ID   VGLC_HHV11              Reviewed;         511 AA.
AC   P10228;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   13-OCT-2009, entry version 56.
DE   RecName: Full=Glycoprotein C;
DE   Flags: Precursor;
GN   Name=GC; Synonyms=UL44;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus
OS   1).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=88274327; PubMed=2839594;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C.,
RA   McNab D., Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
CC   -!- SUBCELLULAR LOCATION: Virion membrane; Single-pass membrane
CC       protein (Potential).
CC   -!- MISCELLANEOUS: There are seven external glycoproteins in HSV-1 and
CC       2: gH, gB, gC, gG, gD, gI, and gE.
CC   -!- SIMILARITY: Belongs to the herpesviridae glycoprotein C family.
CC   -!- SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain.
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DR   EMBL; X14112; CAA32294.1; -; Genomic_DNA.
DR   PIR; H30088; VGBEF4.
DR   RefSeq; NP_044646.1; -.
DR   GeneID; 2703410; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019012; C:virion; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR001038; GA_GC.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF02124; Marek_A; 1.
DR   PRINTS; PR00668; GLYCPROTEINC.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Glycoprotein; Immunoglobulin domain; Membrane;
KW   Signal; Transmembrane; Virion.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25    511       Glycoprotein C.
FT                                /FTId=PRO_0000038197.
FT   TRANSMEM    481    497       Potential.
FT   DOMAIN      267    359       Ig-like.
FT   CARBOHYD     42     42       N-linked (GlcNAc...); by host
FT                                (Potential).
FT   CARBOHYD     70     70       N-linked (GlcNAc...); by host
FT                                (Potential).
FT   CARBOHYD     74     74       N-linked (GlcNAc...); by host
FT                                (Potential).
FT   CARBOHYD    108    108       N-linked (GlcNAc...); by host
FT                                (Potential).
FT   CARBOHYD    148    148       N-linked (GlcNAc...); by host
FT                                (Potential).
FT   CARBOHYD    181    181       N-linked (GlcNAc...); by host
FT                                (Potential).
FT   CARBOHYD    197    197       N-linked (GlcNAc...); by host
FT                                (Potential).
FT   CARBOHYD    362    362       N-linked (GlcNAc...); by host
FT                                (Potential).
SQ   SEQUENCE   511 AA;  54998 MW;  874BE474DC7D71C5 CRC64;
     MAPGRVGLAV VLWSLLWLGA GVSGGSETAS TGPTITAGAV TNASEAPTSG SPGSAASPEV
     TPTSTPNPNN VTQNKTTPTE PASPPTTPKP TSTPKSPPTS TPDPKPKNNT TPAKSGRPTK
     PPGPVWCDRR DPLARYGSRV QIRCRFRNST RMEFRLQIWR YSMGPSPPIA PAPDLEEVLT
     NITAPPGGLL VYDSAPNLTD PHVLWAEGAG PGADPPLYSV TGPLPTQRLI IGEVTPATQG
     MYYLAWGRMD SPHEYGTWVR VRMFRPPSLT LQPHAVMEGQ PFKATCTAAA YYPRNPVEFV
     WFEDDHQVFN PGQIDTQTHE HPDGFTTVST VTSEAVGGQV PPRTFTCQMT WHRDSVTFSR
     RNATGLALVL PRPTITMEFG VRIVVCTAGC VPEGVTFAWF LGDDPSPAAK SAVTAQESCD
     HPGLATVRST LPISYDYSEY ICRLTGYPAG IPVLEHHGSH QPPPRDPTER QVIEAIEWVG
     IGIGVLAAGV LVVTAIVYVV RTSQSRQRHR R
//