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Protein

Myb-related protein B

Gene

MYBL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi54 – 77H-T-H motifPROSITE-ProRule annotationAdd BLAST24
DNA bindingi106 – 129H-T-H motifPROSITE-ProRule annotationAdd BLAST24
DNA bindingi157 – 180H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101057-MONOMER.
ReactomeiR-HSA-1538133. G0 and Early G1.
R-HSA-156711. Polo-like kinase mediated events.
R-HSA-8869496. TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation.
SIGNORiP10244.

Names & Taxonomyi

Protein namesi
Recommended name:
Myb-related protein B
Short name:
B-Myb
Alternative name(s):
Myb-like protein 2
Gene namesi
Name:MYBL2
Synonyms:BMYB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:7548. MYBL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4605.
OpenTargetsiENSG00000101057.
PharmGKBiPA31348.

Polymorphism and mutation databases

BioMutaiMYBL2.
DMDMi127584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001970581 – 700Myb-related protein BAdd BLAST700

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei241PhosphoserineCombined sources1
Modified residuei266PhosphothreonineCombined sources1
Modified residuei282PhosphoserineCombined sources1
Modified residuei393PhosphoserineCombined sources1
Modified residuei440Phosphothreonine; by CDK21 Publication1
Modified residuei444Phosphothreonine; by CDK22 Publications1
Modified residuei487Phosphothreonine; by CDK21 Publication1
Modified residuei494Phosphothreonine; by CDK22 Publications1
Modified residuei505PhosphothreonineCombined sources1
Cross-linki509Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei520Phosphothreonine; by CDK21 Publication1
Cross-linki546Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei577Phosphoserine; by CDK22 Publications1
Cross-linki596Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki639Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP10244.
MaxQBiP10244.
PaxDbiP10244.
PeptideAtlasiP10244.
PRIDEiP10244.

PTM databases

iPTMnetiP10244.
PhosphoSitePlusiP10244.

Expressioni

Gene expression databases

BgeeiENSG00000101057.
CleanExiHS_MYBL2.
GenevisibleiP10244. HS.

Organism-specific databases

HPAiCAB017114.
HPA030530.
HPA055416.

Interactioni

Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LIN54Q6MZP74EBI-1389468,EBI-1389411
LIN9Q5TKA17EBI-1389468,EBI-1389424

Protein-protein interaction databases

BioGridi110690. 45 interactors.
IntActiP10244. 21 interactors.
MINTiMINT-125947.
STRINGi9606.ENSP00000217026.

Structurei

3D structure databases

ProteinModelPortaliP10244.
SMRiP10244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 77HTH myb-type 1PROSITE-ProRule annotationAdd BLAST52
Domaini78 – 133HTH myb-type 2PROSITE-ProRule annotationAdd BLAST56
Domaini134 – 184HTH myb-type 3PROSITE-ProRule annotationAdd BLAST51

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi411 – 417Nuclear localization signal1 Publication7
Motifi564 – 584Bipartite nuclear localization signalAdd BLAST21

Sequence similaritiesi

Contains 3 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
GeneTreeiENSGT00390000001038.
HOGENOMiHOG000231021.
HOVERGENiHBG007964.
InParanoidiP10244.
KOiK09421.
OMAiSDPDGWC.
OrthoDBiEOG091G0I6P.
PhylomeDBiP10244.
TreeFamiTF326257.

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
InterProiIPR015395. C-myb_C.
IPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR028311. MYBL2.
IPR001005. SANT/Myb.
[Graphical view]
PANTHERiPTHR10641:SF461. PTHR10641:SF461. 1 hit.
PfamiPF09316. Cmyb_C. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 3 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51294. HTH_MYB. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P10244-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRTRCEDL DELHYQDTDS DVPEQRDSKC KVKWTHEEDE QLRALVRQFG
60 70 80 90 100
QQDWKFLASH FPNRTDQQCQ YRWLRVLNPD LVKGPWTKEE DQKVIELVKK
110 120 130 140 150
YGTKQWTLIA KHLKGRLGKQ CRERWHNHLN PEVKKSCWTE EEDRIICEAH
160 170 180 190 200
KVLGNRWAEI AKMLPGRTDN AVKNHWNSTI KRKVDTGGFL SESKDCKPPV
210 220 230 240 250
YLLLELEDKD GLQSAQPTEG QGSLLTNWPS VPPTIKEEEN SEEELAAATT
260 270 280 290 300
SKEQEPIGTD LDAVRTPEPL EEFPKREDQE GSPPETSLPY KWVVEAANLL
310 320 330 340 350
IPAVGSSLSE ALDLIESDPD AWCDLSKFDL PEEPSAEDSI NNSLVQLQAS
360 370 380 390 400
HQQQVLPPRQ PSALVPSVTE YRLDGHTISD LSRSSRGELI PISPSTEVGG
410 420 430 440 450
SGIGTPPSVL KRQRKRRVAL SPVTENSTSL SFLDSCNSLT PKSTPVKTLP
460 470 480 490 500
FSPSQFLNFW NKQDTLELES PSLTSTPVCS QKVVVTTPLH RDKTPLHQKH
510 520 530 540 550
AAFVTPDQKY SMDNTPHTPT PFKNALEKYG PLKPLPQTPH LEEDLKEVLR
560 570 580 590 600
SEAGIELIIE DDIRPEKQKR KPGLRRSPIK KVRKSLALDI VDEDVKLMMS
610 620 630 640 650
TLPKSLSLPT TAPSNSSSLT LSGIKEDNSL LNQGFLQAKP EKAAVAQKPR
660 670 680 690 700
SHFTTPAPMS SAWKTVACGG TRDQLFMQEK ARQLLGRLKP SHTSRTLILS
Length:700
Mass (Da):78,764
Last modified:July 1, 1989 - v1
Checksum:iD91B28B3DAB94061
GO
Isoform 2 (identifier: P10244-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-62: Missing.

Note: No experimental confirmation available.
Show »
Length:676
Mass (Da):75,865
Checksum:i322D482BEFD9A724
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184V → A in BAD97202 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050190341N → S.Corresponds to variant rs6017146dbSNPEnsembl.1
Natural variantiVAR_020422427S → G.1 PublicationCorresponds to variant rs2070235dbSNPEnsembl.1
Natural variantiVAR_050191595V → M.Corresponds to variant rs7660dbSNPEnsembl.1
Natural variantiVAR_050192624I → M.Corresponds to variant rs11556379dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05398739 – 62Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13293 mRNA. Translation: CAA31655.1.
AK303249 mRNA. Translation: BAH13925.1.
AK314791 mRNA. Translation: BAG37322.1.
AK223482 mRNA. Translation: BAD97202.1.
AL121886 Genomic DNA. Translation: CAC08392.1.
CH471077 Genomic DNA. Translation: EAW75951.1.
BC007585 mRNA. Translation: AAH07585.1.
BC053555 mRNA. Translation: AAH53555.1.
CCDSiCCDS13322.1. [P10244-1]
CCDS63276.1. [P10244-2]
PIRiS01991.
RefSeqiNP_001265539.1. NM_001278610.1. [P10244-2]
NP_002457.1. NM_002466.3. [P10244-1]
UniGeneiHs.179718.

Genome annotation databases

EnsembliENST00000217026; ENSP00000217026; ENSG00000101057. [P10244-1]
ENST00000396863; ENSP00000380072; ENSG00000101057. [P10244-2]
GeneIDi4605.
KEGGihsa:4605.
UCSCiuc002xlb.3. human. [P10244-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13293 mRNA. Translation: CAA31655.1.
AK303249 mRNA. Translation: BAH13925.1.
AK314791 mRNA. Translation: BAG37322.1.
AK223482 mRNA. Translation: BAD97202.1.
AL121886 Genomic DNA. Translation: CAC08392.1.
CH471077 Genomic DNA. Translation: EAW75951.1.
BC007585 mRNA. Translation: AAH07585.1.
BC053555 mRNA. Translation: AAH53555.1.
CCDSiCCDS13322.1. [P10244-1]
CCDS63276.1. [P10244-2]
PIRiS01991.
RefSeqiNP_001265539.1. NM_001278610.1. [P10244-2]
NP_002457.1. NM_002466.3. [P10244-1]
UniGeneiHs.179718.

3D structure databases

ProteinModelPortaliP10244.
SMRiP10244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110690. 45 interactors.
IntActiP10244. 21 interactors.
MINTiMINT-125947.
STRINGi9606.ENSP00000217026.

PTM databases

iPTMnetiP10244.
PhosphoSitePlusiP10244.

Polymorphism and mutation databases

BioMutaiMYBL2.
DMDMi127584.

Proteomic databases

EPDiP10244.
MaxQBiP10244.
PaxDbiP10244.
PeptideAtlasiP10244.
PRIDEiP10244.

Protocols and materials databases

DNASUi4605.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217026; ENSP00000217026; ENSG00000101057. [P10244-1]
ENST00000396863; ENSP00000380072; ENSG00000101057. [P10244-2]
GeneIDi4605.
KEGGihsa:4605.
UCSCiuc002xlb.3. human. [P10244-1]

Organism-specific databases

CTDi4605.
DisGeNETi4605.
GeneCardsiMYBL2.
HGNCiHGNC:7548. MYBL2.
HPAiCAB017114.
HPA030530.
HPA055416.
MIMi601415. gene.
neXtProtiNX_P10244.
OpenTargetsiENSG00000101057.
PharmGKBiPA31348.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
GeneTreeiENSGT00390000001038.
HOGENOMiHOG000231021.
HOVERGENiHBG007964.
InParanoidiP10244.
KOiK09421.
OMAiSDPDGWC.
OrthoDBiEOG091G0I6P.
PhylomeDBiP10244.
TreeFamiTF326257.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101057-MONOMER.
ReactomeiR-HSA-1538133. G0 and Early G1.
R-HSA-156711. Polo-like kinase mediated events.
R-HSA-8869496. TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation.
SIGNORiP10244.

Miscellaneous databases

ChiTaRSiMYBL2. human.
GeneWikiiMYBL2.
GenomeRNAii4605.
PROiP10244.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101057.
CleanExiHS_MYBL2.
GenevisibleiP10244. HS.

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
InterProiIPR015395. C-myb_C.
IPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR028311. MYBL2.
IPR001005. SANT/Myb.
[Graphical view]
PANTHERiPTHR10641:SF461. PTHR10641:SF461. 1 hit.
PfamiPF09316. Cmyb_C. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 3 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51294. HTH_MYB. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYBB_HUMAN
AccessioniPrimary (citable) accession number: P10244
Secondary accession number(s): B2RBS5
, B7Z8D9, F8W6N6, Q53F07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 184 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.