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P10220

- DEN_HHV11

UniProt

P10220 - DEN_HHV11

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Protein

Deneddylase

Gene

UL36

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei52 – 521Important for catalytic activityPROSITE-ProRule annotation
Active sitei65 – 6511 PublicationPROSITE-ProRule annotation
Active sitei197 – 1971PROSITE-ProRule annotation
Active sitei199 – 1991PROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: InterPro
  2. omega peptidase activity Source: InterPro

GO - Biological processi

  1. modulation by virus of host protein ubiquitination Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Host-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

Protein family/group databases

MEROPSiC76.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Deneddylase (EC:3.4.19.12, EC:3.4.22.-)
Alternative name(s):
Tegument protein VP1-2
Tegument protein VP1/2
Gene namesi
ORF Names:UL36
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion tegument. Host cytoplasm. Host nucleus
Note: Tightly associated with the capsid.

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. host cell nucleus Source: UniProtKB-KW
  3. viral tegument Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi65 – 651C → A: Complete loss of deubiquitination activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31643164DeneddylasePRO_0000116035Add
BLAST

Post-translational modificationi

Proteolytically processed, possibly into several polypeptides. Enzymatic activity is only detectable following cleavage of the UL36 protein, which occurs late during viral replication.1 Publication

Interactioni

Subunit structurei

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins (By similarity). Interacts with UL37.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UL37P102212EBI-7694334,EBI-6880600

Protein-protein interaction databases

IntActiP10220. 2 interactions.
MINTiMINT-6732711.

Structurei

3D structure databases

ProteinModelPortaliP10220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 263219Peptidase C76PROSITE-ProRule annotationAdd
BLAST
Repeati2911 – 291221
Repeati2913 – 291422
Repeati2915 – 291623
Repeati2917 – 291824
Repeati2919 – 292025
Repeati2921 – 292226
Repeati2923 – 292427
Repeati2925 – 292628
Repeati2927 – 292829
Repeati2929 – 2930210
Repeati2931 – 2932211
Repeati2933 – 2934212
Repeati2935 – 2936213
Repeati2937 – 2938214
Repeati2939 – 2940215
Repeati2941 – 2942216
Repeati2943 – 2944217
Repeati2945 – 2946218
Repeati2947 – 2948219
Repeati2949 – 2950220
Repeati2951 – 2952221
Repeati2953 – 2954222
Repeati2955 – 2956223
Repeati2957 – 2958224
Repeati2959 – 2960225
Repeati2961 – 2962226
Repeati2963 – 2964227
Repeati2965 – 2966228
Repeati2967 – 2968229
Repeati2969 – 2970230
Repeati2971 – 2972231
Repeati2973 – 2974232
Repeati2975 – 2976233
Repeati2977 – 2978234
Repeati2979 – 2980235

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 273273Deubiquitination activityBy similarityAdd
BLAST
Regioni579 – 60931Interaction with UL37Add
BLAST
Regioni2911 – 29807035 X 2 AA tandem repeats of P-QAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1020 – 105334Sequence AnalysisAdd
BLAST
Coiled coili1317 – 135438Sequence AnalysisAdd
BLAST
Coiled coili1741 – 176929Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi426 – 4338Nuclear localization signalBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi307 – 494188Pro-richAdd
BLAST
Compositional biasi1161 – 1288128Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the herpesviridae deneddylase family.Curated
Contains 1 peptidase C76 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR005210. Herpes_UL36.
IPR006928. Pept_C76_UL36-USP.
[Graphical view]
PfamiPF04843. Herpes_teg_N. 1 hit.
PF03586. Herpes_UL36. 1 hit.
[Graphical view]
PROSITEiPS51521. HTUSP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10220 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGGGNNTNPG GPVHKQAGSL ASRAHMIAGT PPHSTMERGG DRDIVVTGAR
60 70 80 90 100
NQFAPDLEPG GSVSCMRSSL SFLSLIFDVG PRDVLSAEAI EGCLVEGGEW
110 120 130 140 150
TRATAGPGPP RMCSIVELPN FLEYPGARGG LRCVFSRVYG EVGFFGEPAA
160 170 180 190 200
GLLETQCPAH TFFAGPWALR PLSYTLLTIG PLGMGLFRDG DTAYLFDPHG
210 220 230 240 250
LPEGTPAFIA KVRAGDMYPY LTYYTRDRPD VRWAGAMVFF VPSGPEPAAP
260 270 280 290 300
ADLTAAALHL YGASETYLQD EAFSERRVAI THPLRGEIAG LGEPCVGVGP
310 320 330 340 350
REGVGGPGPH PPTAAQSPPP TRARRDDRAS ETSRGTAGPS AKPEAKRPNR
360 370 380 390 400
APDDVWAVAL KGTPPTDPPS ADPPSADPPS AIPPPPPSAP KTPAAEAAEE
410 420 430 440 450
DDDDMRVLEM GVVPVGRHRA RYSAGLPKRR RPTWTPPSSV EDLTSGEKTK
460 470 480 490 500
RSAPPAKTKK KSTPKGKTPV GAAVPASVPE PVLASAPPDP AGPPVAEAGE
510 520 530 540 550
DDGPTVPASS QALEALKTRR SPEPPGADLA QLFEAHPNVA ATAVKFTACS
560 570 580 590 600
AALAREVAAC SRLTISALRS PYPASPGLLE LCVIFFFERV LAFLIENGAR
610 620 630 640 650
THTQAGVAGP AAALLEFTLN MLPWKTAVGD FLASTRLSLA DVAAHLPLVQ
660 670 680 690 700
HVLDENSLIG RLALAKLILV ARDVIRETDA FYGELADLEL QLRAAPPANL
710 720 730 740 750
YTRLGEWLLE RSQAHPDTLF APATPTHPEP LLYRVQALAK FARGEEIRVE
760 770 780 790 800
AEDRQMREAL DALARGVDAV SQHAGPLGVM PAPAGAAPQG APRPPPLGPE
810 820 830 840 850
AVQVRLEEVR TQARRAIEGA VKEYFYRGAV YSAKALQASD NNDRRFHVAS
860 870 880 890 900
AAVVPVVQLL ESLPVFDQHT RDIAQRAAIP APPPIATSPT AILLRDLIQR
910 920 930 940 950
GQTLDAPEDL AAWLSVLTDA ANQGLIERKP LDELARSIRD INDQQARRSS
960 970 980 990 1000
GLAELRRFDA LDAALGQQLD SDAAFVPAPG ASPYPDDGGL SPEATRMAEE
1010 1020 1030 1040 1050
ALRQARAMDA AKLTAELAPD ARARLRERAR SLEAMLEGAR ERAKVARDAR
1060 1070 1080 1090 1100
EKFLHKLQGV LRPLPDFVGL KACPAVLATL RASLPAGWSD LPEAVRGAPP
1110 1120 1130 1140 1150
EVTAALRADM WGLLGQYRDA LEHPTPDTAT ALSGLHPSFV VVLKNLFADA
1160 1170 1180 1190 1200
PETPFLLQFF ADHAPIIAHA VSNAINAGSA AVATADPAST VDAAVRAHRV
1210 1220 1230 1240 1250
LVDAVTALGA AASDPASPLA FLAAMADSAA GYVKATRLAL DARVAIAQLT
1260 1270 1280 1290 1300
TLGSAAADLV VQVRRAANQP EGEHASLIQA ATRATTGARE SLAGHEGRFG
1310 1320 1330 1340 1350
GLLHAEGTAG DHSPSGRALQ ELGKVIGATR RRADELEAAT ADLREKMAAQ
1360 1370 1380 1390 1400
RARSSHERWA ADVEAVLDRV ESGAEFDVVE LRRLQALAGT HGYNPRDFRK
1410 1420 1430 1440 1450
RAEQALGTNA KAVTLALETA LAFNPYTPEN QRHPMLPPLA AIHRIDWSAA
1460 1470 1480 1490 1500
FGAAADTYAD MFRVDTEPLA RLLRLAGGLL ERAQANDGFI DYHEAVLHLS
1510 1520 1530 1540 1550
EDLGGVPALR QYVPFFQKGY AEYVDIRDRL DALRADARRA IGSVALDLAA
1560 1570 1580 1590 1600
AAEEISAVRN DPAAAAELVR AGVTLPCPSE DALVACVAAL ERVDQSPVKD
1610 1620 1630 1640 1650
TAYAHYVAFV TRQDLADTKD AVVRAKQQRA EATERVTAGL REVLAARERR
1660 1670 1680 1690 1700
AQLEAEGLAN LKTLLKVVAV PATVAKTLDQ ARSAEEIADQ VEILVDQTEK
1710 1720 1730 1740 1750
ARELDVQAVA WLEHAQRTFE THPLSAASGD GPGLLTRQGA RLQALFDTRR
1760 1770 1780 1790 1800
RVEALRRSLE EAEAEWDEVW GRFGRVRGGA WKSPEGFRAA CEQLRALQDT
1810 1820 1830 1840 1850
TNTVSGLRAQ RDYERLPAKY QGVLGAKSAE RAGAVEELGG RVAQHADLSA
1860 1870 1880 1890 1900
RLRDEVVPRV AWEMNFDTLG GLLAEFDAVA GDLAPWAVEE FRGARELIQR
1910 1920 1930 1940 1950
RMGLYSAYAK ATGQTGAGAA AAPAPLLVDL RALDARARAS APPGQEADPQ
1960 1970 1980 1990 2000
MLRRRGEAYL RVSGGPGPLV LREATSTLDR PFAPSFLVPD GTPLQYALCF
2010 2020 2030 2040 2050
PAVTDKLGAL LMCPEAACIR PPLPTDTLES ASTVTAMYVL TVINRLQLAL
2060 2070 2080 2090 2100
SDAQAANFQL FGRFVRHRQA RWGASMDAAA ELYVALVATT LTREFGCRWA
2110 2120 2130 2140 2150
QLEWGGDAAA PGPPLGPQSS TRHRVSFNEN DVLVALVASS PEHIYTFWRL
2160 2170 2180 2190 2200
DLVRQHEYMH LTLPRAFQNA ADSMLFVQRL TPHPDARIRV LPAFSAGGPP
2210 2220 2230 2240 2250
TRGLMFGTRL ADWRRGKLSE TDPLAPWRSV PELGTERGAA LGKLSPAQAL
2260 2270 2280 2290 2300
AAVSVLGRMC LPSTALVALW TCMFPDDYTE YDSFDALLTA RLESGQTLSP
2310 2320 2330 2340 2350
SGGREASPPA PPNALYRPTG QHVAVPAAAT HRTPAARVTA MDLVLAAVLL
2360 2370 2380 2390 2400
GAPVVVALRN TTAFSRESEL ELCLTLFDSR ARGPDAALRD AVSSDIETWA
2410 2420 2430 2440 2450
VRLLHADLNP IENACLAAQL PRLSALIAER PLARGPPCLV LVDISMTPVA
2460 2470 2480 2490 2500
VLWENPDPPG PPDVRFVGSE ATEELPFVAG GEDVLAASAT DEDPFLARAI
2510 2520 2530 2540 2550
LGRPFDASLL SGELFPGHPV YQRAPDDQSP SVPNPTPGPV DLVGAEGSLG
2560 2570 2580 2590 2600
PGSLAPTLFT DATPGEPVPP RMWAWIHGLE ELASDDSGGP APLLAPDPLS
2610 2620 2630 2640 2650
PTADQSVPTS QCAPRPPGPA VTAREARPGV PAESTRPAPV GPRDDFRRLP
2660 2670 2680 2690 2700
SPQSSPAPPD ATAPRPPASS RASAASSSGS RARRHRRARS LARATQASAT
2710 2720 2730 2740 2750
TQGWRPPALP DTVAPVTDFA RPPAPPKPPE PAPHALVSGV PLPLGPQAAG
2760 2770 2780 2790 2800
QASPALPIDP VPPPVATGTV LPGGENRRPP LTSGPAPTPP RVPVGGPQRR
2810 2820 2830 2840 2850
LTRPAVASLS ESRESLPSPW DPADPTAPVL GRNPAEPTSS SPAGPSPPPP
2860 2870 2880 2890 2900
AVQPVAPPPT SGPPPTYLTL EGGVAPGGPV SRRPTTRQPV ATPTTSARPR
2910 2920 2930 2940 2950
GHLTVSRLSA PQPQPQPQPQ PQPQPQPQPQ PQPQPQPQPQ PQPQPQPQPQ
2960 2970 2980 2990 3000
PQPQPQPQPQ PQPQPQPQPQ PQPQPQPQPQ NGHVAPGEYP AVRFRAPQNR
3010 3020 3030 3040 3050
PSVPASASST NPRTGSSLSG VSSWASSLAL HIDATPPPVS LLQTLYVSDD
3060 3070 3080 3090 3100
EDSDATSLFL SDSEAEALDP LPGEPHSPIT NEPFSALSAD DSQEVTRLQF
3110 3120 3130 3140 3150
GPPPVSANAV LSRRYVQRTG RSALAVLIRA CYRLQQQLQR TRRALLHHSD
3160
AVLTSLHHVR MLLG
Length:3,164
Mass (Da):335,862
Last modified:July 1, 1989 - v1
Checksum:iCC5D31FF4F9FE3F4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti234 – 2341A → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti307 – 3071P → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti375 – 3795Missing in strain: Nonneuroinvasive mutant HF10.
Natural varianti392 – 3921T → P in strain: Nonneuroinvasive mutant HF10.
Natural varianti620 – 6201N → S in strain: Nonneuroinvasive mutant HF10.
Natural varianti624 – 6241W → R in strain: Nonneuroinvasive mutant HF10.
Natural varianti671 – 6711A → V in strain: Nonneuroinvasive mutant HF10.
Natural varianti885 – 8851I → M in strain: Nonneuroinvasive mutant HF10.
Natural varianti1023 – 10231A → V in strain: Nonneuroinvasive mutant HF10.
Natural varianti1244 – 12441V → G in strain: Nonneuroinvasive mutant HF10.
Natural varianti1373 – 13731G → S in strain: Nonneuroinvasive mutant HF10.
Natural varianti1389 – 13891G → D in strain: Nonneuroinvasive mutant HF10.
Natural varianti1419 – 14191T → M in strain: Nonneuroinvasive mutant HF10.
Natural varianti1470 – 14701A → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti1604 – 16041A → S in strain: Nonneuroinvasive mutant HF10.
Natural varianti1605 – 16051H → D in strain: 17 syn+ and Nonneuroinvasive mutant HF10.
Natural varianti1642 – 16421E → D in strain: Nonneuroinvasive mutant HF10.
Natural varianti1695 – 16951V → L in strain: Nonneuroinvasive mutant HF10.
Natural varianti1729 – 17291G → S in strain: Nonneuroinvasive mutant HF10.
Natural varianti1777 – 17771R → C in strain: Nonneuroinvasive mutant HF10.
Natural varianti1888 – 18881V → M in strain: Nonneuroinvasive mutant HF10.
Natural varianti1973 – 19731E → K in strain: Nonneuroinvasive mutant HF10.
Natural varianti2267 – 22671V → A in strain: Nonneuroinvasive mutant HF10.
Natural varianti2540 – 25401V → A in strain: Nonneuroinvasive mutant HF10.
Natural varianti2545 – 25451A → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti2646 – 26461F → V in strain: Nonneuroinvasive mutant HF10.
Natural varianti2666 – 26661P → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti2748 – 27481A → S in strain: Nonneuroinvasive mutant HF10.
Natural varianti2856 – 28561A → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti2875 – 28751A → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti2894 – 28941T → A in strain: Nonneuroinvasive mutant HF10.
Natural varianti2973 – 29786Missing in strain: Nonneuroinvasive mutant HF10.
Natural varianti3095 – 30951V → A in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32311.1.
DQ889502 Genomic DNA. Translation: ABI63498.1.
FJ593289 Genomic DNA. Translation: ACM62259.1.
PIRiI30085. WMBEH6.
RefSeqiNP_044638.2. NC_001806.1.

Genome annotation databases

GeneIDi2703357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32311.1 .
DQ889502 Genomic DNA. Translation: ABI63498.1 .
FJ593289 Genomic DNA. Translation: ACM62259.1 .
PIRi I30085. WMBEH6.
RefSeqi NP_044638.2. NC_001806.1.

3D structure databases

ProteinModelPortali P10220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P10220. 2 interactions.
MINTi MINT-6732711.

Protein family/group databases

MEROPSi C76.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703357.

Family and domain databases

InterProi IPR005210. Herpes_UL36.
IPR006928. Pept_C76_UL36-USP.
[Graphical view ]
Pfami PF04843. Herpes_teg_N. 1 hit.
PF03586. Herpes_UL36. 1 hit.
[Graphical view ]
PROSITEi PS51521. HTUSP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  3. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  4. "A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae."
    Kattenhorn L.M., Korbel G.A., Kessler B.M., Spooner E., Ploegh H.L.
    Mol. Cell 19:547-557(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, ACTIVE SITES, MUTAGENESIS OF CYS-65.
    Strain: KOS.
  5. "A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae."
    Schlieker C., Korbel G.A., Kattenhorn L.M., Ploegh H.L.
    J. Virol. 79:15582-15585(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Localization of herpes simplex virus type 1 UL37 in the Golgi complex requires UL36 but not capsid structures."
    Desai P., Sexton G.L., Huang E., Person S.
    J. Virol. 82:11354-11361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL37.
    Strain: KOS.
  7. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.
  8. "Proteolytic cleavage of VP1-2 is required for release of herpes simplex virus 1 DNA into the nucleus."
    Jovasevic V., Liang L., Roizman B.
    J. Virol. 82:3311-3319(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC CLEAVAGE.
    Strain: F.
  9. "UL36p is required for efficient transport of membrane-associated herpes simplex virus type 1 along microtubules."
    Shanda S.K., Wilson D.W.
    J. Virol. 82:7388-7394(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Identification of a highly conserved, functional nuclear localization signal within the N-terminal region of herpes simplex virus type 1 VP1-2 tegument protein."
    Abaitua F., O'Hare P.
    J. Virol. 82:5234-5244(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL.
  11. "Differing roles of inner tegument proteins pUL36 and pUL37 during entry of herpes simplex virus type 1."
    Roberts A.P., Abaitua F., O'Hare P., McNab D., Rixon F.J., Pasdeloup D.
    J. Virol. 83:105-116(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: 17 syn+.
  12. "A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases."
    Gastaldello S., Hildebrand S., Faridani O., Callegari S., Palmkvist M., Di Guglielmo C., Masucci M.G.
    Nat. Cell Biol. 12:351-361(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiDEN_HHV11
AccessioniPrimary (citable) accession number: P10220
Secondary accession number(s): B9VQG4, Q09I97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3