Major prion protein precursor - Bos taurus (Bovine)

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Reviewed, UniProtKB/Swiss-Prot P10279 (PRIO_BOVIN)

Last modified June 16, 2009. Version 103. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Major prion protein
      Short name=PrP
Alternative name(s):
    Major scrapie-associated fibril protein 1
    CD_antigen=CD230

Gene names

Name:	PRNP
Synonyms:	PRP

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	The function of PrP is not known. PrP is encoded in the host genome and is expressed both in normal and infected cells.
Subunit structure	PrP has a tendency to aggregate yielding polymers called "rods". Interacts with GRB2, PRNPIP and SYN1 By similarity.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor. Golgi apparatus By similarity.
Involvement in disease	Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
Sequence similarities	Belongs to the prion family.

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Ontologies

Keywords
Cellular component	Cell membrane Golgi apparatus Membrane
Coding sequence diversity	Polymorphism
Disease	Prion
Domain	Repeat Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	protein homooligomerization Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

Ref.18

Chain

25 – 241

217

Major prion protein

PRO_0000025627

Propeptide

242 – 264

Removed in mature form Potential

PRO_0000025628

Regions

Repeat

Repeat

Repeat

Repeat

Repeat

Repeat

Region

217

Interaction with GRB2, PRNPIP and SYN1 By similarity

Region

54 – 103

6 X 8 AA tandem repeats of P-H-G-G-G-W-G-Q

Amino acid modifications

Lipidation

241

GPI-anchor amidated alanine Potential

Glycosylation

192

N-linked (GlcNAc...) Probable

Glycosylation

208

N-linked (GlcNAc...) Probable

Disulfide bond

190 ↔ 225

Natural variations

Natural variant

W → R Ref.10

Natural variant

71 – 78

Missing in allele 2.

Natural variant

84 – 99

Missing

Natural variant

92 – 99

Missing

Natural variant

Q → R Ref.10

Natural variant

G → GGWGQPHGG

Natural variant

154

S → N Ref.10 Ref.2

Natural variant

211

E → K Ref.9

Natural variant

234

Q → R Ref.10

Experimental info

Sequence conflict

106 – 108

THG → SHS in BAA01469. Ref.2

Sequence conflict

218

E → K in BAA01467. Ref.2

Sequence conflict

218

E → K in BAA19253. Ref.4

Secondary structure

264

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P10279-1 [UniParc].

Last modified November 1, 1991. Version 2.
Checksum: D6D214038316A231
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FASTA

264

28,614

        10         20         30         40         50         60 
MVKSHIGSWI LVLFVAMWSD VGLCKKRPKP GGGWNTGGSR YPGQGSPGGN RYPPQGGGGW 

        70         80         90        100        110        120 
GQPHGGGWGQ PHGGGWGQPH GGGWGQPHGG GWGQPHGGGG WGQGGTHGQW NKPSKPKTNM 

       130        140        150        160        170        180 
KHVAGAAAAG AVVGGLGGYM LGSAMSRPLI HFGSDYEDRY YRENMHRYPN QVYYRPVDQY 

       190        200        210        220        230        240 
SNQNNFVHDC VNITVKEHTV TTTTKGENFT ETDIKMMERV VEQMCITQYQ RESQAYYQRG 

       250        260 
ASVILFSSPP VILLISFLIF LIVG

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Different forms of the bovine PrP gene have five or six copies of a short, G-C-rich element within the protein-coding exon." Goldmann W., Hunter N., Martin T., Dawson M., Hope J. J. Gen. Virol. 72:201-204(1991) [PubMed: 1671225] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Holstein-Friesian.
[2]	"Comparative sequence analysis and expression of bovine PrP gene in mouse L-929 cells." Yoshimoto J., Iinuma T., Ishiguro N., Horiuchi M., Imamura M., Shinagawa M. Virus Genes 6:343-356(1992) [PubMed: 1362024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS 92-TRP--GLY 99 DEL AND ASN-154. Strain: Holstein-Friesian. Tissue: Brain.
[3]	"Immunologic and molecular biologic studies of prion proteins in bovine spongiform encephalopathy." Prusiner S.B., Fuzi M., Scott M., Serban D., Serban H., Taraboulos A., Gabriel J.M., Wells G.A., Wilesmith J.W., Bradley R. J. Infect. Dis. 167:602-613(1993) [PubMed: 8440932] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Genomic organization of bovine PrP gene and complete nucleotide sequence of bovine PrP cDNA." Horiuchi M., Ishiguro N., Nagasawa H., Toyoda Y., Shinagawa M. Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Holstein-Friesian. Tissue: Brain.
[5]	"Complete genomic sequence of the bovine prion gene (PRNP) and polymorphism in its promoter region." Hills D., Comincini S., Schlaepfer J., Dolf G., Ferretti L., Williams J.L. Anim. Genet. 32:231-232(2001) [PubMed: 11531705] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Jersey.
[6]	"Bovine PrP gene for prion protein." Naharro G., Yugueros J., Temprano A. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT 98-GLY-GLY-TRP-GLY-GLN-PRO-HIS-GLY-GLY INS.
[7]	"Nucleotide sequence of PrP cDNA in Korean cattle." Yoo H.S., Kang S.G., Choi I.S., Kang S.K., Hwang W.S. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Korean.
[8]	"Prion gene sequence variation within diverse groups of U.S. sheep, beef cattle, and deer." Heaton M.P., Leymaster K.A., Freking B.A., Hawk D.A., Smith T.P., Keele J.W., Snelling W.M., Fox J.M., Chitko-McKown C.G., Laegreid W.W. Mamm. Genome 14:765-777(2003) [PubMed: 14722726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[9]	"Prevalence of the prion protein gene E211K variant in U.S. cattle." Heaton M.P., Keele J.W., Harhay G.P., Richt J.A., Koohmaraie M., Wheeler T.L., Shackelford S.D., Casas E., King D.A., Sonstegard T.S., Van Tassell C.P., Neibergs H.L., Chase C.C. Jr., Kalbfleisch T.S., Smith T.P.L., Clawson M.L., Laegreid W.W. BMC Vet. Res. 4:25-25(2008) [PubMed: 18625065] [Abstract] Cited for: SEQUENCE REVISION TO 211, VARIANT LYS-211.
[10]	"Cloning and sequence analysis of bovine prion protein gene." Wu R., Xie Q.G., Liu X.T., Chen H.T., Cheng J. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-60; ARG-94; ASN-154 AND ARG-234. Strain: Holstein-Friesian and Qinchuan. Tissue: Blood.
[11]	"Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3." Seabury C.M., Honeycutt R.L., Rooney A.P., Halbert N.D., Derr J.N. Proc. Natl. Acad. Sci. U.S.A. 101:15142-15147(2004) [PubMed: 15477588] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS 84-TRP--GLY 99 DEL; 92-TRP--GLY 99 DEL AND 98-GLY-GLY-TRP-GLY-GLN-PRO-HIS-GLY-GLY INS.
[12]	"Genomic characterization of the bovine PRN loci (PRNP, PRND and PRNT)." Uboldi C., Bertoni A., Del Vecchio I., Comincini S., Hills D., Schlaepfer J., Dolf G., Williams J.L., Ferretti L. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[13]	"Comparative genomic organization of the human and bovine PRNP locus." Choi S.-H., Kim I.-C., Kim D.-S., Kim D.-W., Chae S.-H., Choi H.-H., Choi I., Yeo J.-S., Song M.-N., Park H.-S. Genomics 87:598-607(2006) [PubMed: 16460908] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[14]	"Frequencies of bovine PrP gene polymorphisms in Japanese-black and Holstein bulls in japan." Abe T., Hasebe H., Kobayashi E. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Holstein and Japanese black. Tissue: Semen.
[15]	"Detection of prion protein in various animal species by a new set of monoclonal antibodies." Barbieri I., Brocchi E., Borre A., Moretti M., Gelmetti D., Capucci L. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
[16]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.
[17]	"Characterization of bovine PrP promoter region." Tanaka M., Inoue S., Ikeda T., Horiuchi M., Ishiguro N., Shinagawa M. Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15.
[18]	"Fibrils from brains of cows with new cattle disease contain scrapie-associated protein." Hope J., Reekie L.J.D., Hunter N., Multhaup G., Beyreuther K., White H., Scott A.C., Stack M.J., Dawson M., Wells G.A. Nature 336:390-392(1988) [PubMed: 2904126] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-36.
[19]	"NMR solution structure and membrane interaction of the N-terminal sequence (1-30) of the bovine prion protein." Biverstahl H., Andersson A., Graslund A., Maler L. Biochemistry 43:14940-14947(2004) [PubMed: 15554701] [Abstract] Cited for: STRUCTURE BY NMR OF 1-30.
[20]	"NMR structure of the bovine prion protein." Lopez Garcia F., Zahn R., Riek R., Wuethrich K. Proc. Natl. Acad. Sci. U.S.A. 97:8334-8339(2000) [PubMed: 10899999] [Abstract] Cited for: STRUCTURE BY NMR OF 132-241.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

X55882 Genomic DNA. Translation: CAA39368.1.
D10612 mRNA. Translation: BAA01467.1.
D10613 Genomic DNA. Translation: BAA01468.1.
D10614 Genomic DNA. Translation: BAA01469.1.
S55629 mRNA. Translation: AAB25514.1.
AB001468 mRNA. Translation: BAA19253.1.
AJ298878 Genomic DNA. Translation: CAC37367.1.
AF455119 Genomic DNA. Translation: AAM73856.1.
AF517842 mRNA. Translation: AAM66709.1.
AY335912 Genomic DNA. Translation: AAP84097.2.
AY367638 Genomic DNA. Translation: AAQ64645.1.
AY367639 Genomic DNA. Translation: AAQ64646.1.
AY367640 Genomic DNA. Translation: AAQ64647.1.
AY367641 Genomic DNA. Translation: AAQ64648.1.
AY367642 Genomic DNA. Translation: AAQ64649.1.
AY367643 Genomic DNA. Translation: AAQ64650.1.
AY720445 Genomic DNA. Translation: AAV30252.1.
AY720446 Genomic DNA. Translation: AAV30253.1.
AY720448 Genomic DNA. Translation: AAV30255.1.
AY720449 Genomic DNA. Translation: AAV30256.1.
AY720450 Genomic DNA. Translation: AAV30257.1.
AY720451 Genomic DNA. Translation: AAV30258.1.
AY720452 Genomic DNA. Translation: AAV30259.1.
AY720453 Genomic DNA. Translation: AAV30260.1.
AY720454 Genomic DNA. Translation: AAV30261.1.
AY720455 Genomic DNA. Translation: AAV30262.1.
AY720458 Genomic DNA. Translation: AAV30265.1.
AY720459 Genomic DNA. Translation: AAV30266.1.
AY720460 Genomic DNA. Translation: AAV30267.1.
AY720461 Genomic DNA. Translation: AAV30268.1.
AY720462 Genomic DNA. Translation: AAV30269.1.
AY720463 Genomic DNA. Translation: AAV30270.1.
AY720464 Genomic DNA. Translation: AAV30271.1.
AY720465 Genomic DNA. Translation: AAV30272.1.
AY720466 Genomic DNA. Translation: AAV30273.1.
AY720467 Genomic DNA. Translation: AAV30274.1.
AY720468 Genomic DNA. Translation: AAV30275.1.
AY720469 Genomic DNA. Translation: AAV30276.1.
AY720470 Genomic DNA. Translation: AAV30277.1.
AY720471 Genomic DNA. Translation: AAV30278.1.
AY720472 Genomic DNA. Translation: AAV30279.1.
AY720473 Genomic DNA. Translation: AAV30280.1.
AY720474 Genomic DNA. Translation: AAV30281.1.
AY720475 Genomic DNA. Translation: AAV30282.1.
AY720476 Genomic DNA. Translation: AAV30283.1.
AY720477 Genomic DNA. Translation: AAV30284.1.
AY720478 Genomic DNA. Translation: AAV30285.1.
AY720479 Genomic DNA. Translation: AAV30286.1.
AY720480 Genomic DNA. Translation: AAV30287.1.
AY720481 Genomic DNA. Translation: AAV30288.1.
AY720482 Genomic DNA. Translation: AAV30289.1.
AY720483 Genomic DNA. Translation: AAV30290.1.
AY720484 Genomic DNA. Translation: AAV30291.1.
AY720485 Genomic DNA. Translation: AAV30292.1.
AY720486 Genomic DNA. Translation: AAV30293.1.
AY720488 Genomic DNA. Translation: AAV30295.1.
AY720489 Genomic DNA. Translation: AAV30296.1.
AY720492 Genomic DNA. Translation: AAV30299.1.
AY720493 Genomic DNA. Translation: AAV30300.1.
AY720494 Genomic DNA. Translation: AAV30301.1.
AY720495 Genomic DNA. Translation: AAV30302.1.
AY720496 Genomic DNA. Translation: AAV30303.1.
AY720497 Genomic DNA. Translation: AAV30304.1.
AY720498 Genomic DNA. Translation: AAV30305.1.
AY720503 Genomic DNA. Translation: AAV30310.1.
AY720504 Genomic DNA. Translation: AAV30311.1.
AY720505 Genomic DNA. Translation: AAV30312.1.
AY720506 Genomic DNA. Translation: AAV30313.1.
AY720507 Genomic DNA. Translation: AAV30314.1.
AY720508 Genomic DNA. Translation: AAV30315.1.
AY720509 Genomic DNA. Translation: AAV30316.1.
AY720510 Genomic DNA. Translation: AAV30317.1.
AY720511 Genomic DNA. Translation: AAV30318.1.
AY720512 Genomic DNA. Translation: AAV30319.1.
AY720513 Genomic DNA. Translation: AAV30320.1.
AY720514 Genomic DNA. Translation: AAV30321.1.
AY720525 Genomic DNA. Translation: AAV30332.1.
AY720530 Genomic DNA. Translation: AAV30337.1.
AY720531 Genomic DNA. Translation: AAV30338.1.
AY720532 Genomic DNA. Translation: AAV30339.1.
AY720533 Genomic DNA. Translation: AAV30340.1.
AY720534 Genomic DNA. Translation: AAV30341.1.
AY720535 Genomic DNA. Translation: AAV30342.1.
AY720540 Genomic DNA. Translation: AAV30347.1.
AY720541 Genomic DNA. Translation: AAV30348.1.
AY720544 Genomic DNA. Translation: AAV30351.1.
AY720545 Genomic DNA. Translation: AAV30352.1.
AY720546 Genomic DNA. Translation: AAV30353.1.
AY720547 Genomic DNA. Translation: AAV30354.1.
AY720548 Genomic DNA. Translation: AAV30355.1.
AY720549 Genomic DNA. Translation: AAV30356.1.
AY720550 Genomic DNA. Translation: AAV30357.1.
AY720551 Genomic DNA. Translation: AAV30358.1.
AY720552 Genomic DNA. Translation: AAV30359.1.
AY720553 Genomic DNA. Translation: AAV30360.1.
AY720554 Genomic DNA. Translation: AAV30361.1.
AY720555 Genomic DNA. Translation: AAV30362.1.
AY720556 Genomic DNA. Translation: AAV30363.1.
AY720557 Genomic DNA. Translation: AAV30364.1.
AY720558 Genomic DNA. Translation: AAV30365.1.
AY720559 Genomic DNA. Translation: AAV30366.1.
AY720560 Genomic DNA. Translation: AAV30367.1.
AY720561 Genomic DNA. Translation: AAV30368.1.
AY720562 Genomic DNA. Translation: AAV30369.1.
AY720563 Genomic DNA. Translation: AAV30370.1.
AY720564 Genomic DNA. Translation: AAV30371.1.
AY720565 Genomic DNA. Translation: AAV30372.1.
AY720566 Genomic DNA. Translation: AAV30373.1.
AY720567 Genomic DNA. Translation: AAV30374.1.
AY720568 Genomic DNA. Translation: AAV30375.1.
AY720569 Genomic DNA. Translation: AAV30376.1.
AY720570 Genomic DNA. Translation: AAV30377.1.
AY720571 Genomic DNA. Translation: AAV30378.1.
AY720572 Genomic DNA. Translation: AAV30379.1.
AY720573 Genomic DNA. Translation: AAV30380.1.
AY720574 Genomic DNA. Translation: AAV30381.1.
AY720581 Genomic DNA. Translation: AAV30388.1.
AY720582 Genomic DNA. Translation: AAV30389.1.
AY720583 Genomic DNA. Translation: AAV30390.1.
AY720584 Genomic DNA. Translation: AAV30391.1.
AY720585 Genomic DNA. Translation: AAV30392.1.
AY720588 Genomic DNA. Translation: AAV30395.1.
AY720591 Genomic DNA. Translation: AAV30398.1.
AY720594 Genomic DNA. Translation: AAV30401.1.
AY720595 Genomic DNA. Translation: AAV30402.1.
AY720596 Genomic DNA. Translation: AAV30403.1.
AY720597 Genomic DNA. Translation: AAV30404.1.
AY720600 Genomic DNA. Translation: AAV30407.1.
AY720601 Genomic DNA. Translation: AAV30408.1.
AY720602 Genomic DNA. Translation: AAV30409.1.
AY720603 Genomic DNA. Translation: AAV30410.1.
AY720604 Genomic DNA. Translation: AAV30411.1.
AY720605 Genomic DNA. Translation: AAV30412.1.
AY720606 Genomic DNA. Translation: AAV30413.1.
AY720607 Genomic DNA. Translation: AAV30414.1.
AY720608 Genomic DNA. Translation: AAV30415.1.
AY720609 Genomic DNA. Translation: AAV30416.1.
AY720610 Genomic DNA. Translation: AAV30417.1.
AY720611 Genomic DNA. Translation: AAV30418.1.
AY720612 Genomic DNA. Translation: AAV30419.1.
AY720613 Genomic DNA. Translation: AAV30420.1.
AY720622 Genomic DNA. Translation: AAV30429.1.
AY720623 Genomic DNA. Translation: AAV30430.1.
AY720624 Genomic DNA. Translation: AAV30431.1.
AY720625 Genomic DNA. Translation: AAV30432.1.
AY720626 Genomic DNA. Translation: AAV30433.1.
AY720627 Genomic DNA. Translation: AAV30434.1.
AY720628 Genomic DNA. Translation: AAV30435.1.
AY720629 Genomic DNA. Translation: AAV30436.1.
AY720630 Genomic DNA. Translation: AAV30437.1.
AY720631 Genomic DNA. Translation: AAV30438.1.
AY720632 Genomic DNA. Translation: AAV30439.1.
AY720633 Genomic DNA. Translation: AAV30440.1.
AY720634 Genomic DNA. Translation: AAV30441.1.
AY720635 Genomic DNA. Translation: AAV30442.1.
AY720636 Genomic DNA. Translation: AAV30443.1.
AY720637 Genomic DNA. Translation: AAV30444.1.
AY720640 Genomic DNA. Translation: AAV30447.1.
AY720641 Genomic DNA. Translation: AAV30448.1.
AY720642 Genomic DNA. Translation: AAV30449.1.
AY720643 Genomic DNA. Translation: AAV30450.1.
AY720644 Genomic DNA. Translation: AAV30451.1.
AY720645 Genomic DNA. Translation: AAV30452.1.
AY720648 Genomic DNA. Translation: AAV30455.1.
AY720649 Genomic DNA. Translation: AAV30456.1.
AY720650 Genomic DNA. Translation: AAV30457.1.
AY720651 Genomic DNA. Translation: AAV30458.1.
AY720652 Genomic DNA. Translation: AAV30459.1.
AY720653 Genomic DNA. Translation: AAV30460.1.
AY720654 Genomic DNA. Translation: AAV30461.1.
AY720655 Genomic DNA. Translation: AAV30462.1.
AY720656 Genomic DNA. Translation: AAV30463.1.
AY720657 Genomic DNA. Translation: AAV30464.1.
AY720662 Genomic DNA. Translation: AAV30469.1.
AY720663 Genomic DNA. Translation: AAV30470.1.
AY720664 Genomic DNA. Translation: AAV30471.1.
AY720667 Genomic DNA. Translation: AAV30474.1.
AY720668 Genomic DNA. Translation: AAV30475.1.
AY720669 Genomic DNA. Translation: AAV30476.1.
AY720670 Genomic DNA. Translation: AAV30477.1.
AY720671 Genomic DNA. Translation: AAV30478.1.
AY720672 Genomic DNA. Translation: AAV30479.1.
AY720673 Genomic DNA. Translation: AAV30480.1.
AY720674 Genomic DNA. Translation: AAV30481.1.
AY720675 Genomic DNA. Translation: AAV30482.1.
AY720676 Genomic DNA. Translation: AAV30483.1.
AY720677 Genomic DNA. Translation: AAV30484.1.
AY720678 Genomic DNA. Translation: AAV30485.1.
DQ205538 Genomic DNA. Translation: ABB51165.1.
AY944236 Genomic DNA. Translation: AAY21624.1.
AB248079 Genomic DNA. Translation: BAE78586.1.
AB247937 Genomic DNA. Translation: BAE78583.1.
EF139165 Genomic DNA. Translation: ABL75501.1.
BC119821 mRNA. Translation: AAI19822.1.
D26151 Genomic DNA. Translation: BAA05138.1.

IPI

IPI00702852.

PIR

A54330.
JU0268.

RefSeq

NP_851358.1.

UniGene

Bt.4737

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1DWY	NMR	-	A	132-241	[»]
1DWZ	NMR	-	A	132-241	[»]
1DX0	NMR	-	A	25-241	[»]
1DX1	NMR	-	A	25-241	[»]
1SKH	NMR	-	A	1-30	[»]
2HH0	X-ray	2.85	P	107-115	[»]

ModBase

Search...

Genome annotation databases

Ensembl

ENSBTAG00000027937. Bos taurus. [Contig view]

GeneID

281427.

KEGG

bta:281427.

Phylogenomic databases

HOVERGEN

P10279.

OMA

P10279. PNQVYYR.

Family and domain databases

InterPro

IPR001610. PAC.
IPR000817. Prion.
[Graphical view]

Gene3D

G3DSA:1.10.790.10. Prion. 1 hit.

PANTHER

PTHR11522. Prion. 1 hit.

Pfam

PF00377. Prion. 1 hit.
PF03991. Prion_octapep. 6 hits.
[Graphical view]

PRINTS

PR00341. PRION.

SMART

SM00086. PAC. 1 hit.
SM00157. PRP. 1 hit.
[Graphical view]

PROSITE

PS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.
[Graphical view]

ProtoNet

Search...

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Entry information

Entry name

PRIO_BOVIN

Accession

Primary (citable) accession number: P10279
Secondary accession number(s): A1YVV9

Q8MJI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	November 1, 1991
Last modified:	June 16, 2009
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families