Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P10244

- MYBB_HUMAN

UniProt

P10244 - MYBB_HUMAN

Protein

Myb-related protein B

Gene

MYBL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 161 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi54 – 7724H-T-H motifPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi106 – 12924H-T-H motifPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi157 – 18024H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. protein binding Source: IntAct
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    5. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. G2/M transition of mitotic cell cycle Source: Reactome
    2. mitotic cell cycle Source: Reactome
    3. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    4. regulation of cell cycle Source: Reactome
    5. spindle assembly involved in mitosis Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_1006. Polo-like kinase mediated events.
    REACT_111214. G0 and Early G1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myb-related protein B
    Short name:
    B-Myb
    Alternative name(s):
    Myb-like protein 2
    Gene namesi
    Name:MYBL2
    Synonyms:BMYB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:7548. MYBL2.

    Subcellular locationi

    GO - Cellular componenti

    1. Myb complex Source: Ensembl
    2. nucleoplasm Source: Reactome
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31348.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 700700Myb-related protein BPRO_0000197058Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei241 – 2411Phosphoserine3 Publications
    Modified residuei266 – 2661Phosphothreonine1 Publication
    Modified residuei440 – 4401Phosphothreonine; by CDK21 Publication
    Modified residuei444 – 4441Phosphothreonine; by CDK22 Publications
    Modified residuei487 – 4871Phosphothreonine; by CDK21 Publication
    Modified residuei494 – 4941Phosphothreonine; by CDK22 Publications
    Modified residuei520 – 5201Phosphothreonine; by CDK21 Publication
    Modified residuei577 – 5771Phosphoserine; by CDK22 Publications

    Post-translational modificationi

    Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.6 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP10244.
    PaxDbiP10244.
    PeptideAtlasiP10244.
    PRIDEiP10244.

    PTM databases

    PhosphoSiteiP10244.

    Expressioni

    Gene expression databases

    ArrayExpressiP10244.
    BgeeiP10244.
    CleanExiHS_MYBL2.
    GenevestigatoriP10244.

    Organism-specific databases

    HPAiCAB017114.
    HPA030530.
    HPA055416.

    Interactioni

    Subunit structurei

    Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LIN54Q6MZP74EBI-1389468,EBI-1389411
    LIN9Q5TKA17EBI-1389468,EBI-1389424

    Protein-protein interaction databases

    BioGridi110690. 36 interactions.
    IntActiP10244. 12 interactions.
    MINTiMINT-125947.
    STRINGi9606.ENSP00000217026.

    Structurei

    3D structure databases

    ProteinModelPortaliP10244.
    SMRiP10244. Positions 28-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 7752HTH myb-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini78 – 13356HTH myb-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini134 – 18451HTH myb-type 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi411 – 4177Nuclear localization signal1 Publication
    Motifi564 – 58421Bipartite nuclear localization signalAdd
    BLAST

    Sequence similaritiesi

    Contains 3 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5147.
    HOGENOMiHOG000231021.
    HOVERGENiHBG007964.
    InParanoidiP10244.
    KOiK09421.
    OMAiMTPKSTP.
    OrthoDBiEOG7G7KNQ.
    PhylomeDBiP10244.
    TreeFamiTF326257.

    Family and domain databases

    Gene3Di1.10.10.60. 3 hits.
    InterProiIPR015395. C-myb_C.
    IPR009057. Homeodomain-like.
    IPR017930. Myb_dom.
    IPR028311. MYBL2.
    IPR001005. SANT/Myb.
    [Graphical view]
    PANTHERiPTHR10641:SF37. PTHR10641:SF37. 1 hit.
    PfamiPF09316. Cmyb_C. 1 hit.
    PF00249. Myb_DNA-binding. 1 hit.
    [Graphical view]
    SMARTiSM00717. SANT. 3 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS51294. HTH_MYB. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P10244-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRRTRCEDL DELHYQDTDS DVPEQRDSKC KVKWTHEEDE QLRALVRQFG    50
    QQDWKFLASH FPNRTDQQCQ YRWLRVLNPD LVKGPWTKEE DQKVIELVKK 100
    YGTKQWTLIA KHLKGRLGKQ CRERWHNHLN PEVKKSCWTE EEDRIICEAH 150
    KVLGNRWAEI AKMLPGRTDN AVKNHWNSTI KRKVDTGGFL SESKDCKPPV 200
    YLLLELEDKD GLQSAQPTEG QGSLLTNWPS VPPTIKEEEN SEEELAAATT 250
    SKEQEPIGTD LDAVRTPEPL EEFPKREDQE GSPPETSLPY KWVVEAANLL 300
    IPAVGSSLSE ALDLIESDPD AWCDLSKFDL PEEPSAEDSI NNSLVQLQAS 350
    HQQQVLPPRQ PSALVPSVTE YRLDGHTISD LSRSSRGELI PISPSTEVGG 400
    SGIGTPPSVL KRQRKRRVAL SPVTENSTSL SFLDSCNSLT PKSTPVKTLP 450
    FSPSQFLNFW NKQDTLELES PSLTSTPVCS QKVVVTTPLH RDKTPLHQKH 500
    AAFVTPDQKY SMDNTPHTPT PFKNALEKYG PLKPLPQTPH LEEDLKEVLR 550
    SEAGIELIIE DDIRPEKQKR KPGLRRSPIK KVRKSLALDI VDEDVKLMMS 600
    TLPKSLSLPT TAPSNSSSLT LSGIKEDNSL LNQGFLQAKP EKAAVAQKPR 650
    SHFTTPAPMS SAWKTVACGG TRDQLFMQEK ARQLLGRLKP SHTSRTLILS 700
    Length:700
    Mass (Da):78,764
    Last modified:July 1, 1989 - v1
    Checksum:iD91B28B3DAB94061
    GO
    Isoform 2 (identifier: P10244-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         39-62: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:676
    Mass (Da):75,865
    Checksum:i322D482BEFD9A724
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti184 – 1841V → A in BAD97202. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti341 – 3411N → S.
    Corresponds to variant rs6017146 [ dbSNP | Ensembl ].
    VAR_050190
    Natural varianti427 – 4271S → G.1 Publication
    Corresponds to variant rs2070235 [ dbSNP | Ensembl ].
    VAR_020422
    Natural varianti595 – 5951V → M.
    Corresponds to variant rs7660 [ dbSNP | Ensembl ].
    VAR_050191
    Natural varianti624 – 6241I → M.
    Corresponds to variant rs11556379 [ dbSNP | Ensembl ].
    VAR_050192

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei39 – 6224Missing in isoform 2. 1 PublicationVSP_053987Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13293 mRNA. Translation: CAA31655.1.
    AK303249 mRNA. Translation: BAH13925.1.
    AK314791 mRNA. Translation: BAG37322.1.
    AK223482 mRNA. Translation: BAD97202.1.
    AL121886 Genomic DNA. Translation: CAC08392.1.
    CH471077 Genomic DNA. Translation: EAW75951.1.
    BC007585 mRNA. Translation: AAH07585.1.
    BC053555 mRNA. Translation: AAH53555.1.
    CCDSiCCDS13322.1. [P10244-1]
    CCDS63276.1. [P10244-2]
    PIRiS01991.
    RefSeqiNP_001265539.1. NM_001278610.1. [P10244-2]
    NP_002457.1. NM_002466.3. [P10244-1]
    UniGeneiHs.179718.

    Genome annotation databases

    EnsembliENST00000217026; ENSP00000217026; ENSG00000101057. [P10244-1]
    ENST00000396863; ENSP00000380072; ENSG00000101057. [P10244-2]
    GeneIDi4605.
    KEGGihsa:4605.
    UCSCiuc002xlb.1. human. [P10244-1]

    Polymorphism databases

    DMDMi127584.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13293 mRNA. Translation: CAA31655.1 .
    AK303249 mRNA. Translation: BAH13925.1 .
    AK314791 mRNA. Translation: BAG37322.1 .
    AK223482 mRNA. Translation: BAD97202.1 .
    AL121886 Genomic DNA. Translation: CAC08392.1 .
    CH471077 Genomic DNA. Translation: EAW75951.1 .
    BC007585 mRNA. Translation: AAH07585.1 .
    BC053555 mRNA. Translation: AAH53555.1 .
    CCDSi CCDS13322.1. [P10244-1 ]
    CCDS63276.1. [P10244-2 ]
    PIRi S01991.
    RefSeqi NP_001265539.1. NM_001278610.1. [P10244-2 ]
    NP_002457.1. NM_002466.3. [P10244-1 ]
    UniGenei Hs.179718.

    3D structure databases

    ProteinModelPortali P10244.
    SMRi P10244. Positions 28-186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110690. 36 interactions.
    IntActi P10244. 12 interactions.
    MINTi MINT-125947.
    STRINGi 9606.ENSP00000217026.

    PTM databases

    PhosphoSitei P10244.

    Polymorphism databases

    DMDMi 127584.

    Proteomic databases

    MaxQBi P10244.
    PaxDbi P10244.
    PeptideAtlasi P10244.
    PRIDEi P10244.

    Protocols and materials databases

    DNASUi 4605.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000217026 ; ENSP00000217026 ; ENSG00000101057 . [P10244-1 ]
    ENST00000396863 ; ENSP00000380072 ; ENSG00000101057 . [P10244-2 ]
    GeneIDi 4605.
    KEGGi hsa:4605.
    UCSCi uc002xlb.1. human. [P10244-1 ]

    Organism-specific databases

    CTDi 4605.
    GeneCardsi GC20P042295.
    HGNCi HGNC:7548. MYBL2.
    HPAi CAB017114.
    HPA030530.
    HPA055416.
    MIMi 601415. gene.
    neXtProti NX_P10244.
    PharmGKBi PA31348.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5147.
    HOGENOMi HOG000231021.
    HOVERGENi HBG007964.
    InParanoidi P10244.
    KOi K09421.
    OMAi MTPKSTP.
    OrthoDBi EOG7G7KNQ.
    PhylomeDBi P10244.
    TreeFami TF326257.

    Enzyme and pathway databases

    Reactomei REACT_1006. Polo-like kinase mediated events.
    REACT_111214. G0 and Early G1.

    Miscellaneous databases

    ChiTaRSi MYBL2. human.
    GeneWikii MYBL2.
    GenomeRNAii 4605.
    NextBioi 17724.
    PROi P10244.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10244.
    Bgeei P10244.
    CleanExi HS_MYBL2.
    Genevestigatori P10244.

    Family and domain databases

    Gene3Di 1.10.10.60. 3 hits.
    InterProi IPR015395. C-myb_C.
    IPR009057. Homeodomain-like.
    IPR017930. Myb_dom.
    IPR028311. MYBL2.
    IPR001005. SANT/Myb.
    [Graphical view ]
    PANTHERi PTHR10641:SF37. PTHR10641:SF37. 1 hit.
    Pfami PF09316. Cmyb_C. 1 hit.
    PF00249. Myb_DNA-binding. 1 hit.
    [Graphical view ]
    SMARTi SM00717. SANT. 3 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS51294. HTH_MYB. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of human cDNA clones of myb-related genes, A-myb and B-myb."
      Nomura N., Takahashi M., Matsui M., Ishii S., Date T., Sasamoto S., Ishizaki R.
      Nucleic Acids Res. 16:11075-11089(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-427.
      Tissue: Brain and Thymus.
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Eye.
    7. "The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties."
      Saville M.K., Watson R.J.
      Oncogene 17:2679-2689(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-444; THR-487; THR-494 AND SER-577.
    8. "Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb."
      Bartsch O., Horstmann S., Toprak K., Klempnauer K.H., Ferrari S.
      Eur. J. Biochem. 260:384-391(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-440; THR-444; THR-494; THR-520 AND SER-577.
    9. "Direct transactivation of the anti-apoptotic gene apolipoprotein J (clusterin) by B-MYB."
      Cervellera M., Raschella G., Santilli G., Tanno B., Ventura A., Mancini C., Sevignani C., Calabretta B., Sala A.
      J. Biol. Chem. 275:21055-21060(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Multiple nuclear localization signals of the B-myb gene product."
      Takemoto Y., Tashiro S., Handa H., Ishii S.
      FEBS Lett. 350:55-60(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEAR LOCALIZATION SIGNALS.
    11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."
      Schmit F., Korenjak M., Mannefeld M., Schmitt K., Franke C., von Eyss B., Gagrica S., Haenel F., Brehm A., Gaubatz S.
      Cell Cycle 6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE DREAM COMPLEX.
    13. "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence."
      Litovchick L., Sadasivam S., Florens L., Zhu X., Swanson S.K., Velmurugan S., Chen R., Washburn M.P., Liu X.S., DeCaprio J.A.
      Mol. Cell 26:539-551(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE DREAM COMPLEX.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMYBB_HUMAN
    AccessioniPrimary (citable) accession number: P10244
    Secondary accession number(s): B2RBS5
    , B7Z8D9, F8W6N6, Q53F07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 161 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3