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P10231

- TEG5_HHV11

UniProt

P10231 - TEG5_HHV11

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Protein
Tegument protein UL47
Gene
UL47
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Tegument protein that can bind to various RNA transcripts. Has a high affinity for polyadenylated transcripts but has no apparent selectivity for virus-encoded RNA over cellular RNA. May play a role in RNA biogenesis and/or trafficking during infection By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tegument protein UL47
Alternative name(s):
82/81 kDa tegument protein
VMW82/81
VP13/14
Gene namesi
ORF Names:UL47
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion tegument. Host nucleus. Host cytoplasm
Note: Major tegument protein of the virion. Undergoes nucleocytoplasmic shuttling during infection. Localizes to the major sites of transcription in the infected cell nucleus.3 Publications

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. host cell nucleus Source: UniProtKB-SubCell
  3. viral tegument Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Tegument protein UL47
PRO_0000116073Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Protein-protein interaction databases

IntActiP10231. 1 interaction.
MINTiMINT-6732739.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 7526RNA-binding
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi63 – 7513Nuclear localization signal2 Publications
Add
BLAST
Motifi647 – 67024Nuclear export signal
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 124Poly-Arg
Compositional biasi107 – 1104Poly-Asp

Domaini

The nuclear export signal is CRM1-dependent.

Sequence similaritiesi

Family and domain databases

InterProiIPR005029. Herpes_UL47.
[Graphical view]
PfamiPF03362. Herpes_UL47. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10231-1 [UniParc]FASTAAdd to Basket

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MSAREPAGRR RRASTRPRAS PVADEPAGDG VGFMGYLRAV FRGDDDSELE    50
ALEEMAGDEP PVRRRREGPR ARRRRASEAP PTSHRRASRQ RPGPDAARSQ 100
SVRGRLDDDD EVPRGPPQAR QGGYLGPVDA RAILGRVGGS RVAPSPLFLE 150
ELQYEEDDYP EAVGPEDGGG ARSPPKVEVL EGRVPGPELR AAFPLDRLAP 200
QVAVWDESVR SALALGHPAG FYPCPDSAFG LSRVGVMHFA SPDNPAVFFR 250
QTLQQGEALA WYITGDGILD LTDRRTKTSP AQAMSFLADA VVRLAINGWV 300
CGTRLHAEAR GSDLDDRAAE LRRQFASLTA LRPVGAAAVP LLSAGGLVSP 350
QSGPDAAVFR SSLGSLLYWP GVRALLDRDC RVAARYAGRM TYLATGALLA 400
RFNPDAVRCV LTREAAFLGR VLDVLAVMAE QTVQWLSVVV GARLHPHVHH 450
PAFADVAREE LFRALPLGSP AVVGAEHEAL GDTAARRLLA NSGLNAVLGA 500
AVYALHTALA TVTLKYARAC GDAHRRRDDA AATRAILAAG LVLQRLLGFA 550
DTVVACVTLA AFDGGFTAPE VGTYTPLRYA CVLRATQPLY ARTTPAKFWA 600
DVRAAAEHVD LRPASSAPRA PVSGTADPAF LLKDLEPFPP APVSGGSVLG 650
PRVRVVDIMS QFRKLLMGDE GAAALRAHVS GRRATGLGGP PRP 693
Length:693
Mass (Da):73,817
Last modified:July 1, 1989 - v1
Checksum:i283737D7D33B5C93
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32297.1.
DQ889502 Genomic DNA. Translation: ABI63508.1.
FJ593289 Genomic DNA. Translation: ACM62270.1.
PIRiB30089. TNBEF7.
RefSeqiNP_044649.1. NC_001806.1.

Genome annotation databases

GeneIDi2703415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32297.1 .
DQ889502 Genomic DNA. Translation: ABI63508.1 .
FJ593289 Genomic DNA. Translation: ACM62270.1 .
PIRi B30089. TNBEF7.
RefSeqi NP_044649.1. NC_001806.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

IntActi P10231. 1 interaction.
MINTi MINT-6732739.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703415.

Family and domain databases

InterProi IPR005029. Herpes_UL47.
[Graphical view ]
Pfami PF03362. Herpes_UL47. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  3. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  4. "Identification and characterization of the virion protein products of herpes simplex virus type 1 gene UL47."
    McLean G., Rixon F., Langeland N., Haarr L., Marsden H.
    J. Gen. Virol. 71:2953-2960(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROTEIN, SUBCELLULAR LOCATION.
  5. "Nuclear localization and shuttling of herpes simplex virus tegument protein VP13/14."
    Donnelly M., Elliott G.
    J. Virol. 75:2566-2574(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL.
  6. "RNA binding by the herpes simplex virus type 1 nucleocytoplasmic shuttling protein UL47 is mediated by an N-terminal arginine-rich domain that also functions as its nuclear localization signal."
    Donnelly M., Verhagen J., Elliott G.
    J. Virol. 81:2283-2296(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA-BINDING, NUCLEAR LOCALIZATION SIGNAL.
  7. "Characterization of a CRM1-dependent nuclear export signal in the C terminus of herpes simplex virus type 1 tegument protein UL47."
    Williams P., Verhagen J., Elliott G.
    J. Virol. 82:10946-10952(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL.

Entry informationi

Entry nameiTEG5_HHV11
AccessioniPrimary (citable) accession number: P10231
Secondary accession number(s): Q09I87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Expressed in late in the infection.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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