Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P10219

- VP26_HHV11

UniProt

P10219 - VP26_HHV11

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Capsid protein VP26

Gene

UL35

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument. Complexes composed of the capsid protein VP5 and VP26 assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly.

GO - Biological processi

  1. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid protein VP26
Gene namesi
Name:UL35
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion Curated. Host nucleus 1 Publication

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
  2. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 112112Capsid protein VP26PRO_0000115734Add
BLAST

Interactioni

Subunit structurei

Interacts with VP5. Interacts with host TSPAN7; this interaction may be responsible for the presence of TSPAN7 in extracellular virions.2 Publications

Protein-protein interaction databases

IntActiP10219. 1 interaction.
MINTiMINT-6732662.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae UL35 family.Curated

Family and domain databases

InterProiIPR007584. Herpes_UL35.
[Graphical view]
PfamiPF04496. Herpes_UL35. 1 hit.
[Graphical view]
ProDomiPD010669. UL35. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P10219-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVPQFHRPS TVTTDSVRAL GMRGLVLATN NSQFIMDNNH PHPQGTQGAV
60 70 80 90 100
REFLRGQAAA LTDLGLAHAN NTFTPQPMFA GDAPAAWLRP AFGLRRTYSP
110
FVVREPSTPG TP
Length:112
Mass (Da):12,096
Last modified:July 1, 1989 - v1
Checksum:iACC56F7EA0BA7384
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32310.1.
PIRiH30085. WMBEH5.
RefSeqiNP_044637.1. NC_001806.1.

Genome annotation databases

GeneIDi2703356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32310.1 .
PIRi H30085. WMBEH5.
RefSeqi NP_044637.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P10219. 1 interaction.
MINTi MINT-6732662.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703356.

Family and domain databases

InterProi IPR007584. Herpes_UL35.
[Graphical view ]
Pfami PF04496. Herpes_UL35. 1 hit.
[Graphical view ]
ProDomi PD010669. UL35. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins."
    Rixon F.J., Addison C., McGregor A., Macnab S.J., Nicholson P., Preston V.G., Tatman J.D.
    J. Gen. Virol. 77:2251-2260(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  3. "Residues of VP26 of herpes simplex virus type 1 that are required for its interaction with capsids."
    Desai P., Akpa J.C., Person S.
    J. Virol. 77:391-404(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VP5.
    Strain: KOS.
  4. "Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein."
    Wang L., Liu L., Che Y., Wang L., Jiang L., Dong C., Zhang Y., Li Q.
    Virol. J. 7:156-156(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOST TSPAN7.
  5. "Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1."
    Davison M.D., Rixon F.J., Davison A.J.
    J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-33 AND 37-47.

Entry informationi

Entry nameiVP26_HHV11
AccessioniPrimary (citable) accession number: P10219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3