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P10292

- ITR4_CUCSA

UniProt

P10292 - ITR4_CUCSA

Protein

Trypsin inhibitor 4

Gene
N/A
Organism
Cucumis sativus (Cucumber)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Inhibits trypsin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei5 – 62Reactive bond

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI07.015.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trypsin inhibitor 4
    Alternative name(s):
    CSTI-IV
    Trypsin inhibitor IV
    OrganismiCucumis sativus (Cucumber)
    Taxonomic identifieri3659 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeBenincaseaeCucumis

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3030Trypsin inhibitor 4PRO_0000044377Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi3 ↔ 20By similarity
    Disulfide bondi10 ↔ 22By similarity
    Disulfide bondi16 ↔ 29By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliP10292.
    SMRiP10292. Positions 2-30.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Knottin

    Family and domain databases

    InterProiIPR000737. Prot_inh_squash.
    IPR011052. Proteinase_amylase_inhib_dom.
    [Graphical view]
    PfamiPF00299. Squash. 1 hit.
    [Graphical view]
    PRINTSiPR00293. SQUASHINHBTR.
    SUPFAMiSSF57027. SSF57027. 1 hit.
    PROSITEiPS00286. SQUASH_INHIBITOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10292-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMCPRILMKC KHDSDCLPGC VCLEHIEYCG                         30
    Length:30
    Mass (Da):3,429
    Last modified:July 1, 1989 - v1
    Checksum:i7A4B870E7D2A088F
    GO

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P10292.
    SMRi P10292. Positions 2-30.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I07.015.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000737. Prot_inh_squash.
    IPR011052. Proteinase_amylase_inhib_dom.
    [Graphical view ]
    Pfami PF00299. Squash. 1 hit.
    [Graphical view ]
    PRINTSi PR00293. SQUASHINHBTR.
    SUPFAMi SSF57027. SSF57027. 1 hit.
    PROSITEi PS00286. SQUASH_INHIBITOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The squash family of serine proteinase inhibitors. Amino acid sequences and association equilibrium constants of inhibitors from squash, summer squash, zucchini, and cucumber seeds."
      Wieczorek M., Otlewski J., Cook J., Parks K., Leluk J., Wilimowska-Pelc A., Polanowski A., Wilusz T., Laskowski M. Jr.
      Biochem. Biophys. Res. Commun. 126:646-652(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Seed.

    Entry informationi

    Entry nameiITR4_CUCSA
    AccessioniPrimary (citable) accession number: P10292
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3