Reviewed, UniProtKB/Swiss-Prot P10243 (MYBA_HUMAN)

Names and origin

Protein names

Recommended name:
    Myb-related protein A
Alternative name(s):
    A-Myb

Gene names

Name:	MYBL1
Synonyms:	AMYB

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	752 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.
Subunit structure	Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.
Subcellular location	Nucleus.
Tissue specificity	Expressed in a variety of lymphoid and solid tumor lines cultured in vitro.
Sequence similarities	Contains 3 HTH myb-type DNA-binding domains.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat
Ligand	DNA-binding
Molecular function	Activator
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Non-traceable author statement. Source: UniProtKB transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Ref.2 Non-traceable author statement. Source: UniProtKB
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW transcription activator activity Ref.2 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 752	752	Myb-related protein A		PRO_0000197054
Regions
	Domain	30 – 81	52	HTH myb-type 1
	Domain	82 – 137	56	HTH myb-type 2
	Domain	138 – 188	51	HTH myb-type 3
	DNA binding	58 – 81	24	H-T-H motif By similarity
	DNA binding	110 – 133	24	H-T-H motif By similarity
	DNA binding	161 – 184	24	H-T-H motif By similarity
	Region	230 – 295	66	Transcriptional activation domain By similarity
	Region	298 – 553	256	Negative regulatory domain By similarity
Amino acid modifications
	Modified residue	394	1	N6-acetyllysine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P10243-1 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 4C6D1823A7CAFCDA	FASTA	752	85,887
	10 20 30 40 50 60 MAKRSRSEDE DDDLQYADHD YEVPQQKGLK KLWNRVKWTR DEDDKLKKLV EQHGTDDWTL 70 80 90 100 110 120 IASHLQNRSD FQCQHRWQKV LNPELIKGPW TKEEDQRVIE LVQKYGPKRW SLIAKHLKGR 130 140 150 160 170 180 IGKQCRERWH NHLNPEVKKS SWTEEEDRII YEAHKRLGNR WAEIAKLLPG RTDNSIKNHW 190 200 210 220 230 240 NSTMRRKVEQ EGYLQDGIKS ERSSSKLQHK PCAAMDHMQT QNQFYIPVQI PGYQYVSPEG 250 260 270 280 290 300 NCIEHVQPTS AFIQQPFIDE DPDKEKKIKE LEMLLMSAEN EVRRKRIPSQ PGSFSSWSGS 310 320 330 340 350 360 FLMDDNMSNT LNSLDEHTSE FYSMDENQPV SAQQNSPTKF LAVEANAVLS SLQTIPEFAE 370 380 390 400 410 420 TLELIESDPV AWSDVTSFDI SDAAASPIKS TPVKLMRIQH NEGAMECQFN VSLVLEGKKN 430 440 450 460 470 480 TCNGGNSEAV PLTSPNIAKF STPPAILRKK RKMRVGHSPG SELRDGSLND GGNMALKHTP 490 500 510 520 530 540 LKTLPFSPSQ FFNTCPGNEQ LNIENPSFTS TPICGQKALI TTPLHKETTP KDQKENVGFR 550 560 570 580 590 600 TPTIRRSILG TTPRTPTPFK NALAAQEKKY GPLKIVSQPL AFLEEDIREV LKEETGTDLF 610 620 630 640 650 660 LKEEDEPAYK SCKQENTASG KKVRKSLVLD NWEKEESGTQ LLTEDISDMQ SENRFTTSLL 670 680 690 700 710 720 MIPLLEIHDN RCNLIPEKQD INSTNKTYTL TKKKPNPNTS KVVKLEKNLQ SNCEWETVVY 730 740 750 GKTEDQLIMT EQARRYLSTY TATSSTSRAL IL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of human cDNA clones of myb-related genes, A-myb and B-myb." Nomura N., Takahashi M., Matsui M., Ishii S., Date T., Sasamoto S., Ishizaki R. Nucleic Acids Res. 16:11075-11089(1988) [PubMed: 3060855] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-745.
[2]	"The human A-myb protein is a strong activator of transcription." Golay J., Loffarelli L., Luppi M., Castellano M., Introna M. Oncogene 9:2469-2479(1994) [PubMed: 8058310] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 398-752, CHARACTERIZATION.
[3]	"DNA binding and transactivation activity of A-myb, a C-myb-related gene." Ma X.P., Calabretta B. Cancer Res. 54:6512-6516(1994) [PubMed: 7987850] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 727-752.
[4]	"Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence." Litovchick L., Sadasivam S., Florens L., Zhu X., Swanson S.K., Velmurugan S., Chen R., Washburn M.P., Liu X.S., DeCaprio J.A. Mol. Cell 26:539-551(2007) [PubMed: 17531812] [Abstract] Cited for: IDENTIFICATION IN THE DREAM COMPLEX.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-394, MASS SPECTROMETRY.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	X13294 mRNA. Translation: CAA31656.1. X66087 mRNA. Translation: CAA46886.1.
IPI	IPI00941501.
PIR	S03423.
RefSeq	NP_001073885.1.
UniGene	Hs.445898
3D structure databases
HSSP	HSSP built from PDB template 1MBG based on UniProtKB P06876.
SMR	P10243. Positions 35-185.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:624N.
STRING	P10243.
PTM databases
PhosphoSite	P10243.
Proteomic databases
PRIDE	P10243.
Genome annotation databases
Ensembl	ENST00000331406; ENSP00000332150; ENSG00000185697; Homo sapiens. [Genome view] ENST00000399555; ENSP00000382469; ENSG00000185697; Homo sapiens. [Genome view] ENST00000402282; ENSP00000385360; ENSG00000185697; Homo sapiens. [Genome view]
GeneID	4603.
KEGG	hsa:4603.
UCSC	uc003xwj.1. human.
Organism-specific databases
CTD	4603.
GeneCards	GC08M067636.
H-InvDB	HIX0034339.
HGNC	HGNC:7547. MYBL1.
HPA	CAB017780. HPA008791.
MIM	159405. gene.
PharmGKB	PA31347.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P10243.
HOVERGEN	P10243.
Enzyme and pathway databases
Pathway_Interaction_DB	il4_2pathway. IL4-mediated signaling events.
Gene expression databases
ArrayExpress	P10243.
Bgee	P10243.
CleanEx	HS_MYBL1.
Genevestigator	P10243.
Family and domain databases
InterPro	IPR015395. C-myb_C. IPR012287. Homeodomain-rel. IPR017930. Myb-type_HTH. IPR014778. Myb_DNA-bd. IPR015495. Myb_trans_fac. IPR001005. SANT_DNA-bd. IPR012642. Trans_reg_Wos2-domain. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 3 hits.
PANTHER	PTHR10641. Myb_transfac. 1 hit.
Pfam	PF09316. Cmyb_C. 1 hit. PF00249. Myb_DNA-binding. 3 hits. PF07988. Wos2. 1 hit. [Graphical view]
SMART	SM00717. SANT. 3 hits. [Graphical view]
PROSITE	PS51294. HTH_MYB. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	17704.
SOURCE	Search...

Entry information

Entry name

MYBA_HUMAN

Accession

Primary (citable) accession number: P10243

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	November 1, 1995
Last modified:	October 13, 2009
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.