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Protein

Calcitonin gene-related peptide

Gene

CALCA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide
Short name:
CGRP
Gene namesi
Name:CALCA
Synonyms:CALC
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Propeptidei26 – 7752PRO_0000004074Add
BLAST
Peptidei80 – 11637Calcitonin gene-related peptidePRO_0000004075Add
BLAST
Propeptidei122 – 1254PRO_0000004076

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi81 ↔ 86By similarity
Modified residuei116 – 1161Phenylalanine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000038203.
HOVERGENiHBG031362.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00817. CALCITONINB.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Calcitonin-gene related peptide (identifier: P10286-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMLKISSFL AVYALVVCQM DSFQAAPVRP GLESITDRVT LSDYEARRLL
60 70 80 90 100
NALVKDFIQM TAEELEQASE GNSVTAQKRA CNTATCVTHR LADFLSRSGG
110 120
VGKNNFVPTN VGSKAFGRRR RSVQI
Length:125
Mass (Da):13,729
Last modified:November 1, 1991 - v2
Checksum:iE864A2C9AC111F80
GO
Isoform Calcitonin (identifier: P07660-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P07660.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:138
Mass (Da):15,308
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561D → E in CAA26796 (PubMed:4054101).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06311 Genomic DNA. Translation: CAA29630.1.
X06312 Genomic DNA. No translation available.
X06314 Genomic DNA. Translation: CAA29633.1.
X03012 mRNA. Translation: CAA26796.1. Different termination.
D00007 Genomic DNA. Translation: BAA00006.1.
PIRiS00154. TCCHRP.
UniGeneiGga.1232.
Gga.4991.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06311 Genomic DNA. Translation: CAA29630.1.
X06312 Genomic DNA. No translation available.
X06314 Genomic DNA. Translation: CAA29633.1.
X03012 mRNA. Translation: CAA26796.1. Different termination.
D00007 Genomic DNA. Translation: BAA00006.1.
PIRiS00154. TCCHRP.
UniGeneiGga.1232.
Gga.4991.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000038203.
HOVERGENiHBG031362.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00817. CALCITONINB.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALCA_CHICK
AccessioniPrimary (citable) accession number: P10286
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: November 11, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.