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Protein

Cadherin-2

Gene

CDH2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone. CDH2 may be involved in neuronal recognition mechanism (By similarity).By similarity

GO - Molecular functioni

  • alpha-catenin binding Source: Ensembl
  • cadherin binding Source: AgBase
  • calcium ion binding Source: InterPro
  • extracellular matrix binding Source: AgBase
  • gamma-catenin binding Source: BHF-UCL
  • protein kinase binding Source: Ensembl
  • protein phosphatase binding Source: Ensembl

GO - Biological processi

  • blood vessel morphogenesis Source: Ensembl
  • brain morphogenesis Source: Ensembl
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: Ensembl
  • cartilage condensation Source: AgBase
  • cell adhesion Source: AgBase
  • cell aggregation Source: AgBase
  • cell-cell adhesion mediated by cadherin Source: AgBase
  • cell-cell adhesion via plasma-membrane adhesion molecules Source: AgBase
  • cell migration Source: Ensembl
  • cerebral cortex development Source: Ensembl
  • establishment of protein localization to plasma membrane Source: Ensembl
  • glial cell differentiation Source: UniProtKB
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: Ensembl
  • homeostasis of number of cells Source: Ensembl
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: Ensembl
  • limb development Source: AgBase
  • negative regulation of canonical Wnt signaling pathway Source: Ensembl
  • negative regulation of cell migration Source: AgBase
  • neural crest cell delamination Source: AgBase
  • neural tube formation Source: AgBase
  • neuroepithelial cell differentiation Source: Ensembl
  • neuroligin clustering involved in postsynaptic membrane assembly Source: Ensembl
  • neuronal stem cell population maintenance Source: UniProtKB
  • positive regulation of MAPK cascade Source: Ensembl
  • positive regulation of synaptic vesicle clustering Source: Ensembl
  • radial glial cell differentiation Source: Ensembl
  • regulation of oligodendrocyte progenitor proliferation Source: Ensembl
  • regulation of postsynaptic density protein 95 clustering Source: Ensembl
  • striated muscle cell differentiation Source: Ensembl
  • trigeminal ganglion formation Source: AgBase
  • trigeminal ganglion structural organization Source: AgBase

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-375170. CDO in myogenesis.
R-GGA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-GGA-418990. Adherens junctions interactions.
R-GGA-8957275. Post-translational protein phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-2
Alternative name(s):
Neural cadherin
Short name:
N-cadherin
Gene namesi
Name:CDH2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini165 – 729ExtracellularSequence analysisAdd BLAST565
Transmembranei730 – 752HelicalSequence analysisAdd BLAST23
Topological domaini753 – 912CytoplasmicSequence analysisAdd BLAST160

GO - Cellular componenti

  • adherens junction Source: AgBase
  • apical part of cell Source: AgBase
  • apical plasma membrane Source: Ensembl
  • basolateral plasma membrane Source: Ensembl
  • catenin complex Source: Ensembl
  • cell Source: AgBase
  • cell body Source: AgBase
  • cell-cell adherens junction Source: AgBase
  • cell-cell junction Source: AgBase
  • cell surface Source: AgBase
  • cortical actin cytoskeleton Source: Ensembl
  • cytosol Source: AgBase
  • extracellular exosome Source: Ensembl
  • fascia adherens Source: Ensembl
  • focal adhesion Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • intercalated disc Source: UniProtKB
  • lamellipodium Source: Ensembl
  • neuron projection Source: AgBase
  • plasma membrane Source: AgBase
  • plasma membrane raft Source: Ensembl
  • postsynaptic density Source: Ensembl
  • sarcolemma Source: Ensembl

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
PropeptideiPRO_000000373729 – 164Sequence analysisAdd BLAST136
ChainiPRO_0000003738165 – 912Cadherin-2Add BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi407N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi578N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi628N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi657N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiP10288.

Expressioni

Gene expression databases

BgeeiENSGALG00000015132.

Interactioni

Subunit structurei

Interacts with CTNNA2.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • alpha-catenin binding Source: Ensembl
  • cadherin binding Source: AgBase
  • gamma-catenin binding Source: BHF-UCL
  • protein kinase binding Source: Ensembl
  • protein phosphatase binding Source: Ensembl

Protein-protein interaction databases

DIPiDIP-29636N.
IntActiP10288. 6 interactors.
STRINGi9031.ENSGALP00000024371.

Structurei

3D structure databases

ProteinModelPortaliP10288.
SMRiP10288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 272Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini273 – 387Cadherin 2PROSITE-ProRule annotationAdd BLAST115
Domaini388 – 502Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini503 – 609Cadherin 4PROSITE-ProRule annotationAdd BLAST107
Domaini610 – 720Cadherin 5PROSITE-ProRule annotationAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi869 – 884Ser-richAdd BLAST16

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP10288.
KOiK06736.
OMAiFLEAGIY.
OrthoDBiEOG091G01FV.
PhylomeDBiP10288.
TreeFamiTF316817.

Family and domain databases

Gene3Di4.10.900.10. 1 hit.
InterProiView protein in InterPro
IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
IPR030051. CDH2.
PANTHERiPTHR24027:SF365. PTHR24027:SF365. 1 hit.
PfamiView protein in Pfam
PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
PRINTSiPR00205. CADHERIN.
SMARTiView protein in SMART
SM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiView protein in PROSITE
PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCRIAGTPPR ILPPLALMLL AALQQAPIKA TCEDMLCKMG FPEDVHSAVV
60 70 80 90 100
SRSVHGGQPL LNVRFQSCDE NRKIYFGSSE PEDFRVGEDG VVYAERSFQL
110 120 130 140 150
SAEPTEFVVS ARDKETQEEW QMKVKLTPEP AFTGASEKDQ KKIEDIIFPW
160 170 180 190 200
QQYKDSSHLK RQKRDWVIPP INLPENSRGP FPQELVRIRS DRDKSLSLRY
210 220 230 240 250
SVTGPGADQP PTGIFIINPI SGQLSVTKPL DREQIASFHL RAHAVDVNGN
260 270 280 290 300
QVENPIDIVI NVIDMNDNRP EFLHQVWNGT VPEGSKPGTY VMTVTAIDAD
310 320 330 340 350
DPNAQNGMLR YRILSQAPSS PSPNMFTINN ETGDIITVAA GLDREKVQQY
360 370 380 390 400
TLIIQATDME GNPTYGLSNT ATAVITVTDV NDNPPEFTAM TFYGEVPENR
410 420 430 440 450
VDVIVANLTV TDKDQPHTPA WNARYQMTGG DPTGQFTILT DPNSNDGLVT
460 470 480 490 500
VVKPIDFETN RMFVLTVAAE NQVPLAKGIQ HPPQSTATVS ITVIDVNESP
510 520 530 540 550
YFVPNPKLVR QEEGLLAGSM LTTFTARDPD RYMQQTSLRY SKLSDPANWL
560 570 580 590 600
KIDPVNGQIT TTAVLDRESI YVQNNMYNAT FLASDNGIPP MSGTGTLQIY
610 620 630 640 650
LLDINDNAPQ VNPKEATTCE TLQPNAINIT AVDPDIDPNA GPFAFELPDS
660 670 680 690 700
PPSIKRNWTI VRISGDHAQL SLRIRFLEAG IYDVPIVITD SGNPHASSTS
710 720 730 740 750
VLKVKVCQCD INGDCTDVDR IVGAGLGTGA IIAILLCIII LLILVLMFVV
760 770 780 790 800
WMKRRDKERQ AKQLLIDPED DVRDNILKYD EEGGGEEDQD YDLSQLQQPD
810 820 830 840 850
TVEPDAIKPV GIRRLDERPI HAEPQYPVRS AAPHPGDIGD FINEGLKAAD
860 870 880 890 900
NDPTAPPYDS LLVFDYEGSG STAGSLSSLN SSSSGGEQDY DYLNDWGPRF
910
KKLADMYGGG DD
Length:912
Mass (Da):100,465
Last modified:July 1, 1989 - v1
Checksum:i9BA5AC9DC1FFC489
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21A → G in AAB62980 (PubMed:9210582).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07277 mRNA. Translation: CAA30258.1.
U15563 Genomic DNA. Translation: AAB62980.1.
PIRiA29964. IJCHCN.
RefSeqiNP_001001615.1. NM_001001615.1.
UniGeneiGga.1917.

Genome annotation databases

EnsembliENSGALT00000024417; ENSGALP00000024371; ENSGALG00000015132.
GeneIDi414745.
KEGGigga:414745.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCADH2_CHICK
AccessioniPrimary (citable) accession number: P10288
Secondary accession number(s): Q90630
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 7, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome