Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P10227

- MB43_HHV11

UniProt

P10227 - MB43_HHV11

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Membrane protein UL43

Gene

UL43

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein UL43
Gene namesi
ORF Names:UL43
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated
Note: Not found in extracellular virion.1 Publication

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. viral tegument Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Membrane protein UL43PRO_0000116081Add
BLAST

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 7721HelicalSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence AnalysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence AnalysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence AnalysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence AnalysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence AnalysisAdd
BLAST
Transmembranei389 – 40921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 1888Poly-Ala
Compositional biasi225 – 25026Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR007764. Herpes_UL43.
[Graphical view]
PfamiPF05072. Herpes_UL43. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10227 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRNDSHRAV SPEDGQGRVD DGRPHLACVG ALARGFMHIW LQAATLGFAG
60 70 80 90 100
SVVMSRGPYA NAASGAFAVG CAVLGFMRAP PPLARPTARI YAWLKLAAGG
110 120 130 140 150
AALVLWSLGE PGTQPGAPAP GPATQCLALG AAYAALLVLA DDVYPLFLLA
160 170 180 190 200
PGPLFVGTLG MVVGGLTIGG SARYWWIGGP AAAALAAAVL AGPGATTARD
210 220 230 240 250
CFSRACPDHR RVCVITAGES LSRRPPEDPE RPGVPGPPSP PTPQRSHGPP
260 270 280 290 300
ADEVAPARVA RPENVWVPVV TFLGAGALAV KTVREHARGT PGPGLPLWPQ
310 320 330 340 350
VFLGGHVAVA LTELCQALPP WDLTDPLLFV HAGLQVINLG LVFRFSEVVV
360 370 380 390 400
YAALGGAVWI SLAQVLGLRR RLHRKDPGDG ARLAATLRGL FFSVYALGFG
410
VGVLLCPPGS TGGRSGD
Length:417
Mass (Da):42,948
Last modified:September 22, 2009 - v2
Checksum:iD6D48868B4323C5A
GO

Sequence cautioni

The sequence CAA32306.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti319 – 3191P → A in strain: 17 syn+ and Nonneuroinvasive mutant HF10.
Natural varianti382 – 3843RLA → LPVQ in strain: Nonneuroinvasive mutant HF10.
Natural varianti403 – 4031V → A in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32306.1. Different initiation.
DQ889502 Genomic DNA. No translation available.
FJ593289 Genomic DNA. Translation: ACM62266.1.
PIRiG30088. WMBEF3.
RefSeqiNP_044645.2. NC_001806.1.

Genome annotation databases

GeneIDi2703408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32306.1 . Different initiation.
DQ889502 Genomic DNA. No translation available.
FJ593289 Genomic DNA. Translation: ACM62266.1 .
PIRi G30088. WMBEF3.
RefSeqi NP_044645.2. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703408.

Family and domain databases

InterProi IPR007764. Herpes_UL43.
[Graphical view ]
Pfami PF05072. Herpes_UL43. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  3. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  4. "Characterization of the products of the U(L)43 gene of herpes simplex virus 1: potential implications for regulation of gene expression by antisense transcription."
    Carter K.L., Ward P.L., Roizman B.
    J. Virol. 70:7663-7668(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF START CODON.
    Strain: F.
  5. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.

Entry informationi

Entry nameiMB43_HHV11
AccessioniPrimary (citable) accession number: P10227
Secondary accession number(s): B9VQH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 22, 2009
Last modified: October 1, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3