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Protein

Small capsomere-interacting protein

Gene

SCP

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument. Complexes composed of the major capsid protein and small capsomere-interacting protein/SCP assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly (By similarity). Interaction with host dynein light chains suggests a possible function in the retrogarde transport of incoming viral capsids.UniRule annotation1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Small capsomere-interacting proteinUniRule annotation
Gene namesi
Name:SCPUniRule annotation
Ordered Locus Names:UL35
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157341 – 112Small capsomere-interacting proteinAdd BLAST112

Proteomic databases

PRIDEiP10219.

Interactioni

Subunit structurei

Interacts with the major capsid protein/MCP. Interacts with host TSPAN7; this interaction may be responsible for the presence of TSPAN7 in extracellular virions. Interacts with host MAPRE3 and TCTEX1D1; these interactions mediate retrograde transport of viral capsids.UniRule annotation2 Publications

Protein-protein interaction databases

IntActiP10219. 1 interactor.
MINTiMINT-6732662.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae small capsomere-interacting protein family.UniRule annotation

Family and domain databases

HAMAPiMF_04020. HSV_SCP_alphahv. 1 hit.
InterProiIPR007584. Herpes_UL35.
[Graphical view]
PfamiPF04496. Herpes_UL35. 1 hit.
[Graphical view]
ProDomiPD010669. UL35. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P10219-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPQFHRPS TVTTDSVRAL GMRGLVLATN NSQFIMDNNH PHPQGTQGAV
60 70 80 90 100
REFLRGQAAA LTDLGLAHAN NTFTPQPMFA GDAPAAWLRP AFGLRRTYSP
110
FVVREPSTPG TP
Length:112
Mass (Da):12,096
Last modified:July 1, 1989 - v1
Checksum:iACC56F7EA0BA7384
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32310.1.
PIRiH30085. WMBEH5.
RefSeqiYP_009137110.1. NC_001806.2.

Genome annotation databases

GeneIDi2703356.
KEGGivg:2703356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32310.1.
PIRiH30085. WMBEH5.
RefSeqiYP_009137110.1. NC_001806.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10219. 1 interactor.
MINTiMINT-6732662.

Proteomic databases

PRIDEiP10219.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703356.
KEGGivg:2703356.

Family and domain databases

HAMAPiMF_04020. HSV_SCP_alphahv. 1 hit.
InterProiIPR007584. Herpes_UL35.
[Graphical view]
PfamiPF04496. Herpes_UL35. 1 hit.
[Graphical view]
ProDomiPD010669. UL35. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiSCP_HHV11
AccessioniPrimary (citable) accession number: P10219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 5, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.