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P10293

- ITR3_CUCPE

UniProt

P10293 - ITR3_CUCPE

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Protein
Trypsin inhibitor 3
Gene
N/A
Organism
Cucurbita pepo (Vegetable marrow) (Summer squash)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits trypsin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei8 – 92Reactive bond

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI07.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trypsin inhibitor 3
    Alternative name(s):
    CPTI-III
    Trypsin inhibitor III
    Cleaved into the following chain:
    Alternative name(s):
    CPTI-II
    Trypsin inhibitor II
    OrganismiCucurbita pepo (Vegetable marrow) (Summer squash)
    Taxonomic identifieri3663 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeCucurbiteaeCucurbita

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3232Trypsin inhibitor 3
    PRO_0000033199Add
    BLAST
    Peptidei4 – 3229Trypsin inhibitor 2
    PRO_0000033200Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi6 ↔ 23 By similarity
    Disulfide bondi13 ↔ 25 By similarity
    Disulfide bondi19 ↔ 31 By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-87977.

    Structurei

    Secondary structure

    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 183
    Beta strandi24 – 263
    Beta strandi29 – 324

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2BTCX-ray1.50I4-32[»]
    2STBX-ray1.80I4-32[»]
    ProteinModelPortaliP10293.
    SMRiP10293. Positions 5-32.

    Miscellaneous databases

    EvolutionaryTraceiP10293.

    Family & Domainsi

    Domaini

    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.

    Sequence similaritiesi

    Keywords - Domaini

    Knottin

    Family and domain databases

    InterProiIPR000737. Prot_inh_squash.
    IPR011052. Proteinase_amylase_inhib_dom.
    [Graphical view]
    PfamiPF00299. Squash. 1 hit.
    [Graphical view]
    PRINTSiPR00293. SQUASHINHBTR.
    SUPFAMiSSF57027. SSF57027. 1 hit.
    PROSITEiPS00286. SQUASH_INHIBITOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10293-1 [UniParc]FASTAAdd to Basket

    « Hide

    HEERVCPKIL MECKKDSDCL AECICLEHGY CG                      32
    Length:32
    Mass (Da):3,656
    Last modified:July 1, 1989 - v1
    Checksum:i0F6B9820BA13D512
    GO

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2BTC X-ray 1.50 I 4-32 [» ]
    2STB X-ray 1.80 I 4-32 [» ]
    ProteinModelPortali P10293.
    SMRi P10293. Positions 5-32.
    ModBasei Search...

    Protein-protein interaction databases

    MINTi MINT-87977.

    Protein family/group databases

    MEROPSi I07.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P10293.

    Family and domain databases

    InterProi IPR000737. Prot_inh_squash.
    IPR011052. Proteinase_amylase_inhib_dom.
    [Graphical view ]
    Pfami PF00299. Squash. 1 hit.
    [Graphical view ]
    PRINTSi PR00293. SQUASHINHBTR.
    SUPFAMi SSF57027. SSF57027. 1 hit.
    PROSITEi PS00286. SQUASH_INHIBITOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The squash family of serine proteinase inhibitors. Amino acid sequences and association equilibrium constants of inhibitors from squash, summer squash, zucchini, and cucumber seeds."
      Wieczorek M., Otlewski J., Cook J., Parks K., Leluk J., Wilimowska-Pelc A., Polanowski A., Wilusz T., Laskowski M. Jr.
      Biochem. Biophys. Res. Commun. 126:646-652(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Seed.

    Entry informationi

    Entry nameiITR3_CUCPE
    AccessioniPrimary (citable) accession number: P10293
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: April 16, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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