Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P10234

- DUT_HHV11

UniProt

P10234 - DUT_HHV11

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

UL50

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.By similarity

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    ORF Names:UL50
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182952Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP10234.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi152 – 1554Poly-Pro

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 2 hits.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    P10234-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQWGSGAIL VQPDSLGRGY DGDWHTAVAT RGGGVVQLNL VNRRAVAFMP    50
    KVSGDSGWAV GRVSLDLRMA MPADFCAIIH APALASPGHH VILGLIDSGY 100
    RGTVMAVVVA PKRTREFAPG TLRVDVTFLD ILATPPALTE PISLRQFPQL 150
    APPPPTGAGI REDPWLEGAL GAPSVTTALP ARRRGRSLVY AGELTPVQTE 200
    HGDGVREAIA FLPKREEDAG FDIVVRRPVT VPANGTTVVQ PSLRMLHADA 250
    GPAACYVLGR SSLNARGLLV VPTRWLPGHV CAFVVYNLTG VPVTLEAGAK 300
    VAQLLVAGAD ALPWIPPDNF HGTKALRNYP RGVPDSTAEP RNPPLLVFTN 350
    EFDAEAPPSE RGTGGFGSTG I 371
    Length:371
    Mass (Da):39,128
    Last modified:July 1, 1989 - v1
    Checksum:i5FFA2556AD2F7158
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32301.1.
    DQ889502 Genomic DNA. Translation: ABI63511.1.
    FJ593289 Genomic DNA. Translation: ACM62274.1.
    PIRiE30089. WMBEY0.
    RefSeqiNP_044653.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703421.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32301.1 .
    DQ889502 Genomic DNA. Translation: ABI63511.1 .
    FJ593289 Genomic DNA. Translation: ACM62274.1 .
    PIRi E30089. WMBEY0.
    RefSeqi NP_044653.1. NC_001806.1.

    3D structure databases

    ProteinModelPortali P10234.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703421.

    Family and domain databases

    Gene3Di 2.70.40.10. 2 hits.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    3. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.

    Entry informationi

    Entry nameiDUT_HHV11
    AccessioniPrimary (citable) accession number: P10234
    Secondary accession number(s): Q09I84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3