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P10249 (SUCP_STRMU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sucrose phosphorylase

EC=2.4.1.7
Alternative name(s):
Glucosyltransferase-A
Short name=GTF-A
Sucrose glucosyltransferase
Gene names
Name:gtfA
Ordered Locus Names:SMU_881
OrganismStreptococcus mutans serotype c (strain ATCC 700610 / UA159) [Complete proteome] [HAMAP]
Taxonomic identifier210007 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Intracellular catabolism of sucrose. Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.

Catalytic activity

Sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate.

Miscellaneous

Some earlier publications concluded that the product of the reaction of GtfA with sucrose was a glucan, because of its insolubility in ethanol.

Sequence similarities

Belongs to the sucrose phosphorylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 481480Sucrose phosphorylase
PRO_0000072301

Experimental info

Sequence conflict41I → T Ref.1
Sequence conflict41I → T Ref.2
Sequence conflict51N → I Ref.1
Sequence conflict321G → A in CAA30846. Ref.1
Sequence conflict721C → R Ref.1
Sequence conflict721C → R Ref.2
Sequence conflict2221D → N in AAA26937. Ref.2
Sequence conflict2681S → G Ref.1
Sequence conflict2681S → G Ref.2
Sequence conflict2771L → V in CAA30846. Ref.1
Sequence conflict3931N → I in CAA30846. Ref.1
Sequence conflict4241N → I in CAA30846. Ref.1
Sequence conflict443 – 4442AT → EN in CAA30846. Ref.1
Sequence conflict4591K → T Ref.1
Sequence conflict4591K → T Ref.2
Sequence conflict480 – 4812FE → LSMISCQT in CAA30846. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P10249 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 1B403FD6D95FFC8C

FASTA48155,687
        10         20         30         40         50         60 
MPIINKTMLI TYADSLGKNL KELNENIENY FGDAVGGVHL LPFFPSTGDR GFAPIDYHEV 

        70         80         90        100        110        120 
DSAFGDWDDV KCLGEKYYLM FDFMINHISR QSKYYKDYQE KHEASAYKDL FLNWDKFWPK 

       130        140        150        160        170        180 
NRPTQEDVDL IYKRKDRAPK QEIQFADGSV EHLWNTFGEE QIDLDVTKEV TMDFIRSTIE 

       190        200        210        220        230        240 
NLAANGCDLI RLDAFAYAVK KLDTNDFFVE PEIWTLLDKV RDIAAVSGAE ILPEIHEHYT 

       250        260        270        280        290        300 
IQFKIADHDY YVYDFALPMV TLYSLYSSKV DRLAKWLKMS PMKQFTTLDT HDGIGVVDVK 

       310        320        330        340        350        360 
DILTDEEITY TSNELYKVGA NVNRKYSTAE YNNLDIYQIN STYYSALGDD DQKYFLARLI 

       370        380        390        400        410        420 
QAFAPGIPQV YYVGFLAGKN DLELLESTKE GRNINRHYYS SEEIAKEVKR PVVKALLNLF 

       430        440        450        460        470        480 
TYRNQSAAFD LDGRIEVETP NEATIVIERQ NKDGSHIAKA EINLQDMTYR VTENDQTISF 


E 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the gtfA gene from S. mutans GS-5."
James L.C., Hughes T.A., Curtiss R. III
Nucleic Acids Res. 16:10398-10398(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: GS-5.
[2]"Sequence analysis of the glucosyltransferase A gene (gtfA) from Streptococcus mutans Ingbritt."
Ferretti J.J., Huang T.-T., Russell R.R.B.
Infect. Immun. 56:1585-1588(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-20.
Strain: Ingbritt.
[3]"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen."
Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.
Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700610 / UA159.
[4]"Streptococcus mutans gtfA gene specifies sucrose phosphorylase."
Russell R.R.B., Mukasa H., Shimamura A., Ferretti J.J.
Infect. Immun. 56:2763-2765(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X08057 Genomic DNA. Translation: CAA30846.1.
M77351 Genomic DNA. Translation: AAA26937.1.
AE014133 Genomic DNA. Translation: AAN58596.1.
PIRA27626.
BWSOGM. S01972.
RefSeqNP_721290.1. NC_004350.2.

3D structure databases

ProteinModelPortalP10249.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING210007.SMU.881.

Protein family/group databases

CAZyGH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN58596; AAN58596; SMU_881.
GeneID1028245.
KEGGsmu:SMU_881.
PATRIC19663909. VBIStrMut61772_0787.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0366.
KOK00690.
OMAFRNNEPA.
OrthoDBEOG6XM77N.
PhylomeDBP10249.

Enzyme and pathway databases

BioCycSMUT210007:GC7Z-846-MONOMER.

Family and domain databases

Gene3D3.20.20.80. 2 hits.
InterProIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR016377. Sucrose_phosphorylase.
IPR022527. Sucrose_phosphorylase_GftA.
[Graphical view]
PANTHERPTHR10357. PTHR10357. 1 hit.
PfamPF00128. Alpha-amylase. 1 hit.
[Graphical view]
PIRSFPIRSF003059. Sucrose_phosphorylase. 1 hit.
SUPFAMSSF51445. SSF51445. 1 hit.
TIGRFAMsTIGR03852. sucrose_gtfA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSUCP_STRMU
AccessionPrimary (citable) accession number: P10249
Secondary accession number(s): Q99064
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 114 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families