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Protein

CD48 antigen

Gene

Cd48

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

GO - Molecular functioni

  • antigen binding Source: RGD
  • receptor activity Source: InterPro

GO - Biological processi

  • mast cell activation Source: RGD
  • regulation of adaptive immune response Source: InterPro
  • signal transduction Source: RGD
  • T cell activation Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
CD48 antigen
Alternative name(s):
BCM1 surface antigen
BLAST-1
MRC OX-45 surface antigen1 Publication
SLAM family member 2
Short name:
SLAMF2
Signaling lymphocytic activation molecule 2
CD_antigen: CD48
Gene namesi
Name:Cd48
Synonyms:Bcm-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi620620 Cd48

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000001488523 – 217CD48 antigenAdd BLAST195
PropeptideiPRO_0000014886218 – 240Removed in mature formBy similarityAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi97N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi151 ↔ 1931 Publication
Glycosylationi186N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi203N-linked (GlcNAc...) asparagine1 Publication1
Lipidationi217GPI-anchor amidated serine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP10252
PRIDEiP10252

PTM databases

GlyConnecti371
iPTMnetiP10252
PhosphoSitePlusiP10252
UniCarbKBiP10252

Expressioni

Gene expression databases

BgeeiENSRNOG00000004737
GenevisibleiP10252 RN

Interactioni

Subunit structurei

Interacts with CD2. Interacts with CD244 in a heterophilic manner.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006306

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 34Combined sources5
Beta strandi39 – 41Combined sources3
Beta strandi52 – 61Combined sources10
Beta strandi63 – 67Combined sources5
Beta strandi69 – 71Combined sources3
Beta strandi73 – 75Combined sources3
Turni79 – 83Combined sources5
Beta strandi84 – 86Combined sources3
Turni88 – 90Combined sources3
Beta strandi93 – 95Combined sources3
Helixi100 – 102Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DRUX-ray2.60A23-125[»]
ProteinModelPortaliP10252
SMRiP10252
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10252

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 127Ig-like C2-type 1Add BLAST99
Domaini131 – 207Ig-like C2-type 2Add BLAST77

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J3RS Eukaryota
ENOG410ZR3T LUCA
GeneTreeiENSGT00510000049275
HOGENOMiHOG000111487
HOVERGENiHBG004490
InParanoidiP10252
KOiK06479
OMAiSSGVAWI
OrthoDBiEOG091G0K94
PhylomeDBiP10252
TreeFamiTF334964

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR033548 CD48
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PANTHERiPTHR12080:SF47 PTHR12080:SF47, 1 hit
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYFKKRRWFL ILESLLLSLV TGFQDQSVPN VNAITGSNVT LTILKHPLAS
60 70 80 90 100
YQRLTWLHTT NQKILEYFPN GKKTVFESVF KDRVDLDKTN GALRIYNVSK
110 120 130 140 150
EDRGDYYMRM LHETEDQWKI TMEVYDLVSK PAIKIEKTKN LTDSCHLRLS
160 170 180 190 200
CKVEDQGVDY TWYEDSGPFP QRNPGYVLEI TITPHNKSTF YTCQVSNPVS
210 220 230 240
SENDTLYFIP PCTLARSSGV HWIAAWLVVT LSIIPSILLA
Length:240
Mass (Da):27,680
Last modified:July 1, 1989 - v1
Checksum:i42CBBF9947A0E437
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13016 mRNA Translation: CAA31438.1
BC060542 mRNA Translation: AAH60542.1
PIRiS01299
RefSeqiNP_620803.1, NM_139103.1
UniGeneiRn.3705

Genome annotation databases

EnsembliENSRNOT00000006306; ENSRNOP00000006306; ENSRNOG00000004737
GeneIDi245962
KEGGirno:245962
UCSCiRGD:620620 rat

Similar proteinsi

Entry informationi

Entry nameiCD48_RAT
AccessioniPrimary (citable) accession number: P10252
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 25, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health