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Protein

Homeobox protein Hox-B4

Gene

Hoxb4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi161 – 220HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • bone marrow development Source: MGI
  • cell proliferation Source: MGI
  • definitive hemopoiesis Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • hematopoietic stem cell differentiation Source: MGI
  • hemopoiesis Source: MGI
  • morphogenesis of an epithelial sheet Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of stem cell differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • skeletal system morphogenesis Source: MGI
  • somatic stem cell division Source: MGI
  • spleen development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B4
Alternative name(s):
Homeobox protein Hox-2.6
Gene namesi
Name:Hoxb4
Synonyms:Hox-2.6, Hoxb-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96185 Hoxb4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001231 – 250Homeobox protein Hox-B4Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10284
PeptideAtlasiP10284
PRIDEiP10284

PTM databases

iPTMnetiP10284
PhosphoSitePlusiP10284

Expressioni

Gene expression databases

BgeeiENSMUSG00000038692
CleanExiMM_HOXB4
GenevisibleiP10284 MM

Interactioni

Protein-protein interaction databases

BioGridi200378, 2 interactors
IntActiP10284, 1 interactor
STRINGi10090.ENSMUSP00000048002

Structurei

3D structure databases

ProteinModelPortaliP10284
SMRiP10284
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi140 – 145Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 138Pro-rich (part of the transcriptional activation domain)Add BLAST124
Compositional biasi71 – 86Poly-ProAdd BLAST16

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiP10284
KOiK09304
OMAiPSHSSCK
OrthoDBiEOG091G09XD
PhylomeDBiP10284
TreeFamiTF352857

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P10284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESGFQP
60 70 80 90 100
EAAFGRRAPC TVQRYAACRD PGPPPPPPPP PPPPPPGLSP RAPVQPTAGA
110 120 130 140 150
LLPEPGQRSE AVSSSPPPPP CAQNPLHPSP SHSACKEPVV YPWMRKVHVS
160 170 180 190 200
TVNPNYAGGE PKRSRTAYTR QQVLELEKEF HYNRYLTRRR RVEIAHALCL
210 220 230 240 250
SERQIKIWFQ NRRMKWKKDH KLPNTKIRSG GTAGAAGGPP GRPNGGPPAL
Length:250
Mass (Da):27,519
Last modified:July 1, 1989 - v1
Checksum:iD09D477A0E585BE6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135C → F in AAH95947 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36654 mRNA Translation: AAA37848.1
AK133945 mRNA Translation: BAE21943.1
BC095947 mRNA Translation: AAH95947.1
CCDSiCCDS25297.1
PIRiA31757
RefSeqiNP_034589.3, NM_010459.7
UniGeneiMm.3546

Genome annotation databases

EnsembliENSMUST00000049241; ENSMUSP00000048002; ENSMUSG00000038692
GeneIDi15412
KEGGimmu:15412
UCSCiuc007lbv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHXB4_MOUSE
AccessioniPrimary (citable) accession number: P10284
Secondary accession number(s): Q3UZB4, Q4VBG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 28, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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