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P10299

- GSTP1_CAEEL

UniProt

P10299 - GSTP1_CAEEL

Protein

Glutathione S-transferase P

Gene

gst-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei7 – 71GlutathioneBy similarity
    Binding sitei38 – 381GlutathioneBy similarity
    Binding sitei42 – 421GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: WormBase
    2. protein binding Source: IntAct

    GO - Biological processi

    1. defense response to Gram-negative bacterium Source: WormBase
    2. innate immune response Source: WormBase

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase P (EC:2.5.1.18)
    Alternative name(s):
    GST class-pi
    Gene namesi
    Name:gst-1
    ORF Names:R107.7
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiR107.7; CE00302; WBGene00001749; gst-1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Glutathione S-transferase PPRO_0000185911Add
    BLAST

    Proteomic databases

    PaxDbiP10299.

    Interactioni

    Subunit structurei

    Homodimer.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    gst-23P915055EBI-326030,EBI-326040

    Protein-protein interaction databases

    BioGridi41480. 1 interaction.
    DIPiDIP-24298N.
    IntActiP10299. 1 interaction.
    MINTiMINT-1090976.
    STRINGi6239.R107.7.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP10299.
    SMRiP10299. Positions 1-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 7878GST N-terminalAdd
    BLAST
    Domaini80 – 202123GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni49 – 502Glutathione bindingBy similarity
    Regioni62 – 632Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Pi family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG05174.
    GeneTreeiENSGT00550000074559.
    HOGENOMiHOG000115733.
    InParanoidiP10299.
    KOiK00799.
    OMAiAYLNKRA.
    PhylomeDBiP10299.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003082. GST_pi.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01268. GSTRNSFRASEP.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10299-1 [UniParc]FASTAAdd to Basket

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    MTLKLTYFDI HGLAEPIRLL LADKQVAYED HRVTYEQWAD IKPKMIFGQV    50
    PCLLSGDEEI VQSGAIIRHL ARLNGLNGSN ETETTFIDMF YEGLRDLHTK 100
    YTTMIYRNYE DGKAPYIKDV LPGELARLEK LFHTYKNGEH YVIGDKESYA 150
    DYVLFEELDI HLILTPNALD GVPALKKFHE RFAERPNIKA YLNKRAAINP 200
    PVNGNGKQ 208
    Length:208
    Mass (Da):23,901
    Last modified:July 1, 1989 - v1
    Checksum:i3A0DC439FF8FFFBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13689 mRNA. Translation: CAA31979.1.
    Z14092 Genomic DNA. Translation: CAA78471.1.
    PIRiS03615.
    RefSeqiNP_499006.1. NM_066605.5.
    UniGeneiCel.19723.

    Genome annotation databases

    EnsemblMetazoaiR107.7.1; R107.7.1; WBGene00001749.
    R107.7.2; R107.7.2; WBGene00001749.
    R107.7.3; R107.7.3; WBGene00001749.
    GeneIDi176281.
    KEGGicel:CELE_R107.7.
    UCSCiR107.7.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13689 mRNA. Translation: CAA31979.1 .
    Z14092 Genomic DNA. Translation: CAA78471.1 .
    PIRi S03615.
    RefSeqi NP_499006.1. NM_066605.5.
    UniGenei Cel.19723.

    3D structure databases

    ProteinModelPortali P10299.
    SMRi P10299. Positions 1-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 41480. 1 interaction.
    DIPi DIP-24298N.
    IntActi P10299. 1 interaction.
    MINTi MINT-1090976.
    STRINGi 6239.R107.7.1.

    Proteomic databases

    PaxDbi P10299.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai R107.7.1 ; R107.7.1 ; WBGene00001749 .
    R107.7.2 ; R107.7.2 ; WBGene00001749 .
    R107.7.3 ; R107.7.3 ; WBGene00001749 .
    GeneIDi 176281.
    KEGGi cel:CELE_R107.7.
    UCSCi R107.7.1. c. elegans.

    Organism-specific databases

    CTDi 176281.
    WormBasei R107.7 ; CE00302 ; WBGene00001749 ; gst-1.

    Phylogenomic databases

    eggNOGi NOG05174.
    GeneTreei ENSGT00550000074559.
    HOGENOMi HOG000115733.
    InParanoidi P10299.
    KOi K00799.
    OMAi AYLNKRA.
    PhylomeDBi P10299.

    Miscellaneous databases

    NextBioi 891910.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003082. GST_pi.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01268. GSTRNSFRASEP.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A Caenorhabditis elegans cDNA that encodes a product resembling the rat glutathione S-transferase P subunit."
      Weston K., Yochem J., Greenwald I.
      Nucleic Acids Res. 17:2138-2138(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Bristol N2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGSTP1_CAEEL
    AccessioniPrimary (citable) accession number: P10299
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3