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Protein

CD48 antigen

Gene

Cd48

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

GO - Molecular functioni

  • antigen binding Source: RGD
  • receptor activity Source: InterPro

GO - Biological processi

  • mast cell activation Source: RGD
  • regulation of adaptive immune response Source: InterPro
  • signal transduction Source: Ensembl
  • T cell activation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
CD48 antigen
Alternative name(s):
BCM1 surface antigen
BLAST-1
MRC OX-45 surface antigen
SLAM family member 2
Short name:
SLAMF2
Signaling lymphocytic activation molecule 2
CD_antigen: CD48
Gene namesi
Name:Cd48
Synonyms:Bcm-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi620620. Cd48.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: RGD
  • external side of plasma membrane Source: Ensembl
  • plasma membrane Source: RGD
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000001488523 – 217CD48 antigenAdd BLAST195
PropeptideiPRO_0000014886218 – 240Removed in mature formBy similarityAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)1 Publication1
Glycosylationi97N-linked (GlcNAc...)1 Publication1
Glycosylationi140N-linked (GlcNAc...)1 Publication1
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Glycosylationi203N-linked (GlcNAc...)Sequence analysis1
Lipidationi217GPI-anchor amidated serineBy similarity1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP10252.
PRIDEiP10252.

PTM databases

iPTMnetiP10252.
PhosphoSitePlusiP10252.
UniCarbKBiP10252.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004737.
GenevisibleiP10252. RN.

Interactioni

Subunit structurei

Interacts with CD244 in a heterophilic manner.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006306.

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 34Combined sources5
Beta strandi39 – 41Combined sources3
Beta strandi52 – 61Combined sources10
Beta strandi63 – 67Combined sources5
Beta strandi69 – 71Combined sources3
Beta strandi73 – 75Combined sources3
Turni79 – 83Combined sources5
Beta strandi84 – 86Combined sources3
Turni88 – 90Combined sources3
Beta strandi93 – 95Combined sources3
Helixi100 – 102Combined sources3
Beta strandi104 – 125Combined sources22
Beta strandi132 – 136Combined sources5
Beta strandi142 – 146Combined sources5
Beta strandi154 – 156Combined sources3
Beta strandi159 – 161Combined sources3
Beta strandi164 – 177Combined sources14
Beta strandi191 – 197Combined sources7
Beta strandi200 – 206Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DRUX-ray2.60A23-211[»]
ProteinModelPortaliP10252.
SMRiP10252.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10252.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 127Ig-like C2-type 1Add BLAST99
Domaini131 – 207Ig-like C2-type 2Add BLAST77

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J3RS. Eukaryota.
ENOG410ZR3T. LUCA.
GeneTreeiENSGT00510000049275.
HOGENOMiHOG000111487.
HOVERGENiHBG004490.
InParanoidiP10252.
KOiK06479.
OMAiSSGVAWI.
OrthoDBiEOG091G0K94.
PhylomeDBiP10252.
TreeFamiTF334964.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR033548. CD48.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PANTHERiPTHR12080:SF47. PTHR12080:SF47. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYFKKRRWFL ILESLLLSLV TGFQDQSVPN VNAITGSNVT LTILKHPLAS
60 70 80 90 100
YQRLTWLHTT NQKILEYFPN GKKTVFESVF KDRVDLDKTN GALRIYNVSK
110 120 130 140 150
EDRGDYYMRM LHETEDQWKI TMEVYDLVSK PAIKIEKTKN LTDSCHLRLS
160 170 180 190 200
CKVEDQGVDY TWYEDSGPFP QRNPGYVLEI TITPHNKSTF YTCQVSNPVS
210 220 230 240
SENDTLYFIP PCTLARSSGV HWIAAWLVVT LSIIPSILLA
Length:240
Mass (Da):27,680
Last modified:July 1, 1989 - v1
Checksum:i42CBBF9947A0E437
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13016 mRNA. Translation: CAA31438.1.
BC060542 mRNA. Translation: AAH60542.1.
PIRiS01299.
RefSeqiNP_620803.1. NM_139103.1.
UniGeneiRn.3705.

Genome annotation databases

EnsembliENSRNOT00000006306; ENSRNOP00000006306; ENSRNOG00000004737.
GeneIDi245962.
KEGGirno:245962.
UCSCiRGD:620620. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13016 mRNA. Translation: CAA31438.1.
BC060542 mRNA. Translation: AAH60542.1.
PIRiS01299.
RefSeqiNP_620803.1. NM_139103.1.
UniGeneiRn.3705.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DRUX-ray2.60A23-211[»]
ProteinModelPortaliP10252.
SMRiP10252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006306.

PTM databases

iPTMnetiP10252.
PhosphoSitePlusiP10252.
UniCarbKBiP10252.

Proteomic databases

PaxDbiP10252.
PRIDEiP10252.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006306; ENSRNOP00000006306; ENSRNOG00000004737.
GeneIDi245962.
KEGGirno:245962.
UCSCiRGD:620620. rat.

Organism-specific databases

CTDi962.
RGDi620620. Cd48.

Phylogenomic databases

eggNOGiENOG410J3RS. Eukaryota.
ENOG410ZR3T. LUCA.
GeneTreeiENSGT00510000049275.
HOGENOMiHOG000111487.
HOVERGENiHBG004490.
InParanoidiP10252.
KOiK06479.
OMAiSSGVAWI.
OrthoDBiEOG091G0K94.
PhylomeDBiP10252.
TreeFamiTF334964.

Enzyme and pathway databases

ReactomeiR-RNO-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

EvolutionaryTraceiP10252.
PROiP10252.

Gene expression databases

BgeeiENSRNOG00000004737.
GenevisibleiP10252. RN.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR033548. CD48.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PANTHERiPTHR12080:SF47. PTHR12080:SF47. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD48_RAT
AccessioniPrimary (citable) accession number: P10252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.