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Protein

Modification methylase BepI

Gene

bepIM

Organism
Brevibacterium epidermidis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CGCG, causes specific methylation on C-1 on both strands, and protects the DNA from cleavage by the BepI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei115PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3301 M.BepI

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase BepI (EC:2.1.1.37)
Short name:
M.BepI
Alternative name(s):
Cytosine-specific methyltransferase BepI
Gene namesi
Name:bepIM
OrganismiBrevibacterium epidermidis
Taxonomic identifieri1698 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesBrevibacteriaceaeBrevibacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878701 – 403Modification methylase BepIAdd BLAST403

Structurei

3D structure databases

ProteinModelPortaliP10283
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 400SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST400

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 2 hits
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P10283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLSLFSGC GGMDLGLEGG FLAHRSSINS DLYASYISDH DENYVYLKKT
60 70 80 90 100
GFETVFANDI LPFAKLAWCN FFKNRVNQPE NIFHLESIVD VVNNIENKQF
110 120 130 140 150
SFPNDIDVVT GGFPCQDFSF AGKRKGFDSH KDHNGIIYNE PTEATRGQLY
160 170 180 190 200
LWLKKVVEIT KPKVFIAENV KGLVTLGDVK DIIQKDFRNI DDGYVVLDAQ
210 220 230 240 250
VLNAKNYGVA QNRERVIFIG ISKRYANKKI LDELISLQEK SEVYPYPPYT
260 270 280 290 300
HGTDPELKPY ATLNQILAHL PEPELASTDK SQQSYSKAKL FKKTQGNIEV
310 320 330 340 350
NMNGQAPTIR AEHHGNIEFR RLSKENGGTN LSELHLPQRR LTVRECALIQ
360 370 380 390 400
SFPPDYEFVF NYGKANSVSA SAAYKIIGNA VPPLLGFAIG RHLSQIWDKL

FKT
Length:403
Mass (Da):45,466
Last modified:July 1, 1989 - v1
Checksum:i666CEE1C1C69922E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13555 Genomic DNA Translation: CAA31907.1
PIRiS02856

Similar proteinsi

Entry informationi

Entry nameiMTB1_BREEP
AccessioniPrimary (citable) accession number: P10283
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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