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P10284

- HXB4_MOUSE

UniProt

P10284 - HXB4_MOUSE

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Protein

Homeobox protein Hox-B4

Gene

Hoxb4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi161 – 22060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. bone marrow development Source: MGI
  3. cell proliferation Source: MGI
  4. definitive hemopoiesis Source: MGI
  5. embryonic skeletal system morphogenesis Source: MGI
  6. hematopoietic stem cell differentiation Source: Ensembl
  7. hemopoiesis Source: MGI
  8. morphogenesis of an epithelial sheet Source: MGI
  9. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  10. positive regulation of stem cell differentiation Source: Ensembl
  11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  12. skeletal system morphogenesis Source: MGI
  13. somatic stem cell division Source: MGI
  14. spleen development Source: MGI
  15. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B4
Alternative name(s):
Homeobox protein Hox-2.6
Gene namesi
Name:Hoxb4
Synonyms:Hox-2.6, Hoxb-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96185. Hoxb4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Homeobox protein Hox-B4PRO_0000200123Add
BLAST

Proteomic databases

PRIDEiP10284.

PTM databases

PhosphoSiteiP10284.

Expressioni

Gene expression databases

BgeeiP10284.
CleanExiMM_HOXB4.
GenevestigatoriP10284.

Interactioni

Protein-protein interaction databases

BioGridi200378. 2 interactions.
IntActiP10284. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP10284.
SMRiP10284. Positions 168-221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi140 – 1456Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 138124Pro-rich (part of the transcriptional activation domain)Add
BLAST
Compositional biasi71 – 8616Poly-ProAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314883.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP10284.
KOiK09304.
OMAiRYAACRD.
OrthoDBiEOG780RP4.
PhylomeDBiP10284.
TreeFamiTF352857.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10284-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESGFQP
60 70 80 90 100
EAAFGRRAPC TVQRYAACRD PGPPPPPPPP PPPPPPGLSP RAPVQPTAGA
110 120 130 140 150
LLPEPGQRSE AVSSSPPPPP CAQNPLHPSP SHSACKEPVV YPWMRKVHVS
160 170 180 190 200
TVNPNYAGGE PKRSRTAYTR QQVLELEKEF HYNRYLTRRR RVEIAHALCL
210 220 230 240 250
SERQIKIWFQ NRRMKWKKDH KLPNTKIRSG GTAGAAGGPP GRPNGGPPAL
Length:250
Mass (Da):27,519
Last modified:July 1, 1989 - v1
Checksum:iD09D477A0E585BE6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351C → F in AAH95947. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36654 mRNA. Translation: AAA37848.1.
AK133945 mRNA. Translation: BAE21943.1.
BC095947 mRNA. Translation: AAH95947.1.
CCDSiCCDS25297.1.
PIRiA31757.
RefSeqiNP_034589.3. NM_010459.7.
UniGeneiMm.3546.

Genome annotation databases

EnsembliENSMUST00000049241; ENSMUSP00000048002; ENSMUSG00000038692.
GeneIDi15412.
KEGGimmu:15412.
UCSCiuc007lbv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36654 mRNA. Translation: AAA37848.1 .
AK133945 mRNA. Translation: BAE21943.1 .
BC095947 mRNA. Translation: AAH95947.1 .
CCDSi CCDS25297.1.
PIRi A31757.
RefSeqi NP_034589.3. NM_010459.7.
UniGenei Mm.3546.

3D structure databases

ProteinModelPortali P10284.
SMRi P10284. Positions 168-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200378. 2 interactions.
IntActi P10284. 1 interaction.

PTM databases

PhosphoSitei P10284.

Proteomic databases

PRIDEi P10284.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049241 ; ENSMUSP00000048002 ; ENSMUSG00000038692 .
GeneIDi 15412.
KEGGi mmu:15412.
UCSCi uc007lbv.2. mouse.

Organism-specific databases

CTDi 3214.
MGIi MGI:96185. Hoxb4.

Phylogenomic databases

eggNOGi NOG314883.
GeneTreei ENSGT00760000118945.
HOGENOMi HOG000231179.
HOVERGENi HBG016849.
InParanoidi P10284.
KOi K09304.
OMAi RYAACRD.
OrthoDBi EOG780RP4.
PhylomeDBi P10284.
TreeFami TF352857.

Miscellaneous databases

NextBioi 288134.
PROi P10284.
SOURCEi Search...

Gene expression databases

Bgeei P10284.
CleanExi MM_HOXB4.
Genevestigatori P10284.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene."
    Graham A., Papalopulu N., Lorimer J., McVey J.H., Tuddenham E.G.D., Krumlauf R.
    Genes Dev. 2:1424-1438(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiHXB4_MOUSE
AccessioniPrimary (citable) accession number: P10284
Secondary accession number(s): Q3UZB4, Q4VBG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3