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P10279

- PRIO_BOVIN

UniProt

P10279 - PRIO_BOVIN

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Protein

Major prion protein

Gene
PRNP, PRP
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi72 – 721Copper or zinc 1 By similarity
Metal bindingi73 – 731Copper or zinc 1; via amide nitrogen By similarity
Metal bindingi74 – 741Copper or zinc 1; via amide nitrogen and carbonyl oxygen By similarity
Metal bindingi80 – 801Copper or zinc 2 By similarity
Metal bindingi81 – 811Copper or zinc 2; via amide nitrogen By similarity
Metal bindingi82 – 821Copper or zinc 2; via amide nitrogen and carbonyl oxygen By similarity
Metal bindingi88 – 881Copper or zinc 3 By similarity
Metal bindingi89 – 891Copper or zinc 3; via amide nitrogen By similarity
Metal bindingi90 – 901Copper or zinc 3; via amide nitrogen and carbonyl oxygen By similarity
Metal bindingi96 – 961Copper or zinc 4 By similarity
Metal bindingi97 – 971Copper or zinc 4; via amide nitrogen By similarity
Metal bindingi98 – 981Copper or zinc 4; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. copper ion binding Source: UniProtKB
  2. identical protein binding Source: IntAct
  3. protein binding Source: IntAct

GO - Biological processi

  1. negative regulation of activated T cell proliferation Source: Ensembl
  2. negative regulation of apoptotic process Source: Ensembl
  3. negative regulation of calcineurin-NFAT signaling cascade Source: Ensembl
  4. negative regulation of interferon-gamma production Source: Ensembl
  5. negative regulation of interleukin-17 production Source: Ensembl
  6. negative regulation of interleukin-2 production Source: Ensembl
  7. negative regulation of protein phosphorylation Source: Ensembl
  8. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  9. negative regulation of T cell receptor signaling pathway Source: Ensembl
  10. protein homooligomerization Source: InterPro
  11. response to oxidative stress Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Prion

Keywords - Ligandi

Copper, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_202514. NCAM1 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Major prion protein
Short name:
PrP
Alternative name(s):
Major scrapie-associated fibril protein 1
CD_antigen: CD230
Gene namesi
Name:PRNP
Synonyms:PRP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 13

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor By similarity. Golgi apparatus By similarity
Note: Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of CU2+, to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis By similarity.

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. endoplasmic reticulum Source: Ensembl
  3. Golgi apparatus Source: UniProtKB-SubCell
  4. nucleolus Source: Ensembl
  5. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Variations in PRNP are responsible of transmissible bovine spongiform encephalopathies (BSE), a class of neurodegenerative diseases that affect various mammals. These diseases are caused by abnormally folded prion proteins. BSE can be subdivided into at least three groups: classical, H-type and L-type, with the latter 2 collectively referred to as atypical BSE. Susceptibility or resistance to a BSE disease can be influenced by at least 3 factors related to the host prion protein: protein expression levels, number of octapeptide repeats, and specific polymorphisms. In cattle, as in humans, BSEs can occur as infectious, spontaneous and genetic diseases.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 241217Major prion proteinPRO_0000025627Add
BLAST
Propeptidei242 – 26423Removed in mature form Reviewed predictionPRO_0000025628Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi190 ↔ 225
Glycosylationi192 – 1921N-linked (GlcNAc...) Inferred
Glycosylationi208 – 2081N-linked (GlcNAc...) Inferred
Lipidationi241 – 2411GPI-anchor amidated alanine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiP10279.

Interactioni

Subunit structurei

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement By similarity. Interacts with KIAA1191 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-7430632,EBI-7430632
PRNPP041565EBI-7430632,EBI-977302From a different organism.

Protein-protein interaction databases

BioGridi158758. 3 interactions.
IntActiP10279. 1 interaction.
MINTiMINT-1486044.

Structurei

Secondary structure

1
264
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni6 – 83
Helixi9 – 2113
Beta strandi24 – 263
Beta strandi109 – 1113
Helixi136 – 1383
Beta strandi139 – 1413
Helixi155 – 1628
Helixi165 – 1673
Beta strandi177 – 1793
Helixi184 – 20320
Turni204 – 2063
Helixi211 – 23727

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DWYNMR-A132-241[»]
1DWZNMR-A132-241[»]
1DX0NMR-A25-241[»]
1DX1NMR-A25-241[»]
1SKHNMR-A6-30[»]
2HH0X-ray2.85P107-115[»]
2RSKNMR-C/D108-119[»]
2RU7NMR-C/D108-119[»]
ProteinModelPortaliP10279.
SMRiP10279. Positions 1-30, 135-238.

Miscellaneous databases

EvolutionaryTraceiP10279.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati54 – 6291
Repeati63 – 7082
Repeati71 – 7883
Repeati79 – 8684
Repeati87 – 9485
Repeati95 – 10396

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 241217Interaction with GRB2, ERI3 and SYN1 By similarityAdd
BLAST
Regioni54 – 103506 X 8 AA tandem repeats of P-H-G-G-G-W-G-QAdd
BLAST

Domaini

The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization By similarity.
Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization (By similarity).

Sequence similaritiesi

Belongs to the prion family.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG41716.
GeneTreeiENSGT00510000049083.
HOVERGENiHBG008260.
InParanoidiP10279.
KOiK05634.
OMAiHNPGYPH.
OrthoDBiEOG7DRJ4Q.
TreeFamiTF105188.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR001610. PAC.
IPR000817. Prion.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR025860. Prion_N_dom.
[Graphical view]
PANTHERiPTHR11522. PTHR11522. 1 hit.
PfamiPF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
[Graphical view]
PRINTSiPR00341. PRION.
SMARTiSM00086. PAC. 1 hit.
SM00157. PRP. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.
PROSITEiPS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10279-1 [UniParc]FASTAAdd to Basket

« Hide

MVKSHIGSWI LVLFVAMWSD VGLCKKRPKP GGGWNTGGSR YPGQGSPGGN    50
RYPPQGGGGW GQPHGGGWGQ PHGGGWGQPH GGGWGQPHGG GWGQPHGGGG 100
WGQGGTHGQW NKPSKPKTNM KHVAGAAAAG AVVGGLGGYM LGSAMSRPLI 150
HFGSDYEDRY YRENMHRYPN QVYYRPVDQY SNQNNFVHDC VNITVKEHTV 200
TTTTKGENFT ETDIKMMERV VEQMCITQYQ RESQAYYQRG ASVILFSSPP 250
VILLISFLIF LIVG 264
Length:264
Mass (Da):28,614
Last modified:November 1, 1991 - v2
Checksum:iD6D214038316A231
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601W → R.1 Publication
Natural varianti71 – 788Missing in allele 2.
Natural varianti84 – 9916Missing.
Add
BLAST
Natural varianti92 – 998Missing.
Natural varianti94 – 941Q → R.1 Publication
Natural varianti98 – 981G → GGWGQPHGG.
Natural varianti154 – 1541S → N.2 Publications
Natural varianti211 – 2111E → K.1 Publication
Natural varianti234 – 2341Q → R.1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1083THG → SHS in BAA01469. 1 Publication
Sequence conflicti218 – 2181E → K in BAA01467. 1 Publication
Sequence conflicti218 – 2181E → K in BAA19253. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55882 Genomic DNA. Translation: CAA39368.1.
D10612 mRNA. Translation: BAA01467.1.
D10613 Genomic DNA. Translation: BAA01468.1.
D10614 Genomic DNA. Translation: BAA01469.1.
S55629 mRNA. Translation: AAB25514.1.
AB001468 mRNA. Translation: BAA19253.1.
AJ298878 Genomic DNA. Translation: CAC37367.1.
AF455119 Genomic DNA. Translation: AAM73856.1.
AF517842 mRNA. Translation: AAM66709.1.
AY335912 Genomic DNA. Translation: AAP84097.2.
AY367638 Genomic DNA. Translation: AAQ64645.1.
AY367639 Genomic DNA. Translation: AAQ64646.1.
AY367640 Genomic DNA. Translation: AAQ64647.1.
AY367641 Genomic DNA. Translation: AAQ64648.1.
AY367642 Genomic DNA. Translation: AAQ64649.1.
AY367643 Genomic DNA. Translation: AAQ64650.1.
AY720445 Genomic DNA. Translation: AAV30252.1.
AY720446 Genomic DNA. Translation: AAV30253.1.
AY720448 Genomic DNA. Translation: AAV30255.1.
AY720449 Genomic DNA. Translation: AAV30256.1.
AY720450 Genomic DNA. Translation: AAV30257.1.
AY720451 Genomic DNA. Translation: AAV30258.1.
AY720452 Genomic DNA. Translation: AAV30259.1.
AY720453 Genomic DNA. Translation: AAV30260.1.
AY720454 Genomic DNA. Translation: AAV30261.1.
AY720455 Genomic DNA. Translation: AAV30262.1.
AY720458 Genomic DNA. Translation: AAV30265.1.
AY720459 Genomic DNA. Translation: AAV30266.1.
AY720460 Genomic DNA. Translation: AAV30267.1.
AY720461 Genomic DNA. Translation: AAV30268.1.
AY720462 Genomic DNA. Translation: AAV30269.1.
AY720463 Genomic DNA. Translation: AAV30270.1.
AY720464 Genomic DNA. Translation: AAV30271.1.
AY720465 Genomic DNA. Translation: AAV30272.1.
AY720466 Genomic DNA. Translation: AAV30273.1.
AY720467 Genomic DNA. Translation: AAV30274.1.
AY720468 Genomic DNA. Translation: AAV30275.1.
AY720469 Genomic DNA. Translation: AAV30276.1.
AY720470 Genomic DNA. Translation: AAV30277.1.
AY720471 Genomic DNA. Translation: AAV30278.1.
AY720472 Genomic DNA. Translation: AAV30279.1.
AY720473 Genomic DNA. Translation: AAV30280.1.
AY720474 Genomic DNA. Translation: AAV30281.1.
AY720475 Genomic DNA. Translation: AAV30282.1.
AY720476 Genomic DNA. Translation: AAV30283.1.
AY720477 Genomic DNA. Translation: AAV30284.1.
AY720478 Genomic DNA. Translation: AAV30285.1.
AY720479 Genomic DNA. Translation: AAV30286.1.
AY720480 Genomic DNA. Translation: AAV30287.1.
AY720481 Genomic DNA. Translation: AAV30288.1.
AY720482 Genomic DNA. Translation: AAV30289.1.
AY720483 Genomic DNA. Translation: AAV30290.1.
AY720484 Genomic DNA. Translation: AAV30291.1.
AY720485 Genomic DNA. Translation: AAV30292.1.
AY720486 Genomic DNA. Translation: AAV30293.1.
AY720488 Genomic DNA. Translation: AAV30295.1.
AY720489 Genomic DNA. Translation: AAV30296.1.
AY720492 Genomic DNA. Translation: AAV30299.1.
AY720493 Genomic DNA. Translation: AAV30300.1.
AY720494 Genomic DNA. Translation: AAV30301.1.
AY720495 Genomic DNA. Translation: AAV30302.1.
AY720496 Genomic DNA. Translation: AAV30303.1.
AY720497 Genomic DNA. Translation: AAV30304.1.
AY720498 Genomic DNA. Translation: AAV30305.1.
AY720503 Genomic DNA. Translation: AAV30310.1.
AY720504 Genomic DNA. Translation: AAV30311.1.
AY720505 Genomic DNA. Translation: AAV30312.1.
AY720506 Genomic DNA. Translation: AAV30313.1.
AY720507 Genomic DNA. Translation: AAV30314.1.
AY720508 Genomic DNA. Translation: AAV30315.1.
AY720509 Genomic DNA. Translation: AAV30316.1.
AY720510 Genomic DNA. Translation: AAV30317.1.
AY720511 Genomic DNA. Translation: AAV30318.1.
AY720512 Genomic DNA. Translation: AAV30319.1.
AY720513 Genomic DNA. Translation: AAV30320.1.
AY720514 Genomic DNA. Translation: AAV30321.1.
AY720525 Genomic DNA. Translation: AAV30332.1.
AY720530 Genomic DNA. Translation: AAV30337.1.
AY720531 Genomic DNA. Translation: AAV30338.1.
AY720532 Genomic DNA. Translation: AAV30339.1.
AY720533 Genomic DNA. Translation: AAV30340.1.
AY720534 Genomic DNA. Translation: AAV30341.1.
AY720535 Genomic DNA. Translation: AAV30342.1.
AY720540 Genomic DNA. Translation: AAV30347.1.
AY720541 Genomic DNA. Translation: AAV30348.1.
AY720544 Genomic DNA. Translation: AAV30351.1.
AY720545 Genomic DNA. Translation: AAV30352.1.
AY720546 Genomic DNA. Translation: AAV30353.1.
AY720547 Genomic DNA. Translation: AAV30354.1.
AY720548 Genomic DNA. Translation: AAV30355.1.
AY720549 Genomic DNA. Translation: AAV30356.1.
AY720550 Genomic DNA. Translation: AAV30357.1.
AY720551 Genomic DNA. Translation: AAV30358.1.
AY720552 Genomic DNA. Translation: AAV30359.1.
AY720553 Genomic DNA. Translation: AAV30360.1.
AY720554 Genomic DNA. Translation: AAV30361.1.
AY720555 Genomic DNA. Translation: AAV30362.1.
AY720556 Genomic DNA. Translation: AAV30363.1.
AY720557 Genomic DNA. Translation: AAV30364.1.
AY720558 Genomic DNA. Translation: AAV30365.1.
AY720559 Genomic DNA. Translation: AAV30366.1.
AY720560 Genomic DNA. Translation: AAV30367.1.
AY720561 Genomic DNA. Translation: AAV30368.1.
AY720562 Genomic DNA. Translation: AAV30369.1.
AY720563 Genomic DNA. Translation: AAV30370.1.
AY720564 Genomic DNA. Translation: AAV30371.1.
AY720565 Genomic DNA. Translation: AAV30372.1.
AY720566 Genomic DNA. Translation: AAV30373.1.
AY720567 Genomic DNA. Translation: AAV30374.1.
AY720568 Genomic DNA. Translation: AAV30375.1.
AY720569 Genomic DNA. Translation: AAV30376.1.
AY720570 Genomic DNA. Translation: AAV30377.1.
AY720571 Genomic DNA. Translation: AAV30378.1.
AY720572 Genomic DNA. Translation: AAV30379.1.
AY720573 Genomic DNA. Translation: AAV30380.1.
AY720574 Genomic DNA. Translation: AAV30381.1.
AY720581 Genomic DNA. Translation: AAV30388.1.
AY720582 Genomic DNA. Translation: AAV30389.1.
AY720583 Genomic DNA. Translation: AAV30390.1.
AY720584 Genomic DNA. Translation: AAV30391.1.
AY720585 Genomic DNA. Translation: AAV30392.1.
AY720588 Genomic DNA. Translation: AAV30395.1.
AY720591 Genomic DNA. Translation: AAV30398.1.
AY720594 Genomic DNA. Translation: AAV30401.1.
AY720595 Genomic DNA. Translation: AAV30402.1.
AY720596 Genomic DNA. Translation: AAV30403.1.
AY720597 Genomic DNA. Translation: AAV30404.1.
AY720600 Genomic DNA. Translation: AAV30407.1.
AY720601 Genomic DNA. Translation: AAV30408.1.
AY720602 Genomic DNA. Translation: AAV30409.1.
AY720603 Genomic DNA. Translation: AAV30410.1.
AY720604 Genomic DNA. Translation: AAV30411.1.
AY720605 Genomic DNA. Translation: AAV30412.1.
AY720606 Genomic DNA. Translation: AAV30413.1.
AY720607 Genomic DNA. Translation: AAV30414.1.
AY720608 Genomic DNA. Translation: AAV30415.1.
AY720609 Genomic DNA. Translation: AAV30416.1.
AY720610 Genomic DNA. Translation: AAV30417.1.
AY720611 Genomic DNA. Translation: AAV30418.1.
AY720612 Genomic DNA. Translation: AAV30419.1.
AY720613 Genomic DNA. Translation: AAV30420.1.
AY720622 Genomic DNA. Translation: AAV30429.1.
AY720623 Genomic DNA. Translation: AAV30430.1.
AY720624 Genomic DNA. Translation: AAV30431.1.
AY720625 Genomic DNA. Translation: AAV30432.1.
AY720626 Genomic DNA. Translation: AAV30433.1.
AY720627 Genomic DNA. Translation: AAV30434.1.
AY720628 Genomic DNA. Translation: AAV30435.1.
AY720629 Genomic DNA. Translation: AAV30436.1.
AY720630 Genomic DNA. Translation: AAV30437.1.
AY720631 Genomic DNA. Translation: AAV30438.1.
AY720632 Genomic DNA. Translation: AAV30439.1.
AY720633 Genomic DNA. Translation: AAV30440.1.
AY720634 Genomic DNA. Translation: AAV30441.1.
AY720635 Genomic DNA. Translation: AAV30442.1.
AY720636 Genomic DNA. Translation: AAV30443.1.
AY720637 Genomic DNA. Translation: AAV30444.1.
AY720640 Genomic DNA. Translation: AAV30447.1.
AY720641 Genomic DNA. Translation: AAV30448.1.
AY720642 Genomic DNA. Translation: AAV30449.1.
AY720643 Genomic DNA. Translation: AAV30450.1.
AY720644 Genomic DNA. Translation: AAV30451.1.
AY720645 Genomic DNA. Translation: AAV30452.1.
AY720648 Genomic DNA. Translation: AAV30455.1.
AY720649 Genomic DNA. Translation: AAV30456.1.
AY720650 Genomic DNA. Translation: AAV30457.1.
AY720651 Genomic DNA. Translation: AAV30458.1.
AY720652 Genomic DNA. Translation: AAV30459.1.
AY720653 Genomic DNA. Translation: AAV30460.1.
AY720654 Genomic DNA. Translation: AAV30461.1.
AY720655 Genomic DNA. Translation: AAV30462.1.
AY720656 Genomic DNA. Translation: AAV30463.1.
AY720657 Genomic DNA. Translation: AAV30464.1.
AY720662 Genomic DNA. Translation: AAV30469.1.
AY720663 Genomic DNA. Translation: AAV30470.1.
AY720664 Genomic DNA. Translation: AAV30471.1.
AY720667 Genomic DNA. Translation: AAV30474.1.
AY720668 Genomic DNA. Translation: AAV30475.1.
AY720669 Genomic DNA. Translation: AAV30476.1.
AY720670 Genomic DNA. Translation: AAV30477.1.
AY720671 Genomic DNA. Translation: AAV30478.1.
AY720672 Genomic DNA. Translation: AAV30479.1.
AY720673 Genomic DNA. Translation: AAV30480.1.
AY720674 Genomic DNA. Translation: AAV30481.1.
AY720675 Genomic DNA. Translation: AAV30482.1.
AY720676 Genomic DNA. Translation: AAV30483.1.
AY720677 Genomic DNA. Translation: AAV30484.1.
AY720678 Genomic DNA. Translation: AAV30485.1.
DQ205538 Genomic DNA. Translation: ABB51165.1.
AY944236 Genomic DNA. Translation: AAY21624.1.
AB248079 Genomic DNA. Translation: BAE78586.1.
AB247937 Genomic DNA. Translation: BAE78583.1.
EF139165 Genomic DNA. Translation: ABL75501.1.
BC119821 mRNA. Translation: AAI19822.1.
D26151 Genomic DNA. Translation: BAA05138.1.
PIRiA54330.
JU0268.
RefSeqiNP_001258555.1. NM_001271626.1.
NP_851358.2. NM_181015.2.
UniGeneiBt.4737.

Genome annotation databases

EnsembliENSBTAT00000040292; ENSBTAP00000043233; ENSBTAG00000027937.
GeneIDi281427.
KEGGibta:281427.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55882 Genomic DNA. Translation: CAA39368.1 .
D10612 mRNA. Translation: BAA01467.1 .
D10613 Genomic DNA. Translation: BAA01468.1 .
D10614 Genomic DNA. Translation: BAA01469.1 .
S55629 mRNA. Translation: AAB25514.1 .
AB001468 mRNA. Translation: BAA19253.1 .
AJ298878 Genomic DNA. Translation: CAC37367.1 .
AF455119 Genomic DNA. Translation: AAM73856.1 .
AF517842 mRNA. Translation: AAM66709.1 .
AY335912 Genomic DNA. Translation: AAP84097.2 .
AY367638 Genomic DNA. Translation: AAQ64645.1 .
AY367639 Genomic DNA. Translation: AAQ64646.1 .
AY367640 Genomic DNA. Translation: AAQ64647.1 .
AY367641 Genomic DNA. Translation: AAQ64648.1 .
AY367642 Genomic DNA. Translation: AAQ64649.1 .
AY367643 Genomic DNA. Translation: AAQ64650.1 .
AY720445 Genomic DNA. Translation: AAV30252.1 .
AY720446 Genomic DNA. Translation: AAV30253.1 .
AY720448 Genomic DNA. Translation: AAV30255.1 .
AY720449 Genomic DNA. Translation: AAV30256.1 .
AY720450 Genomic DNA. Translation: AAV30257.1 .
AY720451 Genomic DNA. Translation: AAV30258.1 .
AY720452 Genomic DNA. Translation: AAV30259.1 .
AY720453 Genomic DNA. Translation: AAV30260.1 .
AY720454 Genomic DNA. Translation: AAV30261.1 .
AY720455 Genomic DNA. Translation: AAV30262.1 .
AY720458 Genomic DNA. Translation: AAV30265.1 .
AY720459 Genomic DNA. Translation: AAV30266.1 .
AY720460 Genomic DNA. Translation: AAV30267.1 .
AY720461 Genomic DNA. Translation: AAV30268.1 .
AY720462 Genomic DNA. Translation: AAV30269.1 .
AY720463 Genomic DNA. Translation: AAV30270.1 .
AY720464 Genomic DNA. Translation: AAV30271.1 .
AY720465 Genomic DNA. Translation: AAV30272.1 .
AY720466 Genomic DNA. Translation: AAV30273.1 .
AY720467 Genomic DNA. Translation: AAV30274.1 .
AY720468 Genomic DNA. Translation: AAV30275.1 .
AY720469 Genomic DNA. Translation: AAV30276.1 .
AY720470 Genomic DNA. Translation: AAV30277.1 .
AY720471 Genomic DNA. Translation: AAV30278.1 .
AY720472 Genomic DNA. Translation: AAV30279.1 .
AY720473 Genomic DNA. Translation: AAV30280.1 .
AY720474 Genomic DNA. Translation: AAV30281.1 .
AY720475 Genomic DNA. Translation: AAV30282.1 .
AY720476 Genomic DNA. Translation: AAV30283.1 .
AY720477 Genomic DNA. Translation: AAV30284.1 .
AY720478 Genomic DNA. Translation: AAV30285.1 .
AY720479 Genomic DNA. Translation: AAV30286.1 .
AY720480 Genomic DNA. Translation: AAV30287.1 .
AY720481 Genomic DNA. Translation: AAV30288.1 .
AY720482 Genomic DNA. Translation: AAV30289.1 .
AY720483 Genomic DNA. Translation: AAV30290.1 .
AY720484 Genomic DNA. Translation: AAV30291.1 .
AY720485 Genomic DNA. Translation: AAV30292.1 .
AY720486 Genomic DNA. Translation: AAV30293.1 .
AY720488 Genomic DNA. Translation: AAV30295.1 .
AY720489 Genomic DNA. Translation: AAV30296.1 .
AY720492 Genomic DNA. Translation: AAV30299.1 .
AY720493 Genomic DNA. Translation: AAV30300.1 .
AY720494 Genomic DNA. Translation: AAV30301.1 .
AY720495 Genomic DNA. Translation: AAV30302.1 .
AY720496 Genomic DNA. Translation: AAV30303.1 .
AY720497 Genomic DNA. Translation: AAV30304.1 .
AY720498 Genomic DNA. Translation: AAV30305.1 .
AY720503 Genomic DNA. Translation: AAV30310.1 .
AY720504 Genomic DNA. Translation: AAV30311.1 .
AY720505 Genomic DNA. Translation: AAV30312.1 .
AY720506 Genomic DNA. Translation: AAV30313.1 .
AY720507 Genomic DNA. Translation: AAV30314.1 .
AY720508 Genomic DNA. Translation: AAV30315.1 .
AY720509 Genomic DNA. Translation: AAV30316.1 .
AY720510 Genomic DNA. Translation: AAV30317.1 .
AY720511 Genomic DNA. Translation: AAV30318.1 .
AY720512 Genomic DNA. Translation: AAV30319.1 .
AY720513 Genomic DNA. Translation: AAV30320.1 .
AY720514 Genomic DNA. Translation: AAV30321.1 .
AY720525 Genomic DNA. Translation: AAV30332.1 .
AY720530 Genomic DNA. Translation: AAV30337.1 .
AY720531 Genomic DNA. Translation: AAV30338.1 .
AY720532 Genomic DNA. Translation: AAV30339.1 .
AY720533 Genomic DNA. Translation: AAV30340.1 .
AY720534 Genomic DNA. Translation: AAV30341.1 .
AY720535 Genomic DNA. Translation: AAV30342.1 .
AY720540 Genomic DNA. Translation: AAV30347.1 .
AY720541 Genomic DNA. Translation: AAV30348.1 .
AY720544 Genomic DNA. Translation: AAV30351.1 .
AY720545 Genomic DNA. Translation: AAV30352.1 .
AY720546 Genomic DNA. Translation: AAV30353.1 .
AY720547 Genomic DNA. Translation: AAV30354.1 .
AY720548 Genomic DNA. Translation: AAV30355.1 .
AY720549 Genomic DNA. Translation: AAV30356.1 .
AY720550 Genomic DNA. Translation: AAV30357.1 .
AY720551 Genomic DNA. Translation: AAV30358.1 .
AY720552 Genomic DNA. Translation: AAV30359.1 .
AY720553 Genomic DNA. Translation: AAV30360.1 .
AY720554 Genomic DNA. Translation: AAV30361.1 .
AY720555 Genomic DNA. Translation: AAV30362.1 .
AY720556 Genomic DNA. Translation: AAV30363.1 .
AY720557 Genomic DNA. Translation: AAV30364.1 .
AY720558 Genomic DNA. Translation: AAV30365.1 .
AY720559 Genomic DNA. Translation: AAV30366.1 .
AY720560 Genomic DNA. Translation: AAV30367.1 .
AY720561 Genomic DNA. Translation: AAV30368.1 .
AY720562 Genomic DNA. Translation: AAV30369.1 .
AY720563 Genomic DNA. Translation: AAV30370.1 .
AY720564 Genomic DNA. Translation: AAV30371.1 .
AY720565 Genomic DNA. Translation: AAV30372.1 .
AY720566 Genomic DNA. Translation: AAV30373.1 .
AY720567 Genomic DNA. Translation: AAV30374.1 .
AY720568 Genomic DNA. Translation: AAV30375.1 .
AY720569 Genomic DNA. Translation: AAV30376.1 .
AY720570 Genomic DNA. Translation: AAV30377.1 .
AY720571 Genomic DNA. Translation: AAV30378.1 .
AY720572 Genomic DNA. Translation: AAV30379.1 .
AY720573 Genomic DNA. Translation: AAV30380.1 .
AY720574 Genomic DNA. Translation: AAV30381.1 .
AY720581 Genomic DNA. Translation: AAV30388.1 .
AY720582 Genomic DNA. Translation: AAV30389.1 .
AY720583 Genomic DNA. Translation: AAV30390.1 .
AY720584 Genomic DNA. Translation: AAV30391.1 .
AY720585 Genomic DNA. Translation: AAV30392.1 .
AY720588 Genomic DNA. Translation: AAV30395.1 .
AY720591 Genomic DNA. Translation: AAV30398.1 .
AY720594 Genomic DNA. Translation: AAV30401.1 .
AY720595 Genomic DNA. Translation: AAV30402.1 .
AY720596 Genomic DNA. Translation: AAV30403.1 .
AY720597 Genomic DNA. Translation: AAV30404.1 .
AY720600 Genomic DNA. Translation: AAV30407.1 .
AY720601 Genomic DNA. Translation: AAV30408.1 .
AY720602 Genomic DNA. Translation: AAV30409.1 .
AY720603 Genomic DNA. Translation: AAV30410.1 .
AY720604 Genomic DNA. Translation: AAV30411.1 .
AY720605 Genomic DNA. Translation: AAV30412.1 .
AY720606 Genomic DNA. Translation: AAV30413.1 .
AY720607 Genomic DNA. Translation: AAV30414.1 .
AY720608 Genomic DNA. Translation: AAV30415.1 .
AY720609 Genomic DNA. Translation: AAV30416.1 .
AY720610 Genomic DNA. Translation: AAV30417.1 .
AY720611 Genomic DNA. Translation: AAV30418.1 .
AY720612 Genomic DNA. Translation: AAV30419.1 .
AY720613 Genomic DNA. Translation: AAV30420.1 .
AY720622 Genomic DNA. Translation: AAV30429.1 .
AY720623 Genomic DNA. Translation: AAV30430.1 .
AY720624 Genomic DNA. Translation: AAV30431.1 .
AY720625 Genomic DNA. Translation: AAV30432.1 .
AY720626 Genomic DNA. Translation: AAV30433.1 .
AY720627 Genomic DNA. Translation: AAV30434.1 .
AY720628 Genomic DNA. Translation: AAV30435.1 .
AY720629 Genomic DNA. Translation: AAV30436.1 .
AY720630 Genomic DNA. Translation: AAV30437.1 .
AY720631 Genomic DNA. Translation: AAV30438.1 .
AY720632 Genomic DNA. Translation: AAV30439.1 .
AY720633 Genomic DNA. Translation: AAV30440.1 .
AY720634 Genomic DNA. Translation: AAV30441.1 .
AY720635 Genomic DNA. Translation: AAV30442.1 .
AY720636 Genomic DNA. Translation: AAV30443.1 .
AY720637 Genomic DNA. Translation: AAV30444.1 .
AY720640 Genomic DNA. Translation: AAV30447.1 .
AY720641 Genomic DNA. Translation: AAV30448.1 .
AY720642 Genomic DNA. Translation: AAV30449.1 .
AY720643 Genomic DNA. Translation: AAV30450.1 .
AY720644 Genomic DNA. Translation: AAV30451.1 .
AY720645 Genomic DNA. Translation: AAV30452.1 .
AY720648 Genomic DNA. Translation: AAV30455.1 .
AY720649 Genomic DNA. Translation: AAV30456.1 .
AY720650 Genomic DNA. Translation: AAV30457.1 .
AY720651 Genomic DNA. Translation: AAV30458.1 .
AY720652 Genomic DNA. Translation: AAV30459.1 .
AY720653 Genomic DNA. Translation: AAV30460.1 .
AY720654 Genomic DNA. Translation: AAV30461.1 .
AY720655 Genomic DNA. Translation: AAV30462.1 .
AY720656 Genomic DNA. Translation: AAV30463.1 .
AY720657 Genomic DNA. Translation: AAV30464.1 .
AY720662 Genomic DNA. Translation: AAV30469.1 .
AY720663 Genomic DNA. Translation: AAV30470.1 .
AY720664 Genomic DNA. Translation: AAV30471.1 .
AY720667 Genomic DNA. Translation: AAV30474.1 .
AY720668 Genomic DNA. Translation: AAV30475.1 .
AY720669 Genomic DNA. Translation: AAV30476.1 .
AY720670 Genomic DNA. Translation: AAV30477.1 .
AY720671 Genomic DNA. Translation: AAV30478.1 .
AY720672 Genomic DNA. Translation: AAV30479.1 .
AY720673 Genomic DNA. Translation: AAV30480.1 .
AY720674 Genomic DNA. Translation: AAV30481.1 .
AY720675 Genomic DNA. Translation: AAV30482.1 .
AY720676 Genomic DNA. Translation: AAV30483.1 .
AY720677 Genomic DNA. Translation: AAV30484.1 .
AY720678 Genomic DNA. Translation: AAV30485.1 .
DQ205538 Genomic DNA. Translation: ABB51165.1 .
AY944236 Genomic DNA. Translation: AAY21624.1 .
AB248079 Genomic DNA. Translation: BAE78586.1 .
AB247937 Genomic DNA. Translation: BAE78583.1 .
EF139165 Genomic DNA. Translation: ABL75501.1 .
BC119821 mRNA. Translation: AAI19822.1 .
D26151 Genomic DNA. Translation: BAA05138.1 .
PIRi A54330.
JU0268.
RefSeqi NP_001258555.1. NM_001271626.1.
NP_851358.2. NM_181015.2.
UniGenei Bt.4737.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DWY NMR - A 132-241 [» ]
1DWZ NMR - A 132-241 [» ]
1DX0 NMR - A 25-241 [» ]
1DX1 NMR - A 25-241 [» ]
1SKH NMR - A 6-30 [» ]
2HH0 X-ray 2.85 P 107-115 [» ]
2RSK NMR - C/D 108-119 [» ]
2RU7 NMR - C/D 108-119 [» ]
ProteinModelPortali P10279.
SMRi P10279. Positions 1-30, 135-238.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 158758. 3 interactions.
IntActi P10279. 1 interaction.
MINTi MINT-1486044.

Proteomic databases

PRIDEi P10279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000040292 ; ENSBTAP00000043233 ; ENSBTAG00000027937 .
GeneIDi 281427.
KEGGi bta:281427.

Organism-specific databases

CTDi 5621.

Phylogenomic databases

eggNOGi NOG41716.
GeneTreei ENSGT00510000049083.
HOVERGENi HBG008260.
InParanoidi P10279.
KOi K05634.
OMAi HNPGYPH.
OrthoDBi EOG7DRJ4Q.
TreeFami TF105188.

Enzyme and pathway databases

Reactomei REACT_202514. NCAM1 interactions.

Miscellaneous databases

EvolutionaryTracei P10279.
NextBioi 20805416.

Family and domain databases

Gene3Di 1.10.790.10. 1 hit.
InterProi IPR001610. PAC.
IPR000817. Prion.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR025860. Prion_N_dom.
[Graphical view ]
PANTHERi PTHR11522. PTHR11522. 1 hit.
Pfami PF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
[Graphical view ]
PRINTSi PR00341. PRION.
SMARTi SM00086. PAC. 1 hit.
SM00157. PRP. 1 hit.
[Graphical view ]
SUPFAMi SSF54098. SSF54098. 1 hit.
PROSITEi PS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Different forms of the bovine PrP gene have five or six copies of a short, G-C-rich element within the protein-coding exon."
    Goldmann W., Hunter N., Martin T., Dawson M., Hope J.
    J. Gen. Virol. 72:201-204(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Holstein-Friesian.
  2. "Comparative sequence analysis and expression of bovine PrP gene in mouse L-929 cells."
    Yoshimoto J., Iinuma T., Ishiguro N., Horiuchi M., Imamura M., Shinagawa M.
    Virus Genes 6:343-356(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS 92-TRP--GLY 99 DEL AND ASN-154.
    Strain: Holstein-Friesian.
    Tissue: Brain.
  3. "Immunologic and molecular biologic studies of prion proteins in bovine spongiform encephalopathy."
    Prusiner S.B., Fuzi M., Scott M., Serban D., Serban H., Taraboulos A., Gabriel J.M., Wells G.A., Wilesmith J.W., Bradley R.
    J. Infect. Dis. 167:602-613(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Genomic organization of bovine PrP gene and complete nucleotide sequence of bovine PrP cDNA."
    Horiuchi M., Ishiguro N., Nagasawa H., Toyoda Y., Shinagawa M.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Holstein-Friesian.
    Tissue: Brain.
  5. "Complete genomic sequence of the bovine prion gene (PRNP) and polymorphism in its promoter region."
    Hills D., Comincini S., Schlaepfer J., Dolf G., Ferretti L., Williams J.L.
    Anim. Genet. 32:231-232(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Jersey.
  6. "Bovine PrP gene for prion protein."
    Naharro G., Yugueros J., Temprano A.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT 98-GLY-GLY-TRP-GLY-GLN-PRO-HIS-GLY-GLY INS.
  7. "Nucleotide sequence of PrP cDNA in Korean cattle."
    Yoo H.S., Kang S.G., Choi I.S., Kang S.K., Hwang W.S.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Korean.
  8. "Prion gene sequence variation within diverse groups of U.S. sheep, beef cattle, and deer."
    Heaton M.P., Leymaster K.A., Freking B.A., Hawk D.A., Smith T.P., Keele J.W., Snelling W.M., Fox J.M., Chitko-McKown C.G., Laegreid W.W.
    Mamm. Genome 14:765-777(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  9. Cited for: SEQUENCE REVISION TO 211, VARIANT LYS-211.
  10. "Cloning and sequence analysis of bovine prion protein gene."
    Wu R., Xie Q.G., Liu X.T., Chen H.T., Cheng J.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-60; ARG-94; ASN-154 AND ARG-234.
    Strain: Holstein-Friesian and Qinchuan.
    Tissue: Blood.
  11. "Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3."
    Seabury C.M., Honeycutt R.L., Rooney A.P., Halbert N.D., Derr J.N.
    Proc. Natl. Acad. Sci. U.S.A. 101:15142-15147(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS 84-TRP--GLY 99 DEL; 92-TRP--GLY 99 DEL AND 98-GLY-GLY-TRP-GLY-GLN-PRO-HIS-GLY-GLY INS.
  12. "Genomic characterization of the bovine PRN loci (PRNP, PRND and PRNT)."
    Uboldi C., Bertoni A., Del Vecchio I., Comincini S., Hills D., Schlaepfer J., Dolf G., Williams J.L., Ferretti L.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  13. "Comparative genomic organization of the human and bovine PRNP locus."
    Choi S.-H., Kim I.-C., Kim D.-S., Kim D.-W., Chae S.-H., Choi H.-H., Choi I., Yeo J.-S., Song M.-N., Park H.-S.
    Genomics 87:598-607(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  14. "Frequencies of bovine PrP gene polymorphisms in Japanese-black and Holstein bulls in japan."
    Abe T., Hasebe H., Kobayashi E.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Holstein and Japanese black.
    Tissue: Semen.
  15. "Detection of prion protein in various animal species by a new set of monoclonal antibodies."
    Barbieri I., Brocchi E., Borre A., Moretti M., Gelmetti D., Capucci L.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  16. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.
  17. "Characterization of bovine PrP promoter region."
    Tanaka M., Inoue S., Ikeda T., Horiuchi M., Ishiguro N., Shinagawa M.
    Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15.
  18. "Fibrils from brains of cows with new cattle disease contain scrapie-associated protein."
    Hope J., Reekie L.J.D., Hunter N., Multhaup G., Beyreuther K., White H., Scott A.C., Stack M.J., Dawson M., Wells G.A.
    Nature 336:390-392(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-36.
  19. "NMR solution structure and membrane interaction of the N-terminal sequence (1-30) of the bovine prion protein."
    Biverstahl H., Andersson A., Graslund A., Maler L.
    Biochemistry 43:14940-14947(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-30.
  20. Cited for: STRUCTURE BY NMR OF 132-241.
  21. "Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation."
    Luginbuhl B., Kanyo Z., Jones R.M., Fletterick R.J., Prusiner S.B., Cohen F.E., Williamson R.A., Burton D.R., Pluckthun A.
    J. Mol. Biol. 363:75-97(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 107-115 IN COMPLEX WITH ANTIBODY FRAGMENT.

Entry informationi

Entry nameiPRIO_BOVIN
AccessioniPrimary (citable) accession number: P10279
Secondary accession number(s): A1YVV9
, Q01880, Q0VD57, Q5UJJ5, Q5UJM6, Q5UK69, Q5UK71, Q6UL03, Q6UL04, Q6UL05, Q6UL06, Q7YRN3, Q8MJI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: September 3, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is produced by a bicistronic gene which also produces the major prion protein/PRNP from an overlapping reading frame.
The alternative prion protein/AltPrP (AC F7VJQ2) and PRNP have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP By similarity. In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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