P10299 (GSTP1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase P
EC=2.5.1.18

Alternative name(s):
GST class-pi

Gene names

Name:	gst-1
ORF Names:	R107.7

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the GST superfamily. Pi family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	glutathione transferase activity Inferred from direct assay PubMed 20392130. Source: WormBase
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
gst-23	P91505	5	EBI-326030,EBI-326040

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Glutathione S-transferase P		PRO_0000185911
Regions
	Domain	1 – 78	78	GST N-terminal
	Domain	80 – 202	123	GST C-terminal
	Region	49 – 50	2	Glutathione binding By similarity
	Region	62 – 63	2	Glutathione binding By similarity
Sites
	Binding site	7	1	Glutathione By similarity
	Binding site	38	1	Glutathione By similarity
	Binding site	42	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	P10299 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 3A0DC439FF8FFFBB	FASTA	208	23,901
	10 20 30 40 50 60 MTLKLTYFDI HGLAEPIRLL LADKQVAYED HRVTYEQWAD IKPKMIFGQV PCLLSGDEEI 70 80 90 100 110 120 VQSGAIIRHL ARLNGLNGSN ETETTFIDMF YEGLRDLHTK YTTMIYRNYE DGKAPYIKDV 130 140 150 160 170 180 LPGELARLEK LFHTYKNGEH YVIGDKESYA DYVLFEELDI HLILTPNALD GVPALKKFHE 190 200 RFAERPNIKA YLNKRAAINP PVNGNGKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A Caenorhabditis elegans cDNA that encodes a product resembling the rat glutathione S-transferase P subunit." Weston K., Yochem J., Greenwald I. Nucleic Acids Res. 17:2138-2138(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[2]	"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P. Nature 368:32-38(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[3]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13689 mRNA. Translation: CAA31979.1. Z14092 Genomic DNA. Translation: CAA78471.1.
PIR	S03615.
RefSeq	NP_499006.1. NM_066605.5.
UniGene	Cel.19723.
3D structure databases
ProteinModelPortal	P10299.
SMR	P10299. Positions 1-208.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-24298N.
IntAct	P10299. 1 interaction.
MINT	MINT-1090976.
STRING	6239.R107.7.1.
Proteomic databases
PaxDb	P10299.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	R107.7.1; R107.7.1; R107.7. R107.7.2; R107.7.2; R107.7. R107.7.3; R107.7.3; R107.7.
GeneID	176281.
KEGG	cel:CELE_R107.7.
UCSC	R107.7.1. c. elegans.
Organism-specific databases
CTD	176281.
WormBase	R107.7; CE00302; WBGene00001749; gst-1.
Phylogenomic databases
eggNOG	NOG05174.
GeneTree	ENSGT00550000074559.
HOGENOM	HOG000115733.
InParanoid	P10299.
KO	K00799.
OMA	ERPNIKA.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR003082. GST_pi. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01268. GSTRNSFRASEP.
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	891910.

Entry information

Entry name

GSTP1_CAEEL

Accession

Primary (citable) accession number: P10299

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project