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P10236

- PRIM_HHV11

UniProt

P10236 - PRIM_HHV11

Protein

DNA primase

Gene

UL52

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The UL52 subunit bears the primase activity.1 Publication

    GO - Molecular functioni

    1. DNA primase activity Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    DNA replication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA primase (EC:2.7.7.-)
    Gene namesi
    ORF Names:UL52
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Host nucleus By similarity

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10581058DNA primasePRO_0000116104Add
    BLAST

    Interactioni

    Subunit structurei

    Associates with the helicase-primase complex composed of the primase, the helicase and the primase-associated factor.

    Protein-protein interaction databases

    BioGridi971449. 2 interactions.
    DIPiDIP-1092N.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi177 – 1804Poly-Ala
    Compositional biasi310 – 3134Poly-Ala

    Sequence similaritiesi

    Belongs to the herpesviridae UL52 family.Curated

    Family and domain databases

    InterProiIPR004340. DNA_primase_UL52/UL70_Herpvir.
    [Graphical view]
    PfamiPF03121. Herpes_UL52. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10236-1 [UniParc]FASTAAdd to Basket

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    MGQEDGNRGE RRAAGTPVEV TALYATDGCV ITSSIALLTN SLLGAEPVYI     50
    FSYDAYTHDG RADGPTEQDR FEESRALYQA SGGLNGDSFR VTFCLLGTEV 100
    GGTHQARGRT RPMFVCRFER ADDVAALQDA LAHGTPLQPD HIAATLDAEA 150
    TFALHANMIL ALTVAINNAS PRTGRDAAAA QYDQGASLRS LVGRTSLGQR 200
    GLTTLYVHHE VRVLAAYRRA YYGSAQSPFW FLSKFGPDEK SLVLTTRYYL 250
    LQAQRLGGAG ATYDLQAIKD ICATYAIPHA PRPDTVSAAS LTSFAAITRF 300
    CCTSQYARGA AAAGFPLYVE RRIAADVRET SALEKFITHD RSCLRVSDRE 350
    FITYIYLAHF ECFSPPRLAT HLRAVTTHDP NPAASTEQPS PLGREAVEQF 400
    FCHVRAQLNI GEYVKHNVTP RETVLDGDTA KAYLRARTYA PGALTPAPAY 450
    CGAVDSATKM MGRLADAEKL LVPRGWPAFA PASPGEDTAG GTPPPQTCGI 500
    VKRLLRLAAT EQQGPTPPAI AALIRNAAVQ TPLPVYRISM VPTGQAFAAL 550
    AWDDWARITR DARLAEAVVS AEAAAHPDHG ALGRRLTDRI RAQGPVMPPG 600
    GLDAGGQMYV NRNEIFNGAL AITNIILDLD IALKEPVPFR RLHEALGHFR 650
    RGALAAVQLL FPAARVDPDA YPCYFFKSAC RPGPASVGSG SGLGNDDDGD 700
    WFPCYDDAGD EEWAEDPGAM DTSHDPPDDE VAYFDLCHEV GPTAEPRETD 750
    SPVCSCTDKI GLRVCMPVPA PYVVHGSLTM RGVARVIQQA VLLDRDFVEA 800
    IGSYVKNFLL IDTGVYAHGH SLRLPYFAKI APDGPACGRL LPVFVIPPAC 850
    KDVPAFVAAH ADPRRFHFHA PPTYLASPRE IRVLHSLGGD YVSFFERKAS 900
    RNALEHFGRR ETLTEVLGRY NVQPDAGGTV EGFASELLGR IVACIETHFP 950
    EHAGEYQAVS VRRAVSKDDW VLLQLVPVRG TLQQSLSCLR FKHGRASRAT 1000
    ARTFVALSVG ANNRLCVSLC QQCFAAKCDS NRLHTLFTID AGTPCSPSVP 1050
    CSTSQPSS 1058
    Length:1,058
    Mass (Da):114,424
    Last modified:July 1, 1989 - v1
    Checksum:iCB39341C31B768B4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti211 – 2111V → A in strain: Nonneuroinvasive mutant HF10.
    Natural varianti364 – 3641S → N in strain: Nonneuroinvasive mutant HF10.
    Natural varianti515 – 5151P → T in strain: Nonneuroinvasive mutant HF10.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32288.1.
    M19122 Genomic DNA. Translation: AAA45826.1.
    DQ889502 Genomic DNA. Translation: ABI63513.1.
    FJ593289 Genomic DNA. Translation: ACM62276.1.
    PIRiE29890. WMBE52.
    RefSeqiNP_044655.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703423.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32288.1 .
    M19122 Genomic DNA. Translation: AAA45826.1 .
    DQ889502 Genomic DNA. Translation: ABI63513.1 .
    FJ593289 Genomic DNA. Translation: ACM62276.1 .
    PIRi E29890. WMBE52.
    RefSeqi NP_044655.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 971449. 2 interactions.
    DIPi DIP-1092N.

    Chemistry

    BindingDBi P10236.
    ChEMBLi CHEMBL4380.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703423.

    Family and domain databases

    InterProi IPR004340. DNA_primase_UL52/UL70_Herpvir.
    [Graphical view ]
    Pfami PF03121. Herpes_UL52. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Structures of herpes simplex virus type 1 genes required for replication of virus DNA."
      McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.
      J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    4. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    5. "Helicase-primase complex of herpes simplex virus type 1: a mutation in the UL52 subunit abolishes primase activity."
      Klinedinst D.K., Challberg M.D.
      J. Virol. 68:3693-3701(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiPRIM_HHV11
    AccessioniPrimary (citable) accession number: P10236
    Secondary accession number(s): B9VQI1, Q09I82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3