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P10299 (GSTP1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase P

EC=2.5.1.18
Alternative name(s):
GST class-pi
Gene names
Name:gst-1
ORF Names:R107.7
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the GST superfamily. Pi family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

gst-23P915055EBI-326030,EBI-326040

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Glutathione S-transferase P
PRO_0000185911

Regions

Domain1 – 7878GST N-terminal
Domain80 – 202123GST C-terminal
Region49 – 502Glutathione binding By similarity
Region62 – 632Glutathione binding By similarity

Sites

Binding site71Glutathione By similarity
Binding site381Glutathione By similarity
Binding site421Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P10299 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 3A0DC439FF8FFFBB

FASTA20823,901
        10         20         30         40         50         60 
MTLKLTYFDI HGLAEPIRLL LADKQVAYED HRVTYEQWAD IKPKMIFGQV PCLLSGDEEI 

        70         80         90        100        110        120 
VQSGAIIRHL ARLNGLNGSN ETETTFIDMF YEGLRDLHTK YTTMIYRNYE DGKAPYIKDV 

       130        140        150        160        170        180 
LPGELARLEK LFHTYKNGEH YVIGDKESYA DYVLFEELDI HLILTPNALD GVPALKKFHE 

       190        200 
RFAERPNIKA YLNKRAAINP PVNGNGKQ 

« Hide

References

« Hide 'large scale' references
[1]"A Caenorhabditis elegans cDNA that encodes a product resembling the rat glutathione S-transferase P subunit."
Weston K., Yochem J., Greenwald I.
Nucleic Acids Res. 17:2138-2138(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
[2]"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans."
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. expand/collapse author list , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P.
Nature 368:32-38(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13689 mRNA. Translation: CAA31979.1.
Z14092 Genomic DNA. Translation: CAA78471.1.
PIRS03615.
RefSeqNP_499006.1. NM_066605.5.
UniGeneCel.19723.

3D structure databases

ProteinModelPortalP10299.
SMRP10299. Positions 1-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid41480. 1 interaction.
DIPDIP-24298N.
IntActP10299. 1 interaction.
MINTMINT-1090976.
STRING6239.R107.7.1.

Proteomic databases

PaxDbP10299.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaR107.7.1; R107.7.1; WBGene00001749.
R107.7.2; R107.7.2; WBGene00001749.
R107.7.3; R107.7.3; WBGene00001749.
GeneID176281.
KEGGcel:CELE_R107.7.
UCSCR107.7.1. c. elegans.

Organism-specific databases

CTD176281.
WormBaseR107.7; CE00302; WBGene00001749; gst-1.

Phylogenomic databases

eggNOGNOG05174.
GeneTreeENSGT00550000074559.
HOGENOMHOG000115733.
InParanoidP10299.
KOK00799.
OMAAYLNKRA.
PhylomeDBP10299.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01268. GSTRNSFRASEP.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio891910.

Entry information

Entry nameGSTP1_CAEEL
AccessionPrimary (citable) accession number: P10299
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase