Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P10293

- ITR3_CUCPE

UniProt

P10293 - ITR3_CUCPE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Trypsin inhibitor 3

Gene
N/A
Organism
Cucurbita pepo (Vegetable marrow) (Summer squash)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits trypsin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei8 – 92Reactive bond

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI07.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin inhibitor 3
Alternative name(s):
CPTI-III
Trypsin inhibitor III
Cleaved into the following chain:
Alternative name(s):
CPTI-II
Trypsin inhibitor II
OrganismiCucurbita pepo (Vegetable marrow) (Summer squash)
Taxonomic identifieri3663 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeCucurbiteaeCucurbita

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3232Trypsin inhibitor 3PRO_0000033199Add
BLAST
Peptidei4 – 3229Trypsin inhibitor 2PRO_0000033200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi6 ↔ 23By similarity
Disulfide bondi13 ↔ 25By similarity
Disulfide bondi19 ↔ 31By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

MINTiMINT-87977.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 183
Beta strandi24 – 263
Beta strandi29 – 324

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BTCX-ray1.50I4-32[»]
2STBX-ray1.80I4-32[»]
ProteinModelPortaliP10293.
SMRiP10293. Positions 5-32.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10293.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR000737. Prot_inh_squash.
IPR011052. Proteinase_amylase_inhib_dom.
[Graphical view]
PfamiPF00299. Squash. 1 hit.
[Graphical view]
PRINTSiPR00293. SQUASHINHBTR.
SUPFAMiSSF57027. SSF57027. 1 hit.
PROSITEiPS00286. SQUASH_INHIBITOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10293-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30
HEERVCPKIL MECKKDSDCL AECICLEHGY CG
Length:32
Mass (Da):3,656
Last modified:July 1, 1989 - v1
Checksum:i0F6B9820BA13D512
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BTC X-ray 1.50 I 4-32 [» ]
2STB X-ray 1.80 I 4-32 [» ]
ProteinModelPortali P10293.
SMRi P10293. Positions 5-32.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-87977.

Protein family/group databases

MEROPSi I07.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P10293.

Family and domain databases

InterProi IPR000737. Prot_inh_squash.
IPR011052. Proteinase_amylase_inhib_dom.
[Graphical view ]
Pfami PF00299. Squash. 1 hit.
[Graphical view ]
PRINTSi PR00293. SQUASHINHBTR.
SUPFAMi SSF57027. SSF57027. 1 hit.
PROSITEi PS00286. SQUASH_INHIBITOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The squash family of serine proteinase inhibitors. Amino acid sequences and association equilibrium constants of inhibitors from squash, summer squash, zucchini, and cucumber seeds."
    Wieczorek M., Otlewski J., Cook J., Parks K., Leluk J., Wilimowska-Pelc A., Polanowski A., Wilusz T., Laskowski M. Jr.
    Biochem. Biophys. Res. Commun. 126:646-652(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Seed.

Entry informationi

Entry nameiITR3_CUCPE
AccessioniPrimary (citable) accession number: P10293
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3