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Protein

Gastrotropin

Gene

FABP6

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). Stimulates gastric acid and pepsinogen secretion.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrotropin
Short name:
GT
Alternative name(s):
Fatty acid-binding protein 6
Ileal lipid-binding protein
Short name:
ILBP
Porcine ileal peptide
Short name:
PIP
Gene namesi
Name:FABP6
Synonyms:ILBP, ILLBP
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm
  • Membrane; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000673822 – 128GastrotropinAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP10289.
PeptideAtlasiP10289.
PRIDEiP10289.

Expressioni

Tissue specificityi

Found exclusively in the ileum and to a lesser extent in distal jejunum.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000018050.

Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 13Combined sources9
Helixi17 – 22Combined sources6
Helixi26 – 32Combined sources7
Beta strandi37 – 53Combined sources17
Beta strandi55 – 57Combined sources3
Beta strandi59 – 68Combined sources10
Beta strandi70 – 73Combined sources4
Beta strandi75 – 77Combined sources3
Beta strandi79 – 82Combined sources4
Beta strandi88 – 93Combined sources6
Beta strandi99 – 105Combined sources7
Beta strandi108 – 115Combined sources8
Beta strandi122 – 126Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EALNMR-A2-128[»]
1EIONMR-A2-128[»]
ProteinModelPortaliP10289.
SMRiP10289.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10289.

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Can bind at least two ligands per molecule, however, the stoichiometry is debated.By similarity1 Publication

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004830.
HOVERGENiHBG005633.
InParanoidiP10289.
KOiK08755.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031257. Gastrotropin.
IPR031259. iLBP.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF69. PTHR11955:SF69. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTGKYEIE SEKNYDEFMK RLALPSDAID KARNLKIISE VKQDGQNFTW
60 70 80 90 100
SQQYPGGHSI TNTFTIGKEC DIETIGGKKF KATVQMEGGK VVVNSPNYHH
110 120
TAEIVDGKLV EVSTVGGVTY ERVSKKLA
Length:128
Mass (Da):14,219
Last modified:January 23, 2007 - v3
Checksum:i849D5A446731C3CA
GO

Sequence cautioni

The sequence AAA77657 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119T → S AA sequence (PubMed:3049572).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05136 mRNA. Translation: AAA77657.1. Different initiation.
PIRiA32675.
RefSeqiNP_999380.2. NM_214215.2.
UniGeneiSsc.676.

Genome annotation databases

GeneIDi397423.
KEGGissc:397423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05136 mRNA. Translation: AAA77657.1. Different initiation.
PIRiA32675.
RefSeqiNP_999380.2. NM_214215.2.
UniGeneiSsc.676.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EALNMR-A2-128[»]
1EIONMR-A2-128[»]
ProteinModelPortaliP10289.
SMRiP10289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000018050.

Proteomic databases

PaxDbiP10289.
PeptideAtlasiP10289.
PRIDEiP10289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397423.
KEGGissc:397423.

Organism-specific databases

CTDi2172.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004830.
HOVERGENiHBG005633.
InParanoidiP10289.
KOiK08755.

Miscellaneous databases

EvolutionaryTraceiP10289.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031257. Gastrotropin.
IPR031259. iLBP.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF69. PTHR11955:SF69. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABP6_PIG
AccessioniPrimary (citable) accession number: P10289
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.