UniProtKB - P10221 (ITP_HHV11)
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Protein
Inner tegument protein
Gene
UL37
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Functioni
Plays an essential role in cytoplasmic secondary envelopment during viral egress. Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs. Modulates tegumentation and capsid accumulation at the viral assembly complex.UniRule annotation3 Publications
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- microtubule-dependent intracellular transport of viral material towards cell periphery Source: UniProtKB
- virion assembly Source: InterPro
Names & Taxonomyi
| Protein namesi | Recommended name: Inner tegument proteinUniRule annotation |
| Gene namesi | Name:UL37 |
| Organismi | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) |
| Taxonomic identifieri | 10299 [NCBI] |
| Taxonomic lineagei | Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › |
| Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
| Proteomesi |
|
Subcellular locationi
- Virion tegument UniRule annotation1 Publication
- Host cytoplasm UniRule annotation2 Publications
- Host nucleus UniRule annotation2 Publications
- Host Golgi apparatus › host trans-Golgi network UniRule annotation1 Publication
GO - Cellular componenti
- host cell Golgi apparatus Source: UniProtKB-SubCell
- host cell nucleus Source: UniProtKB-SubCell
- viral tegument Source: CACAO
Keywords - Cellular componenti
Host cytoplasm, Host Golgi apparatus, Host nucleus, Virion, Virion tegumentPTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000116044 | 1 – 1123 | Inner tegument proteinAdd BLAST | 1123 |
Proteomic databases
| PRIDEi | P10221. |
Interactioni
Subunit structurei
Interacts (via C-teminus) with the large tegument protein/LTP (via N-terminus) (By similarity). Interacts with host DST.UniRule annotation3 Publications
Binary interactionsi
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
| BioGridi | 971403. 7 interactors. |
| IntActi | P10221. 2 interactors. |
| MINTi | MINT-6732722. |
Structurei
3D structure databases
| ProteinModelPortali | P10221. |
| SMRi | P10221. |
| ModBasei | Search... |
| MobiDBi | Search... |
Family & Domainsi
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Regioni | 568 – 1123 | Interaction with large tegument proteinUniRule annotationAdd BLAST | 556 |
Sequence similaritiesi
Belongs to the herpesviridae inner tegument protein family.UniRule annotation
Phylogenomic databases
| OrthoDBi | VOG09000013. |
Family and domain databases
| HAMAPi | MF_04043. HSV_ITP. 1 hit. |
| InterProi | View protein in InterPro IPR005655. Herpes_UL37. IPR034738. HSV_ITP. |
| Pfami | View protein in Pfam PF03970. Herpes_UL37_1. 1 hit. |
Sequencei
Sequence statusi: Complete.
P10221-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADRGLPSEA PVVTTSPAGP PSDGPMQRLL ASLAGLRQPP TPTAETANGA
60 70 80 90 100
DDPAFLATAK LRAAMAAFLL SGTAIAPADA RDCWRPLLEH LCALHRAHGL
110 120 130 140 150
PETALLAENL PGLLVHRLVV ALPEAPDQAF REMEVIKDTI LAVTGSDTSH
160 170 180 190 200
ALDSAGLRTA AALGPVRVRQ CAVEWIDRWQ TVTKSCLAMS PRTSIEALGE
210 220 230 240 250
TSLKMAPVPL GQPSANLTTP AYSLLFPAPF VQEGLRFLAL VSNRVTLFSA
260 270 280 290 300
HLQRIDDATL TPLTRALFTL ALVDEYLTTP ERGAVVPPPL LAQFQHTVRE
310 320 330 340 350
IDPAIMIPPL EANKMVRSRE EVRVSTALSR VSPRSACAPP GTLMARVRTD
360 370 380 390 400
VAVFDPDVPF LSSSALAVFQ PAVSSLLQLG EQPSAGAQQR LLALLQQTWT
410 420 430 440 450
LIQNTNSPSV VINTLIDAGF TPSHCTHYLS ALEGFLAAGV PARTPTGHGL
460 470 480 490 500
GEVQQLFGCI ALAGSNVFGL AREYGYYANY VKTFRRVQGA SEHTHGRLCE
510 520 530 540 550
AVGLSGGVLS QTLARIMGPA VPTEHLASLR RALVGEFETA ERRFSSGQPS
560 570 580 590 600
LLRETALIWI DVYGQTHWDI TPTTPATPLS ALLPVGQPSH APSVHLAAAT
610 620 630 640 650
QIRFPALEGI HPNVLADPGF VPYVLALVVG DALRATCSAA YLPRPVEFAL
660 670 680 690 700
RVLAWARDFG LGYLPTVEGH RTKLGALITL LEPAARGGLG PTMQMADNIE
710 720 730 740 750
QLLRELYVIS RGAVEQLRPL VQLQPPPPPE VGTSLLLISM YALAARGVLQ
760 770 780 790 800
DLAERADPLI RQLEDAIVLL RLHMRTLSAF FECRFESDGR RLYAVVGDTP
810 820 830 840 850
DRLGPWPPEA MGDAVSQYCS MYHDAKRALV ASLASLRSVI TETTAHLGVC
860 870 880 890 900
DELAAQVSHE DNVLAVVRRE IHGFLSVVSG IHARASKLLS GDQVPGFCFM
910 920 930 940 950
GQFLARWRRL SACYQAARAA AGPEPVAEFV QELHDTWKGL QTERAVVVAP
960 970 980 990 1000
LVSSADQRAA AIREVMAHAP EDAPPQSPAA DRVVLTSRRD LGAWGDYSLG
1010 1020 1030 1040 1050
PLGQTTAVPD SVDLSRQGLA VTLSMDWLLM NELLRVTDGV FRASAFRPLA
1060 1070 1080 1090 1100
GPESPRDLEV RDAGNSLPAP MPMDAQKPEA YGHGPRQADR EGAPHSNTPV
1110 1120
EDDEMIPEDT VAPPTDLPLT SYQ
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA. Translation: CAA32312.1. |
| PIRi | A30088. WMBEH7. |
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | ITP_HHV11 | |
| Accessioni | P10221Primary (citable) accession number: P10221 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
| Last sequence update: | July 1, 1989 | |
| Last modified: | June 7, 2017 | |
| This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Viral Protein Annotation Program | |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families
