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P10272

- POL_BAEVM

UniProt

P10272 - POL_BAEVM

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Protein

Pol polyprotein

Gene

pol

Organism
Baboon endogenous virus (strain M7)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).PROSITE-ProRule annotation
Endonucleolytic cleavage to 5'-phosphomonoester.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei27 – 271PROSITE-ProRule annotation

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
  3. RNA-directed DNA polymerase activity Source: UniProtKB-KW
  4. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA integration Source: UniProtKB-KW
  2. DNA recombination Source: UniProtKB-KW
  3. establishment of integrated proviral latency Source: UniProtKB-KW
  4. viral entry into host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase

Keywords - Biological processi

DNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Pol polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:pol
OrganismiBaboon endogenous virus (strain M7)
Taxonomic identifieri11764 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusunclassified Gammaretrovirus
Virus hostiPapio (baboons) [TaxID: 9554]
Theropithecus gelada (Gelada baboon) [TaxID: 9565]
ProteomesiUP000007443: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11891189Pol polyproteinPRO_0000259717Add
BLAST
Chaini1 – 120120ProteaseSequence AnalysisPRO_0000026123Add
BLAST
Chaini121 – 797677Reverse transcriptase/ribonuclease HSequence AnalysisPRO_0000026124Add
BLAST
Chaini798 – 1189392IntegraseSequence AnalysisPRO_0000026125Add
BLAST

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins.

Structurei

3D structure databases

ProteinModelPortaliP10272.
SMRiP10272. Positions 143-592, 622-782.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 9271Peptidase A2PROSITE-ProRule annotationAdd
BLAST
Domaini198 – 391194Reverse transcriptasePROSITE-ProRule annotationAdd
BLAST
Domaini634 – 780147RNase HPROSITE-ProRule annotationAdd
BLAST
Domaini900 – 1058159Integrase catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.Curated
Contains 1 integrase catalytic domain.PROSITE-ProRule annotation
Contains 1 peptidase A2 domain.PROSITE-ProRule annotation
Contains 1 reverse transcriptase domain.PROSITE-ProRule annotation
Contains 1 RNase H domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10272-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
GCQGSGAPPE PRLTLSVGGH PTTFLVDTGA QHSVLTKANG PLSSRTSWVQ
60 70 80 90 100
GATGRKMHKW TNRRTVNLGQ GMVTHSFLVV PECPYPLLGR DLLTKLGAQI
110 120 130 140 150
HFSEAGAQVL DRDGQPIQIL TVSLQDEHRL FDIPVTTSLP DVWLQDFPQA
160 170 180 190 200
WAETGGLGRA KCQAPIIIDL KPTAVPVSIK QYPMSLEAHM GIRQHIIKFL
210 220 230 240 250
ELGVLRPCRS PWNTPLLPVK KPGTQDYRPV QDLREINKRT VDIHPTVPNP
260 270 280 290 300
YNLLSTLKPD YSWYTVLDLK DAFFCLPLAP QSQELFAFEW KDPERGISGQ
310 320 330 340 350
LTWTRLPQGF KNSPTLFDEA LHRDLTDFRT QHPEVTLLQY VDDLLLAAPT
360 370 380 390 400
KKACTQGTRH LLQELGEKGY RASAKKAQIC QTKVTYLGYI LSEGKRWLTP
410 420 430 440 450
GRIETVARIP PPRNPREVRE FLGTAGFCRL WIPGFAELAA PLYALTKEST
460 470 480 490 500
PFTWQTEHQL AFEALKKALL SAPALGLPDT SKPFTLFLDE RQGIAKGVLT
510 520 530 540 550
QKLGPWKRPV AYLSKKLDPV AAGWPPCLRI MAATAMLVKD SAKLTLGQPL
560 570 580 590 600
TVITPHTLEA IVRQPPDRWI TNARLTHYQA LLLDTDRVQF GPPVTLNPAT
610 620 630 640 650
LLPVPENQPS PHDCRQVLAE THGTREDLKD QELPDADHTW YTDGSSYLDS
660 670 680 690 700
GTRRAGAAVV DGHNTIWAQS LPPGTSAQKA ELIALTKALE LSKGKKANIY
710 720 730 740 750
TDSRYAFATA HTHGSIYERR GLLTSEGKEI KNKAEIIALL KALFLPQEVA
760 770 780 790 800
IIHCPGHQKG QDPVAVGNRQ ADRVARQAAM AEVLTLATEP DNTSHITIEH
810 820 830 840 850
TYTSEDQEEA RAIGATENKD TRNWEKEGKI VLPQKEALAM IQQMHAWTHL
860 870 880 890 900
GNRKLKLLIE KTDFLIPRAS TLIEQVTSAC KVCQQVNAGA TRVPAGKRTR
910 920 930 940 950
GNRPGVYWEI DFTEVKPHYA GYKYLLVFVD TFSGWVEAFP TRQETAHIVA
960 970 980 990 1000
KKILEEIFPR FGLPKVIGSD NGPAFVSQVS QGLARILGIN WKLHCAYRPQ
1010 1020 1030 1040 1050
SSGQVERMNR TIKETLTKLT LETGLKDWRR LLSLALLRAR NTPNRFGLTP
1060 1070 1080 1090 1100
YEILYGGPPP LSTLLNSFSP SNSKTDLQAR LKGLQAVQAQ IWAPLAELYR
1110 1120 1130 1140 1150
PGHSQTSHPF QVGDSVYVRR HRSQGLEPRW KGPYIVLLTT PTAIKVDGIA
1160 1170 1180
TWIHASHAKA APGTPGPTSS GTWRLRRSED PLKIRLSRT
Length:1,189
Mass (Da):132,246
Last modified:July 1, 1989 - v1
Checksum:i530155B7F9045C81
GO

Sequence cautioni

The sequence BAA89659.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10032 Genomic DNA. Translation: BAA89659.1. Different initiation.
PIRiJT0261. GNMVM7.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10032 Genomic DNA. Translation: BAA89659.1 . Different initiation.
PIRi JT0261. GNMVM7.

3D structure databases

ProteinModelPortali P10272.
SMRi P10272. Positions 143-592, 622-782.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProi IPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view ]
Pfami PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view ]
SUPFAMi SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The entire nucleotide sequence of baboon endogenous virus DNA: a chimeric genome structure of murine type C and simian type D retroviruses."
    Kato S., Matsuo K., Nishimura N., Takahashi N., Takano T.
    Jpn. J. Genet. 62:127-137(1987)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPOL_BAEVM
AccessioniPrimary (citable) accession number: P10272
Secondary accession number(s): Q9IRA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Pol polyprotein.

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3