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P10229 (EV45_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Envelope protein UL45
Alternative name(s):
18 kDa protein
Gene names
ORF Names:UL45
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Important virulence factor of HSV neurotropism. Seems to be required for glycoprotein B-induced fusion. Dispensable for growth in vitro By similarity. Ref.4

Subcellular location

Virion membrane; Single-pass type II membrane protein. Note: In transfected cells, it is retained within the ER By similarity. Ref.5

Sequence similarities

Belongs to the herpesviridae HHV-1 UL45 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 172172Envelope protein UL45
PRO_0000116086

Regions

Topological domain1 – 2727Intravirion Potential
Transmembrane28 – 4821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain49 – 172124Virion surface Potential

Sequences

Sequence LengthMass (Da)Tools
P10229 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: EA57EF40D40003D7

FASTA17218,180
        10         20         30         40         50         60 
MPLRASEHAY RPLGPGTPPM RARLPAAAWV GVGTIIGGVV IIAALVLVPS RASWALSPCD 

        70         80         90        100        110        120 
SGWHEFNLGC ISWDPTPMEH EQAVGGCSAP ATLIPRAAAK QLAAVARVQS ARSSGYWWVS 

       130        140        150        160        170 
GDGIRACLRL VDGVGGIDQF CEEPALRICY YPRSPGGFVQ FVTSTRNALG LP 

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[3]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.
[4]"The UL45 gene product is required for herpes simplex virus type 1 glycoprotein B-induced fusion."
Haanes E.J., Nelson C.M., Soule C.L., Goodman J.L.
J. Virol. 68:5825-5834(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
Loret S., Guay G., Lippe R.
J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32295.1.
DQ889502 Genomic DNA. Translation: ABI63506.1.
FJ593289 Genomic DNA. Translation: ACM62268.1.
PIRWMBEF5. I30088.
RefSeqNP_044647.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703412.

Phylogenomic databases

ProtClustDBCLSP2510165.

Family and domain databases

InterProIPR018002. Herpes_UL45.
IPR008646. Herpes_UL45-like.
[Graphical view]
PfamPF05473. Herpes_UL45. 1 hit.
[Graphical view]
PIRSFPIRSF003509. Herpes_UL45. 1 hit.
ProtoNetSearch...

Entry information

Entry nameEV45_HHV11
AccessionPrimary (citable) accession number: P10229
Secondary accession number(s): Q09I89
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families