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P10219 (VP26_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Capsid protein VP26
Gene names
Name:UL35
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length112 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument. Complexes composed of the capsid protein VP5 and VP26 assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly.

Subunit structure

Interacts with VP5. Interacts with host TSPAN7; this interaction may be responsible for the presence of TSPAN7 in extracellular virions. Ref.3 Ref.4

Subcellular location

Virion Potential. Host nucleus Ref.2.

Sequence similarities

Belongs to the herpesviridae UL35 family.

Ontologies

Keywords
   Biological processHost-virus interaction
   Cellular componentCapsid protein
Host nucleus
Virion
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processviral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral capsid

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 112112Capsid protein VP26
PRO_0000115734

Sequences

Sequence LengthMass (Da)Tools
P10219 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: ACC56F7EA0BA7384

FASTA11212,096
        10         20         30         40         50         60 
MAVPQFHRPS TVTTDSVRAL GMRGLVLATN NSQFIMDNNH PHPQGTQGAV REFLRGQAAA 

        70         80         90        100        110 
LTDLGLAHAN NTFTPQPMFA GDAPAAWLRP AFGLRRTYSP FVVREPSTPG TP 

« Hide

References

[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins."
Rixon F.J., Addison C., McGregor A., Macnab S.J., Nicholson P., Preston V.G., Tatman J.D.
J. Gen. Virol. 77:2251-2260(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[3]"Residues of VP26 of herpes simplex virus type 1 that are required for its interaction with capsids."
Desai P., Akpa J.C., Person S.
J. Virol. 77:391-404(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH VP5.
Strain: KOS.
[4]"Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein."
Wang L., Liu L., Che Y., Wang L., Jiang L., Dong C., Zhang Y., Li Q.
Virol. J. 7:156-156(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HOST TSPAN7.
[5]"Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1."
Davison M.D., Rixon F.J., Davison A.J.
J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-33 AND 37-47.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32310.1.
PIRWMBEH5. H30085.
RefSeqNP_044637.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP10219. 1 interaction.
MINTMINT-6732662.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703356.

Family and domain databases

InterProIPR007584. Herpes_UL35.
[Graphical view]
PfamPF04496. Herpes_UL35. 1 hit.
[Graphical view]
ProDomPD010669. UL35. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameVP26_HHV11
AccessionPrimary (citable) accession number: P10219
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families