P10219 (VP26_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Capsid protein VP26

Gene names

Name:

UL35

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	112 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument. Complexes composed of the capsid protein VP5 and VP26 assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly.
Subunit structure	Interacts with VP5. Interacts with host TSPAN7; this interaction may be responsible for the presence of TSPAN7 in extracellular virions. Ref.3 Ref.4
Subcellular location	Virion Potential. Host nucleus Ref.2.
Sequence similarities	Belongs to the herpesviridae UL35 family.

Ontologies

Keywords
Biological process	Host-virus interaction
Cellular component	Host nucleus Virion
Molecular function	Capsid protein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 112	112	Capsid protein VP26		PRO_0000115734

Sequences

	Sequence		Length	Mass (Da)
	P10219 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: ACC56F7EA0BA7384	FASTA	112	12,096
	10 20 30 40 50 60 MAVPQFHRPS TVTTDSVRAL GMRGLVLATN NSQFIMDNNH PHPQGTQGAV REFLRGQAAA 70 80 90 100 110 LTDLGLAHAN NTFTPQPMFA GDAPAAWLRP AFGLRRTYSP FVVREPSTPG TP

References

[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins." Rixon F.J., Addison C., McGregor A., Macnab S.J., Nicholson P., Preston V.G., Tatman J.D. J. Gen. Virol. 77:2251-2260(1996) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[3]	"Residues of VP26 of herpes simplex virus type 1 that are required for its interaction with capsids." Desai P., Akpa J.C., Person S. J. Virol. 77:391-404(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH VP5. Strain: KOS.
[4]	"Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein." Wang L., Liu L., Che Y., Wang L., Jiang L., Dong C., Zhang Y., Li Q. Virol. J. 7:156-156(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HOST TSPAN7.
[5]	"Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1." Davison M.D., Rixon F.J., Davison A.J. J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-33 AND 37-47.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32310.1.
PIR	WMBEH5. H30085.
RefSeq	NP_044637.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6732662.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703356.
Phylogenomic databases
ProtClustDB	CLSP2510160.
Family and domain databases
InterPro	IPR007584. Herpes_UL35. [Graphical view]
Pfam	PF04496. Herpes_UL35. 1 hit. [Graphical view]
ProDom	PD010669. UL35. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

VP26_HHV11

Accession

Primary (citable) accession number: P10219

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program