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Protein

Small capsomere-interacting protein

Gene

SCP

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument. Complexes composed of the major capsid protein and small capsomere-interacting protein/SCP assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly (By similarity). Interaction with host dynein light chains suggests a possible function in the retrogarde transport of incoming viral capsids.UniRule annotation1 Publication

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Small capsomere-interacting proteinUniRule annotation
Gene namesi
Name:SCPUniRule annotation
Ordered Locus Names:UL35
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157341 – 112Small capsomere-interacting proteinAdd BLAST112

Proteomic databases

PRIDEiP10219.

Interactioni

Subunit structurei

Interacts with the major capsid protein/MCP. Interacts with host TSPAN7; this interaction may be responsible for the presence of TSPAN7 in extracellular virions. Interacts with host MAPRE3 and TCTEX1D1; these interactions mediate retrograde transport of viral capsids.UniRule annotation2 Publications

Protein-protein interaction databases

IntActiP10219. 1 interactor.
MINTiMINT-6732662.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae small capsomere-interacting protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900016F.

Family and domain databases

HAMAPiMF_04020. HSV_SCP_alphahv. 1 hit.
InterProiView protein in InterPro
IPR007584. Herpes_UL35.
PfamiView protein in Pfam
PF04496. Herpes_UL35. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010669. UL35. 1 hit.

Sequencei

Sequence statusi: Complete.

P10219-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPQFHRPS TVTTDSVRAL GMRGLVLATN NSQFIMDNNH PHPQGTQGAV
60 70 80 90 100
REFLRGQAAA LTDLGLAHAN NTFTPQPMFA GDAPAAWLRP AFGLRRTYSP
110
FVVREPSTPG TP
Length:112
Mass (Da):12,096
Last modified:July 1, 1989 - v1
Checksum:iACC56F7EA0BA7384
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32310.1.
PIRiH30085. WMBEH5.
RefSeqiYP_009137110.1. NC_001806.2.

Genome annotation databases

GeneIDi2703356.
KEGGivg:2703356.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSCP_HHV11
AccessioniPrimary (citable) accession number: P10219
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 15, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families