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Protein

H-2 class II histocompatibility antigen gamma chain

Gene

Cd74

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-RNO-202733. Cell surface interactions at the vascular wall.
R-RNO-2132295. MHC class II antigen presentation.

Protein family/group databases

MEROPSiI31.002.

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen gamma chain
Alternative name(s):
Ia antigen-associated invariant chain
Short name:
Ii
MHC class II-associated invariant chain
CD_antigen: CD74
Gene namesi
Name:Cd74
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi2313. Cd74.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030CytoplasmicSequence analysisAdd
BLAST
Transmembranei31 – 5626Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini57 – 280224ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280H-2 class II histocompatibility antigen gamma chainPRO_0000067956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineCombined sources
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence analysis
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Disulfide bondi197 ↔ 216PROSITE-ProRule annotation
Disulfide bondi227 ↔ 234PROSITE-ProRule annotation
Disulfide bondi236 ↔ 255PROSITE-ProRule annotation
Glycosylationi266 – 2661O-linked (Xyl...) (glycosaminoglycan)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiP10247.
PRIDEiP10247.

PTM databases

iPTMnetiP10247.
PhosphoSiteiP10247.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018735.
ExpressionAtlasiP10247. baseline and differential.
GenevisibleiP10247. RN.

Interactioni

Subunit structurei

Nonamer composed of three alpha/beta/gamma heterotrimers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025354.

Structurei

3D structure databases

ProteinModelPortaliP10247.
SMRiP10247. Positions 118-192, 194-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini194 – 25562Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMYW. Eukaryota.
ENOG410Z4PR. LUCA.
GeneTreeiENSGT00390000008961.
HOGENOMiHOG000013145.
HOVERGENiHBG004444.
InParanoidiP10247.
KOiK06505.
OMAiGTEVPNT.
OrthoDBiEOG091G0FT7.
PhylomeDBiP10247.
TreeFamiTF317779.

Family and domain databases

Gene3Di1.10.870.10. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR015386. MHC_II-assoc_invar/CLIP_MHC-bd.
IPR022339. MHC_II-assoc_invar_chain.
IPR011988. MHC_II-assoc_invariant_trimer.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF09307. MHC2-interact. 1 hit.
PF08831. MHCassoc_trimer. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001992. CD74_antigen. 1 hit.
PRINTSiPR01990. CD74ANTIGEN.
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF48305. SSF48305. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P10247-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDQRDLISN HEQLPILGQR ARAPESNCNR GVLYTSVSVL VALLLAGQAT
60 70 80 90 100
TAYFLYQQQG RLDKLTVTSQ NLQLENLRMK LPKSAKPVSP MRMATPLLMR
110 120 130 140 150
PLSMDNMLQA PVKNVTKYGN MTQDHVMHLL TKSGPVNYPQ LKGSFPENLK
160 170 180 190 200
HLKNSMNGLD WKVFESWMKQ WLLFEMSKNS LEEKQPTQTP PKVLTKCQEE
210 220 230 240 250
VSHIPDVHPG AFRPKCDENG NYMPLQCHGS TGYCWCVFPN GTEVPHTKSR
260 270 280
GRHNCSEPLD MEDPSSGLGV TKQDMGQMFL
Length:280
Mass (Da):31,642
Last modified:February 1, 1991 - v2
Checksum:iD935D169A98B5732
GO
Isoform Short (identifier: P10247-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-256: Missing.

Show »
Length:216
Mass (Da):24,503
Checksum:i33677FA259B84F8E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei193 – 25664Missing in isoform Short. CuratedVSP_005333Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14254 mRNA. Translation: CAA32468.1.
X13044 mRNA. Translation: CAA31450.1.
PIRiS04362.
RefSeqiNP_037201.1. NM_013069.2. [P10247-2]
XP_006254823.1. XM_006254761.2. [P10247-1]
UniGeneiRn.33804.

Genome annotation databases

EnsembliENSRNOT00000025344; ENSRNOP00000025342; ENSRNOG00000018735. [P10247-2]
ENSRNOT00000025354; ENSRNOP00000025354; ENSRNOG00000018735. [P10247-1]
GeneIDi25599.
KEGGirno:25599.
UCSCiRGD:2313. rat. [P10247-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14254 mRNA. Translation: CAA32468.1.
X13044 mRNA. Translation: CAA31450.1.
PIRiS04362.
RefSeqiNP_037201.1. NM_013069.2. [P10247-2]
XP_006254823.1. XM_006254761.2. [P10247-1]
UniGeneiRn.33804.

3D structure databases

ProteinModelPortaliP10247.
SMRiP10247. Positions 118-192, 194-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025354.

Protein family/group databases

MEROPSiI31.002.

PTM databases

iPTMnetiP10247.
PhosphoSiteiP10247.

Proteomic databases

PaxDbiP10247.
PRIDEiP10247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025344; ENSRNOP00000025342; ENSRNOG00000018735. [P10247-2]
ENSRNOT00000025354; ENSRNOP00000025354; ENSRNOG00000018735. [P10247-1]
GeneIDi25599.
KEGGirno:25599.
UCSCiRGD:2313. rat. [P10247-1]

Organism-specific databases

CTDi972.
RGDi2313. Cd74.

Phylogenomic databases

eggNOGiENOG410IMYW. Eukaryota.
ENOG410Z4PR. LUCA.
GeneTreeiENSGT00390000008961.
HOGENOMiHOG000013145.
HOVERGENiHBG004444.
InParanoidiP10247.
KOiK06505.
OMAiGTEVPNT.
OrthoDBiEOG091G0FT7.
PhylomeDBiP10247.
TreeFamiTF317779.

Enzyme and pathway databases

ReactomeiR-RNO-202733. Cell surface interactions at the vascular wall.
R-RNO-2132295. MHC class II antigen presentation.

Miscellaneous databases

PROiP10247.

Gene expression databases

BgeeiENSRNOG00000018735.
ExpressionAtlasiP10247. baseline and differential.
GenevisibleiP10247. RN.

Family and domain databases

Gene3Di1.10.870.10. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR015386. MHC_II-assoc_invar/CLIP_MHC-bd.
IPR022339. MHC_II-assoc_invar_chain.
IPR011988. MHC_II-assoc_invariant_trimer.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF09307. MHC2-interact. 1 hit.
PF08831. MHCassoc_trimer. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001992. CD74_antigen. 1 hit.
PRINTSiPR01990. CD74ANTIGEN.
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF48305. SSF48305. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHG2A_RAT
AccessioniPrimary (citable) accession number: P10247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1991
Last modified: September 7, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.