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P10301 (RRAS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 150. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein R-Ras
Alternative name(s):
p23
Gene names
Name:RRAS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates the organization of the actin cytoskeleton. Ref.8

Subunit structure

Interacts with PLCE1. Interacts (active GTP-bound form preferentially) with RGS14 By similarity. Ref.8

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

Sequence similarities

Belongs to the small GTPase superfamily. Ras family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NCK1P163333EBI-968703,EBI-389883

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 215215Ras-related protein R-Ras
PRO_0000082650
Propeptide216 – 2183Removed in mature form By similarity
PRO_0000281300

Regions

Nucleotide binding36 – 449GTP
Nucleotide binding83 – 875GTP By similarity
Nucleotide binding142 – 1454GTP
Nucleotide binding172 – 1743GTP
Motif58 – 669Effector region

Amino acid modifications

Modified residue2151Cysteine methyl ester By similarity
Lipidation2151S-geranylgeranyl cysteine By similarity

Secondary structure

............................. 218
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P10301 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 437F73170670EB28

FASTA21823,480
        10         20         30         40         50         60 
MSSGAASGTG RGRPRGGGPG PGDPPPSETH KLVVVGGGGV GKSALTIQFI QSYFVSDYDP 

        70         80         90        100        110        120 
TIEDSYTKIC SVDGIPARLD ILDTAGQEEF GAMREQYMRA GHGFLLVFAI NDRQSFNEVG 

       130        140        150        160        170        180 
KLFTQILRVK DRDDFPVVLV GNKADLESQR QVPRSEASAF GASHHVAYFE ASAKLRLNVD 

       190        200        210 
EAFEQLVRAV RKYQEQELPP SPPSAPRKKG GGCPCVLL 

« Hide

References

« Hide 'large scale' references
[1]"Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes."
Lowe D.G., Capon D.J., Delwart E., Sakaguchi A.Y., Naylor S.L., Goeddel D.V.
Cell 48:137-146(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Uterus.
[7]"Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 177-188.
Tissue: Adipocyte.
[8]"The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon."
Ada-Nguema A.S., Xenias H., Sheetz M.P., Keely P.J.
J. Cell Sci. 119:1307-1319(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH PLCE1.
[9]"Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype."
Carta C., Pantaleoni F., Bocchinfuso G., Stella L., Vasta I., Sarkozy A., Digilio C., Palleschi A., Pizzuti A., Grammatico P., Zampino G., Dallapiccola B., Gelb B.D., Tartaglia M.
Am. J. Hum. Genet. 79:129-135(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 23-201 IN COMPLEX WITH GDP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M14949, M14948 Genomic DNA. Translation: AAA60256.1.
AF493920 mRNA. Translation: AAM12634.1.
BT006805 mRNA. Translation: AAP35451.1.
CR541944 mRNA. Translation: CAG46742.1.
CR541967 mRNA. Translation: CAG46765.1.
CH471177 Genomic DNA. Translation: EAW52506.1.
BC016286 mRNA. Translation: AAH16286.1.
BC016318 mRNA. Translation: AAH16318.1.
PIRTVHURR. A26159.
RefSeqNP_006261.1. NM_006270.3.
UniGeneHs.515536.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2FN4X-ray1.65A23-201[»]
ProteinModelPortalP10301.
SMRP10301. Positions 24-196.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112151. 12 interactions.
IntActP10301. 14 interactions.
STRING9606.ENSP00000246792.

PTM databases

PhosphoSiteP10301.

Polymorphism databases

DMDM133486.

2D gel databases

SWISS-2DPAGEP10301.

Proteomic databases

PaxDbP10301.
PeptideAtlasP10301.
PRIDEP10301.

Protocols and materials databases

DNASU6237.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000246792; ENSP00000246792; ENSG00000126458.
GeneID6237.
KEGGhsa:6237.
UCSCuc002pop.1. human.

Organism-specific databases

CTD6237.
GeneCardsGC19M050138.
HGNCHGNC:10447. RRAS.
HPACAB010160.
MIM165090. gene.
neXtProtNX_P10301.
PharmGKBPA34861.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233973.
HOVERGENHBG009351.
InParanoidP10301.
KOK07829.
OMAFGASHHV.
OrthoDBEOG7QVM41.
PhylomeDBP10301.
TreeFamTF312796.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_13685. Neuronal System.
SignaLinkP10301.

Gene expression databases

BgeeP10301.
CleanExHS_RRAS.
GenevestigatorP10301.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERPTHR24070. PTHR24070. 1 hit.
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP10301.
GeneWikiRRAS.
GenomeRNAi6237.
NextBio24215.
PROP10301.
SOURCESearch...

Entry information

Entry nameRRAS_HUMAN
AccessionPrimary (citable) accession number: P10301
Secondary accession number(s): Q6FH12
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM