina M., Confer D.L., Hildebrand W.H.
      J. Immunol. 161:1406-1413(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE CW*07:09).
    12. "There is more to HLA -C than exons 2 and 3: sequencing exons 1, 4 and 5."
      van der Vlies S.A., Voorter C.E., van den Berg-Loonen E.M.
      Tissue Antigens 54:169-177(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-338 (ALLELE CW*07:01).
    13. "Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles."
      Pohla H., Kuon W., Tabaczewski P., Doerner C., Weiss E.H.
      Immunogenetics 29:297-307(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-309 (ALLELE CW*07:01).

    Entry informationi

    Entry namei1C07_HUMAN
    AccessioniPrimary (citable) accession number: P10321
    Secondary accession number(s): O78061
    , O78083, Q29631, Q29652, Q29867, Q29990, Q95463, Q95603, Q9MY31, Q9TQP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 141 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3