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P10299

- GSTP1_CAEEL

UniProt

P10299 - GSTP1_CAEEL

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Protein

Glutathione S-transferase P

Gene

gst-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71GlutathioneBy similarity
Binding sitei38 – 381GlutathioneBy similarity
Binding sitei42 – 421GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: WormBase

GO - Biological processi

  1. defense response to Gram-negative bacterium Source: WormBase
  2. innate immune response Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P (EC:2.5.1.18)
Alternative name(s):
GST class-pi
Gene namesi
Name:gst-1
ORF Names:R107.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiR107.7; CE00302; WBGene00001749; gst-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Glutathione S-transferase PPRO_0000185911Add
BLAST

Proteomic databases

PaxDbiP10299.

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
gst-23P915055EBI-326030,EBI-326040

Protein-protein interaction databases

BioGridi41480. 1 interaction.
DIPiDIP-24298N.
IntActiP10299. 1 interaction.
MINTiMINT-1090976.
STRINGi6239.R107.7.1.

Structurei

3D structure databases

ProteinModelPortaliP10299.
SMRiP10299. Positions 1-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7878GST N-terminalAdd
BLAST
Domaini80 – 202123GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 502Glutathione bindingBy similarity
Regioni62 – 632Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG05174.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115733.
InParanoidiP10299.
KOiK00799.
OMAiAYLNKRA.
PhylomeDBiP10299.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10299-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLKLTYFDI HGLAEPIRLL LADKQVAYED HRVTYEQWAD IKPKMIFGQV
60 70 80 90 100
PCLLSGDEEI VQSGAIIRHL ARLNGLNGSN ETETTFIDMF YEGLRDLHTK
110 120 130 140 150
YTTMIYRNYE DGKAPYIKDV LPGELARLEK LFHTYKNGEH YVIGDKESYA
160 170 180 190 200
DYVLFEELDI HLILTPNALD GVPALKKFHE RFAERPNIKA YLNKRAAINP

PVNGNGKQ
Length:208
Mass (Da):23,901
Last modified:July 1, 1989 - v1
Checksum:i3A0DC439FF8FFFBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13689 mRNA. Translation: CAA31979.1.
Z14092 Genomic DNA. Translation: CAA78471.1.
PIRiS03615.
RefSeqiNP_499006.1. NM_066605.5.
UniGeneiCel.19723.

Genome annotation databases

EnsemblMetazoaiR107.7.1; R107.7.1; WBGene00001749.
R107.7.2; R107.7.2; WBGene00001749.
R107.7.3; R107.7.3; WBGene00001749.
GeneIDi176281.
KEGGicel:CELE_R107.7.
UCSCiR107.7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13689 mRNA. Translation: CAA31979.1 .
Z14092 Genomic DNA. Translation: CAA78471.1 .
PIRi S03615.
RefSeqi NP_499006.1. NM_066605.5.
UniGenei Cel.19723.

3D structure databases

ProteinModelPortali P10299.
SMRi P10299. Positions 1-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 41480. 1 interaction.
DIPi DIP-24298N.
IntActi P10299. 1 interaction.
MINTi MINT-1090976.
STRINGi 6239.R107.7.1.

Proteomic databases

PaxDbi P10299.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai R107.7.1 ; R107.7.1 ; WBGene00001749 .
R107.7.2 ; R107.7.2 ; WBGene00001749 .
R107.7.3 ; R107.7.3 ; WBGene00001749 .
GeneIDi 176281.
KEGGi cel:CELE_R107.7.
UCSCi R107.7.1. c. elegans.

Organism-specific databases

CTDi 176281.
WormBasei R107.7 ; CE00302 ; WBGene00001749 ; gst-1.

Phylogenomic databases

eggNOGi NOG05174.
GeneTreei ENSGT00550000074559.
HOGENOMi HOG000115733.
InParanoidi P10299.
KOi K00799.
OMAi AYLNKRA.
PhylomeDBi P10299.

Miscellaneous databases

NextBioi 891910.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01268. GSTRNSFRASEP.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A Caenorhabditis elegans cDNA that encodes a product resembling the rat glutathione S-transferase P subunit."
    Weston K., Yochem J., Greenwald I.
    Nucleic Acids Res. 17:2138-2138(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGSTP1_CAEEL
AccessioniPrimary (citable) accession number: P10299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3