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P10219

- VP26_HHV11

UniProt

P10219 - VP26_HHV11

Protein

Capsid protein VP26

Gene

UL35

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument. Complexes composed of the capsid protein VP5 and VP26 assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly.

    GO - Biological processi

    1. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Capsid protein VP26
    Gene namesi
    Name:UL35
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Virion Curated. Host nucleus 1 Publication

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell
    2. viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host nucleus, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 112112Capsid protein VP26PRO_0000115734Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with VP5. Interacts with host TSPAN7; this interaction may be responsible for the presence of TSPAN7 in extracellular virions.2 Publications

    Protein-protein interaction databases

    IntActiP10219. 1 interaction.
    MINTiMINT-6732662.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the herpesviridae UL35 family.Curated

    Family and domain databases

    InterProiIPR007584. Herpes_UL35.
    [Graphical view]
    PfamiPF04496. Herpes_UL35. 1 hit.
    [Graphical view]
    ProDomiPD010669. UL35. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P10219-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVPQFHRPS TVTTDSVRAL GMRGLVLATN NSQFIMDNNH PHPQGTQGAV    50
    REFLRGQAAA LTDLGLAHAN NTFTPQPMFA GDAPAAWLRP AFGLRRTYSP 100
    FVVREPSTPG TP 112
    Length:112
    Mass (Da):12,096
    Last modified:July 1, 1989 - v1
    Checksum:iACC56F7EA0BA7384
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32310.1.
    PIRiH30085. WMBEH5.
    RefSeqiNP_044637.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32310.1 .
    PIRi H30085. WMBEH5.
    RefSeqi NP_044637.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P10219. 1 interaction.
    MINTi MINT-6732662.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703356.

    Family and domain databases

    InterProi IPR007584. Herpes_UL35.
    [Graphical view ]
    Pfami PF04496. Herpes_UL35. 1 hit.
    [Graphical view ]
    ProDomi PD010669. UL35. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins."
      Rixon F.J., Addison C., McGregor A., Macnab S.J., Nicholson P., Preston V.G., Tatman J.D.
      J. Gen. Virol. 77:2251-2260(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    3. "Residues of VP26 of herpes simplex virus type 1 that are required for its interaction with capsids."
      Desai P., Akpa J.C., Person S.
      J. Virol. 77:391-404(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH VP5.
      Strain: KOS.
    4. "Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein."
      Wang L., Liu L., Che Y., Wang L., Jiang L., Dong C., Zhang Y., Li Q.
      Virol. J. 7:156-156(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HOST TSPAN7.
    5. "Identification of genes encoding two capsid proteins (VP24 and VP26) of herpes simplex virus type 1."
      Davison M.D., Rixon F.J., Davison A.J.
      J. Gen. Virol. 73:2709-2713(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-33 AND 37-47.

    Entry informationi

    Entry nameiVP26_HHV11
    AccessioniPrimary (citable) accession number: P10219
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3