ID   MB43_HHV11              Reviewed;         417 AA.
AC   P10227; B9VQH1;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   24-NOV-2009, entry version 45.
DE   RecName: Full=Membrane protein UL43;
GN   ORFNames=UL43;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus
OS   1).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=88274327; PubMed=2839594;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C.,
RA   McNab D., Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nonneuroinvasive mutant HF10;
RX   PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA   Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT   "Determination and analysis of the DNA sequence of highly attenuated
RT   herpes simplex virus type 1 mutant HF10, a potential oncolytic
RT   virus.";
RL   Microbes Infect. 9:142-149(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17 syn+;
RA   Cunningham C., Davison A.J.;
RT   "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   IDENTIFICATION OF START CODON.
RC   STRAIN=F;
RX   PubMed=8892886;
RA   Carter K.L., Ward P.L., Roizman B.;
RT   "Characterization of the products of the U(L)43 gene of herpes simplex
RT   virus 1: potential implications for regulation of gene expression by
RT   antisense transcription.";
RL   J. Virol. 70:7663-7668(1996).
RN   [5]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=F;
RX   PubMed=18596102; DOI=10.1128/JVI.00904-08;
RA   Loret S., Guay G., Lippe R.;
RT   "Comprehensive characterization of extracellular herpes simplex virus
RT   type 1 virions.";
RL   J. Virol. 82:8605-8618(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC       (Potential). Note=Not found in extracellular virion.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL43 family.
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DR   EMBL; X14112; CAA32306.1; ALT_INIT; Genomic_DNA.
DR   EMBL; DQ889502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FJ593289; ACM62266.1; -; Genomic_DNA.
DR   PIR; G30088; WMBEF3.
DR   RefSeq; NP_044645.2; -.
DR   GeneID; 2703408; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:InterPro.
DR   InterPro; IPR007764; Herpes_UL43.
DR   Pfam; PF05072; Herpes_UL43; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Membrane; Transmembrane; Virus reference strain.
FT   CHAIN         1    417       Membrane protein UL43.
FT                                /FTId=PRO_0000116081.
FT   TRANSMEM     57     77       Potential.
FT   TRANSMEM     90    110       Potential.
FT   TRANSMEM    119    139       Potential.
FT   TRANSMEM    146    166       Potential.
FT   TRANSMEM    175    195       Potential.
FT   TRANSMEM    263    283       Potential.
FT   TRANSMEM    291    311       Potential.
FT   TRANSMEM    323    343       Potential.
FT   TRANSMEM    348    368       Potential.
FT   TRANSMEM    389    409       Potential.
FT   COMPBIAS    181    188       Poly-Ala.
FT   COMPBIAS    225    250       Pro-rich.
FT   VARIANT     319    319       P -> A (in strain: 17 syn+ and
FT                                Nonneuroinvasive mutant HF10).
FT   VARIANT     382    384       RLA -> LPVQ (in strain: Nonneuroinvasive
FT                                mutant HF10).
FT   VARIANT     403    403       V -> A (in strain: Nonneuroinvasive
FT                                mutant HF10).
SQ   SEQUENCE   417 AA;  42948 MW;  D6D48868B4323C5A CRC64;
     MLRNDSHRAV SPEDGQGRVD DGRPHLACVG ALARGFMHIW LQAATLGFAG SVVMSRGPYA
     NAASGAFAVG CAVLGFMRAP PPLARPTARI YAWLKLAAGG AALVLWSLGE PGTQPGAPAP
     GPATQCLALG AAYAALLVLA DDVYPLFLLA PGPLFVGTLG MVVGGLTIGG SARYWWIGGP
     AAAALAAAVL AGPGATTARD CFSRACPDHR RVCVITAGES LSRRPPEDPE RPGVPGPPSP
     PTPQRSHGPP ADEVAPARVA RPENVWVPVV TFLGAGALAV KTVREHARGT PGPGLPLWPQ
     VFLGGHVAVA LTELCQALPP WDLTDPLLFV HAGLQVINLG LVFRFSEVVV YAALGGAVWI
     SLAQVLGLRR RLHRKDPGDG ARLAATLRGL FFSVYALGFG VGVLLCPPGS TGGRSGD
//