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Protein

Cadherin-3

Gene

Cdh3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-3
Alternative name(s):
Placental cadherin
Short name:
P-cadherin
Gene namesi
Name:Cdh3
Synonyms:Cdhp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:88356. Cdh3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini100 – 647ExtracellularSequence analysisAdd BLAST548
Transmembranei648 – 670HelicalSequence analysisAdd BLAST23
Topological domaini671 – 822CytoplasmicSequence analysisAdd BLAST152

GO - Cellular componenti

  • cell-cell adherens junction Source: MGI
  • cytoplasm Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000374726 – 99Add BLAST74
ChainiPRO_0000003748100 – 822Cadherin-3Add BLAST723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi558N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiP10287.
PaxDbiP10287.
PeptideAtlasiP10287.
PRIDEiP10287.

PTM databases

iPTMnetiP10287.
PhosphoSitePlusiP10287.

Miscellaneous databases

PMAP-CutDBP10287.

Expressioni

Developmental stagei

Expression is high in both fetal and newborn testis but minimal in testis of 7-day-old animals. Not detected in testis of 21-day-old or adult.1 Publication

Gene expression databases

BgeeiENSMUSG00000061048.
CleanExiMM_CDH3.
GenevisibleiP10287. MM.

Interactioni

Subunit structurei

Interacts with CDCP1 and CTNNB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079613.

Structurei

Secondary structure

1822
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi106 – 111Combined sources6
Beta strandi116 – 122Combined sources7
Helixi126 – 128Combined sources3
Beta strandi133 – 140Combined sources8
Turni141 – 143Combined sources3
Beta strandi144 – 146Combined sources3
Beta strandi149 – 152Combined sources4
Turni154 – 156Combined sources3
Beta strandi158 – 161Combined sources4
Turni167 – 169Combined sources3
Beta strandi171 – 181Combined sources11
Beta strandi191 – 198Combined sources8
Beta strandi206 – 208Combined sources3
Beta strandi210 – 217Combined sources8
Beta strandi225 – 228Combined sources4
Beta strandi237 – 241Combined sources5
Beta strandi246 – 254Combined sources9
Beta strandi262 – 264Combined sources3
Turni266 – 268Combined sources3
Beta strandi270 – 273Combined sources4
Turni280 – 282Combined sources3
Beta strandi284 – 294Combined sources11
Helixi295 – 297Combined sources3
Beta strandi301 – 311Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NQQX-ray3.20A/B/C/D100-312[»]
ProteinModelPortaliP10287.
SMRiP10287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 207Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini208 – 320Cadherin 2PROSITE-ProRule annotationAdd BLAST113
Domaini321 – 432Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini433 – 538Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini539 – 645Cadherin 5PROSITE-ProRule annotationAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi778 – 793Ser-richAdd BLAST16

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP10287.
KOiK06796.
OMAiAGWLAMD.
OrthoDBiEOG091G05OA.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLSGPHAF LLLLLQVCWL RSVVSEPYRA GFIGEAGVTL EVEGTDLEPS
60 70 80 90 100
QVLGKVALAG QGMHHADNGD IIMLTRGTVQ GGKDAMHSPP TRILRRRKRE
110 120 130 140 150
WVMPPIFVPE NGKGPFPQRL NQLKSNKDRG TKIFYSITGP GADSPPEGVF
160 170 180 190 200
TIEKESGWLL LHMPLDREKI VKYELYGHAV SENGASVEEP MNISIIVTDQ
210 220 230 240 250
NDNKPKFTQD TFRGSVLEGV MPGTSVMQVT ATDEDDAVNT YNGVVAYSIH
260 270 280 290 300
SQEPKEPHDL MFTIHKSTGT ISVISSGLDR EKVPEYRLTV QATDMDGEGS
310 320 330 340 350
TTTAEAVVQI LDANDNAPEF EPQKYEAWVP ENEVGHEVQR LTVTDLDVPN
360 370 380 390 400
SPAWRATYHI VGGDDGDHFT ITTHPETNQG VLTTKKGLDF EAQDQHTLYV
410 420 430 440 450
EVTNEAPFAV KLPTATATVV VHVKDVNEAP VFVPPSKVIE AQEGISIGEL
460 470 480 490 500
VCIYTAQDPD KEDQKISYTI SRDPANWLAV DPDSGQITAA GILDREDEQF
510 520 530 540 550
VKNNVYEVMV LATDSGNPPT TGTGTLLLTL TDINDHGPIP EPRQIIICNQ
560 570 580 590 600
SPVPQVLNIT DKDLSPNSSP FQAQLTHDSD IYWMAEVSEK GDTVALSLKK
610 620 630 640 650
FLKQDTYDLH LSLSDHGNRE QLTMIRATVC DCHGQVFNDC PRPWKGGFIL
660 670 680 690 700
PILGAVLALL TLLLALLLLV RKKRKVKEPL LLPEDDTRDN VFYYGEEGGG
710 720 730 740 750
EEDQDYDITQ LHRGLEARPE VVLRNDVVPT FIPTPMYRPR PANPDEIGNF
760 770 780 790 800
IIENLKAANT DPTAPPYDSL LVFDYEGSGS DAASLSSLTT SASDQDQDYN
810 820
YLNEWGSRFK KLADMYGGGE DD
Length:822
Mass (Da):90,612
Last modified:July 27, 2011 - v2
Checksum:i7C653D58210A595A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti351S → W in CAA29646 (PubMed:3428270).Curated1
Sequence conflicti757A → P in CAA29646 (PubMed:3428270).Curated1
Sequence conflicti771L → M in CAA29646 (PubMed:3428270).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06340 mRNA. Translation: CAA29646.1.
X68057 Genomic DNA. No translation available.
AK031265 mRNA. Translation: BAC27327.1.
CH466525 Genomic DNA. Translation: EDL11370.1.
BC098459 mRNA. Translation: AAH98459.1.
D12688 Genomic DNA. Translation: BAA02186.1.
CCDSiCCDS22637.1.
PIRiS03163. IJMSCP.
RefSeqiNP_001032898.1. NM_001037809.5.
UniGeneiMm.4658.

Genome annotation databases

EnsembliENSMUST00000080797; ENSMUSP00000079613; ENSMUSG00000061048.
GeneIDi12560.
KEGGimmu:12560.
UCSCiuc009ngh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06340 mRNA. Translation: CAA29646.1.
X68057 Genomic DNA. No translation available.
AK031265 mRNA. Translation: BAC27327.1.
CH466525 Genomic DNA. Translation: EDL11370.1.
BC098459 mRNA. Translation: AAH98459.1.
D12688 Genomic DNA. Translation: BAA02186.1.
CCDSiCCDS22637.1.
PIRiS03163. IJMSCP.
RefSeqiNP_001032898.1. NM_001037809.5.
UniGeneiMm.4658.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NQQX-ray3.20A/B/C/D100-312[»]
ProteinModelPortaliP10287.
SMRiP10287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079613.

PTM databases

iPTMnetiP10287.
PhosphoSitePlusiP10287.

Proteomic databases

MaxQBiP10287.
PaxDbiP10287.
PeptideAtlasiP10287.
PRIDEiP10287.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080797; ENSMUSP00000079613; ENSMUSG00000061048.
GeneIDi12560.
KEGGimmu:12560.
UCSCiuc009ngh.2. mouse.

Organism-specific databases

CTDi1001.
MGIiMGI:88356. Cdh3.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP10287.
KOiK06796.
OMAiAGWLAMD.
OrthoDBiEOG091G05OA.
TreeFamiTF316817.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Miscellaneous databases

PMAP-CutDBP10287.
PROiP10287.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061048.
CleanExiMM_CDH3.
GenevisibleiP10287. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADH3_MOUSE
AccessioniPrimary (citable) accession number: P10287
Secondary accession number(s): Q61465, Q8BSL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.