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Protein

Myb-related protein A

Gene

MYBL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi58 – 81H-T-H motifPROSITE-ProRule annotationAdd BLAST24
DNA bindingi110 – 133H-T-H motifPROSITE-ProRule annotationAdd BLAST24
DNA bindingi161 – 184H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32449-MONOMER.
ReactomeiR-HSA-5601884. PIWI-interacting RNA (piRNA) biogenesis.
SIGNORiP10243.

Names & Taxonomyi

Protein namesi
Recommended name:
Myb-related protein A
Short name:
A-Myb
Alternative name(s):
Myb-like protein 1
Gene namesi
Name:MYBL1
Synonyms:AMYB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:7547. MYBL1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4603.
OpenTargetsiENSG00000185697.
PharmGKBiPA31347.

Polymorphism and mutation databases

BioMutaiMYBL1.
DMDMi1171089.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001970541 – 752Myb-related protein AAdd BLAST752

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei394N6-acetyllysineCombined sources1
Cross-linki602Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP10243.
PaxDbiP10243.
PeptideAtlasiP10243.
PRIDEiP10243.

PTM databases

iPTMnetiP10243.
PhosphoSitePlusiP10243.

Expressioni

Tissue specificityi

Expressed in a variety of lymphoid and solid tumor lines cultured in vitro.

Gene expression databases

BgeeiENSG00000185697.
CleanExiHS_MYBL1.
ExpressionAtlasiP10243. baseline and differential.
GenevisibleiP10243. HS.

Organism-specific databases

HPAiCAB017780.
HPA008791.

Interactioni

Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.1 Publication

Protein-protein interaction databases

BioGridi110688. 9 interactors.
DIPiDIP-624N.
IntActiP10243. 4 interactors.
STRINGi9606.ENSP00000429633.

Structurei

3D structure databases

ProteinModelPortaliP10243.
SMRiP10243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 81HTH myb-type 1PROSITE-ProRule annotationAdd BLAST52
Domaini82 – 137HTH myb-type 2PROSITE-ProRule annotationAdd BLAST56
Domaini138 – 188HTH myb-type 3PROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni230 – 295Transcriptional activation domainBy similarityAdd BLAST66
Regioni298 – 553Negative regulatory domainBy similarityAdd BLAST256

Sequence similaritiesi

Contains 3 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
GeneTreeiENSGT00390000001038.
HOGENOMiHOG000231021.
HOVERGENiHBG007964.
InParanoidiP10243.
KOiK09421.
OMAiDSMSNTL.
OrthoDBiEOG091G0I6P.
PhylomeDBiP10243.
TreeFamiTF326257.

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
InterProiIPR015395. C-myb_C.
IPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
IPR012642. Tscrpt_reg_Wos2-domain.
[Graphical view]
PfamiPF09316. Cmyb_C. 1 hit.
PF07988. LMSTEN. 1 hit.
PF00249. Myb_DNA-binding. 3 hits.
[Graphical view]
SMARTiSM00717. SANT. 3 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51294. HTH_MYB. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P10243-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKRSRSEDE DDDLQYADHD YEVPQQKGLK KLWNRVKWTR DEDDKLKKLV
60 70 80 90 100
EQHGTDDWTL IASHLQNRSD FQCQHRWQKV LNPELIKGPW TKEEDQRVIE
110 120 130 140 150
LVQKYGPKRW SLIAKHLKGR IGKQCRERWH NHLNPEVKKS SWTEEEDRII
160 170 180 190 200
YEAHKRLGNR WAEIAKLLPG RTDNSIKNHW NSTMRRKVEQ EGYLQDGIKS
210 220 230 240 250
ERSSSKLQHK PCAAMDHMQT QNQFYIPVQI PGYQYVSPEG NCIEHVQPTS
260 270 280 290 300
AFIQQPFIDE DPDKEKKIKE LEMLLMSAEN EVRRKRIPSQ PGSFSSWSGS
310 320 330 340 350
FLMDDNMSNT LNSLDEHTSE FYSMDENQPV SAQQNSPTKF LAVEANAVLS
360 370 380 390 400
SLQTIPEFAE TLELIESDPV AWSDVTSFDI SDAAASPIKS TPVKLMRIQH
410 420 430 440 450
NEGAMECQFN VSLVLEGKKN TCNGGNSEAV PLTSPNIAKF STPPAILRKK
460 470 480 490 500
RKMRVGHSPG SELRDGSLND GGNMALKHTP LKTLPFSPSQ FFNTCPGNEQ
510 520 530 540 550
LNIENPSFTS TPICGQKALI TTPLHKETTP KDQKENVGFR TPTIRRSILG
560 570 580 590 600
TTPRTPTPFK NALAAQEKKY GPLKIVSQPL AFLEEDIREV LKEETGTDLF
610 620 630 640 650
LKEEDEPAYK SCKQENTASG KKVRKSLVLD NWEKEESGTQ LLTEDISDMQ
660 670 680 690 700
SENRFTTSLL MIPLLEIHDN RCNLIPEKQD INSTNKTYTL TKKKPNPNTS
710 720 730 740 750
KVVKLEKNLQ SNCEWETVVY GKTEDQLIMT EQARRYLSTY TATSSTSRAL

IL
Length:752
Mass (Da):85,887
Last modified:November 1, 1995 - v2
Checksum:i4C6D1823A7CAFCDA
GO
Isoform 2 (identifier: P10243-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     650-709: Missing.

Note: No experimental confirmation available.
Show »
Length:692
Mass (Da):78,951
Checksum:i6925E52F9A3FC52D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042912650 – 709Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083928 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW86912.1.
BC101188 mRNA. Translation: AAI01189.1.
X13294 mRNA. Translation: CAA31656.1.
X66087 mRNA. Translation: CAA46886.1.
CCDSiCCDS47867.1. [P10243-1]
CCDS55241.1. [P10243-2]
PIRiS03423.
RefSeqiNP_001073885.1. NM_001080416.3. [P10243-1]
NP_001138227.1. NM_001144755.2. [P10243-2]
UniGeneiHs.445898.

Genome annotation databases

EnsembliENST00000522677; ENSP00000429633; ENSG00000185697. [P10243-1]
ENST00000524176; ENSP00000428011; ENSG00000185697. [P10243-2]
GeneIDi4603.
KEGGihsa:4603.
UCSCiuc003xwj.4. human. [P10243-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083928 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW86912.1.
BC101188 mRNA. Translation: AAI01189.1.
X13294 mRNA. Translation: CAA31656.1.
X66087 mRNA. Translation: CAA46886.1.
CCDSiCCDS47867.1. [P10243-1]
CCDS55241.1. [P10243-2]
PIRiS03423.
RefSeqiNP_001073885.1. NM_001080416.3. [P10243-1]
NP_001138227.1. NM_001144755.2. [P10243-2]
UniGeneiHs.445898.

3D structure databases

ProteinModelPortaliP10243.
SMRiP10243.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110688. 9 interactors.
DIPiDIP-624N.
IntActiP10243. 4 interactors.
STRINGi9606.ENSP00000429633.

PTM databases

iPTMnetiP10243.
PhosphoSitePlusiP10243.

Polymorphism and mutation databases

BioMutaiMYBL1.
DMDMi1171089.

Proteomic databases

MaxQBiP10243.
PaxDbiP10243.
PeptideAtlasiP10243.
PRIDEiP10243.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000522677; ENSP00000429633; ENSG00000185697. [P10243-1]
ENST00000524176; ENSP00000428011; ENSG00000185697. [P10243-2]
GeneIDi4603.
KEGGihsa:4603.
UCSCiuc003xwj.4. human. [P10243-1]

Organism-specific databases

CTDi4603.
DisGeNETi4603.
GeneCardsiMYBL1.
H-InvDBHIX0034339.
HGNCiHGNC:7547. MYBL1.
HPAiCAB017780.
HPA008791.
MIMi159405. gene.
neXtProtiNX_P10243.
OpenTargetsiENSG00000185697.
PharmGKBiPA31347.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
GeneTreeiENSGT00390000001038.
HOGENOMiHOG000231021.
HOVERGENiHBG007964.
InParanoidiP10243.
KOiK09421.
OMAiDSMSNTL.
OrthoDBiEOG091G0I6P.
PhylomeDBiP10243.
TreeFamiTF326257.

Enzyme and pathway databases

BioCyciZFISH:G66-32449-MONOMER.
ReactomeiR-HSA-5601884. PIWI-interacting RNA (piRNA) biogenesis.
SIGNORiP10243.

Miscellaneous databases

GenomeRNAii4603.
PROiP10243.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185697.
CleanExiHS_MYBL1.
ExpressionAtlasiP10243. baseline and differential.
GenevisibleiP10243. HS.

Family and domain databases

Gene3Di1.10.10.60. 3 hits.
InterProiIPR015395. C-myb_C.
IPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
IPR012642. Tscrpt_reg_Wos2-domain.
[Graphical view]
PfamiPF09316. Cmyb_C. 1 hit.
PF07988. LMSTEN. 1 hit.
PF00249. Myb_DNA-binding. 3 hits.
[Graphical view]
SMARTiSM00717. SANT. 3 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51294. HTH_MYB. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYBA_HUMAN
AccessioniPrimary (citable) accession number: P10243
Secondary accession number(s): E7EW29, Q495F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.