P10228 (GC_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycoprotein C
Short name=gC

Gene names

Name:	GC
Synonyms:	UL44

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate. Plays also several roles in host immune evasion by inhibiting the host complement cascade activation, and by providing a shield against neutralizing antibodies that interfere with gB-gD, gB-gH/gL or gD-gH/gL interactions By similarity.
Subunit structure	Interacts with host complement component C3b; this interaction inhibits host immune response by disregulating complement cascade. Ref.2
Subcellular location	Virion membrane; Single-pass membrane protein Potential.
Miscellaneous	There are seven external glycoproteins in HSV-1 and 2: gH, gB, gC, gG, gD, gI, and gE.
Sequence similarities	Belongs to the herpesviridae glycoprotein C family. Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Inhibition of host complement factors by virus Viral attachment to host cell Viral immunoevasion Virus entry into host cell
Cellular component	Membrane Virion
Coding sequence diversity	Alternative initiation Alternative splicing
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	suppression by virus of host complement activation Inferred from electronic annotation. Source: UniProtKB-KW viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing and alternative initiation. [Align] [Select]

Isoform gC (identifier: P10228-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Membrane-bound gC.

Isoform gCsec (identifier: P10228-2)

The sequence of this isoform differs from the canonical sequence as follows:
     472-511: VIEAIEWVGIGIGVLAAGVLVVTAIVYVVRTSQSRQRHRR → VILGRSRTTHGVEQNASP

Note: Secreted.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 511	487	Glycoprotein C		PRO_0000038197
Regions
	Topological domain	25 – 480	456	Virion surface Potential
	Transmembrane	481 – 497	17	Helical; Potential
	Topological domain	498 – 511	14	Cytoplasmic Potential
	Domain	267 – 359	93	Ig-like
	Region	137 – 151	15	Heparin-binding domain By similarity
Amino acid modifications
	Glycosylation	42	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	70	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	74	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	108	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	148	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	181	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	197	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	362	1	N-linked (GlcNAc...); by host Potential
	Disulfide bond	127 ↔ 144		Ref.3
	Disulfide bond	286 ↔ 347		Ref.3
	Disulfide bond	386 ↔ 442		Ref.3
	Disulfide bond	390 ↔ 419		Ref.3
Natural variations
	Alternative sequence	472 – 511	40	VIEAI…QRHRR → VILGRSRTTHGVEQNASP in isoform gCsec.		VSP_040892

Sequences

	Sequence		Length	Mass (Da)
	Isoform gC [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 874BE474DC7D71C5	FASTA	511	54,998
	10 20 30 40 50 60 MAPGRVGLAV VLWSLLWLGA GVSGGSETAS TGPTITAGAV TNASEAPTSG SPGSAASPEV 70 80 90 100 110 120 TPTSTPNPNN VTQNKTTPTE PASPPTTPKP TSTPKSPPTS TPDPKPKNNT TPAKSGRPTK 130 140 150 160 170 180 PPGPVWCDRR DPLARYGSRV QIRCRFRNST RMEFRLQIWR YSMGPSPPIA PAPDLEEVLT 190 200 210 220 230 240 NITAPPGGLL VYDSAPNLTD PHVLWAEGAG PGADPPLYSV TGPLPTQRLI IGEVTPATQG 250 260 270 280 290 300 MYYLAWGRMD SPHEYGTWVR VRMFRPPSLT LQPHAVMEGQ PFKATCTAAA YYPRNPVEFV 310 320 330 340 350 360 WFEDDHQVFN PGQIDTQTHE HPDGFTTVST VTSEAVGGQV PPRTFTCQMT WHRDSVTFSR 370 380 390 400 410 420 RNATGLALVL PRPTITMEFG VRIVVCTAGC VPEGVTFAWF LGDDPSPAAK SAVTAQESCD 430 440 450 460 470 480 HPGLATVRST LPISYDYSEY ICRLTGYPAG IPVLEHHGSH QPPPRDPTER QVIEAIEWVG 490 500 510 IGIGVLAAGV LVVTAIVYVV RTSQSRQRHR R
	Isoform gCsec [UniParc]. Checksum: 9699C16B1B67CB0E	FASTA	489	52,547
	10 20 30 40 50 60 MAPGRVGLAV VLWSLLWLGA GVSGGSETAS TGPTITAGAV TNASEAPTSG SPGSAASPEV 70 80 90 100 110 120 TPTSTPNPNN VTQNKTTPTE PASPPTTPKP TSTPKSPPTS TPDPKPKNNT TPAKSGRPTK 130 140 150 160 170 180 PPGPVWCDRR DPLARYGSRV QIRCRFRNST RMEFRLQIWR YSMGPSPPIA PAPDLEEVLT 190 200 210 220 230 240 NITAPPGGLL VYDSAPNLTD PHVLWAEGAG PGADPPLYSV TGPLPTQRLI IGEVTPATQG 250 260 270 280 290 300 MYYLAWGRMD SPHEYGTWVR VRMFRPPSLT LQPHAVMEGQ PFKATCTAAA YYPRNPVEFV 310 320 330 340 350 360 WFEDDHQVFN PGQIDTQTHE HPDGFTTVST VTSEAVGGQV PPRTFTCQMT WHRDSVTFSR 370 380 390 400 410 420 RNATGLALVL PRPTITMEFG VRIVVCTAGC VPEGVTFAWF LGDDPSPAAK SAVTAQESCD 430 440 450 460 470 480 HPGLATVRST LPISYDYSEY ICRLTGYPAG IPVLEHHGSH QPPPRDPTER QVILGRSRTT HGVEQNASP

References

[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complement component C3b binds directly to purified glycoprotein C of herpes simplex virus types 1 and 2." Eisenberg R.J., Ponce de Leon M., Friedman H.M., Fries L.F., Frank M.M., Hastings J.C., Cohen G.H. Microb. Pathog. 3:423-435(1987) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HOST C3.
[3]	"Disulfide bond structure determination and biochemical analysis of glycoprotein C from herpes simplex virus." Rux A.H., Moore W.T., Lambris J.D., Abrams W.R., Peng C., Friedman H.M., Cohen G.H., Eisenberg R.J. J. Virol. 70:5455-5465(1996) [PubMed] [Europe PMC] [Abstract] Cited for: DISULFIDE BONDS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32294.1.
PIR	VGBEF4. H30088.
RefSeq	NP_044646.1. NC_001806.1.
3D structure databases
ProteinModelPortal	P10228.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703410.
Phylogenomic databases
ProtClustDB	PHA3270.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR001038. GA_GC. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. [Graphical view]
Pfam	PF02124. Marek_A. 1 hit. [Graphical view]
PRINTS	PR00668. GLYCPROTEINC.
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GC_HHV11

Accession

Primary (citable) accession number: P10228

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program