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Protein

Tegument protein VP22

Gene

UL49

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network. Finally, may prevent nucleosomal deposition onto the viral genome by interacting with and inhibiting host SET.6 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Tegument protein VP22
Gene namesi
ORF Names:UL49
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host Golgi apparatus, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160931 – 301Tegument protein VP22Add BLAST301

Post-translational modificationi

Highly phosphorylated in the host cell. Packaging is selective for underphosphorylated forms.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP10233.

Interactioni

Subunit structurei

Interacts with gE (via C-terminus); this interaction is necessary for the recruitment of VP22 to the Golgi and its packaging into virions. Interacts with gM (via C-terminus). Interacts with VP16; this interaction allows the formation of a tripartite complex composed of VP16, VP22 and UL41/VHS. According PubMed:17035313 interacts with gD (via C-terminus). According PubMed:19279114 does not interact with gD. Interacts with host SET; this interaction may interfere with SET-mediated nucleosomal deposition onto the viral genome. Interacts with the capsid-binding protein UL16.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UL48P064922EBI-7490002,EBI-7489933

Protein-protein interaction databases

BioGridi971444. 8 interactors.
DIPiDIP-57160N.
IntActiP10233. 3 interactors.
MINTiMINT-6732747.

Structurei

Secondary structure

1301
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi182 – 184Combined sources3
Helixi191 – 224Combined sources34
Helixi229 – 238Combined sources10
Beta strandi241 – 244Combined sources4
Helixi248 – 250Combined sources3
Helixi251 – 257Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XALX-ray1.87A174-281[»]
SMRiP10233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni174 – 267Interaction with gEAdd BLAST94

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi163 – 166Nuclear localization signalBy similarity4
Motifi232 – 244Nuclear export signalBy similarityAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi102 – 105Poly-Pro4

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000JT.

Family and domain databases

InterProiView protein in InterPro
IPR006908. Herpes_UL49.
PfamiView protein in Pfam
PF04823. Herpes_UL49_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P10233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRRSVKSG PREVPRDEYE DLYYTPSSGM ASPDSPPDTS RRGALQTRSR
60 70 80 90 100
QRGEVRFVQY DESDYALYGG SSSEDDEHPE VPRTRRPVSG AVLSGPGPAR
110 120 130 140 150
APPPPAGSGG AGRTPTTAPR APRTQRVATK APAAPAAETT RGRKSAQPES
160 170 180 190 200
AALPDAPAST APTRSKTPAQ GLARKLHFST APPNPDAPWT PRVAGFNKRV
210 220 230 240 250
FCAAVGRLAA MHARMAAVQL WDMSRPRTDE DLNELLGITT IRVTVCEGKN
260 270 280 290 300
LLQRANELVN PDVVQDVDAA TATRGRSAAS RPTERPRAPA RSASRPRRPV

E
Length:301
Mass (Da):32,254
Last modified:July 1, 1989 - v1
Checksum:i6E9539C2AEE13E29
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti20E → G in strain: 17 syn+. 1
Natural varianti135P → Q in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti141R → C in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti220L → I in strain: 17 syn+. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32299.1.
DQ889502 Genomic DNA. Translation: ABI63510.1.
FJ593289 Genomic DNA. Translation: ACM62272.1.
PIRiD30089. WMBEF9.
RefSeqiYP_009137124.1. NC_001806.2.

Genome annotation databases

GeneIDi2703417.
KEGGivg:2703417.

Similar proteinsi

Entry informationi

Entry nameiVP22_HHV11
AccessioniPrimary (citable) accession number: P10233
Secondary accession number(s): B9VQH7, Q09I85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 25, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families