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Protein

Envelope glycoprotein C

Gene

gC

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate. Plays also several roles in host immune evasion by inhibiting the host complement cascade activation, and by providing a shield against neutralizing antibodies that interfere with gB-gD, gB-gH/gL or gD-gH/gL interactions (By similarity).By similarity

GO - Molecular functioni

  • complement binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host complement factors by virus, Viral attachment to host adhesion receptor, Viral attachment to host cell, Viral immunoevasion, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein C
Gene namesi
Name:gC
Synonyms:UL44
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 480Virion surfaceSequence analysisAdd BLAST456
Transmembranei481 – 497HelicalSequence analysisAdd BLAST17
Topological domaini498 – 511CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Virion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2364696.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003819725 – 511Envelope glycoprotein CAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi70N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi74N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi108N-linked (GlcNAc...); by hostSequence analysis1
Disulfide bondi127 ↔ 144PROSITE-ProRule annotation1 Publication
Glycosylationi148N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi181N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi197N-linked (GlcNAc...); by hostSequence analysis1
Disulfide bondi286 ↔ 347PROSITE-ProRule annotation1 Publication
Glycosylationi362N-linked (GlcNAc...); by hostSequence analysis1
Disulfide bondi386 ↔ 442PROSITE-ProRule annotation1 Publication
Disulfide bondi390 ↔ 419PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP10228.

Interactioni

Subunit structurei

Interacts with host complement component C3b; this interaction inhibits host immune response by disregulating complement cascade.1 Publication

GO - Molecular functioni

  • complement binding Source: AgBase

Protein-protein interaction databases

IntActiP10228. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliP10228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini267 – 359Ig-likeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 151Heparin-binding domainBy similarityAdd BLAST15

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR001038. GA_GC.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF02124. Marek_A. 1 hit.
[Graphical view]
PRINTSiPR00668. GLYCPROTEINC.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform gC (identifier: P10228-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPGRVGLAV VLWSLLWLGA GVSGGSETAS TGPTITAGAV TNASEAPTSG
60 70 80 90 100
SPGSAASPEV TPTSTPNPNN VTQNKTTPTE PASPPTTPKP TSTPKSPPTS
110 120 130 140 150
TPDPKPKNNT TPAKSGRPTK PPGPVWCDRR DPLARYGSRV QIRCRFRNST
160 170 180 190 200
RMEFRLQIWR YSMGPSPPIA PAPDLEEVLT NITAPPGGLL VYDSAPNLTD
210 220 230 240 250
PHVLWAEGAG PGADPPLYSV TGPLPTQRLI IGEVTPATQG MYYLAWGRMD
260 270 280 290 300
SPHEYGTWVR VRMFRPPSLT LQPHAVMEGQ PFKATCTAAA YYPRNPVEFV
310 320 330 340 350
WFEDDHQVFN PGQIDTQTHE HPDGFTTVST VTSEAVGGQV PPRTFTCQMT
360 370 380 390 400
WHRDSVTFSR RNATGLALVL PRPTITMEFG VRIVVCTAGC VPEGVTFAWF
410 420 430 440 450
LGDDPSPAAK SAVTAQESCD HPGLATVRST LPISYDYSEY ICRLTGYPAG
460 470 480 490 500
IPVLEHHGSH QPPPRDPTER QVIEAIEWVG IGIGVLAAGV LVVTAIVYVV
510
RTSQSRQRHR R
Note: Membrane-bound gC.
Length:511
Mass (Da):54,998
Last modified:July 1, 1989 - v1
Checksum:i874BE474DC7D71C5
GO
Isoform gCsec (identifier: P10228-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     472-511: VIEAIEWVGIGIGVLAAGVLVVTAIVYVVRTSQSRQRHRR → VILGRSRTTHGVEQNASP

Note: Secreted.
Show »
Length:489
Mass (Da):52,547
Checksum:i9699C16B1B67CB0E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040892472 – 511VIEAI…QRHRR → VILGRSRTTHGVEQNASP in isoform gCsec. CuratedAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32294.1.
PIRiH30088. VGBEF4.

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32294.1.
PIRiH30088. VGBEF4.

3D structure databases

ProteinModelPortaliP10228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10228. 2 interactors.

Chemistry databases

ChEMBLiCHEMBL2364696.

Proteomic databases

PRIDEiP10228.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR001038. GA_GC.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF02124. Marek_A. 1 hit.
[Graphical view]
PRINTSiPR00668. GLYCPROTEINC.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGC_HHV11
AccessioniPrimary (citable) accession number: P10228
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

There are seven external glycoproteins in HSV-1 and 2: gH, gB, gC, gG, gD, gI, and gE.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.