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P10284 (HXB4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B4
Alternative name(s):
Homeobox protein Hox-2.6
Gene names
Name:Hoxb4
Synonyms:Hox-2.6, Hoxb-4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family. Deformed subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from genetic interaction PubMed 10885747PubMed 7628700PubMed 9012503. Source: MGI

bone marrow development

Inferred from mutant phenotype PubMed 14962901. Source: MGI

cell proliferation

Inferred from mutant phenotype PubMed 14962901. Source: MGI

definitive hemopoiesis

Inferred from genetic interaction PubMed 17761289. Source: MGI

embryonic skeletal system morphogenesis

Inferred from genetic interaction PubMed 10885747PubMed 7628700. Source: MGI

hematopoietic stem cell differentiation

Inferred from electronic annotation. Source: Ensembl

hemopoiesis

Inferred from mutant phenotype PubMed 14962901. Source: MGI

morphogenesis of an epithelial sheet

Inferred from genetic interaction PubMed 11518511. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 8649375. Source: MGI

positive regulation of stem cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

skeletal system morphogenesis

Inferred from mutant phenotype PubMed 9012503. Source: MGI

somatic stem cell division

Inferred from direct assay PubMed 12717450. Source: MGI

spleen development

Inferred from mutant phenotype PubMed 14962901. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from direct assay PubMed 7911971. Source: MGI

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Homeobox protein Hox-B4
PRO_0000200123

Regions

DNA binding161 – 22060Homeobox
Motif140 – 1456Antp-type hexapeptide
Compositional bias15 – 138124Pro-rich (part of the transcriptional activation domain)
Compositional bias71 – 8616Poly-Pro

Experimental info

Sequence conflict1351C → F in AAH95947. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P10284 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: D09D477A0E585BE6

FASTA25027,519
        10         20         30         40         50         60 
MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESGFQP EAAFGRRAPC 

        70         80         90        100        110        120 
TVQRYAACRD PGPPPPPPPP PPPPPPGLSP RAPVQPTAGA LLPEPGQRSE AVSSSPPPPP 

       130        140        150        160        170        180 
CAQNPLHPSP SHSACKEPVV YPWMRKVHVS TVNPNYAGGE PKRSRTAYTR QQVLELEKEF 

       190        200        210        220        230        240 
HYNRYLTRRR RVEIAHALCL SERQIKIWFQ NRRMKWKKDH KLPNTKIRSG GTAGAAGGPP 

       250 
GRPNGGPPAL 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene."
Graham A., Papalopulu N., Lorimer J., McVey J.H., Tuddenham E.G.D., Krumlauf R.
Genes Dev. 2:1424-1438(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M36654 mRNA. Translation: AAA37848.1.
AK133945 mRNA. Translation: BAE21943.1.
BC095947 mRNA. Translation: AAH95947.1.
CCDSCCDS25297.1.
PIRA31757.
RefSeqNP_034589.3. NM_010459.7.
UniGeneMm.3546.

3D structure databases

ProteinModelPortalP10284.
SMRP10284. Positions 168-221.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200378. 2 interactions.
IntActP10284. 1 interaction.

PTM databases

PhosphoSiteP10284.

Proteomic databases

PRIDEP10284.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049241; ENSMUSP00000048002; ENSMUSG00000038692.
GeneID15412.
KEGGmmu:15412.
UCSCuc007lbv.2. mouse.

Organism-specific databases

CTD3214.
MGIMGI:96185. Hoxb4.

Phylogenomic databases

eggNOGNOG314883.
GeneTreeENSGT00750000117269.
HOGENOMHOG000231179.
HOVERGENHBG016849.
InParanoidP10284.
KOK09304.
OMARYAACRD.
OrthoDBEOG780RP4.
PhylomeDBP10284.
TreeFamTF352857.

Gene expression databases

BgeeP10284.
CleanExMM_HOXB4.
GenevestigatorP10284.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288134.
PROP10284.
SOURCESearch...

Entry information

Entry nameHXB4_MOUSE
AccessionPrimary (citable) accession number: P10284
Secondary accession number(s): Q3UZB4, Q4VBG0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries