P10231 (TG47_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tegument protein UL47

Alternative name(s):
82/81 kDa tegument protein
VMW82/81
VP13/14

Gene names

ORF Names:

UL47

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	693 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tegument protein that can bind to various RNA transcripts. Has a high affinity for polyadenylated transcripts but has no apparent selectivity for virus-encoded RNA over cellular RNA. May play a role in RNA biogenesis and/or trafficking during infection By similarity.
Subcellular location	Virion tegument. Host nucleus. Host cytoplasm. Note: Major tegument protein of the virion. Undergoes nucleocytoplasmic shuttling during infection. Localizes to the major sites of transcription in the infected cell nucleus. Ref.4 Ref.5 Ref.7
Domain	The nuclear export signal is CRM1-dependent.
Miscellaneous	Expressed in late in the infection.
Sequence similarities	Belongs to the alphaherpesvirinae HHV-1 UL47 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Host cytoplasm Host nucleus Virion Virion tegument
Developmental stage	Late protein
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell viral tegument Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 693	693	Tegument protein UL47		PRO_0000116073
Regions
	Region	50 – 75	26	RNA-binding
	Motif	63 – 75	13	Nuclear localization signal Ref.5 Ref.6
	Motif	647 – 670	24	Nuclear export signal
	Compositional bias	9 – 12	4	Poly-Arg
	Compositional bias	107 – 110	4	Poly-Asp

Sequences

	Sequence		Length	Mass (Da)
	P10231 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 283737D7D33B5C93	FASTA	693	73,817
	10 20 30 40 50 60 MSAREPAGRR RRASTRPRAS PVADEPAGDG VGFMGYLRAV FRGDDDSELE ALEEMAGDEP 70 80 90 100 110 120 PVRRRREGPR ARRRRASEAP PTSHRRASRQ RPGPDAARSQ SVRGRLDDDD EVPRGPPQAR 130 140 150 160 170 180 QGGYLGPVDA RAILGRVGGS RVAPSPLFLE ELQYEEDDYP EAVGPEDGGG ARSPPKVEVL 190 200 210 220 230 240 EGRVPGPELR AAFPLDRLAP QVAVWDESVR SALALGHPAG FYPCPDSAFG LSRVGVMHFA 250 260 270 280 290 300 SPDNPAVFFR QTLQQGEALA WYITGDGILD LTDRRTKTSP AQAMSFLADA VVRLAINGWV 310 320 330 340 350 360 CGTRLHAEAR GSDLDDRAAE LRRQFASLTA LRPVGAAAVP LLSAGGLVSP QSGPDAAVFR 370 380 390 400 410 420 SSLGSLLYWP GVRALLDRDC RVAARYAGRM TYLATGALLA RFNPDAVRCV LTREAAFLGR 430 440 450 460 470 480 VLDVLAVMAE QTVQWLSVVV GARLHPHVHH PAFADVAREE LFRALPLGSP AVVGAEHEAL 490 500 510 520 530 540 GDTAARRLLA NSGLNAVLGA AVYALHTALA TVTLKYARAC GDAHRRRDDA AATRAILAAG 550 560 570 580 590 600 LVLQRLLGFA DTVVACVTLA AFDGGFTAPE VGTYTPLRYA CVLRATQPLY ARTTPAKFWA 610 620 630 640 650 660 DVRAAAEHVD LRPASSAPRA PVSGTADPAF LLKDLEPFPP APVSGGSVLG PRVRVVDIMS 670 680 690 QFRKLLMGDE GAAALRAHVS GRRATGLGGP PRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10.
[3]	"Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+.
[4]	"Identification and characterization of the virion protein products of herpes simplex virus type 1 gene UL47." McLean G., Rixon F., Langeland N., Haarr L., Marsden H. J. Gen. Virol. 71:2953-2960(1990) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF PROTEIN, SUBCELLULAR LOCATION.
[5]	"Nuclear localization and shuttling of herpes simplex virus tegument protein VP13/14." Donnelly M., Elliott G. J. Virol. 75:2566-2574(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL.
[6]	"RNA binding by the herpes simplex virus type 1 nucleocytoplasmic shuttling protein UL47 is mediated by an N-terminal arginine-rich domain that also functions as its nuclear localization signal." Donnelly M., Verhagen J., Elliott G. J. Virol. 81:2283-2296(2007) [PubMed] [Europe PMC] [Abstract] Cited for: RNA-BINDING, NUCLEAR LOCALIZATION SIGNAL.
[7]	"Characterization of a CRM1-dependent nuclear export signal in the C terminus of herpes simplex virus type 1 tegument protein UL47." Williams P., Verhagen J., Elliott G. J. Virol. 82:10946-10952(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32297.1. DQ889502 Genomic DNA. Translation: ABI63508.1. FJ593289 Genomic DNA. Translation: ACM62270.1.
PIR	TNBEF7. B30089.
RefSeq	NP_044649.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6732739.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703415.
Phylogenomic databases
ProtClustDB	CLSP2510166.
Family and domain databases
InterPro	IPR005029. Herpes_UL47. [Graphical view]
Pfam	PF03362. Herpes_UL47. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TG47_HHV11

Accession

Primary (citable) accession number: P10231
Secondary accession number(s): Q09I87

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program