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P10227 (MB43_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane protein UL43
Gene names
ORF Names:UL43
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential. Note: Not found in extracellular virion. Ref.5

Sequence similarities

Belongs to the alphaherpesvirinae HHV-1 UL43 family.

Sequence caution

The sequence CAA32306.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral tegument

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Membrane protein UL43
PRO_0000116081

Regions

Transmembrane57 – 7721Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane119 – 13921Helical; Potential
Transmembrane146 – 16621Helical; Potential
Transmembrane175 – 19521Helical; Potential
Transmembrane263 – 28321Helical; Potential
Transmembrane291 – 31121Helical; Potential
Transmembrane323 – 34321Helical; Potential
Transmembrane348 – 36821Helical; Potential
Transmembrane389 – 40921Helical; Potential
Compositional bias181 – 1888Poly-Ala
Compositional bias225 – 25026Pro-rich

Natural variations

Natural variant3191P → A in strain: 17 syn+ and Nonneuroinvasive mutant HF10.
Natural variant382 – 3843RLA → LPVQ in strain: Nonneuroinvasive mutant HF10.
Natural variant4031V → A in strain: Nonneuroinvasive mutant HF10.

Sequences

Sequence LengthMass (Da)Tools
P10227 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: D6D48868B4323C5A

FASTA41742,948
        10         20         30         40         50         60 
MLRNDSHRAV SPEDGQGRVD DGRPHLACVG ALARGFMHIW LQAATLGFAG SVVMSRGPYA 

        70         80         90        100        110        120 
NAASGAFAVG CAVLGFMRAP PPLARPTARI YAWLKLAAGG AALVLWSLGE PGTQPGAPAP 

       130        140        150        160        170        180 
GPATQCLALG AAYAALLVLA DDVYPLFLLA PGPLFVGTLG MVVGGLTIGG SARYWWIGGP 

       190        200        210        220        230        240 
AAAALAAAVL AGPGATTARD CFSRACPDHR RVCVITAGES LSRRPPEDPE RPGVPGPPSP 

       250        260        270        280        290        300 
PTPQRSHGPP ADEVAPARVA RPENVWVPVV TFLGAGALAV KTVREHARGT PGPGLPLWPQ 

       310        320        330        340        350        360 
VFLGGHVAVA LTELCQALPP WDLTDPLLFV HAGLQVINLG LVFRFSEVVV YAALGGAVWI 

       370        380        390        400        410 
SLAQVLGLRR RLHRKDPGDG ARLAATLRGL FFSVYALGFG VGVLLCPPGS TGGRSGD 

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[3]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.
[4]"Characterization of the products of the U(L)43 gene of herpes simplex virus 1: potential implications for regulation of gene expression by antisense transcription."
Carter K.L., Ward P.L., Roizman B.
J. Virol. 70:7663-7668(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF START CODON.
Strain: F.
[5]"Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
Loret S., Guay G., Lippe R.
J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32306.1. Different initiation.
DQ889502 Genomic DNA. No translation available.
FJ593289 Genomic DNA. Translation: ACM62266.1.
PIRWMBEF3. G30088.
RefSeqNP_044645.2. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703408.

Phylogenomic databases

ProtClustDBPHA3179.

Family and domain databases

InterProIPR007764. Herpes_UL43.
[Graphical view]
PfamPF05072. Herpes_UL43. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMB43_HHV11
AccessionPrimary (citable) accession number: P10227
Secondary accession number(s): B9VQH1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 22, 2009
Last modified: February 19, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families