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Protein

Ras-related protein R-Ras

Gene

RRAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 44GTP9
Nucleotide bindingi83 – 87GTPBy similarity5
Nucleotide bindingi142 – 145GTP4
Nucleotide bindingi172 – 174GTP3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • protein complex binding Source: MGI

GO - Biological processi

  • face morphogenesis Source: UniProtKB
  • leukocyte differentiation Source: UniProtKB
  • negative regulation of cell migration Source: Ensembl
  • positive regulation of angiogenesis Source: UniProtKB
  • Ras protein signal transduction Source: ProtInc
  • regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • regulation of protein kinase B signaling Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126458-MONOMER.
ReactomeiR-HSA-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-HSA-416550. Sema4D mediated inhibition of cell attachment and migration.
R-HSA-442742. CREB phosphorylation through the activation of Ras.
SignaLinkiP10301.
SIGNORiP10301.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein R-Ras
Alternative name(s):
p23
Gene namesi
Name:RRAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:10447. RRAS.

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

  • Note: Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38G → V: No effect on interaction with OSBPL3. 1 Publication1
Mutagenesisi43S → N: No effect on interaction with OSBPL3. 1 Publication1

Organism-specific databases

DisGeNETi6237.
OpenTargetsiENSG00000126458.
PharmGKBiPA34861.

Polymorphism and mutation databases

BioMutaiRRAS.
DMDMi133486.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826501 – 215Ras-related protein R-RasAdd BLAST215
PropeptideiPRO_0000281300216 – 218Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215Cysteine methyl esterBy similarity1
Lipidationi215S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP10301.
MaxQBiP10301.
PaxDbiP10301.
PeptideAtlasiP10301.
PRIDEiP10301.

2D gel databases

SWISS-2DPAGEP10301.

PTM databases

iPTMnetiP10301.
PhosphoSitePlusiP10301.
SwissPalmiP10301.

Expressioni

Gene expression databases

BgeeiENSG00000126458.
CleanExiHS_RRAS.
ExpressionAtlasiP10301. baseline and differential.
GenevisibleiP10301. HS.

Organism-specific databases

HPAiCAB010160.
HPA060364.

Interactioni

Subunit structurei

Interacts with PLCE1 (PubMed:16537651). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts with OSBPL3 (PubMed:18270267).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-968703,EBI-389883

GO - Molecular functioni

  • protein complex binding Source: MGI

Protein-protein interaction databases

BioGridi112151. 31 interactors.
IntActiP10301. 23 interactors.
STRINGi9606.ENSP00000246792.

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 36Combined sources8
Helixi42 – 51Combined sources10
Beta strandi64 – 72Combined sources9
Beta strandi75 – 83Combined sources9
Turni87 – 90Combined sources4
Helixi94 – 100Combined sources7
Beta strandi102 – 109Combined sources8
Helixi113 – 130Combined sources18
Beta strandi137 – 142Combined sources6
Helixi144 – 149Combined sources6
Helixi154 – 163Combined sources10
Beta strandi167 – 170Combined sources4
Turni173 – 176Combined sources4
Helixi179 – 193Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FN4X-ray1.65A23-201[»]
ProteinModelPortaliP10301.
SMRiP10301.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10301.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi58 – 66Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiP10301.
KOiK07829.
OMAiRSEASTF.
OrthoDBiEOG091G0UAU.
PhylomeDBiP10301.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGAASGTG RGRPRGGGPG PGDPPPSETH KLVVVGGGGV GKSALTIQFI
60 70 80 90 100
QSYFVSDYDP TIEDSYTKIC SVDGIPARLD ILDTAGQEEF GAMREQYMRA
110 120 130 140 150
GHGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPVVLV GNKADLESQR
160 170 180 190 200
QVPRSEASAF GASHHVAYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP
210
SPPSAPRKKG GGCPCVLL
Length:218
Mass (Da):23,480
Last modified:July 1, 1989 - v1
Checksum:i437F73170670EB28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14949, M14948 Genomic DNA. Translation: AAA60256.1.
AF493920 mRNA. Translation: AAM12634.1.
BT006805 mRNA. Translation: AAP35451.1.
CR541944 mRNA. Translation: CAG46742.1.
CR541967 mRNA. Translation: CAG46765.1.
CH471177 Genomic DNA. Translation: EAW52506.1.
BC016286 mRNA. Translation: AAH16286.1.
BC016318 mRNA. Translation: AAH16318.1.
CCDSiCCDS12774.1.
PIRiA26159. TVHURR.
RefSeqiNP_006261.1. NM_006270.4.
UniGeneiHs.515536.

Genome annotation databases

EnsembliENST00000246792; ENSP00000246792; ENSG00000126458.
GeneIDi6237.
KEGGihsa:6237.
UCSCiuc002pop.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14949, M14948 Genomic DNA. Translation: AAA60256.1.
AF493920 mRNA. Translation: AAM12634.1.
BT006805 mRNA. Translation: AAP35451.1.
CR541944 mRNA. Translation: CAG46742.1.
CR541967 mRNA. Translation: CAG46765.1.
CH471177 Genomic DNA. Translation: EAW52506.1.
BC016286 mRNA. Translation: AAH16286.1.
BC016318 mRNA. Translation: AAH16318.1.
CCDSiCCDS12774.1.
PIRiA26159. TVHURR.
RefSeqiNP_006261.1. NM_006270.4.
UniGeneiHs.515536.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FN4X-ray1.65A23-201[»]
ProteinModelPortaliP10301.
SMRiP10301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112151. 31 interactors.
IntActiP10301. 23 interactors.
STRINGi9606.ENSP00000246792.

PTM databases

iPTMnetiP10301.
PhosphoSitePlusiP10301.
SwissPalmiP10301.

Polymorphism and mutation databases

BioMutaiRRAS.
DMDMi133486.

2D gel databases

SWISS-2DPAGEP10301.

Proteomic databases

EPDiP10301.
MaxQBiP10301.
PaxDbiP10301.
PeptideAtlasiP10301.
PRIDEiP10301.

Protocols and materials databases

DNASUi6237.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246792; ENSP00000246792; ENSG00000126458.
GeneIDi6237.
KEGGihsa:6237.
UCSCiuc002pop.2. human.

Organism-specific databases

CTDi6237.
DisGeNETi6237.
GeneCardsiRRAS.
HGNCiHGNC:10447. RRAS.
HPAiCAB010160.
HPA060364.
MIMi165090. gene.
neXtProtiNX_P10301.
OpenTargetsiENSG00000126458.
PharmGKBiPA34861.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiP10301.
KOiK07829.
OMAiRSEASTF.
OrthoDBiEOG091G0UAU.
PhylomeDBiP10301.
TreeFamiTF312796.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126458-MONOMER.
ReactomeiR-HSA-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-HSA-416550. Sema4D mediated inhibition of cell attachment and migration.
R-HSA-442742. CREB phosphorylation through the activation of Ras.
SignaLinkiP10301.
SIGNORiP10301.

Miscellaneous databases

EvolutionaryTraceiP10301.
GeneWikiiRRAS.
GenomeRNAii6237.
PROiP10301.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126458.
CleanExiHS_RRAS.
ExpressionAtlasiP10301. baseline and differential.
GenevisibleiP10301. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRRAS_HUMAN
AccessioniPrimary (citable) accession number: P10301
Secondary accession number(s): Q6FH12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 180 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.