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Protein

Cadherin-3

Gene

Cdh3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-3
Alternative name(s):
Placental cadherin
Short name:
P-cadherin
Gene namesi
Name:Cdh3
Synonyms:Cdhp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:88356. Cdh3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini100 – 647548ExtracellularSequence analysisAdd
BLAST
Transmembranei648 – 67023HelicalSequence analysisAdd
BLAST
Topological domaini671 – 822152CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell-cell adherens junction Source: MGI
  • cytoplasm Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Propeptidei26 – 9974PRO_0000003747Add
BLAST
Chaini100 – 822723Cadherin-3PRO_0000003748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiP10287.
PRIDEiP10287.

PTM databases

PhosphoSiteiP10287.

Miscellaneous databases

PMAP-CutDBP10287.

Expressioni

Developmental stagei

Expression is high in both fetal and newborn testis but minimal in testis of 7-day-old animals. Not detected in testis of 21-day-old or adult.1 Publication

Gene expression databases

BgeeiP10287.
CleanExiMM_CDH3.
GenevisibleiP10287. MM.

Interactioni

Subunit structurei

Interacts with CDCP1 and CTNNB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079613.

Structurei

Secondary structure

1
822
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi106 – 1116Combined sources
Beta strandi116 – 1227Combined sources
Helixi126 – 1283Combined sources
Beta strandi133 – 1408Combined sources
Turni141 – 1433Combined sources
Beta strandi144 – 1463Combined sources
Beta strandi149 – 1524Combined sources
Turni154 – 1563Combined sources
Beta strandi158 – 1614Combined sources
Turni167 – 1693Combined sources
Beta strandi171 – 18111Combined sources
Beta strandi191 – 1988Combined sources
Beta strandi206 – 2083Combined sources
Beta strandi210 – 2178Combined sources
Beta strandi225 – 2284Combined sources
Beta strandi237 – 2415Combined sources
Beta strandi246 – 2549Combined sources
Beta strandi262 – 2643Combined sources
Turni266 – 2683Combined sources
Beta strandi270 – 2734Combined sources
Turni280 – 2823Combined sources
Beta strandi284 – 29411Combined sources
Helixi295 – 2973Combined sources
Beta strandi301 – 31111Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NQQX-ray3.20A/B/C/D100-312[»]
ProteinModelPortaliP10287.
SMRiP10287. Positions 100-635, 722-815.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 207108Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini208 – 320113Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini321 – 432112Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini433 – 538106Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini539 – 645107Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi778 – 79316Ser-richAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP10287.
KOiK06796.
OMAiAGWLAMD.
OrthoDBiEOG7PS1DS.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLSGPHAF LLLLLQVCWL RSVVSEPYRA GFIGEAGVTL EVEGTDLEPS
60 70 80 90 100
QVLGKVALAG QGMHHADNGD IIMLTRGTVQ GGKDAMHSPP TRILRRRKRE
110 120 130 140 150
WVMPPIFVPE NGKGPFPQRL NQLKSNKDRG TKIFYSITGP GADSPPEGVF
160 170 180 190 200
TIEKESGWLL LHMPLDREKI VKYELYGHAV SENGASVEEP MNISIIVTDQ
210 220 230 240 250
NDNKPKFTQD TFRGSVLEGV MPGTSVMQVT ATDEDDAVNT YNGVVAYSIH
260 270 280 290 300
SQEPKEPHDL MFTIHKSTGT ISVISSGLDR EKVPEYRLTV QATDMDGEGS
310 320 330 340 350
TTTAEAVVQI LDANDNAPEF EPQKYEAWVP ENEVGHEVQR LTVTDLDVPN
360 370 380 390 400
SPAWRATYHI VGGDDGDHFT ITTHPETNQG VLTTKKGLDF EAQDQHTLYV
410 420 430 440 450
EVTNEAPFAV KLPTATATVV VHVKDVNEAP VFVPPSKVIE AQEGISIGEL
460 470 480 490 500
VCIYTAQDPD KEDQKISYTI SRDPANWLAV DPDSGQITAA GILDREDEQF
510 520 530 540 550
VKNNVYEVMV LATDSGNPPT TGTGTLLLTL TDINDHGPIP EPRQIIICNQ
560 570 580 590 600
SPVPQVLNIT DKDLSPNSSP FQAQLTHDSD IYWMAEVSEK GDTVALSLKK
610 620 630 640 650
FLKQDTYDLH LSLSDHGNRE QLTMIRATVC DCHGQVFNDC PRPWKGGFIL
660 670 680 690 700
PILGAVLALL TLLLALLLLV RKKRKVKEPL LLPEDDTRDN VFYYGEEGGG
710 720 730 740 750
EEDQDYDITQ LHRGLEARPE VVLRNDVVPT FIPTPMYRPR PANPDEIGNF
760 770 780 790 800
IIENLKAANT DPTAPPYDSL LVFDYEGSGS DAASLSSLTT SASDQDQDYN
810 820
YLNEWGSRFK KLADMYGGGE DD
Length:822
Mass (Da):90,612
Last modified:July 27, 2011 - v2
Checksum:i7C653D58210A595A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti351 – 3511S → W in CAA29646 (PubMed:3428270).Curated
Sequence conflicti757 – 7571A → P in CAA29646 (PubMed:3428270).Curated
Sequence conflicti771 – 7711L → M in CAA29646 (PubMed:3428270).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06340 mRNA. Translation: CAA29646.1.
X68057 Genomic DNA. No translation available.
AK031265 mRNA. Translation: BAC27327.1.
CH466525 Genomic DNA. Translation: EDL11370.1.
BC098459 mRNA. Translation: AAH98459.1.
D12688 Genomic DNA. Translation: BAA02186.1.
CCDSiCCDS22637.1.
PIRiS03163. IJMSCP.
RefSeqiNP_001032898.1. NM_001037809.5.
UniGeneiMm.4658.

Genome annotation databases

EnsembliENSMUST00000080797; ENSMUSP00000079613; ENSMUSG00000061048.
GeneIDi12560.
KEGGimmu:12560.
UCSCiuc009ngh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06340 mRNA. Translation: CAA29646.1.
X68057 Genomic DNA. No translation available.
AK031265 mRNA. Translation: BAC27327.1.
CH466525 Genomic DNA. Translation: EDL11370.1.
BC098459 mRNA. Translation: AAH98459.1.
D12688 Genomic DNA. Translation: BAA02186.1.
CCDSiCCDS22637.1.
PIRiS03163. IJMSCP.
RefSeqiNP_001032898.1. NM_001037809.5.
UniGeneiMm.4658.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NQQX-ray3.20A/B/C/D100-312[»]
ProteinModelPortaliP10287.
SMRiP10287. Positions 100-635, 722-815.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079613.

PTM databases

PhosphoSiteiP10287.

Proteomic databases

PaxDbiP10287.
PRIDEiP10287.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080797; ENSMUSP00000079613; ENSMUSG00000061048.
GeneIDi12560.
KEGGimmu:12560.
UCSCiuc009ngh.2. mouse.

Organism-specific databases

CTDi1001.
MGIiMGI:88356. Cdh3.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP10287.
KOiK06796.
OMAiAGWLAMD.
OrthoDBiEOG7PS1DS.
TreeFamiTF316817.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Miscellaneous databases

NextBioi281626.
PMAP-CutDBP10287.
PROiP10287.
SOURCEiSearch...

Gene expression databases

BgeeiP10287.
CleanExiMM_CDH3.
GenevisibleiP10287. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of placental cadherin cDNA: identification of a novel gene family of cell-cell adhesion molecules."
    Nose A., Nagafuchi A., Takeichi M.
    EMBO J. 6:3655-3661(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Forelimb.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  5. "Genomic organization and chromosomal mapping of the mouse P-cadherin gene."
    Hatta M., Miyatani S., Copeland N.G., Gilbert D.J., Jenkins N.A., Takeichi M.
    Nucleic Acids Res. 19:4437-4441(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  6. "The 5' flanking sequences of the mouse P-cadherin gene. Homologies to 5' sequences of the E-cadherin gene and identification of a first 215 base-pair intron."
    Faraldo M.L., Cano A.
    J. Mol. Biol. 231:935-941(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-55.
  7. "Complex cell type-specific transcriptional regulation by the promoter and an intron of the mouse P-cadherin gene."
    Hatta M., Takeichi M.
    Dev. Growth Differ. 36:509-519(1994)
    Cited for: NUCLEOTIDE SEQUENCE OF 1-55.
    Strain: C57BL/6J.
  8. "A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction."
    Munro S.B., Blaschuk O.W.
    Biol. Reprod. 55:822-827(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiCADH3_MOUSE
AccessioniPrimary (citable) accession number: P10287
Secondary accession number(s): Q61465, Q8BSL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 27, 2011
Last modified: November 11, 2015
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.