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Reviewed, UniProtKB/Swiss-Prot P10228 (VGLC_HHV11)

Last modified June 16, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glycoprotein C
Gene names
Name: GC
Synonyms: UL44
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Complete proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageViruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

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Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Subcellular location

Virion membrane; Single-pass membrane protein Potential.

Miscellaneous

There are seven external glycoproteins in HSV-1 and 2: gH, gB, gC, gG, gD, gI, and gE.

Sequence similarities

Belongs to the herpesviridae glycoprotein C family.

Contains 1 Ig-like (immunoglobulin-like) domain.

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Ontologies

Keywords
   Cellular componentMembrane
Virion
   DomainImmunoglobulin domain
Signal
Transmembrane
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processsignal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 511487Glycoprotein C
PRO_0000038197

Regions

Transmembrane481 – 49717 Potential
Domain267 – 35993Ig-like

Amino acid modifications

Glycosylation421N-linked (GlcNAc...); by host Potential
Glycosylation701N-linked (GlcNAc...); by host Potential
Glycosylation741N-linked (GlcNAc...); by host Potential
Glycosylation1081N-linked (GlcNAc...); by host Potential
Glycosylation1481N-linked (GlcNAc...); by host Potential
Glycosylation1811N-linked (GlcNAc...); by host Potential
Glycosylation1971N-linked (GlcNAc...); by host Potential
Glycosylation3621N-linked (GlcNAc...); by host Potential

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Sequences

Sequence LengthMass (Da)Tools
P10228-1 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 874BE474DC7D71C5

FASTA51154,998
        10         20         30         40         50         60 
MAPGRVGLAV VLWSLLWLGA GVSGGSETAS TGPTITAGAV TNASEAPTSG SPGSAASPEV 

        70         80         90        100        110        120 
TPTSTPNPNN VTQNKTTPTE PASPPTTPKP TSTPKSPPTS TPDPKPKNNT TPAKSGRPTK 

       130        140        150        160        170        180 
PPGPVWCDRR DPLARYGSRV QIRCRFRNST RMEFRLQIWR YSMGPSPPIA PAPDLEEVLT 

       190        200        210        220        230        240 
NITAPPGGLL VYDSAPNLTD PHVLWAEGAG PGADPPLYSV TGPLPTQRLI IGEVTPATQG 

       250        260        270        280        290        300 
MYYLAWGRMD SPHEYGTWVR VRMFRPPSLT LQPHAVMEGQ PFKATCTAAA YYPRNPVEFV 

       310        320        330        340        350        360 
WFEDDHQVFN PGQIDTQTHE HPDGFTTVST VTSEAVGGQV PPRTFTCQMT WHRDSVTFSR 

       370        380        390        400        410        420 
RNATGLALVL PRPTITMEFG VRIVVCTAGC VPEGVTFAWF LGDDPSPAAK SAVTAQESCD 

       430        440        450        460        470        480 
HPGLATVRST LPISYDYSEY ICRLTGYPAG IPVLEHHGSH QPPPRDPTER QVIEAIEWVG 

       490        500        510 
IGIGVLAAGV LVVTAIVYVV RTSQSRQRHR R

« Hide

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References

[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed: 2839594] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

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Cross-references

Sequence databases

X14112 Genomic DNA. Translation: CAA32294.1.
PIRVGBEF4. H30088.
RefSeqNP_044646.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2703410.

Family and domain databases

InterProIPR001038. GA_GC.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF02124. Marek_A. 1 hit.
[Graphical view]
PRINTSPR00668. GLYCPROTEINC.
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameVGLC_HHV11
AccessionPrimary (citable) accession number: P10228
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents