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P10299

- GSTP1_CAEEL

UniProt

P10299 - GSTP1_CAEEL

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Protein
Glutathione S-transferase P
Gene
gst-1, R107.7
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71Glutathione By similarity
Binding sitei38 – 381Glutathione By similarity
Binding sitei42 – 421Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: WormBase
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. defense response to Gram-negative bacterium Source: WormBase
  2. innate immune response Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P (EC:2.5.1.18)
Alternative name(s):
GST class-pi
Gene namesi
Name:gst-1
ORF Names:R107.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiR107.7; CE00302; WBGene00001749; gst-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Glutathione S-transferase P
PRO_0000185911Add
BLAST

Proteomic databases

PaxDbiP10299.

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
gst-23P915055EBI-326030,EBI-326040

Protein-protein interaction databases

BioGridi41480. 1 interaction.
DIPiDIP-24298N.
IntActiP10299. 1 interaction.
MINTiMINT-1090976.
STRINGi6239.R107.7.1.

Structurei

3D structure databases

ProteinModelPortaliP10299.
SMRiP10299. Positions 1-208.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7878GST N-terminal
Add
BLAST
Domaini80 – 202123GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 502Glutathione binding By similarity
Regioni62 – 632Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.

Phylogenomic databases

eggNOGiNOG05174.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115733.
InParanoidiP10299.
KOiK00799.
OMAiAYLNKRA.
PhylomeDBiP10299.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10299-1 [UniParc]FASTAAdd to Basket

« Hide

MTLKLTYFDI HGLAEPIRLL LADKQVAYED HRVTYEQWAD IKPKMIFGQV    50
PCLLSGDEEI VQSGAIIRHL ARLNGLNGSN ETETTFIDMF YEGLRDLHTK 100
YTTMIYRNYE DGKAPYIKDV LPGELARLEK LFHTYKNGEH YVIGDKESYA 150
DYVLFEELDI HLILTPNALD GVPALKKFHE RFAERPNIKA YLNKRAAINP 200
PVNGNGKQ 208
Length:208
Mass (Da):23,901
Last modified:July 1, 1989 - v1
Checksum:i3A0DC439FF8FFFBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13689 mRNA. Translation: CAA31979.1.
Z14092 Genomic DNA. Translation: CAA78471.1.
PIRiS03615.
RefSeqiNP_499006.1. NM_066605.5.
UniGeneiCel.19723.

Genome annotation databases

EnsemblMetazoaiR107.7.1; R107.7.1; WBGene00001749.
R107.7.2; R107.7.2; WBGene00001749.
R107.7.3; R107.7.3; WBGene00001749.
GeneIDi176281.
KEGGicel:CELE_R107.7.
UCSCiR107.7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13689 mRNA. Translation: CAA31979.1 .
Z14092 Genomic DNA. Translation: CAA78471.1 .
PIRi S03615.
RefSeqi NP_499006.1. NM_066605.5.
UniGenei Cel.19723.

3D structure databases

ProteinModelPortali P10299.
SMRi P10299. Positions 1-208.
ModBasei Search...

Protein-protein interaction databases

BioGridi 41480. 1 interaction.
DIPi DIP-24298N.
IntActi P10299. 1 interaction.
MINTi MINT-1090976.
STRINGi 6239.R107.7.1.

Proteomic databases

PaxDbi P10299.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai R107.7.1 ; R107.7.1 ; WBGene00001749 .
R107.7.2 ; R107.7.2 ; WBGene00001749 .
R107.7.3 ; R107.7.3 ; WBGene00001749 .
GeneIDi 176281.
KEGGi cel:CELE_R107.7.
UCSCi R107.7.1. c. elegans.

Organism-specific databases

CTDi 176281.
WormBasei R107.7 ; CE00302 ; WBGene00001749 ; gst-1.

Phylogenomic databases

eggNOGi NOG05174.
GeneTreei ENSGT00550000074559.
HOGENOMi HOG000115733.
InParanoidi P10299.
KOi K00799.
OMAi AYLNKRA.
PhylomeDBi P10299.

Miscellaneous databases

NextBioi 891910.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01268. GSTRNSFRASEP.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A Caenorhabditis elegans cDNA that encodes a product resembling the rat glutathione S-transferase P subunit."
    Weston K., Yochem J., Greenwald I.
    Nucleic Acids Res. 17:2138-2138(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGSTP1_CAEEL
AccessioniPrimary (citable) accession number: P10299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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