P10229 (EV45_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Envelope protein UL45

Alternative name(s):
18 kDa protein

Gene names

ORF Names:

UL45

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Important virulence factor of HSV neurotropism. Seems to be required for glycoprotein B-induced fusion. Dispensable for growth in vitro By similarity. Ref.4
Subcellular location	Virion membrane; Single-pass type II membrane protein. Note: In transfected cells, it is retained within the ER By similarity. Ref.5
Sequence similarities	Belongs to the herpesviridae HHV-1 UL45 family.

Ontologies

Keywords
Cellular component	Membrane Viral envelope protein Virion
Domain	Signal-anchor Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Envelope protein UL45		PRO_0000116086
Regions
	Topological domain	1 – 27	27	Intravirion Potential
	Transmembrane	28 – 48	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	49 – 172	124	Virion surface Potential

Sequences

	Sequence		Length	Mass (Da)
	P10229 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: EA57EF40D40003D7	FASTA	172	18,180
	10 20 30 40 50 60 MPLRASEHAY RPLGPGTPPM RARLPAAAWV GVGTIIGGVV IIAALVLVPS RASWALSPCD 70 80 90 100 110 120 SGWHEFNLGC ISWDPTPMEH EQAVGGCSAP ATLIPRAAAK QLAAVARVQS ARSSGYWWVS 130 140 150 160 170 GDGIRACLRL VDGVGGIDQF CEEPALRICY YPRSPGGFVQ FVTSTRNALG LP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10.
[3]	"Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+.
[4]	"The UL45 gene product is required for herpes simplex virus type 1 glycoprotein B-induced fusion." Haanes E.J., Nelson C.M., Soule C.L., Goodman J.L. J. Virol. 68:5825-5834(1994) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"Comprehensive characterization of extracellular herpes simplex virus type 1 virions." Loret S., Guay G., Lippe R. J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION. Strain: F.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32295.1. DQ889502 Genomic DNA. Translation: ABI63506.1. FJ593289 Genomic DNA. Translation: ACM62268.1.
PIR	WMBEF5. I30088.
RefSeq	NP_044647.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703412.
Phylogenomic databases
ProtClustDB	CLSP2510165.
Family and domain databases
InterPro	IPR018002. Herpes_UL45. IPR008646. Herpes_UL45-like. [Graphical view]
Pfam	PF05473. Herpes_UL45. 1 hit. [Graphical view]
PIRSF	PIRSF003509. Herpes_UL45. 1 hit.
ProtoNet	Search...

Entry information

Entry name

EV45_HHV11

Accession

Primary (citable) accession number: P10229
Secondary accession number(s): Q09I89

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program