ID   EV45_HHV11              Reviewed;         172 AA.
AC   P10229; Q09I89;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-NOV-2009, entry version 38.
DE   RecName: Full=Envelope protein UL45;
DE   AltName: Full=18 kDa protein;
GN   ORFNames=UL45;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus
OS   1).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=88274327; PubMed=2839594;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C.,
RA   McNab D., Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nonneuroinvasive mutant HF10;
RX   PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA   Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT   "Determination and analysis of the DNA sequence of highly attenuated
RT   herpes simplex virus type 1 mutant HF10, a potential oncolytic
RT   virus.";
RL   Microbes Infect. 9:142-149(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17 syn+;
RA   Cunningham C., Davison A.J.;
RT   "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION.
RX   PubMed=8057463;
RA   Haanes E.J., Nelson C.M., Soule C.L., Goodman J.L.;
RT   "The UL45 gene product is required for herpes simplex virus type 1
RT   glycoprotein B-induced fusion.";
RL   J. Virol. 68:5825-5834(1994).
RN   [5]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=F;
RX   PubMed=18596102; DOI=10.1128/JVI.00904-08;
RA   Loret S., Guay G., Lippe R.;
RT   "Comprehensive characterization of extracellular herpes simplex virus
RT   type 1 virions.";
RL   J. Virol. 82:8605-8618(2008).
CC   -!- FUNCTION: Important virulence factor of HSV neurotropism. Seems to
CC       be required for glycoprotein B-induced fusion. Dispensable for
CC       growth in vitro (By similarity).
CC   -!- SUBCELLULAR LOCATION: Virion membrane; Single-pass type II
CC       membrane protein. Note=In transfected cells, it is retained within
CC       the ER (By similarity).
CC   -!- SIMILARITY: Belongs to the herpesviridae HHV-1 UL45 family.
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DR   EMBL; X14112; CAA32295.1; -; Genomic_DNA.
DR   EMBL; DQ889502; ABI63506.1; -; Genomic_DNA.
DR   EMBL; FJ593289; ACM62268.1; -; Genomic_DNA.
DR   PIR; I30088; WMBEF5.
DR   RefSeq; NP_044647.1; -.
DR   GeneID; 2703412; -.
DR   InterPro; IPR018002; Herpes_UL45.
DR   InterPro; IPR008646; Herpes_UL45-like.
DR   Pfam; PF05473; Herpes_UL45; 1.
DR   PIRSF; PIRSF003509; Herpes_UL45; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Envelope protein; Membrane; Signal-anchor;
KW   Transmembrane; Virion; Virus reference strain.
FT   CHAIN         1    172       Envelope protein UL45.
FT                                /FTId=PRO_0000116086.
FT   TOPO_DOM      1     27       Cytoplasmic (Potential).
FT   TRANSMEM     28     48       Signal-anchor for type II membrane
FT                                protein (Potential).
FT   TOPO_DOM     49    172       Extracellular (Potential).
SQ   SEQUENCE   172 AA;  18180 MW;  EA57EF40D40003D7 CRC64;
     MPLRASEHAY RPLGPGTPPM RARLPAAAWV GVGTIIGGVV IIAALVLVPS RASWALSPCD
     SGWHEFNLGC ISWDPTPMEH EQAVGGCSAP ATLIPRAAAK QLAAVARVQS ARSSGYWWVS
     GDGIRACLRL VDGVGGIDQF CEEPALRICY YPRSPGGFVQ FVTSTRNALG LP
//