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Reviewed, UniProtKB/Swiss-Prot P10229 (EV45_HHV11)

Last modified November 3, 2009. Version 38. Feed History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Envelope protein UL45
Alternative name(s):
    18 kDa protein
Gene names
ORF Names: UL45
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Important virulence factor of HSV neurotropism. Seems to be required for glycoprotein B-induced fusion. Dispensable for growth in vitro By similarity.

Subcellular location

Virion membrane; Single-pass type II membrane protein. Note: In transfected cells, it is retained within the ER By similarity.

Sequence similarities

Belongs to the herpesviridae HHV-1 UL45 family.

Ontologies

Keywords
   Cellular componentEnvelope protein
Membrane
Virion
   DomainSignal-anchor
Transmembrane
   Technical termComplete proteome
Virus reference strain
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 172172Envelope protein UL45
PRO_0000116086

Regions

Topological domain1 – 2727Cytoplasmic Potential
Transmembrane28 – 4821Signal-anchor for type II membrane protein Potential
Topological domain49 – 172124Extracellular Potential

Sequences

Sequence LengthMass (Da)Tools
P10229-1 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: EA57EF40D40003D7

FASTA17218,180
        10         20         30         40         50         60 
MPLRASEHAY RPLGPGTPPM RARLPAAAWV GVGTIIGGVV IIAALVLVPS RASWALSPCD 

        70         80         90        100        110        120 
SGWHEFNLGC ISWDPTPMEH EQAVGGCSAP ATLIPRAAAK QLAAVARVQS ARSSGYWWVS 

       130        140        150        160        170 
GDGIRACLRL VDGVGGIDQF CEEPALRICY YPRSPGGFVQ FVTSTRNALG LP 

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed: 2839594] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed: 17218138] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[3]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.
[4]"The UL45 gene product is required for herpes simplex virus type 1 glycoprotein B-induced fusion."
Haanes E.J., Nelson C.M., Soule C.L., Goodman J.L.
J. Virol. 68:5825-5834(1994) [PubMed: 8057463] [Abstract]
Cited for: FUNCTION.
[5]"Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
Loret S., Guay G., Lippe R.
J. Virol. 82:8605-8618(2008) [PubMed: 18596102] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.

Cross-references

Sequence databases

X14112 Genomic DNA. Translation: CAA32295.1.
DQ889502 Genomic DNA. Translation: ABI63506.1.
FJ593289 Genomic DNA. Translation: ACM62268.1.
PIRWMBEF5. I30088.
RefSeqNP_044647.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2703412.

Family and domain databases

InterProIPR018002. Herpes_UL45.
IPR008646. Herpes_UL45-like.
[Graphical view]
PfamPF05473. Herpes_UL45. 1 hit.
[Graphical view]
PIRSFPIRSF003509. Herpes_UL45. 1 hit.
ProtoNetSearch...

Entry information

Entry nameEV45_HHV11
AccessionPrimary (citable) accession number: P10229
Secondary accession number(s): Q09I89
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents