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P10284

- HXB4_MOUSE

UniProt

P10284 - HXB4_MOUSE

Protein

Homeobox protein Hox-B4

Gene

Hoxb4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi161 – 22060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. bone marrow development Source: MGI
    3. cell proliferation Source: MGI
    4. definitive hemopoiesis Source: MGI
    5. embryonic skeletal system morphogenesis Source: MGI
    6. hematopoietic stem cell differentiation Source: Ensembl
    7. hemopoiesis Source: MGI
    8. morphogenesis of an epithelial sheet Source: MGI
    9. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    10. positive regulation of stem cell differentiation Source: Ensembl
    11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. skeletal system morphogenesis Source: MGI
    13. somatic stem cell division Source: MGI
    14. spleen development Source: MGI
    15. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B4
    Alternative name(s):
    Homeobox protein Hox-2.6
    Gene namesi
    Name:Hoxb4
    Synonyms:Hox-2.6, Hoxb-4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96185. Hoxb4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Homeobox protein Hox-B4PRO_0000200123Add
    BLAST

    Proteomic databases

    PRIDEiP10284.

    PTM databases

    PhosphoSiteiP10284.

    Expressioni

    Gene expression databases

    BgeeiP10284.
    CleanExiMM_HOXB4.
    GenevestigatoriP10284.

    Interactioni

    Protein-protein interaction databases

    BioGridi200378. 2 interactions.
    IntActiP10284. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP10284.
    SMRiP10284. Positions 168-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi140 – 1456Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 138124Pro-rich (part of the transcriptional activation domain)Add
    BLAST
    Compositional biasi71 – 8616Poly-ProAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314883.
    GeneTreeiENSGT00750000117269.
    HOGENOMiHOG000231179.
    HOVERGENiHBG016849.
    InParanoidiP10284.
    KOiK09304.
    OMAiRYAACRD.
    OrthoDBiEOG780RP4.
    PhylomeDBiP10284.
    TreeFamiTF352857.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10284-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESGFQP    50
    EAAFGRRAPC TVQRYAACRD PGPPPPPPPP PPPPPPGLSP RAPVQPTAGA 100
    LLPEPGQRSE AVSSSPPPPP CAQNPLHPSP SHSACKEPVV YPWMRKVHVS 150
    TVNPNYAGGE PKRSRTAYTR QQVLELEKEF HYNRYLTRRR RVEIAHALCL 200
    SERQIKIWFQ NRRMKWKKDH KLPNTKIRSG GTAGAAGGPP GRPNGGPPAL 250
    Length:250
    Mass (Da):27,519
    Last modified:July 1, 1989 - v1
    Checksum:iD09D477A0E585BE6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti135 – 1351C → F in AAH95947. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36654 mRNA. Translation: AAA37848.1.
    AK133945 mRNA. Translation: BAE21943.1.
    BC095947 mRNA. Translation: AAH95947.1.
    CCDSiCCDS25297.1.
    PIRiA31757.
    RefSeqiNP_034589.3. NM_010459.7.
    UniGeneiMm.3546.

    Genome annotation databases

    EnsembliENSMUST00000049241; ENSMUSP00000048002; ENSMUSG00000038692.
    GeneIDi15412.
    KEGGimmu:15412.
    UCSCiuc007lbv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36654 mRNA. Translation: AAA37848.1 .
    AK133945 mRNA. Translation: BAE21943.1 .
    BC095947 mRNA. Translation: AAH95947.1 .
    CCDSi CCDS25297.1.
    PIRi A31757.
    RefSeqi NP_034589.3. NM_010459.7.
    UniGenei Mm.3546.

    3D structure databases

    ProteinModelPortali P10284.
    SMRi P10284. Positions 168-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200378. 2 interactions.
    IntActi P10284. 1 interaction.

    PTM databases

    PhosphoSitei P10284.

    Proteomic databases

    PRIDEi P10284.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049241 ; ENSMUSP00000048002 ; ENSMUSG00000038692 .
    GeneIDi 15412.
    KEGGi mmu:15412.
    UCSCi uc007lbv.2. mouse.

    Organism-specific databases

    CTDi 3214.
    MGIi MGI:96185. Hoxb4.

    Phylogenomic databases

    eggNOGi NOG314883.
    GeneTreei ENSGT00750000117269.
    HOGENOMi HOG000231179.
    HOVERGENi HBG016849.
    InParanoidi P10284.
    KOi K09304.
    OMAi RYAACRD.
    OrthoDBi EOG780RP4.
    PhylomeDBi P10284.
    TreeFami TF352857.

    Miscellaneous databases

    NextBioi 288134.
    PROi P10284.
    SOURCEi Search...

    Gene expression databases

    Bgeei P10284.
    CleanExi MM_HOXB4.
    Genevestigatori P10284.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene."
      Graham A., Papalopulu N., Lorimer J., McVey J.H., Tuddenham E.G.D., Krumlauf R.
      Genes Dev. 2:1424-1438(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiHXB4_MOUSE
    AccessioniPrimary (citable) accession number: P10284
    Secondary accession number(s): Q3UZB4, Q4VBG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3