P10273 (POL_FLV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pol polyprotein

Cleaved into the following 2 chains:

1. Protease
   EC=3.4.23.-
2. Reverse transcriptase/ribonuclease H
   Short name=RT
   EC=2.7.7.49
   EC=3.1.26.4

Gene names

Name:

pol

Organism

Feline leukemia virus

Taxonomic identifier

11768 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus

Virus host

Felidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length	128 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Endonucleolytic cleavage to 5'-phosphomonoester.
Post-translational modification	Specific enzymatic cleavages in vivo yield mature proteins.
Miscellaneous	This protein is synthesized as a Gag-Pol polyprotein.
Sequence similarities	Belongs to the retroviral Pol polyprotein family. Contains 1 peptidase A2 domain.

Ontologies

Keywords
Molecular function	Aspartyl protease Endonuclease Hydrolase Nuclease Nucleotidyltransferase Protease RNA-directed DNA polymerase Transferase
Technical term	Multifunctional enzyme
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW aspartic-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ribonuclease H activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›128	›128	Pol polyprotein		PRO_0000259718
	Chain	1 – 123	123	Protease Potential		PRO_0000026126
	Chain	124 – ›128	›5	Reverse transcriptase/ribonuclease H Potential		PRO_0000026127
Regions
	Domain	25 – 95	71	Peptidase A2
Sites
	Active site	30	1	By similarity
Experimental info
	Non-terminal residue	128	1

Sequences

	Sequence		Length	Mass (Da)
	P10273 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: AC1690EF7378AAC3	FASTA	128	14,116
	10 20 30 40 50 60 KIRRVRARTP PPEPRITLRI GGQPVTFLVD TGAQHSVLTR PDGPLSDRTA LVQGATGSKN 70 80 90 100 110 120 YRWTTDRRVQ LATGKVTHSF LYVPECPYPL LGRDLLTKLK AQIHFTGEGA NVVGPRGLPL QVLTLQLE

References

[1]	"Nucleotide sequence of the gag gene and gag-pol junction of feline leukemia virus." Laprevotte I., Hampe A., Sherr C.J., Galibert F. J. Virol. 50:884-894(1984) [PubMed: 6328019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	K01803 Genomic RNA. Translation: AAA43056.2.
3D structure databases
ProteinModelPortal	P10273.
ModBase	Search...
Protein family/group databases
MEROPS	A02.008.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR018061. Pept_A2A_retrovirus_sg. IPR001995. Peptidase_A2_cat. IPR021109. Peptidase_aspartic. IPR001969. Peptidase_aspartic_AS. IPR009007. Peptidase_aspartic_catalytic. [Graphical view]
Gene3D	G3DSA:2.40.70.10. Pept_Aspartc_cat. 1 hit.
Pfam	PF00077. RVP. 1 hit. [Graphical view]
SUPFAM	SSF50630. Pept_Aspartic. 1 hit.
PROSITE	PS50175. ASP_PROT_RETROV. 1 hit. PS00141. ASP_PROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

POL_FLV

Accession

Primary (citable) accession number: P10273

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	November 16, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program