Reviewed, UniProtKB/Swiss-Prot P10272 (POL_BAEVM)

Names and origin

Protein names

Recommended name:
    Pol polyprotein
Cleaved into the following 3 chains:
    1- Recommended name:
            Protease
              EC=3.4.23.-
    2- Recommended name:
            Reverse transcriptase/ribonuclease H
                Short name=RT
              EC=2.7.7.49
              EC=3.1.26.4
    3- Recommended name:
            Integrase
                Short name=IN

Gene names

Name:

pol

Organism

Baboon endogenous virus (strain M7)

Taxonomic identifier

11764 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus › unclassified Gammaretrovirus

Virus host

Papio (baboons) [TaxID: 9554]
Theropithecus gelada (Gelada baboon) [TaxID: 9565]

Protein attributes

Sequence length	1189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Endonucleolytic cleavage to 5'-phosphomonoester.
Post-translational modification	Specific enzymatic cleavages in vivo yield mature proteins.
Miscellaneous	This protein is synthesized as a Gag-Pol polyprotein.
Sequence similarities	Belongs to the retroviral Pol polyprotein family. Contains 1 integrase catalytic domain. Contains 1 peptidase A2 domain. Contains 1 reverse transcriptase domain. Contains 1 RNase H domain.

Ontologies

Keywords
Biological process	DNA integration DNA recombination
Molecular function	Aspartyl protease Endonuclease Hydrolase Nuclease Nucleotidyltransferase Protease RNA-directed DNA polymerase Transferase
Technical term	Multifunctional enzyme
Gene Ontology (GO)
Biological process	DNA integration Inferred from electronic annotation. Source: UniProtKB-KW DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW RNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW aspartic-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ribonuclease H activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1189	1189	Pol polyprotein		PRO_0000259717
	Chain	1 – 120	120	Protease Potential		PRO_0000026123
	Chain	121 – 797	677	Reverse transcriptase/ribonuclease H Potential		PRO_0000026124
	Chain	798 – 1189	392	Integrase Potential		PRO_0000026125
Regions
	Domain	22 – 92	71	Peptidase A2
	Domain	198 – 391	194	Reverse transcriptase
	Domain	634 – 780	147	RNase H
	Domain	900 – 1058	159	Integrase catalytic
Sites
	Active site	27	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P10272-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 530155B7F9045C81	FASTA	1,189	132,246
	10 20 30 40 50 60 GCQGSGAPPE PRLTLSVGGH PTTFLVDTGA QHSVLTKANG PLSSRTSWVQ GATGRKMHKW 70 80 90 100 110 120 TNRRTVNLGQ GMVTHSFLVV PECPYPLLGR DLLTKLGAQI HFSEAGAQVL DRDGQPIQIL 130 140 150 160 170 180 TVSLQDEHRL FDIPVTTSLP DVWLQDFPQA WAETGGLGRA KCQAPIIIDL KPTAVPVSIK 190 200 210 220 230 240 QYPMSLEAHM GIRQHIIKFL ELGVLRPCRS PWNTPLLPVK KPGTQDYRPV QDLREINKRT 250 260 270 280 290 300 VDIHPTVPNP YNLLSTLKPD YSWYTVLDLK DAFFCLPLAP QSQELFAFEW KDPERGISGQ 310 320 330 340 350 360 LTWTRLPQGF KNSPTLFDEA LHRDLTDFRT QHPEVTLLQY VDDLLLAAPT KKACTQGTRH 370 380 390 400 410 420 LLQELGEKGY RASAKKAQIC QTKVTYLGYI LSEGKRWLTP GRIETVARIP PPRNPREVRE 430 440 450 460 470 480 FLGTAGFCRL WIPGFAELAA PLYALTKEST PFTWQTEHQL AFEALKKALL SAPALGLPDT 490 500 510 520 530 540 SKPFTLFLDE RQGIAKGVLT QKLGPWKRPV AYLSKKLDPV AAGWPPCLRI MAATAMLVKD 550 560 570 580 590 600 SAKLTLGQPL TVITPHTLEA IVRQPPDRWI TNARLTHYQA LLLDTDRVQF GPPVTLNPAT 610 620 630 640 650 660 LLPVPENQPS PHDCRQVLAE THGTREDLKD QELPDADHTW YTDGSSYLDS GTRRAGAAVV 670 680 690 700 710 720 DGHNTIWAQS LPPGTSAQKA ELIALTKALE LSKGKKANIY TDSRYAFATA HTHGSIYERR 730 740 750 760 770 780 GLLTSEGKEI KNKAEIIALL KALFLPQEVA IIHCPGHQKG QDPVAVGNRQ ADRVARQAAM 790 800 810 820 830 840 AEVLTLATEP DNTSHITIEH TYTSEDQEEA RAIGATENKD TRNWEKEGKI VLPQKEALAM 850 860 870 880 890 900 IQQMHAWTHL GNRKLKLLIE KTDFLIPRAS TLIEQVTSAC KVCQQVNAGA TRVPAGKRTR 910 920 930 940 950 960 GNRPGVYWEI DFTEVKPHYA GYKYLLVFVD TFSGWVEAFP TRQETAHIVA KKILEEIFPR 970 980 990 1000 1010 1020 FGLPKVIGSD NGPAFVSQVS QGLARILGIN WKLHCAYRPQ SSGQVERMNR TIKETLTKLT 1030 1040 1050 1060 1070 1080 LETGLKDWRR LLSLALLRAR NTPNRFGLTP YEILYGGPPP LSTLLNSFSP SNSKTDLQAR 1090 1100 1110 1120 1130 1140 LKGLQAVQAQ IWAPLAELYR PGHSQTSHPF QVGDSVYVRR HRSQGLEPRW KGPYIVLLTT 1150 1160 1170 1180 PTAIKVDGIA TWIHASHAKA APGTPGPTSS GTWRLRRSED PLKIRLSRT

References

[1]	"The entire nucleotide sequence of baboon endogenous virus DNA: a chimeric genome structure of murine type C and simian type D retroviruses." Kato S., Matsuo K., Nishimura N., Takahashi N., Takano T. Jpn. J. Genet. 62:127-137(1987) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	D10032 Genomic DNA. Translation: BAA89659.1. Different initiation.
PIR	GNMVM7. JT0261.
3D structure databases
HSSP	HSSP built from PDB template 1I6J based on UniProtKB P03355.
SMR	P10272. Positions 143-592.
ModBase	Search...
Protein family/group databases
MEROPS	A02.008.
Family and domain databases
InterPro	IPR001584. Integrase_cat-core. IPR018061. Pept_A2A_retrovirus_sg. IPR001995. Peptidase_A2_cat. IPR001969. Peptidase_aspartic_AS. IPR009007. Peptidase_aspartic_catalytic. IPR000477. Reverse_transcriptase. IPR002156. RNase_H. [Graphical view]
Gene3D	G3DSA:2.40.70.10. Pept_Aspartc_cat. 1 hit.
Pfam	PF00075. RnaseH. 1 hit. PF00665. rve. 1 hit. PF00077. RVP. 1 hit. PF00078. RVT_1. 1 hit. [Graphical view]
PROSITE	PS50175. ASP_PROT_RETROV. 1 hit. PS00141. ASP_PROTEASE. 1 hit. PS50994. INTEGRASE. 1 hit. PS50879. RNASE_H. 1 hit. PS50878. RT_POL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

POL_BAEVM

Accession

Primary (citable) accession number: P10272
Secondary accession number(s): Q9IRA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	October 13, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)