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P10229

- EV45_HHV11

UniProt

P10229 - EV45_HHV11

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Protein
Envelope protein UL45
Gene
UL45
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Important virulence factor of HSV neurotropism. Seems to be required for glycoprotein B-induced fusion. Dispensable for growth in vitro By similarity.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope protein UL45
Alternative name(s):
18 kDa protein
Gene namesi
ORF Names:UL45
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion membrane; Single-pass type II membrane protein
Note: In transfected cells, it is retained within the ER By similarity.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727Intravirion Reviewed prediction
Add
BLAST
Transmembranei28 – 4821Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini49 – 172124Virion surface Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. viral envelope Source: UniProtKB-KW
  3. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Envelope protein UL45
PRO_0000116086Add
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR018002. Herpes_UL45.
IPR008646. Herpes_UL45-like.
[Graphical view]
PfamiPF05473. Herpes_UL45. 1 hit.
[Graphical view]
PIRSFiPIRSF003509. Herpes_UL45. 1 hit.

Sequencei

Sequence statusi: Complete.

P10229-1 [UniParc]FASTAAdd to Basket

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MPLRASEHAY RPLGPGTPPM RARLPAAAWV GVGTIIGGVV IIAALVLVPS    50
RASWALSPCD SGWHEFNLGC ISWDPTPMEH EQAVGGCSAP ATLIPRAAAK 100
QLAAVARVQS ARSSGYWWVS GDGIRACLRL VDGVGGIDQF CEEPALRICY 150
YPRSPGGFVQ FVTSTRNALG LP 172
Length:172
Mass (Da):18,180
Last modified:July 1, 1989 - v1
Checksum:iEA57EF40D40003D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32295.1.
DQ889502 Genomic DNA. Translation: ABI63506.1.
FJ593289 Genomic DNA. Translation: ACM62268.1.
PIRiI30088. WMBEF5.
RefSeqiNP_044647.1. NC_001806.1.

Genome annotation databases

GeneIDi2703412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32295.1 .
DQ889502 Genomic DNA. Translation: ABI63506.1 .
FJ593289 Genomic DNA. Translation: ACM62268.1 .
PIRi I30088. WMBEF5.
RefSeqi NP_044647.1. NC_001806.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703412.

Family and domain databases

InterProi IPR018002. Herpes_UL45.
IPR008646. Herpes_UL45-like.
[Graphical view ]
Pfami PF05473. Herpes_UL45. 1 hit.
[Graphical view ]
PIRSFi PIRSF003509. Herpes_UL45. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  3. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  4. "The UL45 gene product is required for herpes simplex virus type 1 glycoprotein B-induced fusion."
    Haanes E.J., Nelson C.M., Soule C.L., Goodman J.L.
    J. Virol. 68:5825-5834(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.

Entry informationi

Entry nameiEV45_HHV11
AccessioniPrimary (citable) accession number: P10229
Secondary accession number(s): Q09I89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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