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Protein

Inner tegument protein

Gene

UL37

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in cytoplasmic secondary envelopment during viral egress. Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs. Modulates tegumentation and capsid accumulation at the viral assembly complex.UniRule annotation3 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Inner tegument proteinUniRule annotation
Gene namesi
Name:UL37
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • host cell Golgi apparatus Source: UniProtKB-SubCell
  • host cell nucleus Source: UniProtKB-SubCell
  • viral tegument Source: CACAO

Keywords - Cellular componenti

Host cytoplasm, Host Golgi apparatus, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160441 – 1123Inner tegument proteinAdd BLAST1123

Proteomic databases

PRIDEiP10221.

Interactioni

Subunit structurei

Interacts (via C-teminus) with the large tegument protein/LTP (via N-terminus) (By similarity). Interacts with host DST.UniRule annotation3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi971403. 7 interactors.
IntActiP10221. 2 interactors.
MINTiMINT-6732722.

Structurei

3D structure databases

ProteinModelPortaliP10221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni568 – 1123Interaction with large tegument proteinUniRule annotationAdd BLAST556

Sequence similaritiesi

Belongs to the herpesviridae inner tegument protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG09000013.

Family and domain databases

HAMAPiMF_04043. HSV_ITP. 1 hit.
InterProiView protein in InterPro
IPR005655. Herpes_UL37.
PfamiView protein in Pfam
PF03970. Herpes_UL37_1. 1 hit.

Sequencei

Sequence statusi: Complete.

P10221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRGLPSEA PVVTTSPAGP PSDGPMQRLL ASLAGLRQPP TPTAETANGA
60 70 80 90 100
DDPAFLATAK LRAAMAAFLL SGTAIAPADA RDCWRPLLEH LCALHRAHGL
110 120 130 140 150
PETALLAENL PGLLVHRLVV ALPEAPDQAF REMEVIKDTI LAVTGSDTSH
160 170 180 190 200
ALDSAGLRTA AALGPVRVRQ CAVEWIDRWQ TVTKSCLAMS PRTSIEALGE
210 220 230 240 250
TSLKMAPVPL GQPSANLTTP AYSLLFPAPF VQEGLRFLAL VSNRVTLFSA
260 270 280 290 300
HLQRIDDATL TPLTRALFTL ALVDEYLTTP ERGAVVPPPL LAQFQHTVRE
310 320 330 340 350
IDPAIMIPPL EANKMVRSRE EVRVSTALSR VSPRSACAPP GTLMARVRTD
360 370 380 390 400
VAVFDPDVPF LSSSALAVFQ PAVSSLLQLG EQPSAGAQQR LLALLQQTWT
410 420 430 440 450
LIQNTNSPSV VINTLIDAGF TPSHCTHYLS ALEGFLAAGV PARTPTGHGL
460 470 480 490 500
GEVQQLFGCI ALAGSNVFGL AREYGYYANY VKTFRRVQGA SEHTHGRLCE
510 520 530 540 550
AVGLSGGVLS QTLARIMGPA VPTEHLASLR RALVGEFETA ERRFSSGQPS
560 570 580 590 600
LLRETALIWI DVYGQTHWDI TPTTPATPLS ALLPVGQPSH APSVHLAAAT
610 620 630 640 650
QIRFPALEGI HPNVLADPGF VPYVLALVVG DALRATCSAA YLPRPVEFAL
660 670 680 690 700
RVLAWARDFG LGYLPTVEGH RTKLGALITL LEPAARGGLG PTMQMADNIE
710 720 730 740 750
QLLRELYVIS RGAVEQLRPL VQLQPPPPPE VGTSLLLISM YALAARGVLQ
760 770 780 790 800
DLAERADPLI RQLEDAIVLL RLHMRTLSAF FECRFESDGR RLYAVVGDTP
810 820 830 840 850
DRLGPWPPEA MGDAVSQYCS MYHDAKRALV ASLASLRSVI TETTAHLGVC
860 870 880 890 900
DELAAQVSHE DNVLAVVRRE IHGFLSVVSG IHARASKLLS GDQVPGFCFM
910 920 930 940 950
GQFLARWRRL SACYQAARAA AGPEPVAEFV QELHDTWKGL QTERAVVVAP
960 970 980 990 1000
LVSSADQRAA AIREVMAHAP EDAPPQSPAA DRVVLTSRRD LGAWGDYSLG
1010 1020 1030 1040 1050
PLGQTTAVPD SVDLSRQGLA VTLSMDWLLM NELLRVTDGV FRASAFRPLA
1060 1070 1080 1090 1100
GPESPRDLEV RDAGNSLPAP MPMDAQKPEA YGHGPRQADR EGAPHSNTPV
1110 1120
EDDEMIPEDT VAPPTDLPLT SYQ
Length:1,123
Mass (Da):120,556
Last modified:July 1, 1989 - v1
Checksum:i18425792B4D7EC9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32312.1.
PIRiA30088. WMBEH7.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32312.1.
PIRiA30088. WMBEH7.

3D structure databases

ProteinModelPortaliP10221.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971403. 7 interactors.
IntActiP10221. 2 interactors.
MINTiMINT-6732722.

Proteomic databases

PRIDEiP10221.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG09000013.

Family and domain databases

HAMAPiMF_04043. HSV_ITP. 1 hit.
InterProiView protein in InterPro
IPR005655. Herpes_UL37.
PfamiView protein in Pfam
PF03970. Herpes_UL37_1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiITP_HHV11
AccessioniPrimary (citable) accession number: P10221
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 15, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.