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P10227

- MB43_HHV11

UniProt

P10227 - MB43_HHV11

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Protein

Membrane protein UL43

Gene
UL43
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein UL43
Gene namesi
ORF Names:UL43
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Membrane; Multi-pass membrane protein Reviewed prediction
Note: Not found in extracellular virion.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 7721Helical; Reviewed predictionAdd
BLAST
Transmembranei90 – 11021Helical; Reviewed predictionAdd
BLAST
Transmembranei119 – 13921Helical; Reviewed predictionAdd
BLAST
Transmembranei146 – 16621Helical; Reviewed predictionAdd
BLAST
Transmembranei175 – 19521Helical; Reviewed predictionAdd
BLAST
Transmembranei263 – 28321Helical; Reviewed predictionAdd
BLAST
Transmembranei291 – 31121Helical; Reviewed predictionAdd
BLAST
Transmembranei323 – 34321Helical; Reviewed predictionAdd
BLAST
Transmembranei348 – 36821Helical; Reviewed predictionAdd
BLAST
Transmembranei389 – 40921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. viral tegument Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Membrane protein UL43PRO_0000116081Add
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 1888Poly-Ala
Compositional biasi225 – 25026Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR007764. Herpes_UL43.
[Graphical view]
PfamiPF05072. Herpes_UL43. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10227-1 [UniParc]FASTAAdd to Basket

« Hide

MLRNDSHRAV SPEDGQGRVD DGRPHLACVG ALARGFMHIW LQAATLGFAG    50
SVVMSRGPYA NAASGAFAVG CAVLGFMRAP PPLARPTARI YAWLKLAAGG 100
AALVLWSLGE PGTQPGAPAP GPATQCLALG AAYAALLVLA DDVYPLFLLA 150
PGPLFVGTLG MVVGGLTIGG SARYWWIGGP AAAALAAAVL AGPGATTARD 200
CFSRACPDHR RVCVITAGES LSRRPPEDPE RPGVPGPPSP PTPQRSHGPP 250
ADEVAPARVA RPENVWVPVV TFLGAGALAV KTVREHARGT PGPGLPLWPQ 300
VFLGGHVAVA LTELCQALPP WDLTDPLLFV HAGLQVINLG LVFRFSEVVV 350
YAALGGAVWI SLAQVLGLRR RLHRKDPGDG ARLAATLRGL FFSVYALGFG 400
VGVLLCPPGS TGGRSGD 417
Length:417
Mass (Da):42,948
Last modified:September 22, 2009 - v2
Checksum:iD6D48868B4323C5A
GO

Sequence cautioni

The sequence CAA32306.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti319 – 3191P → A in strain: 17 syn+ and Nonneuroinvasive mutant HF10.
Natural varianti382 – 3843RLA → LPVQ in strain: Nonneuroinvasive mutant HF10.
Natural varianti403 – 4031V → A in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32306.1. Different initiation.
DQ889502 Genomic DNA. No translation available.
FJ593289 Genomic DNA. Translation: ACM62266.1.
PIRiG30088. WMBEF3.
RefSeqiNP_044645.2. NC_001806.1.

Genome annotation databases

GeneIDi2703408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32306.1 . Different initiation.
DQ889502 Genomic DNA. No translation available.
FJ593289 Genomic DNA. Translation: ACM62266.1 .
PIRi G30088. WMBEF3.
RefSeqi NP_044645.2. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703408.

Family and domain databases

InterProi IPR007764. Herpes_UL43.
[Graphical view ]
Pfami PF05072. Herpes_UL43. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  3. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  4. "Characterization of the products of the U(L)43 gene of herpes simplex virus 1: potential implications for regulation of gene expression by antisense transcription."
    Carter K.L., Ward P.L., Roizman B.
    J. Virol. 70:7663-7668(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF START CODON.
    Strain: F.
  5. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.

Entry informationi

Entry nameiMB43_HHV11
AccessioniPrimary (citable) accession number: P10227
Secondary accession number(s): B9VQH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 22, 2009
Last modified: May 14, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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