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Protein

Troponin C, skeletal muscle

Gene

TNNC2

Organism
Meleagris gallopavo (Common turkey)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi30 – 41121Add
BLAST
Calcium bindingi66 – 77122Add
BLAST
Calcium bindingi106 – 117123Add
BLAST
Calcium bindingi142 – 153124Add
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, skeletal muscle
Gene namesi
Name:TNNC2
OrganismiMeleagris gallopavo (Common turkey)
Taxonomic identifieri9103 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaeMeleagridinaeMeleagris
Proteomesi
  • UP000001645 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Troponin C, skeletal musclePRO_0000073708Add
BLAST

Interactioni

Protein-protein interaction databases

MINTiMINT-1771697.
STRINGi9103.ENSMGAP00000008329.

Structurei

Secondary structure

1
162
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1311Combined sources
Helixi16 – 2611Combined sources
Helixi27 – 293Combined sources
Beta strandi31 – 333Combined sources
Beta strandi35 – 384Combined sources
Turni39 – 413Combined sources
Helixi42 – 487Combined sources
Helixi55 – 6511Combined sources
Beta strandi67 – 693Combined sources
Beta strandi72 – 743Combined sources
Helixi75 – 10531Combined sources
Helixi115 – 1239Combined sources
Turni124 – 1263Combined sources
Helixi131 – 14111Combined sources
Beta strandi145 – 1495Combined sources
Helixi151 – 1599Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TRFNMR-A12-87[»]
5TNCX-ray2.00A2-162[»]
ProteinModelPortaliP10246.
SMRiP10246. Positions 2-162.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10246.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 5236EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini53 – 8836EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini93 – 12836EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini129 – 16234EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the troponin C family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOVERGENiHBG012180.
InParanoidiP10246.
KOiK12042.
OMAiVETWEVD.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PSMTDQQAEA RAFLSEEMIA EFKAAFDMFD ADGGGDISTK ELGTVMRMLG
60 70 80 90 100
QNPTKEELDA IIEEVDEDGS GTIDFEEFLV MMVRQMKEDA KGKSEEELAN
110 120 130 140 150
CFRIFDKNAD GFIDIEELGE ILRATGEHVT EEEIEDLMKD SDKNNDGRID
160
FDEFLKMMEG VQ
Length:162
Mass (Da):18,284
Last modified:November 1, 1991 - v2
Checksum:i8B35C5B5B58E7A46
GO

Sequence databases

PIRiA40803.

Genome annotation databases

KEGGimgp:100544678.

Cross-referencesi

Sequence databases

PIRiA40803.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TRFNMR-A12-87[»]
5TNCX-ray2.00A2-162[»]
ProteinModelPortaliP10246.
SMRiP10246. Positions 2-162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1771697.
STRINGi9103.ENSMGAP00000008329.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGimgp:100544678.

Organism-specific databases

CTDi7125.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOVERGENiHBG012180.
InParanoidiP10246.
KOiK12042.
OMAiVETWEVD.

Miscellaneous databases

EvolutionaryTraceiP10246.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNNC2_MELGA
AccessioniPrimary (citable) accession number: P10246
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Skeletal muscle troponin C binds four calcium ions.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.