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Protein

DNA polymerase processivity factor

Gene

UL42

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in viral DNA replication by acting as the polymerase accessory subunit. Associates with the viral polymerase to increase its processivity and forms high-affinity direct interactions with DNA. Facilitates the origin-binding protein UL9 loading onto DNA thus increasing its ability to assemble into a functional complex capable of unwinding duplex DNA.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

  • bidirectional double-stranded viral DNA replication Source: UniProtKB
  • positive regulation of DNA-directed DNA polymerase activity Source: AgBase
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase processivity factor
Alternative name(s):
DNA-binding protein UL42
Polymerase accessory protein
Short name:
PAP
Gene namesi
ORF Names:UL42
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • host cell nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160611 – 488DNA polymerase processivity factorAdd BLAST488

Proteomic databases

PRIDEiP10226.

Interactioni

Subunit structurei

Interacts with the DNA polymerase catalytic subunit UL30. Interacts with the origin-binding protein.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NFKB1P198384EBI-1029310,EBI-300010From a different organism.
RELAQ042066EBI-1029310,EBI-73886From a different organism.
UL30P042933EBI-1029310,EBI-8615017
UL9P101933EBI-1029310,EBI-8596799

Protein-protein interaction databases

BioGridi971437. 1 interactor.
IntActiP10226. 6 interactors.
MINTiMINT-6732523.

Structurei

Secondary structure

1488
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 36Combined sources6
Helixi37 – 47Combined sources11
Helixi48 – 50Combined sources3
Turni51 – 54Combined sources4
Beta strandi58 – 62Combined sources5
Beta strandi65 – 72Combined sources8
Beta strandi75 – 82Combined sources8
Helixi83 – 85Combined sources3
Beta strandi86 – 90Combined sources5
Beta strandi96 – 103Combined sources8
Turni114 – 116Combined sources3
Beta strandi120 – 129Combined sources10
Beta strandi135 – 142Combined sources8
Beta strandi150 – 153Combined sources4
Beta strandi156 – 160Combined sources5
Beta strandi166 – 169Combined sources4
Beta strandi175 – 180Combined sources6
Helixi182 – 191Combined sources10
Beta strandi200 – 204Combined sources5
Beta strandi208 – 213Combined sources6
Beta strandi218 – 222Combined sources5
Helixi228 – 233Combined sources6
Helixi248 – 251Combined sources4
Beta strandi257 – 260Combined sources4
Beta strandi265 – 271Combined sources7
Helixi274 – 280Combined sources7
Beta strandi285 – 291Combined sources7
Beta strandi293 – 296Combined sources4
Beta strandi298 – 307Combined sources10
Beta strandi310 – 315Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DMLX-ray2.70A/C/E/G1-319[»]
ProteinModelPortaliP10226.
SMRiP10226.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10226.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi394 – 413Bipartite nuclear localization signalAdd BLAST20

Sequence similaritiesi

Family and domain databases

InterProiIPR003202. UL42.
[Graphical view]
PfamiPF02282. Herpes_UL42. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDSPGGVAP ASPVEDASDA SLGQPEEGAP CQVVLQGAEL NGILQAFAPL
60 70 80 90 100
RTSLLDSLLV MGDRGILIHN TIFGEQVFLP LEHSQFSRYR WRGPTAAFLS
110 120 130 140 150
LVDQKRSLLS VFRANQYPDL RRVELAITGQ APFRTLVQRI WTTTSDGEAV
160 170 180 190 200
ELASETLMKR ELTSFVVLVP QGTPDVQLRL TRPQLTKVLN ATGADSATPT
210 220 230 240 250
TFELGVNGKF SVFTTSTCVT FAAREEGVSS STSTQVQILS NALTKAGQAA
260 270 280 290 300
ANAKTVYGEN THRTFSVVVD DCSMRAVLRR LQVGGGTLKF FLTTPVPSLC
310 320 330 340 350
VTATGPNAVS AVFLLKPQKI CLDWLGHSQG SPSAGSSASR ASGSEPTDSQ
360 370 380 390 400
DSASDAVSHG DPEDLDGAAR AGEAGALHAC PMPSSTTRVT PTTKRGRSGG
410 420 430 440 450
EDARADTALK KPKTGSPTAP PPADPVPLDT EDDSDAADGT AARPAAPDAR
460 470 480
SGSRYACYFR DLPTGEASPG AFSAFRGGPQ TPYGFGFP
Length:488
Mass (Da):51,159
Last modified:July 1, 1989 - v1
Checksum:i432974563DF0A81B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti349S → N in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32305.1.
M19121 Genomic DNA. Translation: AAA45824.1.
DQ889502 Genomic DNA. Translation: ABI63504.1.
FJ593289 Genomic DNA. Translation: ACM62265.1.
PIRiD29890. WMBE42.
RefSeqiYP_009137117.1. NC_001806.2.

Genome annotation databases

GeneIDi24271471.
KEGGivg:24271471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32305.1.
M19121 Genomic DNA. Translation: AAA45824.1.
DQ889502 Genomic DNA. Translation: ABI63504.1.
FJ593289 Genomic DNA. Translation: ACM62265.1.
PIRiD29890. WMBE42.
RefSeqiYP_009137117.1. NC_001806.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DMLX-ray2.70A/C/E/G1-319[»]
ProteinModelPortaliP10226.
SMRiP10226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971437. 1 interactor.
IntActiP10226. 6 interactors.
MINTiMINT-6732523.

Proteomic databases

PRIDEiP10226.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24271471.
KEGGivg:24271471.

Miscellaneous databases

EvolutionaryTraceiP10226.

Family and domain databases

InterProiIPR003202. UL42.
[Graphical view]
PfamiPF02282. Herpes_UL42. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAP_HHV11
AccessioniPrimary (citable) accession number: P10226
Secondary accession number(s): B9VQH0, Q09I91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.