ID   MYBA_HUMAN              Reviewed;         752 AA.
AC   P10243;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   13-OCT-2009, entry version 93.
DE   RecName: Full=Myb-related protein A;
DE   AltName: Full=A-Myb;
GN   Name=MYBL1; Synonyms=AMYB;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-745.
RX   MEDLINE=89083548; PubMed=3060855; DOI=10.1093/nar/16.23.11075;
RA   Nomura N., Takahashi M., Matsui M., Ishii S., Date T., Sasamoto S.,
RA   Ishizaki R.;
RT   "Isolation of human cDNA clones of myb-related genes, A-myb and B-
RT   myb.";
RL   Nucleic Acids Res. 16:11075-11089(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 398-752, AND CHARACTERIZATION.
RX   MEDLINE=94336200; PubMed=8058310;
RA   Golay J., Loffarelli L., Luppi M., Castellano M., Introna M.;
RT   "The human A-myb protein is a strong activator of transcription.";
RL   Oncogene 9:2469-2479(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 727-752.
RX   MEDLINE=95079434; PubMed=7987850;
RA   Ma X.P., Calabretta B.;
RT   "DNA binding and transactivation activity of A-myb, a C-myb-related
RT   gene.";
RL   Cancer Res. 54:6512-6516(1994).
RN   [4]
RP   IDENTIFICATION IN THE DREAM COMPLEX.
RX   PubMed=17531812; DOI=10.1016/j.molcel.2007.04.015;
RA   Litovchick L., Sadasivam S., Florens L., Zhu X., Swanson S.K.,
RA   Velmurugan S., Chen R., Washburn M.P., Liu X.S., DeCaprio J.A.;
RT   "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein
RT   complex represses human cell cycle-dependent genes in quiescence.";
RL   Mol. Cell 26:539-551(2007).
RN   [5]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-394, AND MASS SPECTROMETRY.
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,
RA   Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
CC   -!- FUNCTION: Strong transcriptional activator; DNA-binding protein
CC       that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could
CC       have a role in the proliferation and/or differentiation of
CC       neurogenic, spermatogenic and B-lymphoid cells.
CC   -!- SUBUNIT: Component of the DREAM complex (also named LINC complex)
CC       at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1,
CC       MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in
CC       quiescent cells where it represses cell cycle-dependent genes. It
CC       dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a
CC       subcomplex that binds to MYBL2.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of lymphoid and solid
CC       tumor lines cultured in vitro.
CC   -!- SIMILARITY: Contains 3 HTH myb-type DNA-binding domains.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/MYBL1ID41468ch8q13.html";
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DR   EMBL; X13294; CAA31656.1; -; mRNA.
DR   EMBL; X66087; CAA46886.1; -; mRNA.
DR   IPI; IPI00941501; -.
DR   PIR; S03423; S03423.
DR   RefSeq; NP_001073885.1; -.
DR   UniGene; Hs.445898; -.
DR   HSSP; P06876; 1MBG.
DR   SMR; P10243; 35-185.
DR   DIP; DIP:624N; -.
DR   STRING; P10243; -.
DR   PhosphoSite; P10243; -.
DR   PRIDE; P10243; -.
DR   Ensembl; ENST00000331406; ENSP00000332150; ENSG00000185697; Homo sapiens.
DR   Ensembl; ENST00000399555; ENSP00000382469; ENSG00000185697; Homo sapiens.
DR   Ensembl; ENST00000402282; ENSP00000385360; ENSG00000185697; Homo sapiens.
DR   GeneID; 4603; -.
DR   KEGG; hsa:4603; -.
DR   UCSC; uc003xwj.1; human.
DR   CTD; 4603; -.
DR   GeneCards; GC08M067636; -.
DR   H-InvDB; HIX0034339; -.
DR   HGNC; HGNC:7547; MYBL1.
DR   HPA; CAB017780; -.
DR   HPA; HPA008791; -.
DR   MIM; 159405; gene.
DR   PharmGKB; PA31347; -.
DR   HOGENOM; P10243; -.
DR   HOVERGEN; P10243; -.
DR   Pathway_Interaction_DB; il4_2pathway; IL4-mediated signaling events.
DR   NextBio; 17704; -.
DR   ArrayExpress; P10243; -.
DR   Bgee; P10243; -.
DR   CleanEx; HS_MYBL1; -.
DR   Genevestigator; P10243; -.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016563; F:transcription activator activity; NAS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR015395; C-myb_C.
DR   InterPro; IPR012287; Homeodomain-rel.
DR   InterPro; IPR017930; Myb-type_HTH.
DR   InterPro; IPR014778; Myb_DNA-bd.
DR   InterPro; IPR015495; Myb_trans_fac.
DR   InterPro; IPR001005; SANT_DNA-bd.
DR   InterPro; IPR012642; Trans_reg_Wos2-domain.
DR   Gene3D; G3DSA:1.10.10.60; Homeodomain-rel; 3.
DR   PANTHER; PTHR10641; Myb_transfac; 1.
DR   Pfam; PF09316; Cmyb_C; 1.
DR   Pfam; PF00249; Myb_DNA-binding; 3.
DR   Pfam; PF07988; Wos2; 1.
DR   SMART; SM00717; SANT; 3.
DR   PROSITE; PS51294; HTH_MYB; 3.
PE   1: Evidence at protein level;
KW   Acetylation; Activator; Complete proteome; DNA-binding; Nucleus;
KW   Repeat; Transcription; Transcription regulation.
FT   CHAIN         1    752       Myb-related protein A.
FT                                /FTId=PRO_0000197054.
FT   DOMAIN       30     81       HTH myb-type 1.
FT   DOMAIN       82    137       HTH myb-type 2.
FT   DOMAIN      138    188       HTH myb-type 3.
FT   DNA_BIND     58     81       H-T-H motif (By similarity).
FT   DNA_BIND    110    133       H-T-H motif (By similarity).
FT   DNA_BIND    161    184       H-T-H motif (By similarity).
FT   REGION      230    295       Transcriptional activation domain (By
FT                                similarity).
FT   REGION      298    553       Negative regulatory domain (By
FT                                similarity).
FT   MOD_RES     394    394       N6-acetyllysine.
SQ   SEQUENCE   752 AA;  85887 MW;  4C6D1823A7CAFCDA CRC64;
     MAKRSRSEDE DDDLQYADHD YEVPQQKGLK KLWNRVKWTR DEDDKLKKLV EQHGTDDWTL
     IASHLQNRSD FQCQHRWQKV LNPELIKGPW TKEEDQRVIE LVQKYGPKRW SLIAKHLKGR
     IGKQCRERWH NHLNPEVKKS SWTEEEDRII YEAHKRLGNR WAEIAKLLPG RTDNSIKNHW
     NSTMRRKVEQ EGYLQDGIKS ERSSSKLQHK PCAAMDHMQT QNQFYIPVQI PGYQYVSPEG
     NCIEHVQPTS AFIQQPFIDE DPDKEKKIKE LEMLLMSAEN EVRRKRIPSQ PGSFSSWSGS
     FLMDDNMSNT LNSLDEHTSE FYSMDENQPV SAQQNSPTKF LAVEANAVLS SLQTIPEFAE
     TLELIESDPV AWSDVTSFDI SDAAASPIKS TPVKLMRIQH NEGAMECQFN VSLVLEGKKN
     TCNGGNSEAV PLTSPNIAKF STPPAILRKK RKMRVGHSPG SELRDGSLND GGNMALKHTP
     LKTLPFSPSQ FFNTCPGNEQ LNIENPSFTS TPICGQKALI TTPLHKETTP KDQKENVGFR
     TPTIRRSILG TTPRTPTPFK NALAAQEKKY GPLKIVSQPL AFLEEDIREV LKEETGTDLF
     LKEEDEPAYK SCKQENTASG KKVRKSLVLD NWEKEESGTQ LLTEDISDMQ SENRFTTSLL
     MIPLLEIHDN RCNLIPEKQD INSTNKTYTL TKKKPNPNTS KVVKLEKNLQ SNCEWETVVY
     GKTEDQLIMT EQARRYLSTY TATSSTSRAL IL
//