ID TG47_HHV11 Reviewed; 693 AA. AC P10231; Q09I87; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1989, sequence version 1. DT 21-SEP-2011, entry version 63. DE RecName: Full=Tegument protein UL47; DE AltName: Full=82/81 kDa tegument protein; DE AltName: Full=VMW82/81; DE AltName: Full=VP13/14; GN ORFNames=UL47; OS Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus OS 1). OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Alphaherpesvirinae; Simplexvirus. OX NCBI_TaxID=10299; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=88274327; PubMed=2839594; RA McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., RA McNab D., Perry L.J., Scott J.E., Taylor P.; RT "The complete DNA sequence of the long unique region in the genome of RT herpes simplex virus type 1."; RL J. Gen. Virol. 69:1531-1574(1988). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nonneuroinvasive mutant HF10; RX PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019; RA Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.; RT "Determination and analysis of the DNA sequence of highly attenuated RT herpes simplex virus type 1 mutant HF10, a potential oncolytic RT virus."; RL Microbes Infect. 9:142-149(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17 syn+; RA Cunningham C., Davison A.J.; RT "Herpes simplex virus type 1 bacterial artificial chromosome."; RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases. RN [4] RP IDENTIFICATION OF PROTEIN, AND SUBCELLULAR LOCATION. RX MEDLINE=91108391; PubMed=2177087; RA McLean G., Rixon F., Langeland N., Haarr L., Marsden H.; RT "Identification and characterization of the virion protein products of RT herpes simplex virus type 1 gene UL47."; RL J. Gen. Virol. 71:2953-2960(1990). RN [5] RP SUBCELLULAR LOCATION, AND NUCLEAR LOCALIZATION SIGNAL. RX PubMed=11222679; DOI=10.1128/JVI.75.6.2566-2574.2001; RA Donnelly M., Elliott G.; RT "Nuclear localization and shuttling of herpes simplex virus tegument RT protein VP13/14."; RL J. Virol. 75:2566-2574(2001). RN [6] RP RNA-BINDING, AND NUCLEAR LOCALIZATION SIGNAL. RX PubMed=17166902; DOI=10.1128/JVI.01677-06; RA Donnelly M., Verhagen J., Elliott G.; RT "RNA binding by the herpes simplex virus type 1 nucleocytoplasmic RT shuttling protein UL47 is mediated by an N-terminal arginine-rich RT domain that also functions as its nuclear localization signal."; RL J. Virol. 81:2283-2296(2007). RN [7] RP SUBCELLULAR LOCATION, AND NUCLEAR EXPORT SIGNAL. RX PubMed=18715912; DOI=10.1128/JVI.01403-08; RA Williams P., Verhagen J., Elliott G.; RT "Characterization of a CRM1-dependent nuclear export signal in the C RT terminus of herpes simplex virus type 1 tegument protein UL47."; RL J. Virol. 82:10946-10952(2008). CC -!- FUNCTION: Tegument protein that can bind to various RNA CC transcripts. Has a high affinity for polyadenylated transcripts CC but has no apparent selectivity for virus-encoded RNA over CC cellular RNA. May play a role in RNA biogenesis and/or trafficking CC during infection (By similarity). CC -!- SUBCELLULAR LOCATION: Virion tegument. Host nucleus. Host CC cytoplasm. Note=Major tegument protein of the virion. Undergoes CC nucleocytoplasmic shuttling during infection. Localizes to the CC major sites of transcription in the infected cell nucleus. CC -!- DOMAIN: The nuclear export signal is CRM1-dependent. CC -!- MISCELLANEOUS: Expressed in late in the infection. CC -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL47 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X14112; CAA32297.1; -; Genomic_DNA. DR EMBL; DQ889502; ABI63508.1; -; Genomic_DNA. DR EMBL; FJ593289; ACM62270.1; -; Genomic_DNA. DR PIR; B30089; TNBEF7. DR RefSeq; NP_044649.1; NC_001806.1. DR MINT; MINT-6732739; -. DR GeneID; 2703415; -. DR ProtClustDB; CLSP2510166; -. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. DR InterPro; IPR005029; Herpes_UL47. DR Pfam; PF03362; Herpes_UL47; 1. PE 1: Evidence at protein level; KW Complete proteome; Host cytoplasm; Host nucleus; Late protein; KW Reference proteome; RNA-binding; Transcription; KW Transcription regulation; Virion; Virion tegument. FT CHAIN 1 693 Tegument protein UL47. FT /FTId=PRO_0000116073. FT REGION 50 75 RNA-binding. FT MOTIF 63 75 Nuclear localization signal. FT MOTIF 647 670 Nuclear export signal. FT COMPBIAS 9 12 Poly-Arg. FT COMPBIAS 107 110 Poly-Asp. SQ SEQUENCE 693 AA; 73817 MW; 283737D7D33B5C93 CRC64; MSAREPAGRR RRASTRPRAS PVADEPAGDG VGFMGYLRAV FRGDDDSELE ALEEMAGDEP PVRRRREGPR ARRRRASEAP PTSHRRASRQ RPGPDAARSQ SVRGRLDDDD EVPRGPPQAR QGGYLGPVDA RAILGRVGGS RVAPSPLFLE ELQYEEDDYP EAVGPEDGGG ARSPPKVEVL EGRVPGPELR AAFPLDRLAP QVAVWDESVR SALALGHPAG FYPCPDSAFG LSRVGVMHFA SPDNPAVFFR QTLQQGEALA WYITGDGILD LTDRRTKTSP AQAMSFLADA VVRLAINGWV CGTRLHAEAR GSDLDDRAAE LRRQFASLTA LRPVGAAAVP LLSAGGLVSP QSGPDAAVFR SSLGSLLYWP GVRALLDRDC RVAARYAGRM TYLATGALLA RFNPDAVRCV LTREAAFLGR VLDVLAVMAE QTVQWLSVVV GARLHPHVHH PAFADVAREE LFRALPLGSP AVVGAEHEAL GDTAARRLLA NSGLNAVLGA AVYALHTALA TVTLKYARAC GDAHRRRDDA AATRAILAAG LVLQRLLGFA DTVVACVTLA AFDGGFTAPE VGTYTPLRYA CVLRATQPLY ARTTPAKFWA DVRAAAEHVD LRPASSAPRA PVSGTADPAF LLKDLEPFPP APVSGGSVLG PRVRVVDIMS QFRKLLMGDE GAAALRAHVS GRRATGLGGP PRP //