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Protein

Spanin, outer lipoprotein subunit

Gene

18.7

Organism
Enterobacteria phage T3 (Bacteriophage T3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the spanin complex that disrupts the host outer membrane and participates in cell lysis during virus exit. The spanin complex conducts the final step in host lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans. Host outer membrane disruption is possibly due to local fusion between the inner and outer membrane performed by the spanin complex.By similarity

GO - Biological processi

Keywordsi

Biological processCytolysis, Host cell lysis by virus, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Spanin, outer lipoprotein subunit
Short name:
o-spanin
Alternative name(s):
Gene product 18.7
Short name:
Gp18.7
Protein 18.7
Gene namesi
Name:18.7
OrganismiEnterobacteria phage T3 (Bacteriophage T3)
Taxonomic identifieri10759 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeAutographivirinaeT7virus
Virus hostiEscherichia coli [TaxID: 562]

Subcellular locationi

  • Host cell outer membrane By similarity; Lipid-anchor By similarity; Periplasmic side By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Host cell outer membrane, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 50Sequence analysisAdd BLAST50
ChainiPRO_000010653851 – 83Spanin, outer lipoprotein subunitSequence analysisAdd BLAST33

Keywords - PTMi

Lipoprotein

Interactioni

Subunit structurei

Homodimer. Interacts (via C-terminus) with the spanin inner membrane subunit (via C-terminus). Part of the spanin complex which spans the entire periplasmic space. The spanin complex is composed of spanin inner membrane subunit and spanin outer membrane subunit.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the T7likevirus o-spanin family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR020130. o-spanin_T7likevirus.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD028580. Phage_T7-like_18.7. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLRELRLR RALKEQSMKY RLSIKKTLPR WKGALIGLFL ICVRTISGSG
60 70 80
SESNLPEPPK VSVDSSLMIE PNLTTEMLNV FSQ
Length:83
Mass (Da):9,393
Last modified:July 1, 1989 - v1
Checksum:i63128984CBAF0531
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14784 Genomic DNA. Translation: AAA92527.1.
PIRiE23476. W8BPT3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14784 Genomic DNA. Translation: AAA92527.1.
PIRiE23476. W8BPT3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR020130. o-spanin_T7likevirus.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD028580. Phage_T7-like_18.7. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSPAN2_BPT3
AccessioniPrimary (citable) accession number: P10302
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: January 18, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.