P10227 (MB43_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane protein UL43

Gene names

ORF Names:

UL43

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential. Note: Not found in extracellular virion. Ref.5
Sequence similarities	Belongs to the alphaherpesvirinae HHV-1 UL43 family.
Sequence caution	The sequence CAA32306.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral tegument Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 417	417	Membrane protein UL43		PRO_0000116081
Regions
	Transmembrane	57 – 77	21	Helical; Potential
	Transmembrane	90 – 110	21	Helical; Potential
	Transmembrane	119 – 139	21	Helical; Potential
	Transmembrane	146 – 166	21	Helical; Potential
	Transmembrane	175 – 195	21	Helical; Potential
	Transmembrane	263 – 283	21	Helical; Potential
	Transmembrane	291 – 311	21	Helical; Potential
	Transmembrane	323 – 343	21	Helical; Potential
	Transmembrane	348 – 368	21	Helical; Potential
	Transmembrane	389 – 409	21	Helical; Potential
	Compositional bias	181 – 188	8	Poly-Ala
	Compositional bias	225 – 250	26	Pro-rich
Natural variations
	Natural variant	319	1	P → A in strain: 17 syn+ and Nonneuroinvasive mutant HF10.
	Natural variant	382 – 384	3	RLA → LPVQ in strain: Nonneuroinvasive mutant HF10.
	Natural variant	403	1	V → A in strain: Nonneuroinvasive mutant HF10.

Sequences

	Sequence		Length	Mass (Da)
	P10227 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: D6D48868B4323C5A	FASTA	417	42,948
	10 20 30 40 50 60 MLRNDSHRAV SPEDGQGRVD DGRPHLACVG ALARGFMHIW LQAATLGFAG SVVMSRGPYA 70 80 90 100 110 120 NAASGAFAVG CAVLGFMRAP PPLARPTARI YAWLKLAAGG AALVLWSLGE PGTQPGAPAP 130 140 150 160 170 180 GPATQCLALG AAYAALLVLA DDVYPLFLLA PGPLFVGTLG MVVGGLTIGG SARYWWIGGP 190 200 210 220 230 240 AAAALAAAVL AGPGATTARD CFSRACPDHR RVCVITAGES LSRRPPEDPE RPGVPGPPSP 250 260 270 280 290 300 PTPQRSHGPP ADEVAPARVA RPENVWVPVV TFLGAGALAV KTVREHARGT PGPGLPLWPQ 310 320 330 340 350 360 VFLGGHVAVA LTELCQALPP WDLTDPLLFV HAGLQVINLG LVFRFSEVVV YAALGGAVWI 370 380 390 400 410 SLAQVLGLRR RLHRKDPGDG ARLAATLRGL FFSVYALGFG VGVLLCPPGS TGGRSGD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10.
[3]	"Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+.
[4]	"Characterization of the products of the U(L)43 gene of herpes simplex virus 1: potential implications for regulation of gene expression by antisense transcription." Carter K.L., Ward P.L., Roizman B. J. Virol. 70:7663-7668(1996) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF START CODON. Strain: F.
[5]	"Comprehensive characterization of extracellular herpes simplex virus type 1 virions." Loret S., Guay G., Lippe R. J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION. Strain: F.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32306.1. Different initiation. DQ889502 Genomic DNA. No translation available. FJ593289 Genomic DNA. Translation: ACM62266.1.
PIR	WMBEF3. G30088.
RefSeq	NP_044645.2. NC_001806.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703408.
Phylogenomic databases
ProtClustDB	PHA3179.
Family and domain databases
InterPro	IPR007764. Herpes_UL43. [Graphical view]
Pfam	PF05072. Herpes_UL43. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MB43_HHV11

Accession

Primary (citable) accession number: P10227
Secondary accession number(s): B9VQH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	September 22, 2009
Last modified:	April 3, 2013
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program