SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P10272

- POL_BAEVM

UniProt

P10272 - POL_BAEVM

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Pol polyprotein
Gene
pol
Organism
Baboon endogenous virus (strain M7)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Endonucleolytic cleavage to 5'-phosphomonoester.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei27 – 271 By similarity

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-EC
  3. RNA-directed DNA polymerase activity Source: UniProtKB-KW
  4. aspartic-type endopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA integration Source: UniProtKB-KW
  2. DNA recombination Source: UniProtKB-KW
  3. establishment of integrated proviral latency Source: UniProtKB-KW
  4. viral entry into host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase

Keywords - Biological processi

DNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Pol polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:pol
OrganismiBaboon endogenous virus (strain M7)
Taxonomic identifieri11764 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusunclassified Gammaretrovirus
Virus hostiPapio (baboons) [TaxID: 9554]
Theropithecus gelada (Gelada baboon) [TaxID: 9565]
ProteomesiUP000007443: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11891189Pol polyprotein
PRO_0000259717Add
BLAST
Chaini1 – 120120Protease Reviewed prediction
PRO_0000026123Add
BLAST
Chaini121 – 797677Reverse transcriptase/ribonuclease H Reviewed prediction
PRO_0000026124Add
BLAST
Chaini798 – 1189392Integrase Reviewed prediction
PRO_0000026125Add
BLAST

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins.

Structurei

3D structure databases

ProteinModelPortaliP10272.
SMRiP10272. Positions 143-592, 622-782.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 9271Peptidase A2
Add
BLAST
Domaini198 – 391194Reverse transcriptase
Add
BLAST
Domaini634 – 780147RNase H
Add
BLAST
Domaini900 – 1058159Integrase catalytic
Add
BLAST

Sequence similaritiesi

Contains 1 RNase H domain.

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10272-1 [UniParc]FASTAAdd to Basket

« Hide

GCQGSGAPPE PRLTLSVGGH PTTFLVDTGA QHSVLTKANG PLSSRTSWVQ     50
GATGRKMHKW TNRRTVNLGQ GMVTHSFLVV PECPYPLLGR DLLTKLGAQI 100
HFSEAGAQVL DRDGQPIQIL TVSLQDEHRL FDIPVTTSLP DVWLQDFPQA 150
WAETGGLGRA KCQAPIIIDL KPTAVPVSIK QYPMSLEAHM GIRQHIIKFL 200
ELGVLRPCRS PWNTPLLPVK KPGTQDYRPV QDLREINKRT VDIHPTVPNP 250
YNLLSTLKPD YSWYTVLDLK DAFFCLPLAP QSQELFAFEW KDPERGISGQ 300
LTWTRLPQGF KNSPTLFDEA LHRDLTDFRT QHPEVTLLQY VDDLLLAAPT 350
KKACTQGTRH LLQELGEKGY RASAKKAQIC QTKVTYLGYI LSEGKRWLTP 400
GRIETVARIP PPRNPREVRE FLGTAGFCRL WIPGFAELAA PLYALTKEST 450
PFTWQTEHQL AFEALKKALL SAPALGLPDT SKPFTLFLDE RQGIAKGVLT 500
QKLGPWKRPV AYLSKKLDPV AAGWPPCLRI MAATAMLVKD SAKLTLGQPL 550
TVITPHTLEA IVRQPPDRWI TNARLTHYQA LLLDTDRVQF GPPVTLNPAT 600
LLPVPENQPS PHDCRQVLAE THGTREDLKD QELPDADHTW YTDGSSYLDS 650
GTRRAGAAVV DGHNTIWAQS LPPGTSAQKA ELIALTKALE LSKGKKANIY 700
TDSRYAFATA HTHGSIYERR GLLTSEGKEI KNKAEIIALL KALFLPQEVA 750
IIHCPGHQKG QDPVAVGNRQ ADRVARQAAM AEVLTLATEP DNTSHITIEH 800
TYTSEDQEEA RAIGATENKD TRNWEKEGKI VLPQKEALAM IQQMHAWTHL 850
GNRKLKLLIE KTDFLIPRAS TLIEQVTSAC KVCQQVNAGA TRVPAGKRTR 900
GNRPGVYWEI DFTEVKPHYA GYKYLLVFVD TFSGWVEAFP TRQETAHIVA 950
KKILEEIFPR FGLPKVIGSD NGPAFVSQVS QGLARILGIN WKLHCAYRPQ 1000
SSGQVERMNR TIKETLTKLT LETGLKDWRR LLSLALLRAR NTPNRFGLTP 1050
YEILYGGPPP LSTLLNSFSP SNSKTDLQAR LKGLQAVQAQ IWAPLAELYR 1100
PGHSQTSHPF QVGDSVYVRR HRSQGLEPRW KGPYIVLLTT PTAIKVDGIA 1150
TWIHASHAKA APGTPGPTSS GTWRLRRSED PLKIRLSRT 1189
Length:1,189
Mass (Da):132,246
Last modified:July 1, 1989 - v1
Checksum:i530155B7F9045C81
GO

Sequence cautioni

The sequence BAA89659.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10032 Genomic DNA. Translation: BAA89659.1. Different initiation.
PIRiJT0261. GNMVM7.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10032 Genomic DNA. Translation: BAA89659.1 . Different initiation.
PIRi JT0261. GNMVM7.

3D structure databases

ProteinModelPortali P10272.
SMRi P10272. Positions 143-592, 622-782.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProi IPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view ]
Pfami PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view ]
SUPFAMi SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The entire nucleotide sequence of baboon endogenous virus DNA: a chimeric genome structure of murine type C and simian type D retroviruses."
    Kato S., Matsuo K., Nishimura N., Takahashi N., Takano T.
    Jpn. J. Genet. 62:127-137(1987)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPOL_BAEVM
AccessioniPrimary (citable) accession number: P10272
Secondary accession number(s): Q9IRA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 14, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Pol polyprotein.

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi