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Protein

Transcriptional activator Myb

Gene

MYB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi63 – 86H-T-H motifPROSITE-ProRule annotationAdd BLAST24
DNA bindingi115 – 138H-T-H motifPROSITE-ProRule annotationAdd BLAST24
DNA bindingi166 – 189H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP10242
SIGNORiP10242

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator Myb
Alternative name(s):
Proto-oncogene c-Myb
Gene namesi
Name:MYB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000118513.18
HGNCiHGNC:7545 MYB
MIMi189990 gene
neXtProtiNX_P10242

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi4602
MalaCardsiMYB
OpenTargetsiENSG00000118513
Orphaneti86849 Acute basophilic leukemia
99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA31345

Polymorphism and mutation databases

BioMutaiMYB
DMDMi2815504

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001970481 – 640Transcriptional activator MybAdd BLAST640

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei471N6-acetyllysineCombined sources1
Modified residuei480N6-acetyllysine; alternateCombined sources1
Cross-linki480Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei532PhosphoserineCombined sources1
Modified residuei534PhosphothreonineCombined sources1

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.Curated
Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.By similarity
Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP10242
PeptideAtlasiP10242
PRIDEiP10242
ProteomicsDBi52578
52579 [P10242-2]
52580 [P10242-3]
52581 [P10242-4]
52582 [P10242-5]
52583 [P10242-6]

PTM databases

iPTMnetiP10242
PhosphoSitePlusiP10242

Expressioni

Inductioni

Negatively regulated by microRNA-155 (miR-155).1 Publication

Gene expression databases

BgeeiENSG00000118513
CleanExiHS_MYB
ExpressionAtlasiP10242 baseline and differential
GenevisibleiP10242 HS

Organism-specific databases

HPAiCAB017704

Interactioni

Subunit structurei

Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1.By similarity2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110687, 50 interactors
ComplexPortaliCPX-504 c-Myb-C/EBPbeta complex
DIPiDIP-1057N
ELMiP10242
IntActiP10242, 35 interactors
MINTiP10242
STRINGi9606.ENSP00000339992

Structurei

3D structure databases

ProteinModelPortaliP10242
SMRiP10242
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 86HTH myb-type 1PROSITE-ProRule annotationAdd BLAST52
Domaini87 – 142HTH myb-type 2PROSITE-ProRule annotationAdd BLAST56
Domaini143 – 193HTH myb-type 3PROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni90 – 193Interaction with HIPK2 and NLKBy similarityAdd BLAST104
Regioni275 – 327Transcription activation domain (PubMed:2189102)1 PublicationAdd BLAST53
Regioni328 – 465Negative regulatory domainBy similarityAdd BLAST138
Regioni376 – 397Leucine-zipperAdd BLAST22

Domaini

Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0048 Eukaryota
COG5147 LUCA
GeneTreeiENSGT00390000001038
HOVERGENiHBG007964
InParanoidiP10242
KOiK09420
OMAiKAGNFFC
OrthoDBiEOG091G0I6P
PhylomeDBiP10242
TreeFamiTF326257

Family and domain databases

CDDicd00167 SANT, 3 hits
InterProiView protein in InterPro
IPR015395 C-myb_C
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR001005 SANT/Myb
IPR012642 Tscrpt_reg_Wos2-domain
PfamiView protein in Pfam
PF09316 Cmyb_C, 1 hit
PF07988 LMSTEN, 1 hit
PF00249 Myb_DNA-binding, 3 hits
SMARTiView protein in SMART
SM00717 SANT, 3 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 3 hits

Sequences (12)i

Sequence statusi: Complete.

This entry describes 12 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P10242-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARRPRHSIY SSDEDDEDFE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK
60 70 80 90 100
LKKLVEQNGT DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED
110 120 130 140 150
QRVIELVQKY GPKRWSVIAK HLKGRIGKQC RERWHNHLNP EVKKTSWTEE
160 170 180 190 200
EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA IKNHWNSTMR RKVEQEGYLQ
210 220 230 240 250
ESSKASQPAV ATSFQKNSHL MGFAQAPPTA QLPATGQPTV NNDYSYYHIS
260 270 280 290 300
EAQNVSSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL
310 320 330 340 350
LLMSTENELK GQQVLPTQNH TCSYPGWHST TIADHTRPHG DSAPVSCLGE
360 370 380 390 400
HHSTPSLPAD PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID
410 420 430 440 450
SFLNTSSNHE NSDLEMPSLT STPLIGHKLT VTTPFHRDQT VKTQKENTVF
460 470 480 490 500
RTPAIKRSIL ESSPRTPTPF KHALAAQEIK YGPLKMLPQT PSHLVEDLQD
510 520 530 540 550
VIKQESDESG IVAEFQENGP PLLKKIKQEV ESPTDKSGNF FCSHHWEGDS
560 570 580 590 600
LNTQLFTQTS PVADAPNILT SSVLMAPASE DEDNVLKAFT VPKNRSLASP
610 620 630 640
LQPCSSTWEP ASCGKMEEQM TSSSQARKYV NAFSARTLVM
Length:640
Mass (Da):72,341
Last modified:November 1, 1997 - v2
Checksum:iFD5E6694020426ED
GO
Isoform 2 (identifier: P10242-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-316: Missing.

Show »
Length:637
Mass (Da):72,032
Checksum:i75D8144FEEC381C5
GO
Isoform 3 (identifier: P10242-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-350: TQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGE → LCGPLLNSDIFSDWAANWDGSLCFATYIVNQQRQ
     351-640: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:350
Mass (Da):40,620
Checksum:i60632631CFEE51FF
GO
Isoform 4 (identifier: P10242-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     401-401: S → SDSSSWCDLS...VKSLPFSPSQ

Show »
Length:761
Mass (Da):85,475
Checksum:i9D11661393B1A85B
GO
Isoform 5 (identifier: P10242-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-402: F → M
     403-640: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:402
Mass (Da):46,065
Checksum:i331FC406EC1C335C
GO
Isoform 6 (identifier: P10242-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     567-640: NILTSSVLMA...NAFSARTLVM → TGVQWHDFGS...LRFNGTSIRR

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:666
Mass (Da):75,526
Checksum:iBF91C8F858EA12DF
GO
Isoform 7 (identifier: P10242-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-316: Missing.
     401-401: S → SDSSSWCDLS...VKSLPFSPSQ

Show »
Length:758
Mass (Da):85,166
Checksum:i0F2142F19B9D4E48
GO
Isoform 8 (identifier: P10242-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-401: VKNLLEFAETLQFIDS → DSSSWCDLSS...VKSLPFSPSQ

Show »
Length:745
Mass (Da):83,626
Checksum:i9B6C4EBD083ED7CF
GO
Isoform 9 (identifier: P10242-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     282-316: Missing.

Show »
Length:605
Mass (Da):68,135
Checksum:i6078B295869F3BDA
GO
Isoform 10 (identifier: P10242-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     530-566: Missing.

Show »
Length:603
Mass (Da):68,308
Checksum:i560AF3F759C690F1
GO
Isoform 11 (identifier: P10242-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-401: Missing.

Show »
Length:555
Mass (Da):63,198
Checksum:iD29BCA8DD3CDA8FE
GO
Isoform 12 (identifier: P10242-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-640: TQNHTCSYPG...NAFSARTLVM → VRLSSCA

Note: No experimental confirmation available.
Show »
Length:323
Mass (Da):37,507
Checksum:i52D7B7EA3EDB98E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti511I → F in AAA52032 (PubMed:3540945).Curated1
Sequence conflicti511I → F in AY787447 (Ref. 6) Curated1
Sequence conflicti511I → F in AY787448 (Ref. 6) Curated1
Sequence conflicti563A → R in AAA52032 (PubMed:3540945).Curated1
Sequence conflicti563A → R in AY787447 (Ref. 6) Curated1
Sequence conflicti563A → R in AY787448 (Ref. 6) Curated1
Isoform 4 (identifier: P10242-4)
Sequence conflicti433L → F in CAA35503 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050188336T → I. Corresponds to variant dbSNP:rs2229999Ensembl.1
Natural variantiVAR_050189422T → N. Corresponds to variant dbSNP:rs2230000Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046658282 – 316Missing in isoform 9. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_003293314 – 316Missing in isoform 2 and isoform 7. 3 Publications3
Alternative sequenceiVSP_053389317 – 640TQNHT…RTLVM → VRLSSCA in isoform 12. 1 PublicationAdd BLAST324
Alternative sequenceiVSP_046659317 – 401Missing in isoform 11. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_003294317 – 350TQNHT…SCLGE → LCGPLLNSDIFSDWAANWDG SLCFATYIVNQQRQ in isoform 3. CuratedAdd BLAST34
Alternative sequenceiVSP_003295351 – 640Missing in isoform 3. CuratedAdd BLAST290
Alternative sequenceiVSP_046660386 – 401VKNLL…QFIDS → DSSSWCDLSSFEFFEEADFS PSQHHTGKALQLQQREGNGT KPAGEPSPRVNKRMLSESSL DPPKVLPPARHSTIPLVILR KKRGQASPLATGDCSSFIFA DVSSSTPKRSPVKSLPFSPS Q in isoform 8. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_003296401S → SDSSSWCDLSSFEFFEEADF SPSQHHTGKALQLQQREGNG TKPAGEPSPRVNKRMLSESS LDPPKVLPPARHSTIPLVIL RKKRGQASPLATGDCSSFIF ADVSSSTPKRSPVKSLPFSP SQ in isoform 4 and isoform 7. 2 Publications1
Alternative sequenceiVSP_003297402F → M in isoform 5. Curated1
Alternative sequenceiVSP_003298403 – 640Missing in isoform 5. CuratedAdd BLAST238
Alternative sequenceiVSP_046661530 – 566Missing in isoform 10. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_003299567 – 640NILTS…RTLVM → TGVQWHDFGSLQPLPPGFKR FSCLSLPRSWDYRHPPPRPA NFEFLVETGFLHVGQAGLEL LTSGDLPASASQSARITGVS HRARPEYSYKLRFNGTSIRR in isoform 6. CuratedAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15024 mRNA Translation: AAA52032.1
X52125 mRNA Translation: CAA36371.1
AJ606319 mRNA Translation: CAE55170.1
AJ606320 mRNA Translation: CAE55171.1
AJ616791 mRNA Translation: CAF04482.1
AJ616791 mRNA Translation: CAF04479.1
U22376 Genomic DNA Translation: AAB49034.1
U22376 Genomic DNA Translation: AAB49035.1
U22376 Genomic DNA Translation: AAB49036.1
U22376 Genomic DNA Translation: AAB49037.1
U22376 Genomic DNA Translation: AAB49038.1
U22376 Genomic DNA Translation: AAB49039.1
AF104863 mRNA Translation: AAC96326.1
AY787443 mRNA No translation available.
AY787447 mRNA No translation available.
AY787448 mRNA No translation available.
AY787461 mRNA No translation available.
AY787468 mRNA No translation available.
AL023693 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47969.1
CH471051 Genomic DNA Translation: EAW47973.1
BC064955 mRNA Translation: AAH64955.1
M13665 mRNA Translation: AAA52030.1
M13666 mRNA Translation: AAA52031.1
X17469 mRNA Translation: CAA35503.1
CCDSiCCDS47481.1 [P10242-4]
CCDS47482.1 [P10242-2]
CCDS5174.1 [P10242-1]
CCDS55058.1 [P10242-7]
CCDS55059.1 [P10242-8]
CCDS55060.1 [P10242-10]
CCDS55061.1 [P10242-11]
CCDS55062.1 [P10242-9]
PIRiA26661 TVHUMB
RefSeqiNP_001123644.1, NM_001130172.1 [P10242-2]
NP_001123645.1, NM_001130173.1 [P10242-4]
NP_001155128.1, NM_001161656.1 [P10242-7]
NP_001155129.1, NM_001161657.1 [P10242-11]
NP_001155130.1, NM_001161658.1 [P10242-8]
NP_001155131.1, NM_001161659.1 [P10242-10]
NP_001155132.1, NM_001161660.1 [P10242-9]
NP_005366.2, NM_005375.3 [P10242-1]
UniGeneiHs.606320
Hs.626299

Genome annotation databases

EnsembliENST00000341911; ENSP00000339992; ENSG00000118513 [P10242-4]
ENST00000367812; ENSP00000356786; ENSG00000118513 [P10242-6]
ENST00000367814; ENSP00000356788; ENSG00000118513 [P10242-1]
ENST00000442647; ENSP00000410825; ENSG00000118513 [P10242-2]
ENST00000525369; ENSP00000435938; ENSG00000118513 [P10242-11]
ENST00000525477; ENSP00000437081; ENSG00000118513 [P10242-3]
ENST00000525514; ENSP00000435578; ENSG00000118513 [P10242-3]
ENST00000528774; ENSP00000434723; ENSG00000118513 [P10242-7]
ENST00000529586; ENSP00000437264; ENSG00000118513 [P10242-3]
ENST00000533384; ENSP00000432811; ENSG00000118513 [P10242-5]
ENST00000533624; ENSP00000436605; ENSG00000118513 [P10242-9]
ENST00000533808; ENSP00000435293; ENSG00000118513 [P10242-5]
ENST00000533837; ENSP00000434639; ENSG00000118513 [P10242-5]
ENST00000534044; ENSP00000435055; ENSG00000118513 [P10242-10]
ENST00000534121; ENSP00000432851; ENSG00000118513 [P10242-8]
GeneIDi4602
KEGGihsa:4602
UCSCiuc003qfh.4 human [P10242-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMYB_HUMAN
AccessioniPrimary (citable) accession number: P10242
Secondary accession number(s): E9PI07
, E9PLZ5, E9PNA4, E9PNL6, E9PRS2, P78391, P78392, P78525, P78526, Q14023, Q14024, Q708E4, Q708E7, Q9UE83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 187 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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