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P10227

- MB43_HHV11

UniProt

P10227 - MB43_HHV11

Protein

Membrane protein UL43

Gene

UL43

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 2 (22 Sep 2009)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane protein UL43
    Gene namesi
    ORF Names:UL43
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated
    Note: Not found in extracellular virion.1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. viral tegument Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Membrane protein UL43PRO_0000116081Add
    BLAST

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei57 – 7721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei119 – 13921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei291 – 31121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei348 – 36821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei389 – 40921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi181 – 1888Poly-Ala
    Compositional biasi225 – 25026Pro-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR007764. Herpes_UL43.
    [Graphical view]
    PfamiPF05072. Herpes_UL43. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10227-1 [UniParc]FASTAAdd to Basket

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    MLRNDSHRAV SPEDGQGRVD DGRPHLACVG ALARGFMHIW LQAATLGFAG    50
    SVVMSRGPYA NAASGAFAVG CAVLGFMRAP PPLARPTARI YAWLKLAAGG 100
    AALVLWSLGE PGTQPGAPAP GPATQCLALG AAYAALLVLA DDVYPLFLLA 150
    PGPLFVGTLG MVVGGLTIGG SARYWWIGGP AAAALAAAVL AGPGATTARD 200
    CFSRACPDHR RVCVITAGES LSRRPPEDPE RPGVPGPPSP PTPQRSHGPP 250
    ADEVAPARVA RPENVWVPVV TFLGAGALAV KTVREHARGT PGPGLPLWPQ 300
    VFLGGHVAVA LTELCQALPP WDLTDPLLFV HAGLQVINLG LVFRFSEVVV 350
    YAALGGAVWI SLAQVLGLRR RLHRKDPGDG ARLAATLRGL FFSVYALGFG 400
    VGVLLCPPGS TGGRSGD 417
    Length:417
    Mass (Da):42,948
    Last modified:September 22, 2009 - v2
    Checksum:iD6D48868B4323C5A
    GO

    Sequence cautioni

    The sequence CAA32306.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti319 – 3191P → A in strain: 17 syn+ and Nonneuroinvasive mutant HF10.
    Natural varianti382 – 3843RLA → LPVQ in strain: Nonneuroinvasive mutant HF10.
    Natural varianti403 – 4031V → A in strain: Nonneuroinvasive mutant HF10.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32306.1. Different initiation.
    DQ889502 Genomic DNA. No translation available.
    FJ593289 Genomic DNA. Translation: ACM62266.1.
    PIRiG30088. WMBEF3.
    RefSeqiNP_044645.2. NC_001806.1.

    Genome annotation databases

    GeneIDi2703408.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32306.1 . Different initiation.
    DQ889502 Genomic DNA. No translation available.
    FJ593289 Genomic DNA. Translation: ACM62266.1 .
    PIRi G30088. WMBEF3.
    RefSeqi NP_044645.2. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703408.

    Family and domain databases

    InterProi IPR007764. Herpes_UL43.
    [Graphical view ]
    Pfami PF05072. Herpes_UL43. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    3. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    4. "Characterization of the products of the U(L)43 gene of herpes simplex virus 1: potential implications for regulation of gene expression by antisense transcription."
      Carter K.L., Ward P.L., Roizman B.
      J. Virol. 70:7663-7668(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF START CODON.
      Strain: F.
    5. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
      Loret S., Guay G., Lippe R.
      J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.

    Entry informationi

    Entry nameiMB43_HHV11
    AccessioniPrimary (citable) accession number: P10227
    Secondary accession number(s): B9VQH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 55 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3