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Protein

Ras-related protein R-Ras

Gene

RRAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 44GTP9
Nucleotide bindingi83 – 87GTPBy similarity5
Nucleotide bindingi142 – 145GTP4
Nucleotide bindingi172 – 174GTP3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • protein-containing complex binding Source: MGI

GO - Biological processi

  • face morphogenesis Source: UniProtKB
  • leukocyte differentiation Source: UniProtKB
  • negative regulation of cell migration Source: Ensembl
  • positive regulation of angiogenesis Source: UniProtKB
  • Ras protein signal transduction Source: ProtInc
  • regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • regulation of protein kinase B signaling Source: UniProtKB

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration
R-HSA-442742 CREB phosphorylation through the activation of Ras
SignaLinkiP10301
SIGNORiP10301

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein R-Ras
Alternative name(s):
p23
Gene namesi
Name:RRAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000126458.3
HGNCiHGNC:10447 RRAS
MIMi165090 gene
neXtProtiNX_P10301

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38G → V: No effect on interaction with OSBPL3. 1 Publication1
Mutagenesisi43S → N: No effect on interaction with OSBPL3. 1 Publication1

Organism-specific databases

DisGeNETi6237
MalaCardsiRRAS
OpenTargetsiENSG00000126458
PharmGKBiPA34861

Polymorphism and mutation databases

BioMutaiRRAS
DMDMi133486

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826501 – 215Ras-related protein R-RasAdd BLAST215
PropeptideiPRO_0000281300216 – 218Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215Cysteine methyl esterBy similarity1
Lipidationi215S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP10301
MaxQBiP10301
PaxDbiP10301
PeptideAtlasiP10301
PRIDEiP10301

2D gel databases

SWISS-2DPAGEiP10301

PTM databases

iPTMnetiP10301
PhosphoSitePlusiP10301
SwissPalmiP10301

Expressioni

Gene expression databases

BgeeiENSG00000126458
CleanExiHS_RRAS
ExpressionAtlasiP10301 baseline and differential
GenevisibleiP10301 HS

Organism-specific databases

HPAiCAB010160
CAB069439
HPA060364

Interactioni

Subunit structurei

Interacts with PLCE1 (PubMed:16537651). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts with OSBPL3 (PubMed:18270267).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-968703,EBI-389883

Protein-protein interaction databases

BioGridi112151, 32 interactors
IntActiP10301, 25 interactors
MINTiP10301
STRINGi9606.ENSP00000246792

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 36Combined sources8
Helixi42 – 51Combined sources10
Beta strandi64 – 72Combined sources9
Beta strandi75 – 83Combined sources9
Turni87 – 90Combined sources4
Helixi94 – 100Combined sources7
Beta strandi102 – 109Combined sources8
Helixi113 – 130Combined sources18
Beta strandi137 – 142Combined sources6
Helixi144 – 149Combined sources6
Helixi154 – 163Combined sources10
Beta strandi167 – 170Combined sources4
Turni173 – 176Combined sources4
Helixi179 – 193Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FN4X-ray1.65A23-201[»]
ProteinModelPortaliP10301
SMRiP10301
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10301

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi58 – 66Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiP10301
KOiK07829
OMAiRSEASTF
OrthoDBiEOG091G0UAU
PhylomeDBiP10301
TreeFamiTF312796

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGAASGTG RGRPRGGGPG PGDPPPSETH KLVVVGGGGV GKSALTIQFI
60 70 80 90 100
QSYFVSDYDP TIEDSYTKIC SVDGIPARLD ILDTAGQEEF GAMREQYMRA
110 120 130 140 150
GHGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPVVLV GNKADLESQR
160 170 180 190 200
QVPRSEASAF GASHHVAYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP
210
SPPSAPRKKG GGCPCVLL
Length:218
Mass (Da):23,480
Last modified:July 1, 1989 - v1
Checksum:i437F73170670EB28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14949, M14948 Genomic DNA Translation: AAA60256.1
AF493920 mRNA Translation: AAM12634.1
BT006805 mRNA Translation: AAP35451.1
CR541944 mRNA Translation: CAG46742.1
CR541967 mRNA Translation: CAG46765.1
CH471177 Genomic DNA Translation: EAW52506.1
BC016286 mRNA Translation: AAH16286.1
BC016318 mRNA Translation: AAH16318.1
CCDSiCCDS12774.1
PIRiA26159 TVHURR
RefSeqiNP_006261.1, NM_006270.4
UniGeneiHs.515536

Genome annotation databases

EnsembliENST00000246792; ENSP00000246792; ENSG00000126458
GeneIDi6237
KEGGihsa:6237
UCSCiuc002pop.2 human

Similar proteinsi

Entry informationi

Entry nameiRRAS_HUMAN
AccessioniPrimary (citable) accession number: P10301
Secondary accession number(s): Q6FH12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 188 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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