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Protein

Glutathione S-transferase P

Gene

gst-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71GlutathioneBy similarity
Binding sitei38 – 381GlutathioneBy similarity
Binding sitei42 – 421GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: WormBase

GO - Biological processi

  1. defense response to Gram-negative bacterium Source: WormBase
  2. innate immune response Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_324379. Detoxification of Reactive Oxygen Species.
REACT_326456. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P (EC:2.5.1.18)
Alternative name(s):
GST class-pi
Gene namesi
Name:gst-1
ORF Names:R107.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiR107.7; CE00302; WBGene00001749; gst-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Glutathione S-transferase PPRO_0000185911Add
BLAST

Proteomic databases

PaxDbiP10299.

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
gst-23P915055EBI-326030,EBI-326040

Protein-protein interaction databases

BioGridi41480. 1 interaction.
DIPiDIP-24298N.
IntActiP10299. 1 interaction.
MINTiMINT-1090976.
STRINGi6239.R107.7.1.

Structurei

3D structure databases

SMRiP10299. Positions 1-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7878GST N-terminalAdd
BLAST
Domaini80 – 202123GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 502Glutathione bindingBy similarity
Regioni62 – 632Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG05174.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115733.
InParanoidiP10299.
KOiK00799.
OMAiAYLNKRA.
PhylomeDBiP10299.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLKLTYFDI HGLAEPIRLL LADKQVAYED HRVTYEQWAD IKPKMIFGQV
60 70 80 90 100
PCLLSGDEEI VQSGAIIRHL ARLNGLNGSN ETETTFIDMF YEGLRDLHTK
110 120 130 140 150
YTTMIYRNYE DGKAPYIKDV LPGELARLEK LFHTYKNGEH YVIGDKESYA
160 170 180 190 200
DYVLFEELDI HLILTPNALD GVPALKKFHE RFAERPNIKA YLNKRAAINP

PVNGNGKQ
Length:208
Mass (Da):23,901
Last modified:July 1, 1989 - v1
Checksum:i3A0DC439FF8FFFBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13689 mRNA. Translation: CAA31979.1.
Z14092 Genomic DNA. Translation: CAA78471.1.
PIRiS03615.
RefSeqiNP_499006.1. NM_066605.5.
UniGeneiCel.19723.

Genome annotation databases

EnsemblMetazoaiR107.7.1; R107.7.1; WBGene00001749.
R107.7.2; R107.7.2; WBGene00001749.
R107.7.3; R107.7.3; WBGene00001749.
GeneIDi176281.
KEGGicel:CELE_R107.7.
UCSCiR107.7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13689 mRNA. Translation: CAA31979.1.
Z14092 Genomic DNA. Translation: CAA78471.1.
PIRiS03615.
RefSeqiNP_499006.1. NM_066605.5.
UniGeneiCel.19723.

3D structure databases

SMRiP10299. Positions 1-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41480. 1 interaction.
DIPiDIP-24298N.
IntActiP10299. 1 interaction.
MINTiMINT-1090976.
STRINGi6239.R107.7.1.

Proteomic databases

PaxDbiP10299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR107.7.1; R107.7.1; WBGene00001749.
R107.7.2; R107.7.2; WBGene00001749.
R107.7.3; R107.7.3; WBGene00001749.
GeneIDi176281.
KEGGicel:CELE_R107.7.
UCSCiR107.7.1. c. elegans.

Organism-specific databases

CTDi176281.
WormBaseiR107.7; CE00302; WBGene00001749; gst-1.

Phylogenomic databases

eggNOGiNOG05174.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115733.
InParanoidiP10299.
KOiK00799.
OMAiAYLNKRA.
PhylomeDBiP10299.

Enzyme and pathway databases

ReactomeiREACT_324379. Detoxification of Reactive Oxygen Species.
REACT_326456. Glutathione conjugation.

Miscellaneous databases

NextBioi891910.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A Caenorhabditis elegans cDNA that encodes a product resembling the rat glutathione S-transferase P subunit."
    Weston K., Yochem J., Greenwald I.
    Nucleic Acids Res. 17:2138-2138(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGSTP1_CAEEL
AccessioniPrimary (citable) accession number: P10299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 1, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.