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P10231 (TEG5_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tegument protein UL47
Alternative name(s):
82/81 kDa tegument protein
VMW82/81
VP13/14
Gene names
ORF Names:UL47
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length693 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tegument protein that can bind to various RNA transcripts. Has a high affinity for polyadenylated transcripts but has no apparent selectivity for virus-encoded RNA over cellular RNA. May play a role in RNA biogenesis and/or trafficking during infection By similarity.

Subcellular location

Virion tegument. Host nucleus. Host cytoplasm. Note: Major tegument protein of the virion. Undergoes nucleocytoplasmic shuttling during infection. Localizes to the major sites of transcription in the infected cell nucleus. Ref.4 Ref.5 Ref.7

Domain

The nuclear export signal is CRM1-dependent.

Miscellaneous

Expressed in late in the infection.

Sequence similarities

Belongs to the alphaherpesvirinae HHV-1 UL47 family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentHost cytoplasm
Host nucleus
Virion
Virion tegument
   Developmental stageLate protein
   LigandRNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral tegument

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 693693Tegument protein UL47
PRO_0000116073

Regions

Region50 – 7526RNA-binding
Motif63 – 7513Nuclear localization signal Ref.5 Ref.6
Motif647 – 67024Nuclear export signal
Compositional bias9 – 124Poly-Arg
Compositional bias107 – 1104Poly-Asp

Sequences

Sequence LengthMass (Da)Tools
P10231 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 283737D7D33B5C93

FASTA69373,817
        10         20         30         40         50         60 
MSAREPAGRR RRASTRPRAS PVADEPAGDG VGFMGYLRAV FRGDDDSELE ALEEMAGDEP 

        70         80         90        100        110        120 
PVRRRREGPR ARRRRASEAP PTSHRRASRQ RPGPDAARSQ SVRGRLDDDD EVPRGPPQAR 

       130        140        150        160        170        180 
QGGYLGPVDA RAILGRVGGS RVAPSPLFLE ELQYEEDDYP EAVGPEDGGG ARSPPKVEVL 

       190        200        210        220        230        240 
EGRVPGPELR AAFPLDRLAP QVAVWDESVR SALALGHPAG FYPCPDSAFG LSRVGVMHFA 

       250        260        270        280        290        300 
SPDNPAVFFR QTLQQGEALA WYITGDGILD LTDRRTKTSP AQAMSFLADA VVRLAINGWV 

       310        320        330        340        350        360 
CGTRLHAEAR GSDLDDRAAE LRRQFASLTA LRPVGAAAVP LLSAGGLVSP QSGPDAAVFR 

       370        380        390        400        410        420 
SSLGSLLYWP GVRALLDRDC RVAARYAGRM TYLATGALLA RFNPDAVRCV LTREAAFLGR 

       430        440        450        460        470        480 
VLDVLAVMAE QTVQWLSVVV GARLHPHVHH PAFADVAREE LFRALPLGSP AVVGAEHEAL 

       490        500        510        520        530        540 
GDTAARRLLA NSGLNAVLGA AVYALHTALA TVTLKYARAC GDAHRRRDDA AATRAILAAG 

       550        560        570        580        590        600 
LVLQRLLGFA DTVVACVTLA AFDGGFTAPE VGTYTPLRYA CVLRATQPLY ARTTPAKFWA 

       610        620        630        640        650        660 
DVRAAAEHVD LRPASSAPRA PVSGTADPAF LLKDLEPFPP APVSGGSVLG PRVRVVDIMS 

       670        680        690 
QFRKLLMGDE GAAALRAHVS GRRATGLGGP PRP 

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[3]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.
[4]"Identification and characterization of the virion protein products of herpes simplex virus type 1 gene UL47."
McLean G., Rixon F., Langeland N., Haarr L., Marsden H.
J. Gen. Virol. 71:2953-2960(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF PROTEIN, SUBCELLULAR LOCATION.
[5]"Nuclear localization and shuttling of herpes simplex virus tegument protein VP13/14."
Donnelly M., Elliott G.
J. Virol. 75:2566-2574(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL.
[6]"RNA binding by the herpes simplex virus type 1 nucleocytoplasmic shuttling protein UL47 is mediated by an N-terminal arginine-rich domain that also functions as its nuclear localization signal."
Donnelly M., Verhagen J., Elliott G.
J. Virol. 81:2283-2296(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: RNA-BINDING, NUCLEAR LOCALIZATION SIGNAL.
[7]"Characterization of a CRM1-dependent nuclear export signal in the C terminus of herpes simplex virus type 1 tegument protein UL47."
Williams P., Verhagen J., Elliott G.
J. Virol. 82:10946-10952(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32297.1.
DQ889502 Genomic DNA. Translation: ABI63508.1.
FJ593289 Genomic DNA. Translation: ACM62270.1.
PIRTNBEF7. B30089.
RefSeqNP_044649.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP10231. 1 interaction.
MINTMINT-6732739.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703415.

Family and domain databases

InterProIPR005029. Herpes_UL47.
[Graphical view]
PfamPF03362. Herpes_UL47. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTEG5_HHV11
AccessionPrimary (citable) accession number: P10231
Secondary accession number(s): Q09I87
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families