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Protein

Peptidyl-prolyl cis-trans isomerase, mitochondrial

Gene

csr-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase, mitochondrial (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Cyclophilin
Short name:
CPH
Cyclosporin A-binding protein
Rotamase
Gene namesi
Name:csr-1
Synonyms:cyp
ORF Names:NCU00726
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU00726.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 44MitochondrionAdd BLAST44
ChainiPRO_000002547545 – 223Peptidyl-prolyl cis-trans isomerase, mitochondrialAdd BLAST179

Structurei

3D structure databases

ProteinModelPortaliP10255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 222PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST161

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000065981.
InParanoidiP10255.
OrthoDBiEOG092C5DG5.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform Mitochondrial (identifier: P10255-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGPRHFSVL KTTGSLVSST FSSSLKPTAT FSCARAFSQT SSIMSKVFFD
60 70 80 90 100
LEWEGPVLGP NNKPTSEIKA QSGRINFTLY DDVVPKTARN FKELCTGQNG
110 120 130 140 150
FGYKGSSFHR IIPEFMLQGG DFTRGNGTGG KSIYGEKFAD ENFAKKHVRP
160 170 180 190 200
GLLSMANAGP NTNGSQFFVT TVPTSWLDGR HVVFGEVADD ESMKVVKALE
210 220
ATGSSSGAIR YSKKPTIVDC GAL
Length:223
Mass (Da):24,064
Last modified:July 1, 1989 - v1
Checksum:iD494AB77F9768AE0
GO
Isoform Cytosolic (identifier: P10255-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: Produced by alternative initiation.
Show »
Length:180
Mass (Da):19,523
Checksum:iDF4C5CFB7E2C59F3
GO
Isoform Short (identifier: P10255-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-223: GGDFTRGNGT...KPTIVDCGAL → AAVLFVTPRSPPLSTAALSKFPCGHCRGF

Note: Produced by alternative splicing. This isoform is found in the cell following 22 hours growth in dark.
Show »
Length:147
Mass (Da):16,083
Checksum:i993E29376C83382B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188631 – 43Missing in isoform Cytosolic. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_029976119 – 223GGDFT…DCGAL → AAVLFVTPRSPPLSTAALSK FPCGHCRGF in isoform Short. CuratedAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03963 mRNA. Translation: AAA33584.1.
X17692 Genomic DNA. Translation: CAA35681.1.
X17692 Genomic DNA. Translation: CAA35682.1.
CM002236 Genomic DNA. Translation: ESA44269.1.
PIRiB30809. CSNCM.
RefSeqiXP_011392822.1. XM_011394520.1. [P10255-1]

Genome annotation databases

EnsemblFungiiESA44269; ESA44269; NCU00726. [P10255-1]
GeneIDi5847832.
KEGGincr:NCU00726.

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03963 mRNA. Translation: AAA33584.1.
X17692 Genomic DNA. Translation: CAA35681.1.
X17692 Genomic DNA. Translation: CAA35682.1.
CM002236 Genomic DNA. Translation: ESA44269.1.
PIRiB30809. CSNCM.
RefSeqiXP_011392822.1. XM_011394520.1. [P10255-1]

3D structure databases

ProteinModelPortaliP10255.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiESA44269; ESA44269; NCU00726. [P10255-1]
GeneIDi5847832.
KEGGincr:NCU00726.

Organism-specific databases

EuPathDBiFungiDB:NCU00726.

Phylogenomic databases

HOGENOMiHOG000065981.
InParanoidiP10255.
OrthoDBiEOG092C5DG5.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYPH_NEUCR
AccessioniPrimary (citable) accession number: P10255
Secondary accession number(s): A7UVW7
, A7UVW8, Q7RV39, V5IRD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.