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P10220

- DEN_HHV11

UniProt

P10220 - DEN_HHV11

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Protein
Deneddylase
Gene
UL36
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Deneddylase that deregulates the host cell cycle S phase to create a favorable environment allowing efficient viral genome replication. Interacts with and deneddylates host cullins including CUL1 and CUL4A, thereby reducing their E3 ubiquitin ligase activity. Inhibition of cullins leads to the stabilization of cullin-RING ligase substrates such as host CDN1A/p21, CDKN1B/p27kip and CDC25A, preventing S phase progression. Additionally, acts as a deubiquitinase and cleaves both 'Lys-48' and 'Lys-63'-linked ubiquitin chains By similarity.4 Publications

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei52 – 521Important for catalytic activity By similarity
Active sitei65 – 6511 Publication
Active sitei197 – 1971 By similarity
Active sitei199 – 1991 By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: InterPro
  2. omega peptidase activity Source: InterPro
  3. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. modulation by virus of host protein ubiquitination Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Host-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

Protein family/group databases

MEROPSiC76.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Deneddylase (EC:3.4.19.12, EC:3.4.22.-)
Alternative name(s):
Tegument protein VP1-2
Tegument protein VP1/2
Gene namesi
ORF Names:UL36
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion tegument. Host cytoplasm. Host nucleus
Note: Tightly associated with the capsid.2 Publications

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. host cell nucleus Source: UniProtKB-SubCell
  3. viral tegument Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi65 – 651C → A: Complete loss of deubiquitination activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31643164Deneddylase
PRO_0000116035Add
BLAST

Post-translational modificationi

Proteolytically processed, possibly into several polypeptides. Enzymatic activity is only detectable following cleavage of the UL36 protein, which occurs late during viral replication.

Interactioni

Subunit structurei

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins By similarity. Interacts with UL37.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UL37P102212EBI-7694334,EBI-6880600

Protein-protein interaction databases

IntActiP10220. 2 interactions.
MINTiMINT-6732711.

Structurei

3D structure databases

ProteinModelPortaliP10220.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 263219Peptidase C76
Add
BLAST
Repeati2911 – 291221
Repeati2913 – 291422
Repeati2915 – 291623
Repeati2917 – 291824
Repeati2919 – 292025
Repeati2921 – 292226
Repeati2923 – 292427
Repeati2925 – 292628
Repeati2927 – 292829
Repeati2929 – 2930210
Repeati2931 – 2932211
Repeati2933 – 2934212
Repeati2935 – 2936213
Repeati2937 – 2938214
Repeati2939 – 2940215
Repeati2941 – 2942216
Repeati2943 – 2944217
Repeati2945 – 2946218
Repeati2947 – 2948219
Repeati2949 – 2950220
Repeati2951 – 2952221
Repeati2953 – 2954222
Repeati2955 – 2956223
Repeati2957 – 2958224
Repeati2959 – 2960225
Repeati2961 – 2962226
Repeati2963 – 2964227
Repeati2965 – 2966228
Repeati2967 – 2968229
Repeati2969 – 2970230
Repeati2971 – 2972231
Repeati2973 – 2974232
Repeati2975 – 2976233
Repeati2977 – 2978234
Repeati2979 – 2980235

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 273273Deubiquitination activity By similarity
Add
BLAST
Regioni579 – 60931Interaction with UL37
Add
BLAST
Regioni2911 – 29807035 X 2 AA tandem repeats of P-Q
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1020 – 105334 Reviewed prediction
Add
BLAST
Coiled coili1317 – 135438 Reviewed prediction
Add
BLAST
Coiled coili1741 – 176929 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi426 – 4338Nuclear localization signal By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi307 – 494188Pro-rich
Add
BLAST
Compositional biasi1161 – 1288128Ala-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR005210. Herpes_UL36.
IPR006928. Pept_C76_UL36-USP.
[Graphical view]
PfamiPF04843. Herpes_teg_N. 1 hit.
PF03586. Herpes_UL36. 1 hit.
[Graphical view]
PROSITEiPS51521. HTUSP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10220-1 [UniParc]FASTAAdd to Basket

« Hide

MGGGNNTNPG GPVHKQAGSL ASRAHMIAGT PPHSTMERGG DRDIVVTGAR     50
NQFAPDLEPG GSVSCMRSSL SFLSLIFDVG PRDVLSAEAI EGCLVEGGEW 100
TRATAGPGPP RMCSIVELPN FLEYPGARGG LRCVFSRVYG EVGFFGEPAA 150
GLLETQCPAH TFFAGPWALR PLSYTLLTIG PLGMGLFRDG DTAYLFDPHG 200
LPEGTPAFIA KVRAGDMYPY LTYYTRDRPD VRWAGAMVFF VPSGPEPAAP 250
ADLTAAALHL YGASETYLQD EAFSERRVAI THPLRGEIAG LGEPCVGVGP 300
REGVGGPGPH PPTAAQSPPP TRARRDDRAS ETSRGTAGPS AKPEAKRPNR 350
APDDVWAVAL KGTPPTDPPS ADPPSADPPS AIPPPPPSAP KTPAAEAAEE 400
DDDDMRVLEM GVVPVGRHRA RYSAGLPKRR RPTWTPPSSV EDLTSGEKTK 450
RSAPPAKTKK KSTPKGKTPV GAAVPASVPE PVLASAPPDP AGPPVAEAGE 500
DDGPTVPASS QALEALKTRR SPEPPGADLA QLFEAHPNVA ATAVKFTACS 550
AALAREVAAC SRLTISALRS PYPASPGLLE LCVIFFFERV LAFLIENGAR 600
THTQAGVAGP AAALLEFTLN MLPWKTAVGD FLASTRLSLA DVAAHLPLVQ 650
HVLDENSLIG RLALAKLILV ARDVIRETDA FYGELADLEL QLRAAPPANL 700
YTRLGEWLLE RSQAHPDTLF APATPTHPEP LLYRVQALAK FARGEEIRVE 750
AEDRQMREAL DALARGVDAV SQHAGPLGVM PAPAGAAPQG APRPPPLGPE 800
AVQVRLEEVR TQARRAIEGA VKEYFYRGAV YSAKALQASD NNDRRFHVAS 850
AAVVPVVQLL ESLPVFDQHT RDIAQRAAIP APPPIATSPT AILLRDLIQR 900
GQTLDAPEDL AAWLSVLTDA ANQGLIERKP LDELARSIRD INDQQARRSS 950
GLAELRRFDA LDAALGQQLD SDAAFVPAPG ASPYPDDGGL SPEATRMAEE 1000
ALRQARAMDA AKLTAELAPD ARARLRERAR SLEAMLEGAR ERAKVARDAR 1050
EKFLHKLQGV LRPLPDFVGL KACPAVLATL RASLPAGWSD LPEAVRGAPP 1100
EVTAALRADM WGLLGQYRDA LEHPTPDTAT ALSGLHPSFV VVLKNLFADA 1150
PETPFLLQFF ADHAPIIAHA VSNAINAGSA AVATADPAST VDAAVRAHRV 1200
LVDAVTALGA AASDPASPLA FLAAMADSAA GYVKATRLAL DARVAIAQLT 1250
TLGSAAADLV VQVRRAANQP EGEHASLIQA ATRATTGARE SLAGHEGRFG 1300
GLLHAEGTAG DHSPSGRALQ ELGKVIGATR RRADELEAAT ADLREKMAAQ 1350
RARSSHERWA ADVEAVLDRV ESGAEFDVVE LRRLQALAGT HGYNPRDFRK 1400
RAEQALGTNA KAVTLALETA LAFNPYTPEN QRHPMLPPLA AIHRIDWSAA 1450
FGAAADTYAD MFRVDTEPLA RLLRLAGGLL ERAQANDGFI DYHEAVLHLS 1500
EDLGGVPALR QYVPFFQKGY AEYVDIRDRL DALRADARRA IGSVALDLAA 1550
AAEEISAVRN DPAAAAELVR AGVTLPCPSE DALVACVAAL ERVDQSPVKD 1600
TAYAHYVAFV TRQDLADTKD AVVRAKQQRA EATERVTAGL REVLAARERR 1650
AQLEAEGLAN LKTLLKVVAV PATVAKTLDQ ARSAEEIADQ VEILVDQTEK 1700
ARELDVQAVA WLEHAQRTFE THPLSAASGD GPGLLTRQGA RLQALFDTRR 1750
RVEALRRSLE EAEAEWDEVW GRFGRVRGGA WKSPEGFRAA CEQLRALQDT 1800
TNTVSGLRAQ RDYERLPAKY QGVLGAKSAE RAGAVEELGG RVAQHADLSA 1850
RLRDEVVPRV AWEMNFDTLG GLLAEFDAVA GDLAPWAVEE FRGARELIQR 1900
RMGLYSAYAK ATGQTGAGAA AAPAPLLVDL RALDARARAS APPGQEADPQ 1950
MLRRRGEAYL RVSGGPGPLV LREATSTLDR PFAPSFLVPD GTPLQYALCF 2000
PAVTDKLGAL LMCPEAACIR PPLPTDTLES ASTVTAMYVL TVINRLQLAL 2050
SDAQAANFQL FGRFVRHRQA RWGASMDAAA ELYVALVATT LTREFGCRWA 2100
QLEWGGDAAA PGPPLGPQSS TRHRVSFNEN DVLVALVASS PEHIYTFWRL 2150
DLVRQHEYMH LTLPRAFQNA ADSMLFVQRL TPHPDARIRV LPAFSAGGPP 2200
TRGLMFGTRL ADWRRGKLSE TDPLAPWRSV PELGTERGAA LGKLSPAQAL 2250
AAVSVLGRMC LPSTALVALW TCMFPDDYTE YDSFDALLTA RLESGQTLSP 2300
SGGREASPPA PPNALYRPTG QHVAVPAAAT HRTPAARVTA MDLVLAAVLL 2350
GAPVVVALRN TTAFSRESEL ELCLTLFDSR ARGPDAALRD AVSSDIETWA 2400
VRLLHADLNP IENACLAAQL PRLSALIAER PLARGPPCLV LVDISMTPVA 2450
VLWENPDPPG PPDVRFVGSE ATEELPFVAG GEDVLAASAT DEDPFLARAI 2500
LGRPFDASLL SGELFPGHPV YQRAPDDQSP SVPNPTPGPV DLVGAEGSLG 2550
PGSLAPTLFT DATPGEPVPP RMWAWIHGLE ELASDDSGGP APLLAPDPLS 2600
PTADQSVPTS QCAPRPPGPA VTAREARPGV PAESTRPAPV GPRDDFRRLP 2650
SPQSSPAPPD ATAPRPPASS RASAASSSGS RARRHRRARS LARATQASAT 2700
TQGWRPPALP DTVAPVTDFA RPPAPPKPPE PAPHALVSGV PLPLGPQAAG 2750
QASPALPIDP VPPPVATGTV LPGGENRRPP LTSGPAPTPP RVPVGGPQRR 2800
LTRPAVASLS ESRESLPSPW DPADPTAPVL GRNPAEPTSS SPAGPSPPPP 2850
AVQPVAPPPT SGPPPTYLTL EGGVAPGGPV SRRPTTRQPV ATPTTSARPR 2900
GHLTVSRLSA PQPQPQPQPQ PQPQPQPQPQ PQPQPQPQPQ PQPQPQPQPQ 2950
PQPQPQPQPQ PQPQPQPQPQ PQPQPQPQPQ NGHVAPGEYP AVRFRAPQNR 3000
PSVPASASST NPRTGSSLSG VSSWASSLAL HIDATPPPVS LLQTLYVSDD 3050
EDSDATSLFL SDSEAEALDP LPGEPHSPIT NEPFSALSAD DSQEVTRLQF 3100
GPPPVSANAV LSRRYVQRTG RSALAVLIRA CYRLQQQLQR TRRALLHHSD 3150
AVLTSLHHVR MLLG 3164
Length:3,164
Mass (Da):335,862
Last modified:July 1, 1989 - v1
Checksum:iCC5D31FF4F9FE3F4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti234 – 2341A → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti307 – 3071P → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti375 – 3795Missing in strain: Nonneuroinvasive mutant HF10.
Natural varianti392 – 3921T → P in strain: Nonneuroinvasive mutant HF10.
Natural varianti620 – 6201N → S in strain: Nonneuroinvasive mutant HF10.
Natural varianti624 – 6241W → R in strain: Nonneuroinvasive mutant HF10.
Natural varianti671 – 6711A → V in strain: Nonneuroinvasive mutant HF10.
Natural varianti885 – 8851I → M in strain: Nonneuroinvasive mutant HF10.
Natural varianti1023 – 10231A → V in strain: Nonneuroinvasive mutant HF10.
Natural varianti1244 – 12441V → G in strain: Nonneuroinvasive mutant HF10.
Natural varianti1373 – 13731G → S in strain: Nonneuroinvasive mutant HF10.
Natural varianti1389 – 13891G → D in strain: Nonneuroinvasive mutant HF10.
Natural varianti1419 – 14191T → M in strain: Nonneuroinvasive mutant HF10.
Natural varianti1470 – 14701A → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti1604 – 16041A → S in strain: Nonneuroinvasive mutant HF10.
Natural varianti1605 – 16051H → D in strain: 17 syn+ and Nonneuroinvasive mutant HF10.
Natural varianti1642 – 16421E → D in strain: Nonneuroinvasive mutant HF10.
Natural varianti1695 – 16951V → L in strain: Nonneuroinvasive mutant HF10.
Natural varianti1729 – 17291G → S in strain: Nonneuroinvasive mutant HF10.
Natural varianti1777 – 17771R → C in strain: Nonneuroinvasive mutant HF10.
Natural varianti1888 – 18881V → M in strain: Nonneuroinvasive mutant HF10.
Natural varianti1973 – 19731E → K in strain: Nonneuroinvasive mutant HF10.
Natural varianti2267 – 22671V → A in strain: Nonneuroinvasive mutant HF10.
Natural varianti2540 – 25401V → A in strain: Nonneuroinvasive mutant HF10.
Natural varianti2545 – 25451A → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti2646 – 26461F → V in strain: Nonneuroinvasive mutant HF10.
Natural varianti2666 – 26661P → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti2748 – 27481A → S in strain: Nonneuroinvasive mutant HF10.
Natural varianti2856 – 28561A → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti2875 – 28751A → T in strain: Nonneuroinvasive mutant HF10.
Natural varianti2894 – 28941T → A in strain: Nonneuroinvasive mutant HF10.
Natural varianti2973 – 29786Missing in strain: Nonneuroinvasive mutant HF10.
Natural varianti3095 – 30951V → A in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32311.1.
DQ889502 Genomic DNA. Translation: ABI63498.1.
FJ593289 Genomic DNA. Translation: ACM62259.1.
PIRiI30085. WMBEH6.
RefSeqiNP_044638.2. NC_001806.1.

Genome annotation databases

GeneIDi2703357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32311.1 .
DQ889502 Genomic DNA. Translation: ABI63498.1 .
FJ593289 Genomic DNA. Translation: ACM62259.1 .
PIRi I30085. WMBEH6.
RefSeqi NP_044638.2. NC_001806.1.

3D structure databases

ProteinModelPortali P10220.
ModBasei Search...

Protein-protein interaction databases

IntActi P10220. 2 interactions.
MINTi MINT-6732711.

Protein family/group databases

MEROPSi C76.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703357.

Family and domain databases

InterProi IPR005210. Herpes_UL36.
IPR006928. Pept_C76_UL36-USP.
[Graphical view ]
Pfami PF04843. Herpes_teg_N. 1 hit.
PF03586. Herpes_UL36. 1 hit.
[Graphical view ]
PROSITEi PS51521. HTUSP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  3. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  4. "A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae."
    Kattenhorn L.M., Korbel G.A., Kessler B.M., Spooner E., Ploegh H.L.
    Mol. Cell 19:547-557(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, ACTIVE SITES, MUTAGENESIS OF CYS-65.
    Strain: KOS.
  5. "A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae."
    Schlieker C., Korbel G.A., Kattenhorn L.M., Ploegh H.L.
    J. Virol. 79:15582-15585(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Localization of herpes simplex virus type 1 UL37 in the Golgi complex requires UL36 but not capsid structures."
    Desai P., Sexton G.L., Huang E., Person S.
    J. Virol. 82:11354-11361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL37.
    Strain: KOS.
  7. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.
  8. "Proteolytic cleavage of VP1-2 is required for release of herpes simplex virus 1 DNA into the nucleus."
    Jovasevic V., Liang L., Roizman B.
    J. Virol. 82:3311-3319(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC CLEAVAGE.
    Strain: F.
  9. "UL36p is required for efficient transport of membrane-associated herpes simplex virus type 1 along microtubules."
    Shanda S.K., Wilson D.W.
    J. Virol. 82:7388-7394(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Identification of a highly conserved, functional nuclear localization signal within the N-terminal region of herpes simplex virus type 1 VP1-2 tegument protein."
    Abaitua F., O'Hare P.
    J. Virol. 82:5234-5244(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL.
  11. "Differing roles of inner tegument proteins pUL36 and pUL37 during entry of herpes simplex virus type 1."
    Roberts A.P., Abaitua F., O'Hare P., McNab D., Rixon F.J., Pasdeloup D.
    J. Virol. 83:105-116(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: 17 syn+.
  12. "A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases."
    Gastaldello S., Hildebrand S., Faridani O., Callegari S., Palmkvist M., Di Guglielmo C., Masucci M.G.
    Nat. Cell Biol. 12:351-361(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiDEN_HHV11
AccessioniPrimary (citable) accession number: P10220
Secondary accession number(s): B9VQG4, Q09I97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi