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P10229

- EV45_HHV11

UniProt

P10229 - EV45_HHV11

Protein

Envelope protein UL45

Gene

UL45

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Important virulence factor of HSV neurotropism. Seems to be required for glycoprotein B-induced fusion. Dispensable for growth in vitro By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope protein UL45
    Alternative name(s):
    18 kDa protein
    Gene namesi
    ORF Names:UL45
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Virion membrane 1 Publication; Single-pass type II membrane protein 1 Publication
    Note: In transfected cells, it is retained within the ER.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. viral envelope Source: UniProtKB-KW
    3. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 172172Envelope protein UL45PRO_0000116086Add
    BLAST

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini49 – 172124Virion surfaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the herpesviridae HHV-1 UL45 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR018002. Herpes_UL45.
    IPR008646. Herpes_UL45-like.
    [Graphical view]
    PfamiPF05473. Herpes_UL45. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003509. Herpes_UL45. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P10229-1 [UniParc]FASTAAdd to Basket

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    MPLRASEHAY RPLGPGTPPM RARLPAAAWV GVGTIIGGVV IIAALVLVPS    50
    RASWALSPCD SGWHEFNLGC ISWDPTPMEH EQAVGGCSAP ATLIPRAAAK 100
    QLAAVARVQS ARSSGYWWVS GDGIRACLRL VDGVGGIDQF CEEPALRICY 150
    YPRSPGGFVQ FVTSTRNALG LP 172
    Length:172
    Mass (Da):18,180
    Last modified:July 1, 1989 - v1
    Checksum:iEA57EF40D40003D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32295.1.
    DQ889502 Genomic DNA. Translation: ABI63506.1.
    FJ593289 Genomic DNA. Translation: ACM62268.1.
    PIRiI30088. WMBEF5.
    RefSeqiNP_044647.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703412.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32295.1 .
    DQ889502 Genomic DNA. Translation: ABI63506.1 .
    FJ593289 Genomic DNA. Translation: ACM62268.1 .
    PIRi I30088. WMBEF5.
    RefSeqi NP_044647.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703412.

    Family and domain databases

    InterProi IPR018002. Herpes_UL45.
    IPR008646. Herpes_UL45-like.
    [Graphical view ]
    Pfami PF05473. Herpes_UL45. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003509. Herpes_UL45. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    3. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    4. "The UL45 gene product is required for herpes simplex virus type 1 glycoprotein B-induced fusion."
      Haanes E.J., Nelson C.M., Soule C.L., Goodman J.L.
      J. Virol. 68:5825-5834(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
      Loret S., Guay G., Lippe R.
      J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.

    Entry informationi

    Entry nameiEV45_HHV11
    AccessioniPrimary (citable) accession number: P10229
    Secondary accession number(s): Q09I89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3