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P10272 (POL_BAEVM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pol polyprotein

Cleaved into the following 3 chains:

  1. Protease
    EC=3.4.23.-
  2. Reverse transcriptase/ribonuclease H
    Short name=RT
    EC=2.7.7.49
    EC=3.1.26.4
  3. Integrase
    Short name=IN
Gene names
Name:pol
OrganismBaboon endogenous virus (strain M7) [Complete proteome]
Taxonomic identifier11764 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusunclassified Gammaretrovirus
Virus hostPapio (baboons) [TaxID: 9554]
Theropithecus gelada (Gelada baboon) [TaxID: 9565]

Protein attributes

Sequence length1189 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Endonucleolytic cleavage to 5'-phosphomonoester.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins.

Miscellaneous

This protein is synthesized as a Gag-Pol polyprotein.

Sequence similarities

Belongs to the retroviral Pol polyprotein family.

Contains 1 integrase catalytic domain.

Contains 1 peptidase A2 domain.

Contains 1 reverse transcriptase domain.

Contains 1 RNase H domain.

Sequence caution

The sequence BAA89659.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11891189Pol polyprotein
PRO_0000259717
Chain1 – 120120Protease Potential
PRO_0000026123
Chain121 – 797677Reverse transcriptase/ribonuclease H Potential
PRO_0000026124
Chain798 – 1189392Integrase Potential
PRO_0000026125

Regions

Domain22 – 9271Peptidase A2
Domain198 – 391194Reverse transcriptase
Domain634 – 780147RNase H
Domain900 – 1058159Integrase catalytic

Sites

Active site271 By similarity

Sequences

Sequence LengthMass (Da)Tools
P10272 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 530155B7F9045C81

FASTA1,189132,246
        10         20         30         40         50         60 
GCQGSGAPPE PRLTLSVGGH PTTFLVDTGA QHSVLTKANG PLSSRTSWVQ GATGRKMHKW 

        70         80         90        100        110        120 
TNRRTVNLGQ GMVTHSFLVV PECPYPLLGR DLLTKLGAQI HFSEAGAQVL DRDGQPIQIL 

       130        140        150        160        170        180 
TVSLQDEHRL FDIPVTTSLP DVWLQDFPQA WAETGGLGRA KCQAPIIIDL KPTAVPVSIK 

       190        200        210        220        230        240 
QYPMSLEAHM GIRQHIIKFL ELGVLRPCRS PWNTPLLPVK KPGTQDYRPV QDLREINKRT 

       250        260        270        280        290        300 
VDIHPTVPNP YNLLSTLKPD YSWYTVLDLK DAFFCLPLAP QSQELFAFEW KDPERGISGQ 

       310        320        330        340        350        360 
LTWTRLPQGF KNSPTLFDEA LHRDLTDFRT QHPEVTLLQY VDDLLLAAPT KKACTQGTRH 

       370        380        390        400        410        420 
LLQELGEKGY RASAKKAQIC QTKVTYLGYI LSEGKRWLTP GRIETVARIP PPRNPREVRE 

       430        440        450        460        470        480 
FLGTAGFCRL WIPGFAELAA PLYALTKEST PFTWQTEHQL AFEALKKALL SAPALGLPDT 

       490        500        510        520        530        540 
SKPFTLFLDE RQGIAKGVLT QKLGPWKRPV AYLSKKLDPV AAGWPPCLRI MAATAMLVKD 

       550        560        570        580        590        600 
SAKLTLGQPL TVITPHTLEA IVRQPPDRWI TNARLTHYQA LLLDTDRVQF GPPVTLNPAT 

       610        620        630        640        650        660 
LLPVPENQPS PHDCRQVLAE THGTREDLKD QELPDADHTW YTDGSSYLDS GTRRAGAAVV 

       670        680        690        700        710        720 
DGHNTIWAQS LPPGTSAQKA ELIALTKALE LSKGKKANIY TDSRYAFATA HTHGSIYERR 

       730        740        750        760        770        780 
GLLTSEGKEI KNKAEIIALL KALFLPQEVA IIHCPGHQKG QDPVAVGNRQ ADRVARQAAM 

       790        800        810        820        830        840 
AEVLTLATEP DNTSHITIEH TYTSEDQEEA RAIGATENKD TRNWEKEGKI VLPQKEALAM 

       850        860        870        880        890        900 
IQQMHAWTHL GNRKLKLLIE KTDFLIPRAS TLIEQVTSAC KVCQQVNAGA TRVPAGKRTR 

       910        920        930        940        950        960 
GNRPGVYWEI DFTEVKPHYA GYKYLLVFVD TFSGWVEAFP TRQETAHIVA KKILEEIFPR 

       970        980        990       1000       1010       1020 
FGLPKVIGSD NGPAFVSQVS QGLARILGIN WKLHCAYRPQ SSGQVERMNR TIKETLTKLT 

      1030       1040       1050       1060       1070       1080 
LETGLKDWRR LLSLALLRAR NTPNRFGLTP YEILYGGPPP LSTLLNSFSP SNSKTDLQAR 

      1090       1100       1110       1120       1130       1140 
LKGLQAVQAQ IWAPLAELYR PGHSQTSHPF QVGDSVYVRR HRSQGLEPRW KGPYIVLLTT 

      1150       1160       1170       1180 
PTAIKVDGIA TWIHASHAKA APGTPGPTSS GTWRLRRSED PLKIRLSRT 

« Hide

References

[1]"The entire nucleotide sequence of baboon endogenous virus DNA: a chimeric genome structure of murine type C and simian type D retroviruses."
Kato S., Matsuo K., Nishimura N., Takahashi N., Takano T.
Jpn. J. Genet. 62:127-137(1987)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10032 Genomic DNA. Translation: BAA89659.1. Different initiation.
PIRGNMVM7. JT0261.

3D structure databases

ProteinModelPortalP10272.
SMRP10272. Positions 143-592, 622-782.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProIPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view]
PfamPF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePOL_BAEVM
AccessionPrimary (citable) accession number: P10272
Secondary accession number(s): Q9IRA3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries