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Reviewed, UniProtKB/Swiss-Prot P10234 (DUT_HHV11)

Last modified September 22, 2009. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
      Short name=dUTPase
    EC=3.6.1.23
Alternative name(s):
    dUTP pyrophosphatase
Gene names
ORF Names: UL50
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Virus reference strain
Gene Ontology (GO)
   Biological processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182952

Regions

Compositional bias152 – 1554Poly-Pro

Sequences

Sequence LengthMass (Da)Tools
P10234-1 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 5FFA2556AD2F7158

FASTA37139,128
        10         20         30         40         50         60 
MSQWGSGAIL VQPDSLGRGY DGDWHTAVAT RGGGVVQLNL VNRRAVAFMP KVSGDSGWAV 

        70         80         90        100        110        120 
GRVSLDLRMA MPADFCAIIH APALASPGHH VILGLIDSGY RGTVMAVVVA PKRTREFAPG 

       130        140        150        160        170        180 
TLRVDVTFLD ILATPPALTE PISLRQFPQL APPPPTGAGI REDPWLEGAL GAPSVTTALP 

       190        200        210        220        230        240 
ARRRGRSLVY AGELTPVQTE HGDGVREAIA FLPKREEDAG FDIVVRRPVT VPANGTTVVQ 

       250        260        270        280        290        300 
PSLRMLHADA GPAACYVLGR SSLNARGLLV VPTRWLPGHV CAFVVYNLTG VPVTLEAGAK 

       310        320        330        340        350        360 
VAQLLVAGAD ALPWIPPDNF HGTKALRNYP RGVPDSTAEP RNPPLLVFTN EFDAEAPPSE 

       370 
RGTGGFGSTG I 

« Hide

References

[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed: 2839594] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed: 17218138] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[3]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.

Cross-references

Sequence databases

X14112 Genomic DNA. Translation: CAA32301.1.
DQ889502 Genomic DNA. Translation: ABI63511.1.
FJ593289 Genomic DNA. Translation: ACM62274.1.
PIRWMBEY0. E30089.
RefSeqNP_044653.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2703421.

Family and domain databases

InterProIPR008180. DeoxyUTP_pyroPase_dom.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_HHV11
AccessionPrimary (citable) accession number: P10234
Secondary accession number(s): Q09I84
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 22, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents