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P10244

- MYBB_HUMAN

UniProt

P10244 - MYBB_HUMAN

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Protein

Myb-related protein B

Gene

MYBL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi54 – 7724H-T-H motifPROSITE-ProRule annotationAdd
BLAST
DNA bindingi106 – 12924H-T-H motifPROSITE-ProRule annotationAdd
BLAST
DNA bindingi157 – 18024H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: Reactome
  2. mitotic cell cycle Source: Reactome
  3. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  4. regulation of cell cycle Source: Reactome
  5. spindle assembly involved in mitosis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_1006. Polo-like kinase mediated events.
REACT_111214. G0 and Early G1.

Names & Taxonomyi

Protein namesi
Recommended name:
Myb-related protein B
Short name:
B-Myb
Alternative name(s):
Myb-like protein 2
Gene namesi
Name:MYBL2
Synonyms:BMYB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:7548. MYBL2.

Subcellular locationi

GO - Cellular componenti

  1. Myb complex Source: Ensembl
  2. nucleoplasm Source: Reactome
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31348.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 700700Myb-related protein BPRO_0000197058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei241 – 2411Phosphoserine3 Publications
Modified residuei266 – 2661Phosphothreonine1 Publication
Modified residuei440 – 4401Phosphothreonine; by CDK21 Publication
Modified residuei444 – 4441Phosphothreonine; by CDK22 Publications
Modified residuei487 – 4871Phosphothreonine; by CDK21 Publication
Modified residuei494 – 4941Phosphothreonine; by CDK22 Publications
Modified residuei520 – 5201Phosphothreonine; by CDK21 Publication
Modified residuei577 – 5771Phosphoserine; by CDK22 Publications

Post-translational modificationi

Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.6 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP10244.
PaxDbiP10244.
PeptideAtlasiP10244.
PRIDEiP10244.

PTM databases

PhosphoSiteiP10244.

Expressioni

Gene expression databases

BgeeiP10244.
CleanExiHS_MYBL2.
GenevestigatoriP10244.

Organism-specific databases

HPAiCAB017114.
HPA030530.
HPA055416.

Interactioni

Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LIN54Q6MZP74EBI-1389468,EBI-1389411
LIN9Q5TKA17EBI-1389468,EBI-1389424

Protein-protein interaction databases

BioGridi110690. 36 interactions.
IntActiP10244. 12 interactions.
MINTiMINT-125947.
STRINGi9606.ENSP00000217026.

Structurei

3D structure databases

ProteinModelPortaliP10244.
SMRiP10244. Positions 28-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 7752HTH myb-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini78 – 13356HTH myb-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 18451HTH myb-type 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi411 – 4177Nuclear localization signal1 Publication
Motifi564 – 58421Bipartite nuclear localization signalAdd
BLAST

Sequence similaritiesi

Contains 3 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5147.
GeneTreeiENSGT00390000001038.
HOGENOMiHOG000231021.
HOVERGENiHBG007964.
InParanoidiP10244.
KOiK09421.
OMAiMTPKSTP.
OrthoDBiEOG7G7KNQ.
PhylomeDBiP10244.
TreeFamiTF326257.

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
InterProiIPR015395. C-myb_C.
IPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR028311. MYBL2.
IPR001005. SANT/Myb.
[Graphical view]
PANTHERiPTHR10641:SF37. PTHR10641:SF37. 1 hit.
PfamiPF09316. Cmyb_C. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 3 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51294. HTH_MYB. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P10244-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRRTRCEDL DELHYQDTDS DVPEQRDSKC KVKWTHEEDE QLRALVRQFG
60 70 80 90 100
QQDWKFLASH FPNRTDQQCQ YRWLRVLNPD LVKGPWTKEE DQKVIELVKK
110 120 130 140 150
YGTKQWTLIA KHLKGRLGKQ CRERWHNHLN PEVKKSCWTE EEDRIICEAH
160 170 180 190 200
KVLGNRWAEI AKMLPGRTDN AVKNHWNSTI KRKVDTGGFL SESKDCKPPV
210 220 230 240 250
YLLLELEDKD GLQSAQPTEG QGSLLTNWPS VPPTIKEEEN SEEELAAATT
260 270 280 290 300
SKEQEPIGTD LDAVRTPEPL EEFPKREDQE GSPPETSLPY KWVVEAANLL
310 320 330 340 350
IPAVGSSLSE ALDLIESDPD AWCDLSKFDL PEEPSAEDSI NNSLVQLQAS
360 370 380 390 400
HQQQVLPPRQ PSALVPSVTE YRLDGHTISD LSRSSRGELI PISPSTEVGG
410 420 430 440 450
SGIGTPPSVL KRQRKRRVAL SPVTENSTSL SFLDSCNSLT PKSTPVKTLP
460 470 480 490 500
FSPSQFLNFW NKQDTLELES PSLTSTPVCS QKVVVTTPLH RDKTPLHQKH
510 520 530 540 550
AAFVTPDQKY SMDNTPHTPT PFKNALEKYG PLKPLPQTPH LEEDLKEVLR
560 570 580 590 600
SEAGIELIIE DDIRPEKQKR KPGLRRSPIK KVRKSLALDI VDEDVKLMMS
610 620 630 640 650
TLPKSLSLPT TAPSNSSSLT LSGIKEDNSL LNQGFLQAKP EKAAVAQKPR
660 670 680 690 700
SHFTTPAPMS SAWKTVACGG TRDQLFMQEK ARQLLGRLKP SHTSRTLILS
Length:700
Mass (Da):78,764
Last modified:July 1, 1989 - v1
Checksum:iD91B28B3DAB94061
GO
Isoform 2 (identifier: P10244-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-62: Missing.

Note: No experimental confirmation available.

Show »
Length:676
Mass (Da):75,865
Checksum:i322D482BEFD9A724
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841V → A in BAD97202. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti341 – 3411N → S.
Corresponds to variant rs6017146 [ dbSNP | Ensembl ].
VAR_050190
Natural varianti427 – 4271S → G.1 Publication
Corresponds to variant rs2070235 [ dbSNP | Ensembl ].
VAR_020422
Natural varianti595 – 5951V → M.
Corresponds to variant rs7660 [ dbSNP | Ensembl ].
VAR_050191
Natural varianti624 – 6241I → M.
Corresponds to variant rs11556379 [ dbSNP | Ensembl ].
VAR_050192

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 6224Missing in isoform 2. 1 PublicationVSP_053987Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13293 mRNA. Translation: CAA31655.1.
AK303249 mRNA. Translation: BAH13925.1.
AK314791 mRNA. Translation: BAG37322.1.
AK223482 mRNA. Translation: BAD97202.1.
AL121886 Genomic DNA. Translation: CAC08392.1.
CH471077 Genomic DNA. Translation: EAW75951.1.
BC007585 mRNA. Translation: AAH07585.1.
BC053555 mRNA. Translation: AAH53555.1.
CCDSiCCDS13322.1. [P10244-1]
CCDS63276.1. [P10244-2]
PIRiS01991.
RefSeqiNP_001265539.1. NM_001278610.1. [P10244-2]
NP_002457.1. NM_002466.3. [P10244-1]
UniGeneiHs.179718.

Genome annotation databases

EnsembliENST00000217026; ENSP00000217026; ENSG00000101057. [P10244-1]
ENST00000396863; ENSP00000380072; ENSG00000101057. [P10244-2]
GeneIDi4605.
KEGGihsa:4605.
UCSCiuc002xlb.1. human. [P10244-1]

Polymorphism databases

DMDMi127584.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13293 mRNA. Translation: CAA31655.1 .
AK303249 mRNA. Translation: BAH13925.1 .
AK314791 mRNA. Translation: BAG37322.1 .
AK223482 mRNA. Translation: BAD97202.1 .
AL121886 Genomic DNA. Translation: CAC08392.1 .
CH471077 Genomic DNA. Translation: EAW75951.1 .
BC007585 mRNA. Translation: AAH07585.1 .
BC053555 mRNA. Translation: AAH53555.1 .
CCDSi CCDS13322.1. [P10244-1 ]
CCDS63276.1. [P10244-2 ]
PIRi S01991.
RefSeqi NP_001265539.1. NM_001278610.1. [P10244-2 ]
NP_002457.1. NM_002466.3. [P10244-1 ]
UniGenei Hs.179718.

3D structure databases

ProteinModelPortali P10244.
SMRi P10244. Positions 28-186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110690. 36 interactions.
IntActi P10244. 12 interactions.
MINTi MINT-125947.
STRINGi 9606.ENSP00000217026.

PTM databases

PhosphoSitei P10244.

Polymorphism databases

DMDMi 127584.

Proteomic databases

MaxQBi P10244.
PaxDbi P10244.
PeptideAtlasi P10244.
PRIDEi P10244.

Protocols and materials databases

DNASUi 4605.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000217026 ; ENSP00000217026 ; ENSG00000101057 . [P10244-1 ]
ENST00000396863 ; ENSP00000380072 ; ENSG00000101057 . [P10244-2 ]
GeneIDi 4605.
KEGGi hsa:4605.
UCSCi uc002xlb.1. human. [P10244-1 ]

Organism-specific databases

CTDi 4605.
GeneCardsi GC20P042295.
HGNCi HGNC:7548. MYBL2.
HPAi CAB017114.
HPA030530.
HPA055416.
MIMi 601415. gene.
neXtProti NX_P10244.
PharmGKBi PA31348.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5147.
GeneTreei ENSGT00390000001038.
HOGENOMi HOG000231021.
HOVERGENi HBG007964.
InParanoidi P10244.
KOi K09421.
OMAi MTPKSTP.
OrthoDBi EOG7G7KNQ.
PhylomeDBi P10244.
TreeFami TF326257.

Enzyme and pathway databases

Reactomei REACT_1006. Polo-like kinase mediated events.
REACT_111214. G0 and Early G1.

Miscellaneous databases

ChiTaRSi MYBL2. human.
GeneWikii MYBL2.
GenomeRNAii 4605.
NextBioi 17724.
PROi P10244.
SOURCEi Search...

Gene expression databases

Bgeei P10244.
CleanExi HS_MYBL2.
Genevestigatori P10244.

Family and domain databases

Gene3Di 1.10.10.60. 3 hits.
InterProi IPR015395. C-myb_C.
IPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR028311. MYBL2.
IPR001005. SANT/Myb.
[Graphical view ]
PANTHERi PTHR10641:SF37. PTHR10641:SF37. 1 hit.
Pfami PF09316. Cmyb_C. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view ]
SMARTi SM00717. SANT. 3 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS51294. HTH_MYB. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of human cDNA clones of myb-related genes, A-myb and B-myb."
    Nomura N., Takahashi M., Matsui M., Ishii S., Date T., Sasamoto S., Ishizaki R.
    Nucleic Acids Res. 16:11075-11089(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-427.
    Tissue: Brain and Thymus.
  3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Eye.
  7. "The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties."
    Saville M.K., Watson R.J.
    Oncogene 17:2679-2689(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-444; THR-487; THR-494 AND SER-577.
  8. "Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb."
    Bartsch O., Horstmann S., Toprak K., Klempnauer K.H., Ferrari S.
    Eur. J. Biochem. 260:384-391(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-440; THR-444; THR-494; THR-520 AND SER-577.
  9. "Direct transactivation of the anti-apoptotic gene apolipoprotein J (clusterin) by B-MYB."
    Cervellera M., Raschella G., Santilli G., Tanno B., Ventura A., Mancini C., Sevignani C., Calabretta B., Sala A.
    J. Biol. Chem. 275:21055-21060(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Multiple nuclear localization signals of the B-myb gene product."
    Takemoto Y., Tashiro S., Handa H., Ishii S.
    FEBS Lett. 350:55-60(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEAR LOCALIZATION SIGNALS.
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."
    Schmit F., Korenjak M., Mannefeld M., Schmitt K., Franke C., von Eyss B., Gagrica S., Haenel F., Brehm A., Gaubatz S.
    Cell Cycle 6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE DREAM COMPLEX.
  13. "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence."
    Litovchick L., Sadasivam S., Florens L., Zhu X., Swanson S.K., Velmurugan S., Chen R., Washburn M.P., Liu X.S., DeCaprio J.A.
    Mol. Cell 26:539-551(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE DREAM COMPLEX.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMYBB_HUMAN
AccessioniPrimary (citable) accession number: P10244
Secondary accession number(s): B2RBS5
, B7Z8D9, F8W6N6, Q53F07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 162 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3