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Protein

Major prion protein

Gene

PRNP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as a agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi72Copper or zinc 1By similarity1
Metal bindingi73Copper or zinc 1; via amide nitrogenBy similarity1
Metal bindingi74Copper or zinc 1; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi80Copper or zinc 2By similarity1
Metal bindingi81Copper or zinc 2; via amide nitrogenBy similarity1
Metal bindingi82Copper or zinc 2; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi88Copper or zinc 3By similarity1
Metal bindingi89Copper or zinc 3; via amide nitrogenBy similarity1
Metal bindingi90Copper or zinc 3; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi96Copper or zinc 4By similarity1
Metal bindingi98Copper or zinc 4; via amide nitrogenBy similarity1
Metal bindingi99Copper or zinc 4; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prion

Keywords - Ligandi

Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Major prion protein
Short name:
PrP
Alternative name(s):
Major scrapie-associated fibril protein 1
CD_antigen: CD230
Gene namesi
Name:PRNP
Synonyms:PRP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity
  • Golgi apparatus By similarity

  • Note: Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu2+, to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Variations in PRNP are responsible of transmissible bovine spongiform encephalopathies (BSE), a class of neurodegenerative diseases that affect various mammals. These diseases are caused by abnormally folded prion proteins. BSE can be subdivided into at least three groups: classical, H-type and L-type, with the latter 2 collectively referred to as atypical BSE. Susceptibility or resistance to a BSE disease can be influenced by at least 3 factors related to the host prion protein: protein expression levels, number of octapeptide repeats, and specific polymorphisms. In cattle, as in humans, BSEs can occur as infectious, spontaneous and genetic diseases.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000002562725 – 241Major prion proteinAdd BLAST217
PropeptideiPRO_0000025628242 – 264Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi190 ↔ 225
Glycosylationi192N-linked (GlcNAc...)Curated1
Glycosylationi208N-linked (GlcNAc...)Curated1
Lipidationi241GPI-anchor amidated alanineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP10279.
PRIDEiP10279.

Expressioni

Gene expression databases

BgeeiENSBTAG00000027937.
ExpressionAtlasiP10279. baseline and differential.

Interactioni

Subunit structurei

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1 (By similarity). Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement (By similarity). Interacts with APP. Interacts with KIAA1191 (By similarity). Interacts with ADGRG6 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-7430632,EBI-7430632
PRNPP041565EBI-7430632,EBI-977302From a different organism.

Protein-protein interaction databases

BioGridi158758. 3 interactors.
IntActiP10279. 1 interactor.
MINTiMINT-1486044.
STRINGi9913.ENSBTAP00000043233.

Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni6 – 8Combined sources3
Helixi9 – 21Combined sources13
Beta strandi24 – 26Combined sources3
Beta strandi109 – 111Combined sources3
Helixi136 – 138Combined sources3
Beta strandi139 – 141Combined sources3
Helixi155 – 164Combined sources10
Helixi165 – 167Combined sources3
Helixi177 – 179Combined sources3
Beta strandi180 – 182Combined sources3
Helixi183 – 204Combined sources22
Helixi211 – 233Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DWYNMR-A132-241[»]
1DWZNMR-A132-241[»]
1DX0NMR-A25-241[»]
1DX1NMR-A25-241[»]
1SKHNMR-A6-30[»]
2HH0X-ray2.85P107-115[»]
2RSKNMR-C/D108-119[»]
2RU7NMR-C/D108-119[»]
4YX2X-ray2.19A103-242[»]
ProteinModelPortaliP10279.
SMRiP10279.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10279.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati54 – 6219
Repeati63 – 7028
Repeati71 – 7838
Repeati79 – 8648
Repeati87 – 9458
Repeati95 – 10369

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 241Interaction with GRB2, ERI3 and SYN1By similarityAdd BLAST217
Regioni25 – 41Interaction with ADGRG6By similarityAdd BLAST17
Regioni54 – 1036 X 8 AA tandem repeats of P-H-G-G-G-W-G-QAdd BLAST50

Domaini

The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization.By similarity
Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.By similarity

Sequence similaritiesi

Belongs to the prion family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJMM. Eukaryota.
ENOG410YXUU. LUCA.
GeneTreeiENSGT00510000049083.
HOVERGENiHBG008260.
InParanoidiP10279.
OMAiHNPGYPH.
OrthoDBiEOG091G0HMV.
TreeFamiTF105188.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR000817. Prion.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR025860. Prion_N_dom.
[Graphical view]
PANTHERiPTHR10502:SF11. PTHR10502:SF11. 1 hit.
PfamiPF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
[Graphical view]
PRINTSiPR00341. PRION.
SMARTiSM00157. PRP. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.
PROSITEiPS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKSHIGSWI LVLFVAMWSD VGLCKKRPKP GGGWNTGGSR YPGQGSPGGN
60 70 80 90 100
RYPPQGGGGW GQPHGGGWGQ PHGGGWGQPH GGGWGQPHGG GWGQPHGGGG
110 120 130 140 150
WGQGGTHGQW NKPSKPKTNM KHVAGAAAAG AVVGGLGGYM LGSAMSRPLI
160 170 180 190 200
HFGSDYEDRY YRENMHRYPN QVYYRPVDQY SNQNNFVHDC VNITVKEHTV
210 220 230 240 250
TTTTKGENFT ETDIKMMERV VEQMCITQYQ RESQAYYQRG ASVILFSSPP
260
VILLISFLIF LIVG
Length:264
Mass (Da):28,614
Last modified:November 1, 1991 - v2
Checksum:iD6D214038316A231
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106 – 108THG → SHS in BAA01469 (PubMed:1362024).Curated3
Sequence conflicti218E → K in BAA01467 (PubMed:1362024).Curated1
Sequence conflicti218E → K in BAA19253 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti60W → R.1 Publication1
Natural varianti71 – 78Missing in allele 2. 8
Natural varianti84 – 99Missing .1 PublicationAdd BLAST16
Natural varianti92 – 99Missing .2 Publications8
Natural varianti94Q → R.1 Publication1
Natural varianti98G → GGWGQPHGG.1 Publication1
Natural varianti154S → N.2 Publications1
Natural varianti211E → K.1 Publication1
Natural varianti234Q → R.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55882 Genomic DNA. Translation: CAA39368.1.
D10612 mRNA. Translation: BAA01467.1.
D10613 Genomic DNA. Translation: BAA01468.1.
D10614 Genomic DNA. Translation: BAA01469.1.
S55629 mRNA. Translation: AAB25514.1.
AB001468 mRNA. Translation: BAA19253.1.
AJ298878 Genomic DNA. Translation: CAC37367.1.
AF455119 Genomic DNA. Translation: AAM73856.1.
AF517842 mRNA. Translation: AAM66709.1.
AY335912 Genomic DNA. Translation: AAP84097.2.
AY367638 Genomic DNA. Translation: AAQ64645.1.
AY367639 Genomic DNA. Translation: AAQ64646.1.
AY367640 Genomic DNA. Translation: AAQ64647.1.
AY367641 Genomic DNA. Translation: AAQ64648.1.
AY367642 Genomic DNA. Translation: AAQ64649.1.
AY367643 Genomic DNA. Translation: AAQ64650.1.
AY720445 Genomic DNA. Translation: AAV30252.1.
AY720446 Genomic DNA. Translation: AAV30253.1.
AY720448 Genomic DNA. Translation: AAV30255.1.
AY720449 Genomic DNA. Translation: AAV30256.1.
AY720450 Genomic DNA. Translation: AAV30257.1.
AY720451 Genomic DNA. Translation: AAV30258.1.
AY720452 Genomic DNA. Translation: AAV30259.1.
AY720453 Genomic DNA. Translation: AAV30260.1.
AY720454 Genomic DNA. Translation: AAV30261.1.
AY720455 Genomic DNA. Translation: AAV30262.1.
AY720458 Genomic DNA. Translation: AAV30265.1.
AY720459 Genomic DNA. Translation: AAV30266.1.
AY720460 Genomic DNA. Translation: AAV30267.1.
AY720461 Genomic DNA. Translation: AAV30268.1.
AY720462 Genomic DNA. Translation: AAV30269.1.
AY720463 Genomic DNA. Translation: AAV30270.1.
AY720464 Genomic DNA. Translation: AAV30271.1.
AY720465 Genomic DNA. Translation: AAV30272.1.
AY720466 Genomic DNA. Translation: AAV30273.1.
AY720467 Genomic DNA. Translation: AAV30274.1.
AY720468 Genomic DNA. Translation: AAV30275.1.
AY720469 Genomic DNA. Translation: AAV30276.1.
AY720470 Genomic DNA. Translation: AAV30277.1.
AY720471 Genomic DNA. Translation: AAV30278.1.
AY720472 Genomic DNA. Translation: AAV30279.1.
AY720473 Genomic DNA. Translation: AAV30280.1.
AY720474 Genomic DNA. Translation: AAV30281.1.
AY720475 Genomic DNA. Translation: AAV30282.1.
AY720476 Genomic DNA. Translation: AAV30283.1.
AY720477 Genomic DNA. Translation: AAV30284.1.
AY720478 Genomic DNA. Translation: AAV30285.1.
AY720479 Genomic DNA. Translation: AAV30286.1.
AY720480 Genomic DNA. Translation: AAV30287.1.
AY720481 Genomic DNA. Translation: AAV30288.1.
AY720482 Genomic DNA. Translation: AAV30289.1.
AY720483 Genomic DNA. Translation: AAV30290.1.
AY720484 Genomic DNA. Translation: AAV30291.1.
AY720485 Genomic DNA. Translation: AAV30292.1.
AY720486 Genomic DNA. Translation: AAV30293.1.
AY720488 Genomic DNA. Translation: AAV30295.1.
AY720489 Genomic DNA. Translation: AAV30296.1.
AY720492 Genomic DNA. Translation: AAV30299.1.
AY720493 Genomic DNA. Translation: AAV30300.1.
AY720494 Genomic DNA. Translation: AAV30301.1.
AY720495 Genomic DNA. Translation: AAV30302.1.
AY720496 Genomic DNA. Translation: AAV30303.1.
AY720497 Genomic DNA. Translation: AAV30304.1.
AY720498 Genomic DNA. Translation: AAV30305.1.
AY720503 Genomic DNA. Translation: AAV30310.1.
AY720504 Genomic DNA. Translation: AAV30311.1.
AY720505 Genomic DNA. Translation: AAV30312.1.
AY720506 Genomic DNA. Translation: AAV30313.1.
AY720507 Genomic DNA. Translation: AAV30314.1.
AY720508 Genomic DNA. Translation: AAV30315.1.
AY720509 Genomic DNA. Translation: AAV30316.1.
AY720510 Genomic DNA. Translation: AAV30317.1.
AY720511 Genomic DNA. Translation: AAV30318.1.
AY720512 Genomic DNA. Translation: AAV30319.1.
AY720513 Genomic DNA. Translation: AAV30320.1.
AY720514 Genomic DNA. Translation: AAV30321.1.
AY720525 Genomic DNA. Translation: AAV30332.1.
AY720530 Genomic DNA. Translation: AAV30337.1.
AY720531 Genomic DNA. Translation: AAV30338.1.
AY720532 Genomic DNA. Translation: AAV30339.1.
AY720533 Genomic DNA. Translation: AAV30340.1.
AY720534 Genomic DNA. Translation: AAV30341.1.
AY720535 Genomic DNA. Translation: AAV30342.1.
AY720540 Genomic DNA. Translation: AAV30347.1.
AY720541 Genomic DNA. Translation: AAV30348.1.
AY720544 Genomic DNA. Translation: AAV30351.1.
AY720545 Genomic DNA. Translation: AAV30352.1.
AY720546 Genomic DNA. Translation: AAV30353.1.
AY720547 Genomic DNA. Translation: AAV30354.1.
AY720548 Genomic DNA. Translation: AAV30355.1.
AY720549 Genomic DNA. Translation: AAV30356.1.
AY720550 Genomic DNA. Translation: AAV30357.1.
AY720551 Genomic DNA. Translation: AAV30358.1.
AY720552 Genomic DNA. Translation: AAV30359.1.
AY720553 Genomic DNA. Translation: AAV30360.1.
AY720554 Genomic DNA. Translation: AAV30361.1.
AY720555 Genomic DNA. Translation: AAV30362.1.
AY720556 Genomic DNA. Translation: AAV30363.1.
AY720557 Genomic DNA. Translation: AAV30364.1.
AY720558 Genomic DNA. Translation: AAV30365.1.
AY720559 Genomic DNA. Translation: AAV30366.1.
AY720560 Genomic DNA. Translation: AAV30367.1.
AY720561 Genomic DNA. Translation: AAV30368.1.
AY720562 Genomic DNA. Translation: AAV30369.1.
AY720563 Genomic DNA. Translation: AAV30370.1.
AY720564 Genomic DNA. Translation: AAV30371.1.
AY720565 Genomic DNA. Translation: AAV30372.1.
AY720566 Genomic DNA. Translation: AAV30373.1.
AY720567 Genomic DNA. Translation: AAV30374.1.
AY720568 Genomic DNA. Translation: AAV30375.1.
AY720569 Genomic DNA. Translation: AAV30376.1.
AY720570 Genomic DNA. Translation: AAV30377.1.
AY720571 Genomic DNA. Translation: AAV30378.1.
AY720572 Genomic DNA. Translation: AAV30379.1.
AY720573 Genomic DNA. Translation: AAV30380.1.
AY720574 Genomic DNA. Translation: AAV30381.1.
AY720581 Genomic DNA. Translation: AAV30388.1.
AY720582 Genomic DNA. Translation: AAV30389.1.
AY720583 Genomic DNA. Translation: AAV30390.1.
AY720584 Genomic DNA. Translation: AAV30391.1.
AY720585 Genomic DNA. Translation: AAV30392.1.
AY720588 Genomic DNA. Translation: AAV30395.1.
AY720591 Genomic DNA. Translation: AAV30398.1.
AY720594 Genomic DNA. Translation: AAV30401.1.
AY720595 Genomic DNA. Translation: AAV30402.1.
AY720596 Genomic DNA. Translation: AAV30403.1.
AY720597 Genomic DNA. Translation: AAV30404.1.
AY720600 Genomic DNA. Translation: AAV30407.1.
AY720601 Genomic DNA. Translation: AAV30408.1.
AY720602 Genomic DNA. Translation: AAV30409.1.
AY720603 Genomic DNA. Translation: AAV30410.1.
AY720604 Genomic DNA. Translation: AAV30411.1.
AY720605 Genomic DNA. Translation: AAV30412.1.
AY720606 Genomic DNA. Translation: AAV30413.1.
AY720607 Genomic DNA. Translation: AAV30414.1.
AY720608 Genomic DNA. Translation: AAV30415.1.
AY720609 Genomic DNA. Translation: AAV30416.1.
AY720610 Genomic DNA. Translation: AAV30417.1.
AY720611 Genomic DNA. Translation: AAV30418.1.
AY720612 Genomic DNA. Translation: AAV30419.1.
AY720613 Genomic DNA. Translation: AAV30420.1.
AY720622 Genomic DNA. Translation: AAV30429.1.
AY720623 Genomic DNA. Translation: AAV30430.1.
AY720624 Genomic DNA. Translation: AAV30431.1.
AY720625 Genomic DNA. Translation: AAV30432.1.
AY720626 Genomic DNA. Translation: AAV30433.1.
AY720627 Genomic DNA. Translation: AAV30434.1.
AY720628 Genomic DNA. Translation: AAV30435.1.
AY720629 Genomic DNA. Translation: AAV30436.1.
AY720630 Genomic DNA. Translation: AAV30437.1.
AY720631 Genomic DNA. Translation: AAV30438.1.
AY720632 Genomic DNA. Translation: AAV30439.1.
AY720633 Genomic DNA. Translation: AAV30440.1.
AY720634 Genomic DNA. Translation: AAV30441.1.
AY720635 Genomic DNA. Translation: AAV30442.1.
AY720636 Genomic DNA. Translation: AAV30443.1.
AY720637 Genomic DNA. Translation: AAV30444.1.
AY720640 Genomic DNA. Translation: AAV30447.1.
AY720641 Genomic DNA. Translation: AAV30448.1.
AY720642 Genomic DNA. Translation: AAV30449.1.
AY720643 Genomic DNA. Translation: AAV30450.1.
AY720644 Genomic DNA. Translation: AAV30451.1.
AY720645 Genomic DNA. Translation: AAV30452.1.
AY720648 Genomic DNA. Translation: AAV30455.1.
AY720649 Genomic DNA. Translation: AAV30456.1.
AY720650 Genomic DNA. Translation: AAV30457.1.
AY720651 Genomic DNA. Translation: AAV30458.1.
AY720652 Genomic DNA. Translation: AAV30459.1.
AY720653 Genomic DNA. Translation: AAV30460.1.
AY720654 Genomic DNA. Translation: AAV30461.1.
AY720655 Genomic DNA. Translation: AAV30462.1.
AY720656 Genomic DNA. Translation: AAV30463.1.
AY720657 Genomic DNA. Translation: AAV30464.1.
AY720662 Genomic DNA. Translation: AAV30469.1.
AY720663 Genomic DNA. Translation: AAV30470.1.
AY720664 Genomic DNA. Translation: AAV30471.1.
AY720667 Genomic DNA. Translation: AAV30474.1.
AY720668 Genomic DNA. Translation: AAV30475.1.
AY720669 Genomic DNA. Translation: AAV30476.1.
AY720670 Genomic DNA. Translation: AAV30477.1.
AY720671 Genomic DNA. Translation: AAV30478.1.
AY720672 Genomic DNA. Translation: AAV30479.1.
AY720673 Genomic DNA. Translation: AAV30480.1.
AY720674 Genomic DNA. Translation: AAV30481.1.
AY720675 Genomic DNA. Translation: AAV30482.1.
AY720676 Genomic DNA. Translation: AAV30483.1.
AY720677 Genomic DNA. Translation: AAV30484.1.
AY720678 Genomic DNA. Translation: AAV30485.1.
DQ205538 Genomic DNA. Translation: ABB51165.1.
AY944236 Genomic DNA. Translation: AAY21624.1.
AB248079 Genomic DNA. Translation: BAE78586.1.
AB247937 Genomic DNA. Translation: BAE78583.1.
EF139165 Genomic DNA. Translation: ABL75501.1.
BC119821 mRNA. Translation: AAI19822.1.
D26151 Genomic DNA. Translation: BAA05138.1.
PIRiA54330.
JU0268.
RefSeqiNP_001258555.1. NM_001271626.2.
NP_851358.2. NM_181015.3.
UniGeneiBt.4737.

Genome annotation databases

EnsembliENSBTAT00000040292; ENSBTAP00000043233; ENSBTAG00000027937.
GeneIDi281427.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55882 Genomic DNA. Translation: CAA39368.1.
D10612 mRNA. Translation: BAA01467.1.
D10613 Genomic DNA. Translation: BAA01468.1.
D10614 Genomic DNA. Translation: BAA01469.1.
S55629 mRNA. Translation: AAB25514.1.
AB001468 mRNA. Translation: BAA19253.1.
AJ298878 Genomic DNA. Translation: CAC37367.1.
AF455119 Genomic DNA. Translation: AAM73856.1.
AF517842 mRNA. Translation: AAM66709.1.
AY335912 Genomic DNA. Translation: AAP84097.2.
AY367638 Genomic DNA. Translation: AAQ64645.1.
AY367639 Genomic DNA. Translation: AAQ64646.1.
AY367640 Genomic DNA. Translation: AAQ64647.1.
AY367641 Genomic DNA. Translation: AAQ64648.1.
AY367642 Genomic DNA. Translation: AAQ64649.1.
AY367643 Genomic DNA. Translation: AAQ64650.1.
AY720445 Genomic DNA. Translation: AAV30252.1.
AY720446 Genomic DNA. Translation: AAV30253.1.
AY720448 Genomic DNA. Translation: AAV30255.1.
AY720449 Genomic DNA. Translation: AAV30256.1.
AY720450 Genomic DNA. Translation: AAV30257.1.
AY720451 Genomic DNA. Translation: AAV30258.1.
AY720452 Genomic DNA. Translation: AAV30259.1.
AY720453 Genomic DNA. Translation: AAV30260.1.
AY720454 Genomic DNA. Translation: AAV30261.1.
AY720455 Genomic DNA. Translation: AAV30262.1.
AY720458 Genomic DNA. Translation: AAV30265.1.
AY720459 Genomic DNA. Translation: AAV30266.1.
AY720460 Genomic DNA. Translation: AAV30267.1.
AY720461 Genomic DNA. Translation: AAV30268.1.
AY720462 Genomic DNA. Translation: AAV30269.1.
AY720463 Genomic DNA. Translation: AAV30270.1.
AY720464 Genomic DNA. Translation: AAV30271.1.
AY720465 Genomic DNA. Translation: AAV30272.1.
AY720466 Genomic DNA. Translation: AAV30273.1.
AY720467 Genomic DNA. Translation: AAV30274.1.
AY720468 Genomic DNA. Translation: AAV30275.1.
AY720469 Genomic DNA. Translation: AAV30276.1.
AY720470 Genomic DNA. Translation: AAV30277.1.
AY720471 Genomic DNA. Translation: AAV30278.1.
AY720472 Genomic DNA. Translation: AAV30279.1.
AY720473 Genomic DNA. Translation: AAV30280.1.
AY720474 Genomic DNA. Translation: AAV30281.1.
AY720475 Genomic DNA. Translation: AAV30282.1.
AY720476 Genomic DNA. Translation: AAV30283.1.
AY720477 Genomic DNA. Translation: AAV30284.1.
AY720478 Genomic DNA. Translation: AAV30285.1.
AY720479 Genomic DNA. Translation: AAV30286.1.
AY720480 Genomic DNA. Translation: AAV30287.1.
AY720481 Genomic DNA. Translation: AAV30288.1.
AY720482 Genomic DNA. Translation: AAV30289.1.
AY720483 Genomic DNA. Translation: AAV30290.1.
AY720484 Genomic DNA. Translation: AAV30291.1.
AY720485 Genomic DNA. Translation: AAV30292.1.
AY720486 Genomic DNA. Translation: AAV30293.1.
AY720488 Genomic DNA. Translation: AAV30295.1.
AY720489 Genomic DNA. Translation: AAV30296.1.
AY720492 Genomic DNA. Translation: AAV30299.1.
AY720493 Genomic DNA. Translation: AAV30300.1.
AY720494 Genomic DNA. Translation: AAV30301.1.
AY720495 Genomic DNA. Translation: AAV30302.1.
AY720496 Genomic DNA. Translation: AAV30303.1.
AY720497 Genomic DNA. Translation: AAV30304.1.
AY720498 Genomic DNA. Translation: AAV30305.1.
AY720503 Genomic DNA. Translation: AAV30310.1.
AY720504 Genomic DNA. Translation: AAV30311.1.
AY720505 Genomic DNA. Translation: AAV30312.1.
AY720506 Genomic DNA. Translation: AAV30313.1.
AY720507 Genomic DNA. Translation: AAV30314.1.
AY720508 Genomic DNA. Translation: AAV30315.1.
AY720509 Genomic DNA. Translation: AAV30316.1.
AY720510 Genomic DNA. Translation: AAV30317.1.
AY720511 Genomic DNA. Translation: AAV30318.1.
AY720512 Genomic DNA. Translation: AAV30319.1.
AY720513 Genomic DNA. Translation: AAV30320.1.
AY720514 Genomic DNA. Translation: AAV30321.1.
AY720525 Genomic DNA. Translation: AAV30332.1.
AY720530 Genomic DNA. Translation: AAV30337.1.
AY720531 Genomic DNA. Translation: AAV30338.1.
AY720532 Genomic DNA. Translation: AAV30339.1.
AY720533 Genomic DNA. Translation: AAV30340.1.
AY720534 Genomic DNA. Translation: AAV30341.1.
AY720535 Genomic DNA. Translation: AAV30342.1.
AY720540 Genomic DNA. Translation: AAV30347.1.
AY720541 Genomic DNA. Translation: AAV30348.1.
AY720544 Genomic DNA. Translation: AAV30351.1.
AY720545 Genomic DNA. Translation: AAV30352.1.
AY720546 Genomic DNA. Translation: AAV30353.1.
AY720547 Genomic DNA. Translation: AAV30354.1.
AY720548 Genomic DNA. Translation: AAV30355.1.
AY720549 Genomic DNA. Translation: AAV30356.1.
AY720550 Genomic DNA. Translation: AAV30357.1.
AY720551 Genomic DNA. Translation: AAV30358.1.
AY720552 Genomic DNA. Translation: AAV30359.1.
AY720553 Genomic DNA. Translation: AAV30360.1.
AY720554 Genomic DNA. Translation: AAV30361.1.
AY720555 Genomic DNA. Translation: AAV30362.1.
AY720556 Genomic DNA. Translation: AAV30363.1.
AY720557 Genomic DNA. Translation: AAV30364.1.
AY720558 Genomic DNA. Translation: AAV30365.1.
AY720559 Genomic DNA. Translation: AAV30366.1.
AY720560 Genomic DNA. Translation: AAV30367.1.
AY720561 Genomic DNA. Translation: AAV30368.1.
AY720562 Genomic DNA. Translation: AAV30369.1.
AY720563 Genomic DNA. Translation: AAV30370.1.
AY720564 Genomic DNA. Translation: AAV30371.1.
AY720565 Genomic DNA. Translation: AAV30372.1.
AY720566 Genomic DNA. Translation: AAV30373.1.
AY720567 Genomic DNA. Translation: AAV30374.1.
AY720568 Genomic DNA. Translation: AAV30375.1.
AY720569 Genomic DNA. Translation: AAV30376.1.
AY720570 Genomic DNA. Translation: AAV30377.1.
AY720571 Genomic DNA. Translation: AAV30378.1.
AY720572 Genomic DNA. Translation: AAV30379.1.
AY720573 Genomic DNA. Translation: AAV30380.1.
AY720574 Genomic DNA. Translation: AAV30381.1.
AY720581 Genomic DNA. Translation: AAV30388.1.
AY720582 Genomic DNA. Translation: AAV30389.1.
AY720583 Genomic DNA. Translation: AAV30390.1.
AY720584 Genomic DNA. Translation: AAV30391.1.
AY720585 Genomic DNA. Translation: AAV30392.1.
AY720588 Genomic DNA. Translation: AAV30395.1.
AY720591 Genomic DNA. Translation: AAV30398.1.
AY720594 Genomic DNA. Translation: AAV30401.1.
AY720595 Genomic DNA. Translation: AAV30402.1.
AY720596 Genomic DNA. Translation: AAV30403.1.
AY720597 Genomic DNA. Translation: AAV30404.1.
AY720600 Genomic DNA. Translation: AAV30407.1.
AY720601 Genomic DNA. Translation: AAV30408.1.
AY720602 Genomic DNA. Translation: AAV30409.1.
AY720603 Genomic DNA. Translation: AAV30410.1.
AY720604 Genomic DNA. Translation: AAV30411.1.
AY720605 Genomic DNA. Translation: AAV30412.1.
AY720606 Genomic DNA. Translation: AAV30413.1.
AY720607 Genomic DNA. Translation: AAV30414.1.
AY720608 Genomic DNA. Translation: AAV30415.1.
AY720609 Genomic DNA. Translation: AAV30416.1.
AY720610 Genomic DNA. Translation: AAV30417.1.
AY720611 Genomic DNA. Translation: AAV30418.1.
AY720612 Genomic DNA. Translation: AAV30419.1.
AY720613 Genomic DNA. Translation: AAV30420.1.
AY720622 Genomic DNA. Translation: AAV30429.1.
AY720623 Genomic DNA. Translation: AAV30430.1.
AY720624 Genomic DNA. Translation: AAV30431.1.
AY720625 Genomic DNA. Translation: AAV30432.1.
AY720626 Genomic DNA. Translation: AAV30433.1.
AY720627 Genomic DNA. Translation: AAV30434.1.
AY720628 Genomic DNA. Translation: AAV30435.1.
AY720629 Genomic DNA. Translation: AAV30436.1.
AY720630 Genomic DNA. Translation: AAV30437.1.
AY720631 Genomic DNA. Translation: AAV30438.1.
AY720632 Genomic DNA. Translation: AAV30439.1.
AY720633 Genomic DNA. Translation: AAV30440.1.
AY720634 Genomic DNA. Translation: AAV30441.1.
AY720635 Genomic DNA. Translation: AAV30442.1.
AY720636 Genomic DNA. Translation: AAV30443.1.
AY720637 Genomic DNA. Translation: AAV30444.1.
AY720640 Genomic DNA. Translation: AAV30447.1.
AY720641 Genomic DNA. Translation: AAV30448.1.
AY720642 Genomic DNA. Translation: AAV30449.1.
AY720643 Genomic DNA. Translation: AAV30450.1.
AY720644 Genomic DNA. Translation: AAV30451.1.
AY720645 Genomic DNA. Translation: AAV30452.1.
AY720648 Genomic DNA. Translation: AAV30455.1.
AY720649 Genomic DNA. Translation: AAV30456.1.
AY720650 Genomic DNA. Translation: AAV30457.1.
AY720651 Genomic DNA. Translation: AAV30458.1.
AY720652 Genomic DNA. Translation: AAV30459.1.
AY720653 Genomic DNA. Translation: AAV30460.1.
AY720654 Genomic DNA. Translation: AAV30461.1.
AY720655 Genomic DNA. Translation: AAV30462.1.
AY720656 Genomic DNA. Translation: AAV30463.1.
AY720657 Genomic DNA. Translation: AAV30464.1.
AY720662 Genomic DNA. Translation: AAV30469.1.
AY720663 Genomic DNA. Translation: AAV30470.1.
AY720664 Genomic DNA. Translation: AAV30471.1.
AY720667 Genomic DNA. Translation: AAV30474.1.
AY720668 Genomic DNA. Translation: AAV30475.1.
AY720669 Genomic DNA. Translation: AAV30476.1.
AY720670 Genomic DNA. Translation: AAV30477.1.
AY720671 Genomic DNA. Translation: AAV30478.1.
AY720672 Genomic DNA. Translation: AAV30479.1.
AY720673 Genomic DNA. Translation: AAV30480.1.
AY720674 Genomic DNA. Translation: AAV30481.1.
AY720675 Genomic DNA. Translation: AAV30482.1.
AY720676 Genomic DNA. Translation: AAV30483.1.
AY720677 Genomic DNA. Translation: AAV30484.1.
AY720678 Genomic DNA. Translation: AAV30485.1.
DQ205538 Genomic DNA. Translation: ABB51165.1.
AY944236 Genomic DNA. Translation: AAY21624.1.
AB248079 Genomic DNA. Translation: BAE78586.1.
AB247937 Genomic DNA. Translation: BAE78583.1.
EF139165 Genomic DNA. Translation: ABL75501.1.
BC119821 mRNA. Translation: AAI19822.1.
D26151 Genomic DNA. Translation: BAA05138.1.
PIRiA54330.
JU0268.
RefSeqiNP_001258555.1. NM_001271626.2.
NP_851358.2. NM_181015.3.
UniGeneiBt.4737.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DWYNMR-A132-241[»]
1DWZNMR-A132-241[»]
1DX0NMR-A25-241[»]
1DX1NMR-A25-241[»]
1SKHNMR-A6-30[»]
2HH0X-ray2.85P107-115[»]
2RSKNMR-C/D108-119[»]
2RU7NMR-C/D108-119[»]
4YX2X-ray2.19A103-242[»]
ProteinModelPortaliP10279.
SMRiP10279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi158758. 3 interactors.
IntActiP10279. 1 interactor.
MINTiMINT-1486044.
STRINGi9913.ENSBTAP00000043233.

Proteomic databases

PaxDbiP10279.
PRIDEiP10279.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000040292; ENSBTAP00000043233; ENSBTAG00000027937.
GeneIDi281427.

Organism-specific databases

CTDi5621.

Phylogenomic databases

eggNOGiENOG410IJMM. Eukaryota.
ENOG410YXUU. LUCA.
GeneTreeiENSGT00510000049083.
HOVERGENiHBG008260.
InParanoidiP10279.
OMAiHNPGYPH.
OrthoDBiEOG091G0HMV.
TreeFamiTF105188.

Miscellaneous databases

EvolutionaryTraceiP10279.

Gene expression databases

BgeeiENSBTAG00000027937.
ExpressionAtlasiP10279. baseline and differential.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR000817. Prion.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR025860. Prion_N_dom.
[Graphical view]
PANTHERiPTHR10502:SF11. PTHR10502:SF11. 1 hit.
PfamiPF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
[Graphical view]
PRINTSiPR00341. PRION.
SMARTiSM00157. PRP. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.
PROSITEiPS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRIO_BOVIN
AccessioniPrimary (citable) accession number: P10279
Secondary accession number(s): A1YVV9
, Q01880, Q0VD57, Q5UJJ5, Q5UJM6, Q5UK69, Q5UK71, Q6UL03, Q6UL04, Q6UL05, Q6UL06, Q7YRN3, Q8MJI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: November 30, 2016
This is version 167 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is produced by a bicistronic gene which also produces the major prion protein/PRNP from an overlapping reading frame.
The alternative prion protein/AltPrP (AC F7VJQ2) and PRNP have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP (By similarity). In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.