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Protein

Cadherin-2

Gene

CDH2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone. CDH2 may be involved in neuronal recognition mechanism (By similarity).By similarity

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • extracellular matrix binding Source: AgBase
  • gamma-catenin binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-375170. CDO in myogenesis.
R-GGA-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-2
Alternative name(s):
Neural cadherin
Short name:
N-cadherin
Gene namesi
Name:CDH2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini165 – 729565ExtracellularSequence analysisAdd
BLAST
Transmembranei730 – 75223HelicalSequence analysisAdd
BLAST
Topological domaini753 – 912160CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • adherens junction Source: AgBase
  • apical part of cell Source: AgBase
  • apical plasma membrane Source: Ensembl
  • basolateral plasma membrane Source: Ensembl
  • catenin complex Source: Ensembl
  • cell Source: AgBase
  • cell body Source: AgBase
  • cell-cell adherens junction Source: AgBase
  • cell-cell junction Source: AgBase
  • cell surface Source: AgBase
  • cortical actin cytoskeleton Source: Ensembl
  • extracellular exosome Source: Ensembl
  • fascia adherens Source: Ensembl
  • focal adhesion Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • intercalated disc Source: UniProtKB
  • lamellipodium Source: Ensembl
  • neuron projection Source: AgBase
  • plasma membrane Source: UniProtKB
  • plasma membrane raft Source: Ensembl
  • synapse Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Propeptidei29 – 164136Sequence analysisPRO_0000003737Add
BLAST
Chaini165 – 912748Cadherin-2PRO_0000003738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence analysis
Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence analysis
Glycosylationi578 – 5781N-linked (GlcNAc...)Sequence analysis
Glycosylationi628 – 6281N-linked (GlcNAc...)Sequence analysis
Glycosylationi657 – 6571N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiP10288.

Interactioni

Subunit structurei

Interacts with CTNNA2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
chBcatO424865EBI-985728,EBI-972394
PTPN1O1301610EBI-985728,EBI-6938259

GO - Molecular functioni

  • gamma-catenin binding Source: BHF-UCL

Protein-protein interaction databases

DIPiDIP-29636N.
IntActiP10288. 6 interactions.
STRINGi9031.ENSGALP00000024371.

Structurei

3D structure databases

ProteinModelPortaliP10288.
SMRiP10288. Positions 30-379, 842-907.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 272108Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini273 – 387115Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini388 – 502115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini503 – 609107Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini610 – 720111Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi869 – 88416Ser-richAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP10288.
KOiK06736.
OMAiHSGHLQR.
OrthoDBiEOG7RJPQM.
PhylomeDBiP10288.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
IPR030051. CDH2.
[Graphical view]
PANTHERiPTHR24027:SF79. PTHR24027:SF79. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCRIAGTPPR ILPPLALMLL AALQQAPIKA TCEDMLCKMG FPEDVHSAVV
60 70 80 90 100
SRSVHGGQPL LNVRFQSCDE NRKIYFGSSE PEDFRVGEDG VVYAERSFQL
110 120 130 140 150
SAEPTEFVVS ARDKETQEEW QMKVKLTPEP AFTGASEKDQ KKIEDIIFPW
160 170 180 190 200
QQYKDSSHLK RQKRDWVIPP INLPENSRGP FPQELVRIRS DRDKSLSLRY
210 220 230 240 250
SVTGPGADQP PTGIFIINPI SGQLSVTKPL DREQIASFHL RAHAVDVNGN
260 270 280 290 300
QVENPIDIVI NVIDMNDNRP EFLHQVWNGT VPEGSKPGTY VMTVTAIDAD
310 320 330 340 350
DPNAQNGMLR YRILSQAPSS PSPNMFTINN ETGDIITVAA GLDREKVQQY
360 370 380 390 400
TLIIQATDME GNPTYGLSNT ATAVITVTDV NDNPPEFTAM TFYGEVPENR
410 420 430 440 450
VDVIVANLTV TDKDQPHTPA WNARYQMTGG DPTGQFTILT DPNSNDGLVT
460 470 480 490 500
VVKPIDFETN RMFVLTVAAE NQVPLAKGIQ HPPQSTATVS ITVIDVNESP
510 520 530 540 550
YFVPNPKLVR QEEGLLAGSM LTTFTARDPD RYMQQTSLRY SKLSDPANWL
560 570 580 590 600
KIDPVNGQIT TTAVLDRESI YVQNNMYNAT FLASDNGIPP MSGTGTLQIY
610 620 630 640 650
LLDINDNAPQ VNPKEATTCE TLQPNAINIT AVDPDIDPNA GPFAFELPDS
660 670 680 690 700
PPSIKRNWTI VRISGDHAQL SLRIRFLEAG IYDVPIVITD SGNPHASSTS
710 720 730 740 750
VLKVKVCQCD INGDCTDVDR IVGAGLGTGA IIAILLCIII LLILVLMFVV
760 770 780 790 800
WMKRRDKERQ AKQLLIDPED DVRDNILKYD EEGGGEEDQD YDLSQLQQPD
810 820 830 840 850
TVEPDAIKPV GIRRLDERPI HAEPQYPVRS AAPHPGDIGD FINEGLKAAD
860 870 880 890 900
NDPTAPPYDS LLVFDYEGSG STAGSLSSLN SSSSGGEQDY DYLNDWGPRF
910
KKLADMYGGG DD
Length:912
Mass (Da):100,465
Last modified:July 1, 1989 - v1
Checksum:i9BA5AC9DC1FFC489
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211A → G in AAB62980 (PubMed:9210582).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07277 mRNA. Translation: CAA30258.1.
U15563 Genomic DNA. Translation: AAB62980.1.
PIRiA29964. IJCHCN.
RefSeqiNP_001001615.1. NM_001001615.1.
UniGeneiGga.1917.

Genome annotation databases

EnsembliENSGALT00000024417; ENSGALP00000024371; ENSGALG00000015132.
GeneIDi414745.
KEGGigga:414745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07277 mRNA. Translation: CAA30258.1.
U15563 Genomic DNA. Translation: AAB62980.1.
PIRiA29964. IJCHCN.
RefSeqiNP_001001615.1. NM_001001615.1.
UniGeneiGga.1917.

3D structure databases

ProteinModelPortaliP10288.
SMRiP10288. Positions 30-379, 842-907.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29636N.
IntActiP10288. 6 interactions.
STRINGi9031.ENSGALP00000024371.

Proteomic databases

PaxDbiP10288.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000024417; ENSGALP00000024371; ENSGALG00000015132.
GeneIDi414745.
KEGGigga:414745.

Organism-specific databases

CTDi1000.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP10288.
KOiK06736.
OMAiHSGHLQR.
OrthoDBiEOG7RJPQM.
PhylomeDBiP10288.
TreeFamiTF316817.

Enzyme and pathway databases

ReactomeiR-GGA-375170. CDO in myogenesis.
R-GGA-418990. Adherens junctions interactions.

Miscellaneous databases

NextBioi20818714.
PROiP10288.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
IPR030051. CDH2.
[Graphical view]
PANTHERiPTHR24027:SF79. PTHR24027:SF79. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family."
    Hatta K., Nose A., Nagafuchi A., Takeichi M.
    J. Cell Biol. 106:873-881(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of the promoter region of the chicken N-cadherin gene."
    Li B., Paradies N.E., Brackenbury R.W.
    Gene 191:7-13(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.
    Strain: Cornish white rock Cockerel.
  3. "Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization."
    Hirano S., Kimoto N., Shimoyama Y., Hirohashi S., Takeichi M.
    Cell 70:293-301(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTNNA2.
    Tissue: Embryonic brain.

Entry informationi

Entry nameiCADH2_CHICK
AccessioniPrimary (citable) accession number: P10288
Secondary accession number(s): Q90630
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 11, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.