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Protein

Virion host shutoff protein

Gene

UL41

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Minor structural protein that acts as an endoribonuclease during lytic infection. Degrades host mRNAs in the cytoplasm by cutting them at preferred sites, including some in regions of translation initiation. Together with inhibition of host splicing by ICP27, contributes to an overall decrease in host protein synthesis. Also, after the onset of viral transcription, accelerates the turnover of viral mRNA, thereby facilitating the sequential expression of different classes of viral genes. Binds translation initiation factors eIF4H, eIF4AI, and eIF4AII, thereby may interact directly with the translation initiation complex and thus digest specifically mRNAs. Also impedes antigen presentation by major histocompatibility complex class I and class II molecules, inhibits secretion of cytokines that would otherwise recruit lymphocytes and neutrophils cells to the site of infection and blocks the activation of dendritic cells. Impedes the alpha/beta interferon-mediated response to infection.6 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Decay of host mRNAs by virus, Eukaryotic host gene expression shutoff by virus, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Interferon antiviral system evasion, Viral immunoevasion

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Virion host shutoff protein (EC:3.1.27.-)
Short name:
Vhs
Gene namesi
Name:UL41
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160541 – 489Virion host shutoff proteinAdd BLAST489

Proteomic databases

PRIDEiP10225.

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with human EIF4H, EIF4A1 and EIF4A2; interaction with eIF4AI and EIF4A2 presumably allows Vhs protein to associate with the eIF4F cap-binding complex.1 Publication

Protein-protein interaction databases

BioGridi971408. 1 interactor.
DIPiDIP-57855N.
IntActiP10225. 8 interactors.
MINTiMINT-6732794.

Structurei

3D structure databases

ProteinModelPortaliP10225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae VHS protein family.Curated

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
[Graphical view]
PfamiPF00867. XPG_I. 1 hit.
[Graphical view]
SUPFAMiSSF88723. SSF88723. 2 hits.

Sequencei

Sequence statusi: Complete.

P10225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLFGMMKFA HTHHLVKRRG LGAPAGYFTP IAVDLWNVMY TLVVKYQRRY
60 70 80 90 100
PSYDREAITL HCLCRLLKVF TQKSLFPIFV TDRGVNCMEP VVFGAKAILA
110 120 130 140 150
RTTAQCRTDE EASDVDASPP PSPITDSRPS SAFSNMRRRG TSLASGTRGT
160 170 180 190 200
AGSGAALPSA APSKPALRLA HLFCIRVLRA LGYAYINSGQ LEADDACANL
210 220 230 240 250
YHTNTVAYVY TTDTDLLLMG CDIVLDISAC YIPTINCRDI LKYFKMSYPQ
260 270 280 290 300
FLALFVRCHT DLHPNNTYAS VEDVLRECHW TPPSRSQTRR AIRREHTSSR
310 320 330 340 350
STETRPPLPP AAGGTETRVS WTEILTQQIA GGYEDDEDLP LDPRDVTGGH
360 370 380 390 400
PGPRSSSSEI LTPPELVQVP NAQLLEEHRS YVANPRRHVI HDAPESLDWL
410 420 430 440 450
PDPMTITELV EHRYIKYVIS LIGPKERGPW TLLKRLPIYQ DIRDENLARS
460 470 480
IVTRHITAPD IADRFLEQLR TQAPPPAFYK DVLAKFWDE
Length:489
Mass (Da):54,918
Last modified:July 1, 1989 - v1
Checksum:i3DD706B26A1873BD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti18R → H in strain: HSZP. 1
Natural varianti115V → A in strain: HSZP. 1
Natural varianti316E → K in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti364P → S in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti374L → R in strain: HSZP. 1
Natural varianti384 – 386NPR → SRQ in strain: HSZP. 3
Natural varianti385P → R in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti392D → N in strain: HSZP. 1
Natural varianti452V → M in strain: HSZP. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32304.1.
DQ889502 Genomic DNA. Translation: ABI63503.1.
Z72337 Genomic DNA. Translation: CAA96524.1.
PIRiE30088. WMBEF1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32304.1.
DQ889502 Genomic DNA. Translation: ABI63503.1.
Z72337 Genomic DNA. Translation: CAA96524.1.
PIRiE30088. WMBEF1.

3D structure databases

ProteinModelPortaliP10225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971408. 1 interactor.
DIPiDIP-57855N.
IntActiP10225. 8 interactors.
MINTiMINT-6732794.

Proteomic databases

PRIDEiP10225.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
[Graphical view]
PfamiPF00867. XPG_I. 1 hit.
[Graphical view]
SUPFAMiSSF88723. SSF88723. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSHUT_HHV11
AccessioniPrimary (citable) accession number: P10225
Secondary accession number(s): Q09I92, Q82170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 5, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Strain 17 is relatively weak regarding early shutoff compared to strain KOS. Strain HSZP protein is non-functional for host protein shutoff.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.