ID   HXB4_MOUSE              Reviewed;         250 AA.
AC   P10284; Q3UZB4; Q4VBG0;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   27-MAR-2024, entry version 182.
DE   RecName: Full=Homeobox protein Hox-B4;
DE   AltName: Full=Homeobox protein Hox-2.6;
GN   Name=Hoxb4; Synonyms=Hox-2.6, Hoxb-4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2463210; DOI=10.1101/gad.2.11.1424;
RA   Graham A., Papalopulu N., Lorimer J., McVey J.H., Tuddenham E.G.D.,
RA   Krumlauf R.;
RT   "Characterization of a murine homeo box gene, Hox-2.6, related to the
RT   Drosophila Deformed gene.";
RL   Genes Dev. 2:1424-1438(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M36654; AAA37848.1; -; mRNA.
DR   EMBL; AK133945; BAE21943.1; -; mRNA.
DR   EMBL; BC095947; AAH95947.1; -; mRNA.
DR   CCDS; CCDS25297.1; -.
DR   PIR; A31757; A31757.
DR   RefSeq; NP_034589.3; NM_010459.7.
DR   AlphaFoldDB; P10284; -.
DR   SMR; P10284; -.
DR   BioGRID; 200378; 13.
DR   IntAct; P10284; 2.
DR   STRING; 10090.ENSMUSP00000048002; -.
DR   iPTMnet; P10284; -.
DR   PhosphoSitePlus; P10284; -.
DR   PaxDb; 10090-ENSMUSP00000048002; -.
DR   PeptideAtlas; P10284; -.
DR   ProteomicsDB; 266929; -.
DR   Antibodypedia; 17849; 373 antibodies from 35 providers.
DR   DNASU; 15412; -.
DR   Ensembl; ENSMUST00000049241.9; ENSMUSP00000048002.8; ENSMUSG00000038692.9.
DR   GeneID; 15412; -.
DR   KEGG; mmu:15412; -.
DR   UCSC; uc007lbv.2; mouse.
DR   AGR; MGI:96185; -.
DR   CTD; 3214; -.
DR   MGI; MGI:96185; Hoxb4.
DR   VEuPathDB; HostDB:ENSMUSG00000038692; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000162072; -.
DR   HOGENOM; CLU_061398_0_0_1; -.
DR   InParanoid; P10284; -.
DR   OMA; YASCQEP; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P10284; -.
DR   TreeFam; TF352857; -.
DR   BioGRID-ORCS; 15412; 1 hit in 79 CRISPR screens.
DR   PRO; PR:P10284; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; P10284; Protein.
DR   Bgee; ENSMUSG00000038692; Expressed in rhombomere 7 and 120 other cell types or tissues.
DR   GO; GO:0005813; C:centrosome; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0003677; F:DNA binding; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR   GO; GO:0048539; P:bone marrow development; IMP:MGI.
DR   GO; GO:0060216; P:definitive hemopoiesis; IGI:MGI.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR   GO; GO:0060218; P:hematopoietic stem cell differentiation; ISO:MGI.
DR   GO; GO:0071425; P:hematopoietic stem cell proliferation; IMP:MGI.
DR   GO; GO:0030097; P:hemopoiesis; IMP:MGI.
DR   GO; GO:0002011; P:morphogenesis of an epithelial sheet; IGI:MGI.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:2000738; P:positive regulation of stem cell differentiation; ISO:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0048705; P:skeletal system morphogenesis; IMP:MGI.
DR   GO; GO:0048103; P:somatic stem cell division; IDA:MGI.
DR   GO; GO:0048536; P:spleen development; IMP:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45771:SF3; HOMEOBOX PROTEIN HOX-B4; 1.
DR   PANTHER; PTHR45771; HOMEOTIC PROTEIN DEFORMED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P10284; MM.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..250
FT                   /note="Homeobox protein Hox-B4"
FT                   /id="PRO_0000200123"
FT   DNA_BIND        161..220
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          219..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           140..145
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        69..92
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..126
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         89
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P17483"
FT   CONFLICT        135
FT                   /note="C -> F (in Ref. 3; AAH95947)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   250 AA;  27519 MW;  D09D477A0E585BE6 CRC64;
     MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESGFQP EAAFGRRAPC
     TVQRYAACRD PGPPPPPPPP PPPPPPGLSP RAPVQPTAGA LLPEPGQRSE AVSSSPPPPP
     CAQNPLHPSP SHSACKEPVV YPWMRKVHVS TVNPNYAGGE PKRSRTAYTR QQVLELEKEF
     HYNRYLTRRR RVEIAHALCL SERQIKIWFQ NRRMKWKKDH KLPNTKIRSG GTAGAAGGPP
     GRPNGGPPAL
//