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Protein

Androgen receptor

Gene

AR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.8 Publications
Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.1 Publication

Miscellaneous

In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
Transcriptional activity is enhanced by binding to RANBP9.
The level of tyrosine phosphorylation may serve as a diagnostic tool to predict patient outcome in response to hormone-ablation therapy. Inhibition of tyrosine phosphorylation may be an effective intervention target for hormone-refractory prostate cancer.

Enzyme regulationi

AIM-100 (4-amino-5,6-biaryl-furo[2,3-d]pyrimidine) suppresses TNK2-mediated phosphorylation at Tyr-269. Inhibits the binding of the Tyr-269 phosphorylated form to androgen-responsive enhancers (AREs) and its transcriptional activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei706AndrogenCombined sources4 Publications1
Binding sitei753AndrogenCombined sources4 Publications1
Binding sitei878AndrogenCombined sources4 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi560 – 632Nuclear receptorPROSITE-ProRule annotationAdd BLAST73
Zinc fingeri560 – 580NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri596 – 620NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • androgen binding Source: UniProtKB
  • androgen receptor activity Source: UniProtKB
  • ATPase binding Source: MGI
  • beta-catenin binding Source: BHF-UCL
  • chromatin binding Source: UniProtKB
  • DNA binding Source: ProtInc
  • DNA binding transcription factor activity Source: UniProtKB
  • enzyme binding Source: UniProtKB
  • nuclear receptor activity Source: BHF-UCL
  • POU domain binding Source: Ensembl
  • protein dimerization activity Source: UniProtKB
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription factor binding Source: BHF-UCL
  • signaling receptor binding Source: UniProtKB
  • steroid binding Source: UniProtKB-KW
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcription factor binding Source: BHF-UCL
  • transcription regulatory region DNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Metal-binding, Steroid-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-5689880 Ub-specific processing proteases
R-HSA-8940973 RUNX2 regulates osteoblast differentiation
SignaLinkiP10275
SIGNORiP10275

Chemistry databases

SwissLipidsiSLP:000001553

Names & Taxonomyi

Protein namesi
Recommended name:
Androgen receptor
Alternative name(s):
Dihydrotestosterone receptor
Nuclear receptor subfamily 3 group C member 4
Gene namesi
Name:AR
Synonyms:DHTR, NR3C4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000169083.15
HGNCiHGNC:644 AR
MIMi313700 gene
neXtProtiNX_P10275

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Androgen insensitivity syndrome (AIS)74 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Affected males have female external genitalia, female breast development, blind vagina, absent uterus and female adnexa, and abdominal or inguinal testes, despite a normal 46,XY karyotype.
See also OMIM:300068
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009224196Q → R in AIS. 1 Publication1
Natural variantiVAR_009225257L → P in AIS. 1 Publication1
Natural variantiVAR_009226392P → R in AIS. 1 PublicationCorresponds to variant dbSNP:rs773996740Ensembl.1
Natural variantiVAR_009227392P → S in AIS. Corresponds to variant dbSNP:rs201934623EnsemblClinVar.1
Natural variantiVAR_009228445Q → R in AIS; unknown pathological significance. 1 Publication1
Natural variantiVAR_009719492G → S in AIS. 1
Natural variantiVAR_009722549P → S in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852588EnsemblClinVar.1
Natural variantiVAR_009723560C → Y in AIS. 1 Publication1
Natural variantiVAR_009727572Y → C in AIS. 1 Publication1
Natural variantiVAR_009728574A → D in AIS. 1
Natural variantiVAR_009731577C → F in AIS. 1 Publication1
Natural variantiVAR_009732577C → R in AIS. 1 Publication1
Natural variantiVAR_009733580C → F in AIS; reduced transcription and DNA binding. 1 PublicationCorresponds to variant dbSNP:rs137852586EnsemblClinVar.1
Natural variantiVAR_009734580C → Y in AIS. 1
Natural variantiVAR_009736582V → F in AIS. 2 Publications1
Natural variantiVAR_009739583Missing in AIS. 1 Publication1
Natural variantiVAR_009740586R → K in AIS. 1
Natural variantiVAR_009743597A → T in AIS; abolishes dimerization. 2 PublicationsCorresponds to variant dbSNP:rs137852569EnsemblClinVar.1
Natural variantiVAR_009746602C → F in AIS. 1 Publication1
Natural variantiVAR_009749612C → Y in AIS. 1
Natural variantiVAR_009752616R → P in AIS. 1
Natural variantiVAR_009750616Missing in AIS. 1 Publication1
Natural variantiVAR_009753617L → P in AIS. 1 Publication1
Natural variantiVAR_004688678L → P in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852579EnsemblClinVar.1
Natural variantiVAR_009764682E → K in AIS. 2 Publications1
Natural variantiVAR_009766685V → I in AIS. 1
Natural variantiVAR_009769689G → E in AIS. 1
Natural variantiVAR_004689693Missing in AIS. 1
Natural variantiVAR_004690696D → H in AIS. 1 Publication1
Natural variantiVAR_004691696D → N in AIS; almost complete loss of androgen binding and transcription activation. 2 Publications1
Natural variantiVAR_004692696D → V in AIS. 1 Publication1
Natural variantiVAR_009771701L → M in AIS. 1
Natural variantiVAR_009772702L → F in AIS. 1
Natural variantiVAR_009774703S → A in AIS. 1
Natural variantiVAR_009775704S → C in AIS. 1
Natural variantiVAR_009776706N → S in AIS. 2 Publications1
Natural variantiVAR_013475706N → Y in AIS. 1 Publication1
Natural variantiVAR_004694708L → R in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852585EnsemblClinVar.1
Natural variantiVAR_009778709G → V in AIS. 1
Natural variantiVAR_009779711R → T in AIS. 1
Natural variantiVAR_009785723L → F in AIS. 1
Natural variantiVAR_009786724P → S in AIS. 1
Natural variantiVAR_009790728N → K in AIS. 1 PublicationCorresponds to variant dbSNP:rs768869912Ensembl.1
Natural variantiVAR_004696733D → N in AIS. 1 Publication1
Natural variantiVAR_004697733D → Y in AIS. 1
Natural variantiVAR_009794742W → R in AIS. 1 Publication1
Natural variantiVAR_013477744G → E in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852600EnsemblClinVar.1
Natural variantiVAR_004701751G → D in AIS; loss of androgen binding. 1 Publication1
Natural variantiVAR_009804752W → R in AIS. 1
Natural variantiVAR_004702753R → Q in AIS. 2 Publications1
Natural variantiVAR_004703755F → V in AIS. 2 Publications1
Natural variantiVAR_009810760S → F in AIS. 1 Publication1
Natural variantiVAR_004704763L → F in AIS; loss of androgen binding. 1 Publication1
Natural variantiVAR_009812764Y → H in AIS. 1 Publication1
Natural variantiVAR_009813765F → L in AIS. 1 Publication1
Natural variantiVAR_004707766A → T in AIS; loss of androgen binding. 4 Publications1
Natural variantiVAR_009814766A → V in AIS. 1
Natural variantiVAR_009815767P → S in AIS. 1
Natural variantiVAR_009816768D → E in AIS. 1 Publication1
Natural variantiVAR_009817769L → P in AIS. 1
Natural variantiVAR_004709775R → C in AIS; frequent mutation; loss of androgen binding. 5 PublicationsCorresponds to variant dbSNP:rs137852562EnsemblClinVar.1
Natural variantiVAR_004710780R → W in AIS. 3 Publications1
Natural variantiVAR_004712785C → Y in AIS; loss of androgen binding and of transactivation. 1 Publication1
Natural variantiVAR_004713788M → V in AIS. 1 PublicationCorresponds to variant dbSNP:rs137852570EnsemblClinVar.1
Natural variantiVAR_009822789R → S in AIS. 1
Natural variantiVAR_009823791L → F in AIS. 1 Publication1
Natural variantiVAR_004714795F → S in AIS. 1 Publication1
Natural variantiVAR_004716808M → R in AIS; loss of transactivation. 1 Publication1
Natural variantiVAR_004717808M → V in AIS; 25% androgen binding. 1 Publication1
Natural variantiVAR_009828813L → F in AIS. 1 Publication1
Natural variantiVAR_009829821G → A in AIS. 1 Publication1
Natural variantiVAR_004719832R → L in AIS. 1 Publication1
Natural variantiVAR_004720832R → Q in AIS; loss of androgen binding. 3 Publications1
Natural variantiVAR_009832835Y → C in AIS; loss of androgen binding. 1 Publication1
Natural variantiVAR_004721841R → C in AIS. 3 PublicationsCorresponds to variant dbSNP:rs137852577EnsemblClinVar.1
Natural variantiVAR_004723841R → H in AIS. 7 PublicationsCorresponds to variant dbSNP:rs9332969EnsemblClinVar.1
Natural variantiVAR_004724843I → T in AIS. 2 PublicationsCorresponds to variant dbSNP:rs9332970Ensembl.1
Natural variantiVAR_004725856R → C in AIS. 5 PublicationsCorresponds to variant dbSNP:rs886041132EnsemblClinVar.1
Natural variantiVAR_004726856R → H in AIS; strongly reduced transcription activation. 5 PublicationsCorresponds to variant dbSNP:rs9332971EnsemblClinVar.1
Natural variantiVAR_009836857F → L in AIS. Corresponds to variant dbSNP:rs137852598EnsemblClinVar.1
Natural variantiVAR_009837864L → R in AIS. 1
Natural variantiVAR_009838865D → G in AIS. 1 Publication1
Natural variantiVAR_004727865D → N in AIS; loss of androgen binding. 1 Publication1
Natural variantiVAR_009839866S → P in AIS. Corresponds to variant dbSNP:rs137852597EnsemblClinVar.1
Natural variantiVAR_004728867V → E in AIS. 1
Natural variantiVAR_009842872R → G in AIS. 1 Publication1
Natural variantiVAR_013479875H → R in AIS. 1 Publication1
Natural variantiVAR_013480880D → Y in AIS. 1 Publication1
Natural variantiVAR_009846882L → V in AIS. 1 Publication1
Natural variantiVAR_009847887M → V in AIS. Corresponds to variant dbSNP:rs755226547EnsemblClinVar.1
Natural variantiVAR_004733893P → L in AIS. 3 Publications1
Natural variantiVAR_004734896M → T in AIS; low androgen binding and transactivation. 2 Publications1
Natural variantiVAR_009852899I → T in AIS. 1
Natural variantiVAR_009855905P → H in AIS. 1
Natural variantiVAR_009856905P → S in AIS. 1
Natural variantiVAR_004735908L → F in AIS; almost complete loss of transcription activation. 2 Publications1
Natural variantiVAR_009861917F → L in AIS. 1 Publication1
Natural variantiVAR_009862918H → R in AIS. 1
Spinal and bulbar muscular atrophy X-linked 1 (SMAX1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. Caused by trinucleotide CAG repeat expansion. In SMAX1 patients the number of Gln ranges from 38 to 62. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.
Disease descriptionAn X-linked recessive form of spinal muscular atrophy. Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX1 occurs only in men. Age at onset is usually in the third to fifth decade of life, but earlier involvement has been reported. It is characterized by slowly progressive limb and bulbar muscle weakness with fasciculations, muscle atrophy, and gynecomastia. The disorder is clinically similar to classic forms of autosomal spinal muscular atrophy.
See also OMIM:313200
Defects in AR may play a role in metastatic prostate cancer. The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor.10 Publications
Androgen insensitivity, partial (PAIS)42 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder that is characterized by hypospadias, hypogonadism, gynecomastia, genital ambiguity, normal XY karyotype, and a pedigree pattern consistent with X-linked recessive inheritance. Some patients present azoospermia or severe oligospermia without other clinical manifestations.
See also OMIM:312300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0046792E → K in PAIS. 1 PublicationCorresponds to variant dbSNP:rs104894742EnsemblClinVar.1
Natural variantiVAR_009721548L → F in PAIS. Corresponds to variant dbSNP:rs139524801Ensembl.1
Natural variantiVAR_009726569G → W in PAIS. 1 Publication1
Natural variantiVAR_009737583F → S in PAIS. 1 Publication1
Natural variantiVAR_009738583F → Y in PAIS. 1 PublicationCorresponds to variant dbSNP:rs137852587EnsemblClinVar.1
Natural variantiVAR_009744598S → G in PAIS; associated with P-618 in a PAIS patient; normal androgen binding; does not activate transcription; impairs DNA binding. 1 PublicationCorresponds to variant dbSNP:rs142280455Ensembl.1
Natural variantiVAR_009747605D → Y in PAIS. 1 Publication1
Natural variantiVAR_009748611N → T in PAIS. 1 Publication1
Natural variantiVAR_009754617L → R in PAIS. 1 Publication1
Natural variantiVAR_009762672P → H in PAIS. 1
Natural variantiVAR_013474683P → T in PAIS. 1 Publication1
Natural variantiVAR_009767687C → R in PAIS. 1
Natural variantiVAR_009768688A → V in PAIS. 1
Natural variantiVAR_009770691Missing in PAIS. 1 Publication1
Natural variantiVAR_009777709G → A in PAIS. 2 Publications1
Natural variantiVAR_013476712Q → E in PAIS. 1 Publication1
Natural variantiVAR_009780713L → F in PAIS. Corresponds to variant dbSNP:rs137852595EnsemblClinVar.1
Natural variantiVAR_009791729L → S in PAIS. 1
Natural variantiVAR_009792734Q → H in PAIS. 1
Natural variantiVAR_009793738I → T in PAIS. 1 Publication1
Natural variantiVAR_004698743M → I in PAIS. 1 Publication1
Natural variantiVAR_009795743M → V in PAIS. 1 Publication1
Natural variantiVAR_009797746M → T in PAIS. 1 Publication1
Natural variantiVAR_009798747V → M in PAIS. 1
Natural variantiVAR_009799749A → D in PAIS. 1
Natural variantiVAR_009807757N → S in PAIS. Corresponds to variant dbSNP:rs141425171Ensembl.1
Natural variantiVAR_009809759N → T in PAIS; 50% reduction in transactivation. 1 Publication1
Natural variantiVAR_009818772N → H in PAIS. 1 PublicationCorresponds to variant dbSNP:rs886041352EnsemblClinVar.1
Natural variantiVAR_009819773E → A in PAIS. 1 Publication1
Natural variantiVAR_009820773E → G in PAIS. 1 Publication1
Natural variantiVAR_004715799Q → E in PAIS, AIS and prostate cancer; reduced transcription activation. 6 PublicationsCorresponds to variant dbSNP:rs137852591EnsemblClinVar.1
Natural variantiVAR_009826807C → Y in PAIS. 1
Natural variantiVAR_009827808M → T in PAIS. 1 PublicationCorresponds to variant dbSNP:rs137852592EnsemblClinVar.1
Natural variantiVAR_009830822L → V in PAIS. 1
Natural variantiVAR_013478828F → V in PAIS. 1 Publication1
Natural variantiVAR_004722841R → G in PAIS. 1 Publication1
Natural variantiVAR_009229841R → S in PAIS. 1 Publication1
Natural variantiVAR_009833842I → S in PAIS. 1
Natural variantiVAR_009835855R → K in PAIS. 1
Natural variantiVAR_004729867V → L in PAIS. 3 PublicationsCorresponds to variant dbSNP:rs137852564EnsemblClinVar.1
Natural variantiVAR_004731870I → M in PAIS. 2 PublicationsCorresponds to variant dbSNP:rs137852574EnsemblClinVar.1
Natural variantiVAR_009840871A → G in PAIS. 1 Publication1
Natural variantiVAR_009841871A → V in PAIS. 1 PublicationCorresponds to variant dbSNP:rs143040492EnsemblClinVar.1
Natural variantiVAR_009854904V → M in PAIS. 1
Natural variantiVAR_009858910G → R in PAIS. 1 Publication1
Natural variantiVAR_009860912V → L in PAIS. 1 Publication1
Natural variantiVAR_004736914P → S in PAIS. 1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi83S → A: Reduced cell growth. 1 Publication1
Mutagenesisi225Y → F: Decrease of CSK-induced phosphorylation. 1 Publication1
Mutagenesisi269Y → F: Decrease of CSK-induced phosphorylation and phosphorylation by TNK2. Complete loss of TNK2-dependent phosphorylation; when associated with F-365. 2 Publications1
Mutagenesisi309Y → F: Decrease of CSK-induced phosphorylation. 1 Publication1
Mutagenesisi348Y → F: Decrease of CSK-induced phosphorylation. 1 Publication1
Mutagenesisi359Y → F: Decrease of CSK-induced phosphorylation. 1 Publication1
Mutagenesisi364Y → F: Decrease of CSK-induced phosphorylation. 1 Publication1
Mutagenesisi365Y → F: Decrease of CSK-induced phosphorylation and phosphorylation by TNK2. Complete loss of TNK2-dependent phosphorylation; when associated with F-269. 2 Publications1
Mutagenesisi395Y → F: Decrease of CSK-induced phosphorylation. 1 Publication1
Mutagenesisi535Y → F: Greatest decrease of CSK-induced phosphorylation and inhibition of transcriptional activity induced by EGF. 1 Publication1
Mutagenesisi552Y → F: Decrease in CSK-induced phosphorylation. 1 Publication1
Mutagenesisi702L → A: Alters receptor specificity, so that transcription is activated by the antiandrogen cyproterone acetate. 1 Publication1
Mutagenesisi721K → A: Loss of transcription activation in the presence of androgen and of interaction with NCOA2. 2 Publications1
Mutagenesisi742W → L: Strongly decreased transcription activation in the presence of androgen. 1 Publication1
Mutagenesisi846K → R: Prevents ubiquitination by RNF6. Prevents AR transcriptional activation by RNF14 in absence of hormone. 1 Publication1
Mutagenesisi848K → R: Partially prevents ubiquitination by RNF6. 1 Publication1
Mutagenesisi898E → A or Q: Reduced transcription activation in the presence of androgen. 2 Publications1
Mutagenesisi898E → K or R: Loss of transcription activation in the presence of androgen. 2 Publications1
Mutagenesisi916Y → F: Decrease in CSK-induced phosphorylation. 1 Publication1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Pseudohermaphroditism

Organism-specific databases

DisGeNETi367
GeneReviewsiAR
MalaCardsiAR
MIMi300068 phenotype
312300 phenotype
313200 phenotype
OpenTargetsiENSG00000169083
Orphaneti99429 Complete androgen insensitivity syndrome
440 Familial hypospadias
481 Kennedy disease
90797 Partial androgen insensitivity syndrome
PharmGKBiPA57

Chemistry databases

ChEMBLiCHEMBL1871
DrugBankiDB02932 (2r)-N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Sulfonyl]-2-Hydroxy-2-Methylpropanamide
DB07422 (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide
DB07419 (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
DB07423 (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
DB07039 (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
DB07454 (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
DB01128 Bicalutamide
DB01541 Boldenone
DB01564 Calusterone
DB04839 Cyproterone acetate
DB01406 Danazol
DB01481 Delta1-dihydrotestosterone
DB02901 Dihydrotestosterone
DB01395 Drospirenone
DB00858 Drostanolone
DB08899 Enzalutamide
DB13155 Esculin
DB00687 Fludrocortisone
DB02266 Flufenamic Acid
DB01185 Fluoxymesterone
DB00499 Flutamide
DB01026 Ketoconazole
DB00367 Levonorgestrel
DB05234 LGD2941
DB05094 MDV3100
DB06710 Methyltestosterone
DB02998 Methyltrienolone
DB08804 Nandrolone decanoate
DB00984 Nandrolone phenpropionate
DB00665 Nilutamide
DB09389 Norgestrel
DB00621 Oxandrolone
DB06412 Oxymetholone
DB01708 Prasterone
DB07769 S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
DB00421 Spironolactone
DB00624 Testosterone
DB01420 Testosterone Propionate
DB08867 Ulipristal
GuidetoPHARMACOLOGYi628

Polymorphism and mutation databases

BioMutaiAR
DMDMi113830

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537041 – 920Androgen receptorAdd BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83Phosphoserine; by CDK91 Publication1
Modified residuei96PhosphoserineCombined sources1
Modified residuei225Phosphotyrosine; by CSK1 Publication1
Modified residuei258PhosphoserineCombined sources1
Modified residuei269Phosphotyrosine; by CSK and TNK23 Publications1
Modified residuei309Phosphotyrosine; by CSK1 Publication1
Modified residuei348Phosphotyrosine; by CSK1 Publication1
Modified residuei359Phosphotyrosine; by CSK1 Publication1
Modified residuei364Phosphotyrosine; by CSK1 Publication1
Modified residuei365Phosphotyrosine; by CSK and TNK22 Publications1
Cross-linki388Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei395Phosphotyrosine; by CSK1 Publication1
Cross-linki521Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei535Phosphotyrosine; by CSK1 Publication1
Modified residuei552Phosphotyrosine; by CSK1 Publication1
Modified residuei651Phosphoserine; by STK4/MST11 Publication1
Cross-linki846Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki848Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication