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Protein

Trypsin inhibitor 2

Gene
N/A
Organism
Momordica charantia (Bitter gourd) (Balsam pear)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits trypsin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei5 – 6Reactive bond2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI07.008

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin inhibitor 2
Alternative name(s):
MCTI-A
MCTI-II
Trypsin inhibitor II
OrganismiMomordica charantia (Bitter gourd) (Balsam pear)
Taxonomic identifieri3673 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeMomordiceaeMomordica

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000443871 – 28Trypsin inhibitor 2Add BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 201 Publication
Disulfide bondi10 ↔ 221 Publication
Disulfide bondi16 ↔ 271 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

IntActiP10295, 1 interactor
MINTiP10295

Structurei

Secondary structure

128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 15Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F2SX-ray1.79I1-28[»]
SMRiP10295
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10295

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

CDDicd00150 PlantTI, 1 hit
InterProiView protein in InterPro
IPR000737 Prot_inh_squash
IPR011052 Proteinase_amylase_inhib_sf
PfamiView protein in Pfam
PF00299 Squash, 1 hit
PRINTSiPR00293 SQUASHINHBTR
SUPFAMiSSF57027 SSF57027, 1 hit
PROSITEiView protein in PROSITE
PS00286 SQUASH_INHIBITOR, 1 hit

Sequencei

Sequence statusi: Complete.

P10295-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
RICPRIWMEC KRDSDCMAQC ICVDGHCG
Length:28
Mass (Da):3,230
Last modified:July 1, 1989 - v1
Checksum:i67E263D36974FEDF
GO

Sequence databases

PIRiJC2507
JX0058

Similar proteinsi

Entry informationi

Entry nameiITR2_MOMCH
AccessioniPrimary (citable) accession number: P10295
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
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Main funding by: National Institutes of Health