Skip Header

Contribute Send feedback
Read comments (?) or add your own

P10288 (CADH2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin-2
Alternative name(s):
Neural cadherin
Short name=N-cadherin
Gene names
Name:CDH2
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length912 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism.

Subunit structure

Interacts with CTNNA2. Ref.3

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 5 cadherin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Propeptide29 – 164136 Potential
PRO_0000003737
Chain165 – 912748Cadherin-2
PRO_0000003738

Regions

Topological domain165 – 729565Extracellular Potential
Transmembrane730 – 75223Helical; Potential
Topological domain753 – 912160Cytoplasmic Potential
Domain165 – 272108Cadherin 1
Domain273 – 387115Cadherin 2
Domain388 – 502115Cadherin 3
Domain503 – 609107Cadherin 4
Domain610 – 720111Cadherin 5
Compositional bias869 – 88416Ser-rich

Amino acid modifications

Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation4071N-linked (GlcNAc...) Potential
Glycosylation5781N-linked (GlcNAc...) Potential
Glycosylation6281N-linked (GlcNAc...) Potential
Glycosylation6571N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict211A → G in AAB62980. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P10288 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 9BA5AC9DC1FFC489

FASTA912100,465
        10         20         30         40         50         60 
MCRIAGTPPR ILPPLALMLL AALQQAPIKA TCEDMLCKMG FPEDVHSAVV SRSVHGGQPL 

        70         80         90        100        110        120 
LNVRFQSCDE NRKIYFGSSE PEDFRVGEDG VVYAERSFQL SAEPTEFVVS ARDKETQEEW 

       130        140        150        160        170        180 
QMKVKLTPEP AFTGASEKDQ KKIEDIIFPW QQYKDSSHLK RQKRDWVIPP INLPENSRGP 

       190        200        210        220        230        240 
FPQELVRIRS DRDKSLSLRY SVTGPGADQP PTGIFIINPI SGQLSVTKPL DREQIASFHL 

       250        260        270        280        290        300 
RAHAVDVNGN QVENPIDIVI NVIDMNDNRP EFLHQVWNGT VPEGSKPGTY VMTVTAIDAD 

       310        320        330        340        350        360 
DPNAQNGMLR YRILSQAPSS PSPNMFTINN ETGDIITVAA GLDREKVQQY TLIIQATDME 

       370        380        390        400        410        420 
GNPTYGLSNT ATAVITVTDV NDNPPEFTAM TFYGEVPENR VDVIVANLTV TDKDQPHTPA 

       430        440        450        460        470        480 
WNARYQMTGG DPTGQFTILT DPNSNDGLVT VVKPIDFETN RMFVLTVAAE NQVPLAKGIQ 

       490        500        510        520        530        540 
HPPQSTATVS ITVIDVNESP YFVPNPKLVR QEEGLLAGSM LTTFTARDPD RYMQQTSLRY 

       550        560        570        580        590        600 
SKLSDPANWL KIDPVNGQIT TTAVLDRESI YVQNNMYNAT FLASDNGIPP MSGTGTLQIY 

       610        620        630        640        650        660 
LLDINDNAPQ VNPKEATTCE TLQPNAINIT AVDPDIDPNA GPFAFELPDS PPSIKRNWTI 

       670        680        690        700        710        720 
VRISGDHAQL SLRIRFLEAG IYDVPIVITD SGNPHASSTS VLKVKVCQCD INGDCTDVDR 

       730        740        750        760        770        780 
IVGAGLGTGA IIAILLCIII LLILVLMFVV WMKRRDKERQ AKQLLIDPED DVRDNILKYD 

       790        800        810        820        830        840 
EEGGGEEDQD YDLSQLQQPD TVEPDAIKPV GIRRLDERPI HAEPQYPVRS AAPHPGDIGD 

       850        860        870        880        890        900 
FINEGLKAAD NDPTAPPYDS LLVFDYEGSG STAGSLSSLN SSSSGGEQDY DYLNDWGPRF 

       910 
KKLADMYGGG DD

« Hide

References

[1]"Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family."
Hatta K., Nose A., Nagafuchi A., Takeichi M.
J. Cell Biol. 106:873-881(1988) [PubMed: 2831236] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Isolation and characterization of the promoter region of the chicken N-cadherin gene."
Li B., Paradies N.E., Brackenbury R.W.
Gene 191:7-13(1997) [PubMed: 9210582] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.
Strain: Cornish white rock Cockerel.
[3]"Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization."
Hirano S., Kimoto N., Shimoyama Y., Hirohashi S., Takeichi M.
Cell 70:293-301(1992) [PubMed: 1638632] [Abstract]
Cited for: INTERACTION WITH CTNNA2.
Tissue: Embryonic brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X07277 mRNA. Translation: CAA30258.1.
U15563 Genomic DNA. Translation: AAB62980.1.
IPIIPI00587782.
PIRIJCHCN. A29964.
RefSeqNP_001001615.1. NM_001001615.1.
UniGeneGga.1917.

3D structure databases

ProteinModelPortalP10288.
SMRP10288. Positions 30-379, 842-907.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29636N.
IntActP10288. 3 interactions.
STRINGP10288.

Proteomic databases

PRIDEP10288.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000024417; ENSGALP00000024371; ENSGALG00000015132.
GeneID414745.
KEGGgga:414745.

Organism-specific databases

CTD1000.

Phylogenomic databases

eggNOGveNOG11829.
GeneTreeENSGT00550000074431.
HOGENOMHBG505775.
HOVERGENHBG106438.
InParanoidP10288.
OMAPYFVPNP.
OrthoDBEOG483D43.
PhylomeDBP10288.

Family and domain databases

InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR009124. Desmocollin.
[Graphical view]
Gene3DG3DSA:2.60.40.60. Cadherin. 5 hits.
KOK06736.
PfamPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMSSF49313. Cadherin. 6 hits.
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCADH2_CHICK
AccessionPrimary (citable) accession number: P10288
Secondary accession number(s): Q90630
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: January 25, 2012
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents