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P10301

- RRAS_HUMAN

UniProt

P10301 - RRAS_HUMAN

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Protein
Ras-related protein R-Ras
Gene
RRAS
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates the organization of the actin cytoskeleton.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 449GTP
Nucleotide bindingi83 – 875GTP By similarity
Nucleotide bindingi142 – 1454GTP
Nucleotide bindingi172 – 1743GTP

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB-KW
  3. GTPase activity Source: UniProtKB
  4. protein binding Source: UniProtKB
  5. protein complex binding Source: MGI

GO - Biological processi

  1. Ras protein signal transduction Source: ProtInc
  2. axon guidance Source: Reactome
  3. negative regulation of cell migration Source: Ensembl
  4. positive regulation of angiogenesis Source: UniProtKB
  5. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_19266. Sema4D mediated inhibition of cell attachment and migration.
REACT_19279. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
REACT_20568. CREB phosphorylation through the activation of Ras.
SignaLinkiP10301.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein R-Ras
Alternative name(s):
p23
Gene namesi
Name:RRAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:10447. RRAS.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity
Note: Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34861.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Ras-related protein R-Ras
PRO_0000082650Add
BLAST
Propeptidei216 – 2183Removed in mature form By similarity
PRO_0000281300

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei215 – 2151Cysteine methyl ester By similarity
Lipidationi215 – 2151S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP10301.
PaxDbiP10301.
PeptideAtlasiP10301.
PRIDEiP10301.

2D gel databases

SWISS-2DPAGEP10301.

PTM databases

PhosphoSiteiP10301.

Expressioni

Gene expression databases

BgeeiP10301.
CleanExiHS_RRAS.
GenevestigatoriP10301.

Organism-specific databases

HPAiCAB010160.

Interactioni

Subunit structurei

Interacts with PLCE1. Interacts (active GTP-bound form preferentially) with RGS14 By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-968703,EBI-389883

Protein-protein interaction databases

BioGridi112151. 12 interactions.
IntActiP10301. 14 interactions.
STRINGi9606.ENSP00000246792.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 368
Helixi42 – 5110
Beta strandi64 – 729
Beta strandi75 – 839
Turni87 – 904
Helixi94 – 1007
Beta strandi102 – 1098
Helixi113 – 13018
Beta strandi137 – 1426
Helixi144 – 1496
Helixi154 – 16310
Beta strandi167 – 1704
Turni173 – 1764
Helixi179 – 19315

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FN4X-ray1.65A23-201[»]
ProteinModelPortaliP10301.
SMRiP10301. Positions 24-196.

Miscellaneous databases

EvolutionaryTraceiP10301.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi58 – 669Effector region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiP10301.
KOiK07829.
OMAiRSEASTF.
OrthoDBiEOG7QVM41.
PhylomeDBiP10301.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10301-1 [UniParc]FASTAAdd to Basket

« Hide

MSSGAASGTG RGRPRGGGPG PGDPPPSETH KLVVVGGGGV GKSALTIQFI    50
QSYFVSDYDP TIEDSYTKIC SVDGIPARLD ILDTAGQEEF GAMREQYMRA 100
GHGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPVVLV GNKADLESQR 150
QVPRSEASAF GASHHVAYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP 200
SPPSAPRKKG GGCPCVLL 218
Length:218
Mass (Da):23,480
Last modified:July 1, 1989 - v1
Checksum:i437F73170670EB28
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14949, M14948 Genomic DNA. Translation: AAA60256.1.
AF493920 mRNA. Translation: AAM12634.1.
BT006805 mRNA. Translation: AAP35451.1.
CR541944 mRNA. Translation: CAG46742.1.
CR541967 mRNA. Translation: CAG46765.1.
CH471177 Genomic DNA. Translation: EAW52506.1.
BC016286 mRNA. Translation: AAH16286.1.
BC016318 mRNA. Translation: AAH16318.1.
CCDSiCCDS12774.1.
PIRiA26159. TVHURR.
RefSeqiNP_006261.1. NM_006270.3.
UniGeneiHs.515536.

Genome annotation databases

EnsembliENST00000246792; ENSP00000246792; ENSG00000126458.
GeneIDi6237.
KEGGihsa:6237.
UCSCiuc002pop.1. human.

Polymorphism databases

DMDMi133486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14949 , M14948 Genomic DNA. Translation: AAA60256.1 .
AF493920 mRNA. Translation: AAM12634.1 .
BT006805 mRNA. Translation: AAP35451.1 .
CR541944 mRNA. Translation: CAG46742.1 .
CR541967 mRNA. Translation: CAG46765.1 .
CH471177 Genomic DNA. Translation: EAW52506.1 .
BC016286 mRNA. Translation: AAH16286.1 .
BC016318 mRNA. Translation: AAH16318.1 .
CCDSi CCDS12774.1.
PIRi A26159. TVHURR.
RefSeqi NP_006261.1. NM_006270.3.
UniGenei Hs.515536.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FN4 X-ray 1.65 A 23-201 [» ]
ProteinModelPortali P10301.
SMRi P10301. Positions 24-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112151. 12 interactions.
IntActi P10301. 14 interactions.
STRINGi 9606.ENSP00000246792.

PTM databases

PhosphoSitei P10301.

Polymorphism databases

DMDMi 133486.

2D gel databases

SWISS-2DPAGE P10301.

Proteomic databases

MaxQBi P10301.
PaxDbi P10301.
PeptideAtlasi P10301.
PRIDEi P10301.

Protocols and materials databases

DNASUi 6237.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000246792 ; ENSP00000246792 ; ENSG00000126458 .
GeneIDi 6237.
KEGGi hsa:6237.
UCSCi uc002pop.1. human.

Organism-specific databases

CTDi 6237.
GeneCardsi GC19M050138.
HGNCi HGNC:10447. RRAS.
HPAi CAB010160.
MIMi 165090. gene.
neXtProti NX_P10301.
PharmGKBi PA34861.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233973.
HOVERGENi HBG009351.
InParanoidi P10301.
KOi K07829.
OMAi RSEASTF.
OrthoDBi EOG7QVM41.
PhylomeDBi P10301.
TreeFami TF312796.

Enzyme and pathway databases

Reactomei REACT_19266. Sema4D mediated inhibition of cell attachment and migration.
REACT_19279. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
REACT_20568. CREB phosphorylation through the activation of Ras.
SignaLinki P10301.

Miscellaneous databases

EvolutionaryTracei P10301.
GeneWikii RRAS.
GenomeRNAii 6237.
NextBioi 24215.
PROi P10301.
SOURCEi Search...

Gene expression databases

Bgeei P10301.
CleanExi HS_RRAS.
Genevestigatori P10301.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00173. RAS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes."
    Lowe D.G., Capon D.J., Delwart E., Sakaguchi A.Y., Naylor S.L., Goeddel D.V.
    Cell 48:137-146(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Uterus.
  7. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
    Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
    Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 177-188.
    Tissue: Adipocyte.
  8. "The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon."
    Ada-Nguema A.S., Xenias H., Sheetz M.P., Keely P.J.
    J. Cell Sci. 119:1307-1319(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PLCE1.
  9. "Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype."
    Carta C., Pantaleoni F., Bocchinfuso G., Stella L., Vasta I., Sarkozy A., Digilio C., Palleschi A., Pizzuti A., Grammatico P., Zampino G., Dallapiccola B., Gelb B.D., Tartaglia M.
    Am. J. Hum. Genet. 79:129-135(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 23-201 IN COMPLEX WITH GDP.

Entry informationi

Entry nameiRRAS_HUMAN
AccessioniPrimary (citable) accession number: P10301
Secondary accession number(s): Q6FH12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 3, 2014
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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