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P10269

- ENV_BAEVM

UniProt

P10269 - ENV_BAEVM

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Protein
Envelope glycoprotein
Gene
env
Organism
Baboon endogenous virus (strain M7)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane By similarity.
The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei376 – 3772Cleavage; by host By similarity
Sitei546 – 5472Cleavage; by viral protease By similarity

GO - Biological processi

  1. fusion of virus membrane with host plasma membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Alternative name(s):
Env polyprotein
Cleaved into the following 3 chains:
Surface protein
Short name:
SU
Alternative name(s):
Glycoprotein 70
Short name:
gp70
Transmembrane protein
Short name:
TM
Alternative name(s):
Glycoprotein p20E
Alternative name(s):
p2E
Gene namesi
Name:env
OrganismiBaboon endogenous virus (strain M7)
Taxonomic identifieri11764 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusunclassified Gammaretrovirus
Virus hostiPapio (baboons) [TaxID: 9554]
Theropithecus gelada (Gelada baboon) [TaxID: 9565]
ProteomesiUP000007443: Genome

Subcellular locationi

Chain Transmembrane protein : Virion membrane; Single-pass type I membrane protein By similarity. Host cell membrane; Single-pass type I membrane protein By similarity
Note: It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag By similarity.
Chain Surface protein : Virion membrane; Peripheral membrane protein By similarity. Host cell membrane; Peripheral membrane protein By similarity
Note: The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag By similarity.
R-peptide : Host cell membrane; Peripheral membrane protein
Note: The R-peptide is membrane-associated through its palmitate By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 503485Extracellular Reviewed prediction
Add
BLAST
Transmembranei504 – 52421Helical; Reviewed prediction
Add
BLAST
Topological domaini525 – 56339Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 563545Envelope glycoprotein
PRO_0000239549Add
BLAST
Chaini19 – 376358Surface protein By similarity
PRO_0000040687Add
BLAST
Chaini377 – 546170Transmembrane protein By similarity
PRO_0000040688Add
BLAST
Peptidei547 – 56317R-peptide By similarity
PRO_0000239550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi219 – 2191N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi229 – 2291N-linked (GlcNAc...); by host Reviewed prediction
Disulfide bondi236 ↔ 465Interchain (between SU and TM chains, or C-239 with C-465); in linked form By similarity
Disulfide bondi236 ↔ 239 By similarity
Glycosylationi264 – 2641N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi282 – 2821N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi292 – 2921N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi306 – 3061N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi312 – 3121N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi321 – 3211N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi339 – 3391N-linked (GlcNAc...); by host Reviewed prediction
Disulfide bondi457 ↔ 464 By similarity
Glycosylationi469 – 4691N-linked (GlcNAc...); by host Reviewed prediction
Lipidationi527 – 5271S-palmitoyl cysteine; by host By similarity

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as a inactive precursor that is N-glycosylated and processed likely by host cell furin or by a furin-like protease in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. The R-peptide is released from the C-terminus of the cytoplasmic tail of the TM protein upon particle formation as a result of proteolytic cleavage by the viral protease. Cleavage of this peptide is required for TM to become fusogenic By similarity.
The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion By similarity.
The transmembrane protein is palmitoylated By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

The mature envelope protein (Env) consists of a trimer of SU-TM heterodimers attached by a labile interchain disulfide bond By similarity.

Structurei

3D structure databases

ProteinModelPortaliP10269.
SMRiP10269. Positions 417-469.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni380 – 40021Fusion peptide Reviewed prediction
Add
BLAST
Regioni440 – 45617Immunosuppression By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili401 – 45151 Reviewed prediction
Add
BLAST
Coiled coili461 – 49737 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi236 – 2394CXXC
Motifi457 – 4659CX6CC
Motifi552 – 5554YXXL motif; contains endocytosis signal By similarity

Domaini

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo By similarity.
The YXXL motif is involved in determining the exact site of viral release at the surface of infected mononuclear cells and promotes endocytosis.

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR018154. TLV/ENV_coat_polyprotein.
[Graphical view]
PANTHERiPTHR10424. PTHR10424. 1 hit.
PfamiPF00429. TLV_coat. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10269-1 [UniParc]FASTAAdd to Basket

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MGFTTKIIFL YNLVLVYAGF DDPRKAIELV QKRYGRPCDC SGGQVSEPPS    50
DRVSQVTCSG KTAYLMPDQR WKCKSIPKDT SPSGPLQECP CNSYQSSVHS 100
SCYTSYQQCR SGNKTYYTAT LLKTQTGGTS DVQVLGSTNK LIQSPCNGIK 150
GQSICWSTTA PIHVSDGGGP LDTTRIKSVQ RKLEEIHKAL YPELQYHPLA 200
IPKVRDNLMV DAQTLNILNA TYNLLLMSNT SLVDDCWLCL KLGPPTPLAI 250
PNFLLSYVTR SSDNISCLII PPLLVQPMQF SNSSCLFSPS YNSTEEIDLG 300
HVAFSNCTSI TNVTGPICAV NGSVFLCGNN MAYTYLPTNW TGLCVLATLL 350
PDIDIIPGDE PVPIPAIDHF IYRPKRAIQF IPLLAGLGIT AAFTTGATGL 400
GVSVTQYTKL SNQLISDVQI LSSTIQDLQD QVDSLAEVVL QNRRGLDLLT 450
AEQGGICLAL QEKCCFYVNK SGIVRDKIKT LQEELERRRK DLASNPLWTG 500
LQGLLPYLLP FLGPLLTLLL LLTIGPCIFN RLTAFINDKL NIIHAMVLTQ 550
QYQVLRTDEE AQD 563
Length:563
Mass (Da):61,879
Last modified:July 1, 1989 - v1
Checksum:i9573137DC4620BB7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10032 Genomic DNA. Translation: BAA00924.1.
X05470 Genomic DNA. Translation: CAA29028.1.
PIRiJT0262. VCMVM7.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10032 Genomic DNA. Translation: BAA00924.1 .
X05470 Genomic DNA. Translation: CAA29028.1 .
PIRi JT0262. VCMVM7.

3D structure databases

ProteinModelPortali P10269.
SMRi P10269. Positions 417-469.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR018154. TLV/ENV_coat_polyprotein.
[Graphical view ]
PANTHERi PTHR10424. PTHR10424. 1 hit.
Pfami PF00429. TLV_coat. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The entire nucleotide sequence of baboon endogenous virus DNA: a chimeric genome structure of murine type C and simian type D retroviruses."
    Kato S., Matsuo K., Nishimura N., Takahashi N., Takano T.
    Jpn. J. Genet. 62:127-137(1987)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiENV_BAEVM
AccessioniPrimary (citable) accession number: P10269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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